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Effect of gas mixing on Xe ion currents from an ECR ion source

Published: Jun 7, 2019

Author(s): Anuvab Mandal, K.V. Thulasiram, W. Fernandes, Lokesh C. Tribedi

Journal: X-Ray Spectrometry

Gas mixing technique has been used in order to increase the current of highly charged ions of Xe at the TIFR‐ECRIA. The He, N2, O2, Ne, and Ar are used as support gases, and their effect on output currents of Xe ions is studied. The effective ion charge and the total loss rate of ions are calculated from the measured currents. It is found that molecular gases, such as N2 and O2, exhibit better mixing effect in the enhancement of output of highly charged Xe ions. Furthermore, we describe this...

Read More thumbnail image: Effect of gas mixing on Xe ion currents from an ECR ion source

Understanding hydrophobicity variations in dense medium ferrosilicon from different production routes

Published: Jun 6, 2019

Author(s): Iyiola Olatunji Otunniyi, Oluwayimika O. Oluokun

Journal: Surface and Interface Analysis

Dense medium ferrosilicon (FeSi) powders produced via submerged arc furnace smelting, granulation, and milling route show varying hydrophobicity, sometimes totally nonwetting, amounting to production losses. This does not occur in powders produced via induction furnace smelting and atomization. Although wetting is fundamentally a surface phenomenon, bulk property can dictate surface behavior. Hence, for detailed insight into the cause of the variation, particles of powders from different...

Read More thumbnail image: Understanding hydrophobicity variations in dense medium ferrosilicon from different production routes

Comparative proteomics analysis between biofilm and planktonic cells of Mycobacterium tuberculosis

Published: Jun 6, 2019

Author(s): Chao Wang, Qiaoli Zhang, Yang Wang, Xudong Tang, Yanan An, Shulin Li, Hongyue Xu, Yan Li, Wenjing Luan, Xuefei Wang, Mingyuan Liu, Lu Yu

Journal: ELECTROPHORESIS

Abstract Tuberculosis is highly persistent and displays phenotypic resistance to high concentrations of antimicrobials. Recent reports exhibited that Mycobacterium tuberculosis biofilm was implicated to its pathogenicity and drug resistance. In this study, there were 47 kinds of differential proteins in the biofilm of M. tuberculosis H37Rv cells compared with the planktonic bacteria, and 37 proteins were nonredundant and identified by proteomics approach, such as 2DE and LC‐MS/MS. Moreover,...

Read More thumbnail image: Comparative proteomics analysis between biofilm and planktonic cells of Mycobacterium tuberculosis

CE‐SDS method development, validation, and best practice—An overview

Published: Jun 6, 2019

Author(s): Cari E. Sänger–van de Griend

Journal: ELECTROPHORESIS

Abstract CE‐SDS has been implemented in the biopharmaceutical industry and is being used for the characterization of therapeutic proteins in most Biological License Applications currently submitted. An overview is presented on the separation mechanism, methodology, and good working practices/best practices. The CE‐SDS platform method development and validation are discussed and typical scientifically and regulatory issues and troubleshooting situations are highlighted.

Read More thumbnail image: CESDS method development validation and best practiceAn overview

A proposal for the adsorption of anastrozole anticancer drug on gold nanoparticle surfaces

Published: Jun 6, 2019

Author(s): Raïssa A.R. Teixeira, Luiz Antônio S. Costa, Antonio C. Sant'Ana

Journal: Journal of Raman Spectroscopy

Abstract Anastrozole is a well‐known anticancer drug used in aromatase‐dependent cancer chemotherapy as a nonsteroidal aromatase inhibitor. Investigations involving the adsorption of anastrozole on gold surfaces are on demand, because gold nanoparticles (AuNPs) have been used as nanocarriers of drugs, and such a compound can be used against aromatase‐expressing neoplastic cells. In this work, surface‐enhanced Raman scattering (SERS) spectroscopy was used to investigate the interaction between...

