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Investigation of the enantioselectivity of tetramethylammonium‐lactobionate chiral ionic liquid based dual selector systems toward basic drugs in capillary electrophoresis

Published: Feb 21, 2019

Author(s): Xiaodong Sun, Kang Liu, Yingxiang Du, Jie Liu, Xiaofei Ma

Journal: ELECTROPHORESIS

Abstract Recently, chiral ionic liquids (CILs) have received increasing interest in chiral separation by CE. Nevertheless, the lack of deep perception of the specific mechanism about CILs in CE for enantioseparation still perplexes a legion of researchers, despite the strenuous efforts. In this paper, a lactobionic acid based ionic liquid, tetramethylammonium‐lactobionate (TMA‐LA) was applied for the first time in CE to establish dual selector system with clindamycin phosphate (CP) for...

Read More thumbnail image: Investigation of the enantioselectivity of tetramethylammoniumlactobionate chiral ionic liquid based dual selector systems toward basic drugs in capillary electrophoresis

Chiral separation of rasagiline using sulfobutylether‐β‐cyclodextrin: capillary electrophoresis, NMR and molecular modeling study

Published: Feb 21, 2019

Author(s): Zoltán‐István Szabó, Róbert Ludmerczki, Béla Fiser, Béla Noszál, Gergő Tóth

Journal: ELECTROPHORESIS

Abstract Pressure‐assisted stereospecific capillary electrophoresis method was developed for the determination of enantiomeric purity of the antiparkinsonian agent (R)‐rasagiline. The optimized method, 50 mM glycine‐HCl buffer pH 2, supplied with 30 mM sulfobutylether‐β‐cyclodextrin, at 35°C, applying 12 kV in reversed polarity, and –8 mbar pressure (vacuum), short‐end injection with ‐25 mbar × 2 s, was successful for baseline separation of rasagiline enantiomers (Rs = 3.5 ± 0.1) in a short...

Read More thumbnail image: Chiral separation of rasagiline using sulfobutylethercyclodextrin capillary electrophoresis NMR and molecular modeling study

Assessing serum albumin concentration following exercise‐induced fluid shifts in the context of the athlete biological passport

Published: Feb 20, 2019

Author(s): Geoffrey D. Miller, Masaru Teramoto, Stacy J. Smeal, Dan Cushman, Daniel Eichner

Journal: Drug Testing and Analysis

Abstract Purpose The hydration status of an athlete at the time of a doping control sample collection is an important factor to consider when reviewing athlete biological passports (ABPs). Dehydration results in a reduction of the circulating plasma volume (PV), which may lead to artificially high values of some blood parameters. This study aimed to identify whether serum albumin could serve as a single marker of fluid shifts, which are not currently accounted for in the hematological...

Read More thumbnail image: Assessing serum albumin concentration following exerciseinduced fluid shifts in the context of the athlete biological passport

Surface oxide development on aluminum alloy 6063 during heat treatment

Published: Feb 20, 2019

Author(s): Lisa Rullik, Jonas Evertsson, Niclas Johansson, Florian Bertram, Jan‐Olov Nilsson, Alexei A. Zakharov, Anders Mikkelsen, Edvin Lundgren, Watts John

Journal: Surface and Interface Analysis

We report on the influence of oxygen partial pressure for the development of surface oxides covering the industrial aluminum alloy standard 6063 at temperatures ranging from room temperature to 500° C. Using an array of synchrotron‐based techniques, we followed the change in oxide thickness, chemical composition, and the lateral distribution of alloying elements. The impact of the oxygen chemical potential is most visible at high temperatures where the oxide composition changes from mostly Al...

Read More thumbnail image: Surface oxide development on aluminum alloy 6063 during heat treatment

The effect of trace additions of copper and pretreatment conditions on the filiform corrosion of powder‐coated aluminium alloy AA6060

Published: Feb 20, 2019

Author(s): Malgorzata Halseid, Jan Tore B. Gundersen, Øystein Bauger, Thomas Hentschel

Journal: Surface and Interface Analysis

This paper presents a short review of the literature data and the newest studies of filiform corrosion (FFC) testing of profiles extruded using a recycling‐friendly AA 6xxx aluminium alloy, with Cu content up to 0.09 wt%. As the pretreatment plays a significant role in avoiding FFC on powder‐coated aluminium profiles, the profiles were pretreated and coated at three different production sites. They have been tested at 40°C, 82% RH for 1000 hours (according to modified ISO 4623‐2). It was...

Read More thumbnail image: The effect of trace additions of copper and pretreatment conditions on the filiform corrosion of powdercoated aluminium alloy AA6060

Application of X‐ray fluorescence spectroscopy to provenance studies of Algerian archaeological pottery

Published: Feb 19, 2019

Author(s): Lynda Idjouadiene, Toufik A. Mostefaoui, Hocine Djermoune, Letizia Bonizzoni

Journal: X-Ray Spectrometry

The North African regions boast a multimillenary tradition of pottery production that represents a decisive progress in all societies. In this paper, we present the analysis of several fragments of pottery dating from the Middle Ages and collected in the archaeological site of Gouraya in Béjaïa (Algeria). Energy‐dispersive X‐ray fluorescence measurements were performed to obtain the elemental composition of the clays and to attempt a classification of the samples through multivariate analysis...

Read More thumbnail image: Application of Xray fluorescence spectroscopy to provenance studies of Algerian archaeological pottery

Three‐color coherent anti‐Stokes Raman scattering with optical nonresonant background removal

Published: Feb 18, 2019

Author(s): Brad Littleton, Priyank Shah, Thomas Kavanagh, David Richards

Journal: Journal of Raman Spectroscopy

Abstract Broadband coherent anti‐Stokes Raman scattering (B‐CARS), excited through intrapulse three‐color processes in which both the pump and Stokes photons are derived from a broadband beam, enable diffraction‐limited hyperspectral Raman imaging over the entire fingerprint spectral region with a speed and sensitivity far superior to that possible with conventional spontaneous Raman confocal microspectroscopy. We extend the theory of spectral interferometric polarization coherent anti‐Stokes...

Read More thumbnail image: Threecolor coherent antiStokes Raman scattering with optical nonresonant background removal

Dual‐probe polarization spectroscopy as a concept for combustion diagnostics

Published: Feb 18, 2019

Author(s): Johannes Kiefer

Journal: Journal of Raman Spectroscopy

Abstract Studying the line‐broadening effects of combustion intermediates in flames is the key to derive quantitative information via spectroscopic techniques. In this communication, an extension to polarization spectroscopy via employing two probe beams, one of which is copropagating whereas the other one is counterpropagating to the pump beam, is proposed. This gives rise to dual‐probe polarization spectroscopy, which enables recording a Doppler‐broadened and a Doppler‐free signal...

Read More thumbnail image: Dualprobe polarization spectroscopy as a concept for combustion diagnostics

Investigations into the performance of travelling wave enabled conventional and cyclic ion mobility systems to characterise protomers of fluoroquinolone antibiotic residues

Published: Feb 18, 2019

Author(s): Michael McCullagh, Kevin Giles, Keith Richardson, Sara Stead, Martin Palmer

Journal: Rapid Communications in Mass Spectrometry

Rationale Fluoroquinolones (FLQs) have been shown to form protomers with distinctive fragment profiles. Experimental parameters affect protomer formation, impacting observed conventional tandem mass spectrometric (MS/MS) dissociation and multiple reaction monitoring (MRM) transition reproducibility. Collision cross section (CCS) measurement can provide an additional identification metric and improved ion mobility (IM) separation strategies could provide further understanding of fluctuations in...

Read More thumbnail image: Investigations into the performance of travelling wave enabled conventional and cyclic ion mobility systems to characterise protomers of fluoroquinolone antibiotic residues

Single‐stranded DNA structural diversity: TAGGGT from monomers to dimers to tetramer formation

Published: Feb 18, 2019

Author(s): Jacob E. Porter, Prem Chapagain, Francisco Fernandez‐Lima

Journal: Rapid Communications in Mass Spectrometry

Rationale DNA quadruplex structures have emerged as novel drug targets due to their role in preventing abnormal gene transcription and maintaining telomere stability. Trapped Ion Mobility Spectrometry–Mass Spectrometry (TIMS–MS), combined with theoretical modeling, is a powerful tool for studying the kinetic intermediates of DNA complexes formed in solution and interrogated in the gas phase after desolvation. Methods A TAGGGT ssDNA sequence was purchased and studied in 10 mM ammonium acetate...