Read More thumbnail image: A proposal for the adsorption of anastrozole anticancer drug on gold nanoparticle surfaces

Low‐level LIBS and Raman data fusion in the context of in situ Mars exploration

Published: Jun 6, 2019

Author(s): Kristin Rammelkamp, Susanne Schröder, Simon Kubitza, David S. Vogt, Sven Frohmann, Peder B. Hansen, Ute Böttger, Franziska Hanke, Heinz‐Wilhelm Hübers

Journal: Journal of Raman Spectroscopy

Abstract Laser‐induced breakdown spectroscopy (LIBS) and Raman spectroscopy are powerful key techniques for the geoanalytical exploration of extraterrestrial bodies, especially when combined. Their data are complementary, which motivates the question of how it can be best combined to maximize the scientific output. For this study, LIBS and Raman data from pure sulfates and their mixtures as well as from other Mars‐relevant salts such as carbonates, chlorides, perchlorates, and sulfates in a...

Read More thumbnail image: Lowlevel LIBS and Raman data fusion in the context of in situ Mars exploration

Simultaneous determination of short‐chain fatty acids in human feces by HPLC with ultraviolet detection following chemical derivatization and solid‐phase extraction segmental elution

Published: Jun 6, 2019

Author(s): Huai‐You Wang, Cheng Wang, Lin‐Xiu Guo, Yun‐Feng Zheng, Wei‐Hui Hu, Tina T. X. Dong, Tie‐Jie Wang, Karl W. K. Tsim

Journal: Journal of Separation Science

Abstract Short‐chain fatty acids are currently the most studied metabolites of gut microbiota, but the analysis of them, simultaneously, is still challenging due to their unique property and wide concentration range. Here, we developed a sensitive and versatile high‐performance liquid chromatography with ultraviolet detection method, using pre‐column derivatization and solid‐phase extraction segmental elution, for the quantification of both major and trace amounts of short‐chain fatty acids in...

Read More thumbnail image: Simultaneous determination of shortchain fatty acids in human feces by HPLC with ultraviolet detection following chemical derivatization and solidphase extraction segmental elution

The feasibility of using dielectrophoresis for isolation of glioblastoma subpopulations with increased stemness

Published: Jun 6, 2019

Author(s): Nastaran Alinezhadbalalami, Temple A. Douglas, Nikita Balani, Scott S. Verbridge, Rafael V. Davalos

Journal: ELECTROPHORESIS

Abstract Cancer stem cells (CSCs) are aggressive subpopulations with increased stem‐like properties. CSCs are usually resistant to most standard therapies and are responsible for tumor repropagation. Similar to normal stem cells, isolation of CSCs is challenging due to the lack of reliable markers. Antigen‐based sorting of CSCs usually requires staining with multiple markers, making the experiments complicated, expensive, and sometimes unreliable. Here, we study the feasibility of using...

Read More thumbnail image: The feasibility of using dielectrophoresis for isolation of glioblastoma subpopulations with increased stemness

K‐K electron capture from adenine and CO2 molecule by fast carbon ions using KLL‐Auger electron technique

Published: Jun 6, 2019

Author(s): Chandan Bagdia, Shamik Bhattacharjee, Madhusree Roychowdhury, Anuvab Mandal, Gregory Lapicki, Lokesh C. Tribedi

Journal: X-Ray Spectrometry

The experimental measurement of total electron transfer cross section in Bragg peak energy region is important to understand energy loss in the biomolecular system. In this study, we have measured state selective, K‐K electron capture and K‐ionization cross sections for adenine (C 5H 5N 5) in collisions with fast (2.5–5 MeV/u) C ions. These are compared with the data for smaller gas molecule, CO 2. These are derived from a study of the KLL‐Auger electron emission yields as a function...

Read More thumbnail image: KK electron capture from adenine and CO2 molecule by fast carbon ions using KLLAuger electron technique

Theoretical fluorescence yields and widths of the K shell and the L subshells, for the Ne, Ar, and Kr isoelectronic sequences

Published: Jun 6, 2019

Author(s): José P. Marques, Jorge M. Sampaio, José Paulo Santos, Paul Indelicato, Fernando Parente

Journal: X-Ray Spectrometry

In this work, we present fluorescence yield and width values of Ne‐, Ar‐, and Kr‐like ion levels for selected values of Z, using a state‐of‐the‐art multiconfiguration Dirac–Fock approach. The results may be useful for the interpretation of spectra from plasmas, in both laboratory and astrophysics, as well as from ion collision experiments.