Read More thumbnail image: Singlestranded DNA structural diversity TAGGGT from monomers to dimers to tetramer formation

Can cells maintain their bioactivity in ionic liquids? A novel single‐cell assessment by Raman microspectroscopy

Published: Feb 18, 2019

Author(s): Ami Matsuda, Naoko Sakaguchi, Shinsuke Shigeto

Journal: Journal of Raman Spectroscopy

Abstract Ionic liquids (ILs) are widely exploited in numerous applications in chemistry, biology, and materials science. Assessment of the toxicity of ILs is thus urgently needed to develop genuinely “green” ILs that do not pose hazards to the environment and humans. Despite considerable efforts mostly with cell viability assays, little has been understood about how, at the molecular level, ILs affect the bioactivity and intracellular chemistry of single individual cells. Here, we report a new...

Read More thumbnail image: Can cells maintain their bioactivity in ionic liquids A novel singlecell assessment by Raman microspectroscopy

X‐ray fluorescence analysis of samples simulating blood collected from uranium‐contaminated wounds

Published: Feb 14, 2019

Author(s): Yukie Izumoto, Tsugufumi Matsuyama, Kota Ishii, Yasuhiro Sakai, Yoshiyuki Oguri, Hiroshi Yoshii

Journal: X-Ray Spectrometry

Personnel working in nuclear fuel handling facilities incur a finite risk of injury and uranium contamination in any resulting wounds. The accidental absorption of uranium from the likes of wounds can lead to a significant degree of internal exposure due to its hazardous nature. Although an appropriate surgical resection of tissue in the contaminated wound is useful for suppressing the additional intake of uranium, the rapid quantification of uranium in the wound is required to avoid...

Read More thumbnail image: Xray fluorescence analysis of samples simulating blood collected from uraniumcontaminated wounds

Cationic surfactant regulated synthesis of Au nanorods for sensitive detection of negatively charged colorants by surface‐enhanced Raman spectroscopy

Published: Feb 13, 2019

Author(s): Miao Qin, Pan Li, Xia Zhou, Jun Zhu, Hongyan Wang, Liangbao Yang

Journal: Journal of Raman Spectroscopy

Abstract Although surface‐enhanced Raman spectroscopy (SERS) has recently emerged as a powerful analytical tool, its widespread use is hindered by several inherent problems (e.g., low reproducibility) that need to be solved before further progress is possible. Herein, we used dodecyltrimethylammonium bromide (DTAB), N‐dodecyl‐N‐2‐hydroxyethyl‐N,N‐dimethylammonium bromide (C12HDAB), and N‐dodecyl‐N,N‐2‐dihydroxyethyl‐N‐methylammonium bromide (C12DHAB) as templates for the seed‐mediated growth...

Read More thumbnail image: Cationic surfactant regulated synthesis of Au nanorods for sensitive detection of negatively charged colorants by surfaceenhanced Raman spectroscopy

Metabolic profiling of synthetic cannabinoid 5F‐ADB by human liver microsome incubations and urine samples using high‐resolution mass spectrometry

Published: Feb 13, 2019

Author(s): Oya Yeter, Yeter Erol Ozturk

Journal: Drug Testing and Analysis

Abstract 5F‐ADB (methyl 2‐{[1‐(5‐fluoropentyl)‐1H‐indazole‐3‐carbonyl] amino}‐3,3‐dimethylbutanoate) is a frequently abused new synthetic cannabinoid that has been sold since at least the end of 2014 on the drug market and has been classified as an illicit drug in most European countries, as well as Turkey, Japan, and the United States. In this study, the in vitro metabolism of 5F‐ADB was investigated by using pooled human liver microsomes (HLMs) assay and liquid chromatography‐high‐resolution...

Read More thumbnail image: Metabolic profiling of synthetic cannabinoid 5FADB by human liver microsome incubations and urine samples using highresolution mass spectrometry

Diagram, valence‐to‐core, and hypersatellite Kβ X‐ray transitions in metallic chromium

Published: Feb 13, 2019

Author(s): Faisal Zeeshan, Joanna Hoszowska, Jean‐Claude Dousse, Dimosthenis Sokaras, Tsu‐Chien Weng, Roberto Alonso‐Mori, Matjaz Kavčič, Mauro Guerra, Jorge Miguel Sampaio, Fernando Parente, Paul Indelicato, José Pires Marques, José Paulo Santos

Journal: X-Ray Spectrometry

We report on measurements of the Kβ diagram, valence‐to‐core (VtC), and hypersatellite X‐ray spectra induced in metallic Cr by photon single and double K‐shell ionization. The experiment was carried out at the Stanford Synchrotron Radiation Lightsource using the seven‐crystal Johann‐type hard X‐ray spectrometer of the beamline 6‐2. For the Kβ diagram and VtC transitions, the present study confirms the line shape features observed in previous works, whereas the Khβ hypersatellite transition was...