Read More thumbnail image: Theoretical fluorescence yields and widths of the K shell and the L subshells for the Ne Ar and Kr isoelectronic sequences

High‐sensitivity simultaneous quantification of tacrolimus and 13‐O‐demethyl tacrolimus in human whole blood using ultra‐performance liquid chromatography coupled to tandem mass spectrometry

Published: Jun 6, 2019

Author(s): Hiroyuki Ono, Yosuke Suzuki, Tetsuya Kaneko, Ryota Tanaka, Fuminori Sato, Yuhki Sato, Hiromitsu Mimata, Hiroki Itoh

Journal: Biomedical Chromatography

Abstract Blood concentrations of tacrolimus show large variability among patients and the narrow therapeutic range is related to adverse effects. Therefore, therapeutic drug monitoring is needed for strict management. 13‐O‐Demethyl tacrolimus (13‐O‐DMT) was reported as the major metabolite formed by cytochrome P450 (CYP)3A such as CYP3A5. In previous studies, the best lower limit of quantification (LLOQ) was 0.1 ng/mL for both substances. However, this LLOQ may not be low enough now because...

Read More thumbnail image: Highsensitivity simultaneous quantification of tacrolimus and 13Odemethyl tacrolimus in human whole blood using ultraperformance liquid chromatography coupled to tandem mass spectrometry

Metabolic profile of rosmarinic acid from Java tea (Orthosiphon stamineus) by ultra‐high‐performance liquid chromatography coupled to quadrupole‐time‐of‐flight tandem mass spectrometry with a three‐step data mining strategy

Published: Jun 6, 2019

Author(s): Jing Zhang, Quan Wen, Kai Qian, Yulin Feng, Yun Luo, Ting Tan

Journal: Biomedical Chromatography

Abstract Rosmarinic acid (RA) is a caffeic acid derivative and one of the most abundant and bioactive constituents in Java tea (Orthosiphon stamineus), which has significant biological activities. However, relatively few studies have been conducted to describe this compound's metabolites in vivo. Therefore, an ultra‐high‐performance liquid chromatography coupled to quadrupole‐time‐of‐flight tandem mass spectrometry (UHPLC–QTOF–MS/MS) analysis with a three‐step data mining strategy was...

Read More thumbnail image: Metabolic profile of rosmarinic acid from Java tea Orthosiphon stamineus by ultrahighperformance liquid chromatography coupled to quadrupoletimeofflight tandem mass spectrometry with a threestep data mining strategy

Preparation of restricted access media molecularly imprinted polymers for efficient separation and enrichment ofloxacin in bovine serum samples

Published: Jun 5, 2019

Author(s): Jianmin Li, Lijuan Zhao, Chanling Wei, Zhian Sun, Shanwen Zhao, Tianpei Cai, Bolin Gong

Journal: Journal of Separation Science

Abstract We prepared ofloxacin restricted access media molecularly imprinted polymers using surface‐initiated atom transfer radical polymerization on the surface of brominated silica gel using ofloxacin as a template molecule, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinking agent. We then characterized and studied the surface morphology and adsorption properties of the polymer. Experimental results show that saturation is reached within 25 min,...

Read More thumbnail image: Preparation of restricted access media molecularly imprinted polymers for efficient separation and enrichment ofloxacin in bovine serum samples

A robust LC–MS/MS assay with online cleanup for measurement of serum testosterone

Published: Jun 5, 2019

Author(s): Yu Zhou, Sihe Wang

Journal: Journal of Separation Science

Abstract Accurate measurement of low levels of testosterone is critical for diagnosis and treatment of androgen disorders. The very low concentrations of testosterone in children, females, and males with androgen suppression therapies necessitate the use of mass spectrometry‐based methods. We aimed to develop a liquid chromatography with tandem mass spectrometry method with simplified sample preparation and online solid‐phase extraction cleanup to achieve enhanced precision, accuracy,...