Read More thumbnail image: Diagram valencetocore and hypersatellite K Xray transitions in metallic chromium

Advances in the histopathological characterization of breast tissue using combined X‐ray fluorescence and X‐ray diffraction data in a multivariate analysis approach

Published: Feb 13, 2019

Author(s): Eric M. Johnston, Erica Dao, Michael J. Farquharson

Journal: X-Ray Spectrometry

Previous studies have shown that the combination of X‐ray fluorescence and X‐ray diffraction data can be used as a histopathological characterization tool for breast tissue. Recent advances in energy‐dispersive X‐ray fluorescence techniques have allowed for benchtop systems to produce useful results in a reasonable time frame, allowing for clinical implementation to be realized. Using a polarized energy‐dispersive X‐ray fluorescence and energy‐dispersive X‐ray diffraction system optimized for...

Read More thumbnail image: Advances in the histopathological characterization of breast tissue using combined Xray fluorescence and Xray diffraction data in a multivariate analysis approach

DIY XES—development of an inexpensive, versatile, and easy to fabricate XES analyzer and sample delivery system

Published: Feb 13, 2019

Author(s): Scott C. Jensen, Brendan Sullivan, Daniel A. Hartzler, Yulia Pushkar

Journal: X-Ray Spectrometry

The application of X‐ray emission spectroscopy (XES) has grown substantially with the development of X‐ray free‐electron lasers, third and fourth generation synchrotron sources, and high‐power benchtop sources. By providing the high X‐ray flux required for XES, these sources broaden the availability and application of this method of probing electronic structure. As the number of sources increase, so does the demand for X‐ray emission detection and sample delivery systems that are cost...

Read More thumbnail image: DIY XESdevelopment of an inexpensive versatile and easy to fabricate XES analyzer and sample delivery system

Enantioseparation of tryptophan and its unnatural derivatives by nano‐LC on CSP‐teicoplanin silica based

Published: Feb 12, 2019

Author(s): Giovanni D'Orazio, Chiara Fanali, Alessandra Gentili, Salvatore Fanali

Journal: ELECTROPHORESIS

Abstract This work deals with the potentiality of nano liquid chromatography (Nano‐LC) for the chiral separation of racemic mixture of tryptophan and some selected derivatives by using 100 μm i.d. fused silica capillary packed with teicoplanin bonded to 5 μm diol silica stationary phase. The experiments were carried out by using a cheap and laboratory‐assembled nano‐LC–UV system. Elution was done in an isocratic mode using a polar organic mobile phase. In order to find the optimum chiral...

Read More thumbnail image: Enantioseparation of tryptophan and its unnatural derivatives by nanoLC on CSPteicoplanin silica based

Recent studies of docking and molecular dynamics simulation for liquid‐phase enantioseparations

Published: Feb 12, 2019

Author(s): Sergio Cossu, Victor Mamane, Roberto Dallocchio, Alessandro Dessì, Paola Peluso

Journal: ELECTROPHORESIS

Abstract Liquid‐phase enantioseparations have been fruitfully applied in several fields of science. Various applications along with technical and theoretical advancements contributed to increase significantly the knowledge in this area. Nowadays, chromatographic techniques, in particular HPLC on chiral stationary phase, are considered as mature technologies. In the last thirty years, CE has been also recognized as one of the most versatile technique for analytical scale separation of...

Read More thumbnail image: Recent studies of docking and molecular dynamics simulation for liquidphase enantioseparations

Effect of surface treatments on the localized corrosion resistance of the AA2198‐T8 aluminum lithium alloy welded by FSW process

Published: Feb 11, 2019

Author(s): Caruline S. C. Machado, Rafael E. Klumpp, Victor H. Ayusso, Uyime Donatus, Mariana X. Milagre, João V. S. Araujo, Glauson A. F. Machado, I. Costa

Journal: Surface and Interface Analysis

In this work, the effect of eight types of surface treatments on the corrosion resistance of friction stir welded samples of an AA2198‐T8 Al‐Cu‐Li alloy were tested and compared in an attempt to find suitable alternatives to toxic and carcinogenic hexavalent chromium treatments. All the samples were anodized and subjected to different post‐anodizing treatments. The post‐anodizing treatments were (1) hydrothermal treatment in Ce (NO3)3 6H2O solution; (2) hydrothermal treatment in Ce (NO3)3 6H2O...

Read More thumbnail image: Effect of surface treatments on the localized corrosion resistance of the AA2198T8 aluminum lithium alloy welded by FSW process
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