Read More thumbnail image: A robust LCMSMS assay with online cleanup for measurement of serum testosterone

Corrigendum

Published: Jun 5, 2019

Author(s):

Journal: ELECTROPHORESIS

Read More thumbnail image: Corrigendum

Capillary electrophoresis‐based enzyme assays for β‐lactamase enzymes

Published: Jun 4, 2019

Author(s): Chunyang Chen, Jan S. Kramer, Steffen Brunst, Ewgenij Proschak, Gerhard K.E. Scriba

Journal: ELECTROPHORESIS

Abstract Generic in‐capillary as well as offline CE‐based enzyme assays were developed for serine‐β‐lactamases and metallo‐β‐lactamases. The hydrolysis of benzylpenicillin to benzylpenicilloic acid was analyzed using 100 mM sodium phosphate solution, pH 6.0, as a background electrolyte. In‐capillary assays employed an uncoated as well as a polyethylene oxide‐coated capillary, while the offline assays employing long end and short end injection were performed in an uncoated capillary. Using...

Read More thumbnail image: Capillary electrophoresisbased enzyme assays for lactamase enzymes

Analyte focusing by micelle collapse for liquid extraction surface analysis coupled with capillary electrophoresis of neutral analytes on a solid surface

Published: Jun 4, 2019

Author(s): Sunkyung Jeong, Farid Shakerian, Doo Soo Chung

Journal: ELECTROPHORESIS

Abstract Liquid extraction surface analysis (LESA) has an advantage of directly sampling analytes on a surface, thus avoiding unnecessary dilution by homogenization of the bulk sample commonly practiced in solid sample analysis. By combining LESA with CE, the additional advantage of separating analytes before detection can be accomplished. For neutral molecules, MEKC needs to be used. Since the detection sensitivity of CE in general suffers from the small capillary dimension, analyte focusing...

Read More thumbnail image: Analyte focusing by micelle collapse for liquid extraction surface analysis coupled with capillary electrophoresis of neutral analytes on a solid surface

CE–MS for anionic metabolic profiling: An overview of methodological developments

Published: Jun 4, 2019

Author(s): Marlien Mever, Thomas Hankemeier, Rawi Ramautar

Journal: ELECTROPHORESIS

Abstract The efficient profiling of highly polar and charged metabolites in biological samples remains a huge analytical challenge in metabolomics. Over the last decade, new analytical techniques have been developed for the selective and sensitive analysis of polar ionogenic compounds in various matrices. Still, the analysis of such compounds, notably for acidic ionogenic metabolites, remains a challenging endeavor, even more when the available sample size becomes an issue for the total...

Read More thumbnail image: CEMS for anionic metabolic profiling An overview of methodological developments

Highly selective enrichment of phosphopeptides using poly(dibenzo‐18‐crown‐6) as a solid‐phase extraction material

Published: Jun 4, 2019

Author(s): Munazza Raza Mirza, Matthias Rainer, Shahid Duran, Syed Tarique Moin, M. Iqbal Choudhary, Günther K. Bonn

Journal: Biomedical Chromatography

Abstract A poly(dibenzo‐18‐crown‐6) was used as a new solid‐phase extraction material for the selective enrichment of phosphopeptides. Isolation of phosphopeptides was achieved based on specific ionic interactions between poly(dibenzo‐18‐crown‐6) and the phosphate group of phosphopeptides. Thus, a method was developed and optimized, including loading, washing and elution steps, for the selective enrichment of phosphopeptides. To assess this potential, tryptic digest of three proteins (α‐...

Read More thumbnail image: Highly selective enrichment of phosphopeptides using polydibenzo18crown6 as a solidphase extraction material

Stereo‐dynamical ion‐pair formation in collisions of highly‐charged ions with argon dimers

Published: Jun 4, 2019

Author(s): Tomoko Ohyama‐Yamaguchi, Atsushi Ichimura

Journal: X-Ray Spectrometry

Multiple ionization process of a rare gas dimer BC collided with a slow highly charged ion Aq+ is investigated with the three‐center Coulombic over‐barrier model previously developed by the present authors. To reveal stereodynamical effects, we calculate asymmetric ion‐pair formation cross sections σ(QB,QC) as a function of the orientation angle. We introduce a pair of atomic impact parameters bB and bC with which we distinguish the near and far sites. Furthermore, we distinguish the forward...

Read More thumbnail image: Stereodynamical ionpair formation in collisions of highlycharged ions with argon dimers
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