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Rapid simultaneous quantification of fructooligosaccharides in Morinda officianalis by ultra‐high performance liquid chromatography

Published: May 15, 2019

Author(s): Yi Yu, Lanping Guo, Liping Kang, Li Zhou, Tiegui Nan, Qingxiu Hao

Journal: Journal of Separation Science

Abstract Many Chinese herbal medicines with tonifying effects contain high levels of inulin fructooligosaccharides. These herbal medicines have high development and utilization value because of their effects against dementia, depression, and oxidative stress; on improving learning and memory ability; and on enhancing immunity. In this study, a method was developed for the separation and simultaneous quantitation of fructose, glucose, sucrose, and ten inulin fructooligosaccharides by...

Read More thumbnail image: Rapid simultaneous quantification of fructooligosaccharides in Morinda officianalis by ultrahigh performance liquid chromatography

Three‐phase hollow‐fiber liquid‐phase microextraction based on deep eutectic solvent as acceptor phase for extraction and preconcentration of main active compounds in a traditional Chinese medicinal formula

Published: May 15, 2019

Author(s): Jiao Xue, Run‐qin Wang, Xuan Chen, Shuang Hu, Xiao‐hong Bai

Journal: Journal of Separation Science

Abstract A three‐phase hollow‐fiber liquid‐phase microextraction based on deep eutectic solvent as acceptor phase was developed and coupled with high‐performance capillary electrophoresis for the simultaneous extraction, enrichment, and determination of main active compounds (hesperidin, honokiol, shikonin, magnolol, emodin, and β,β′‐dimethylacrylshikonin) in a traditional Chinese medicinal formula. In this procedure, two hollow fibers, impregnated with n‐heptanol/n‐nonanol (7:3, v/v) mixture...

Read More thumbnail image: Threephase hollowfiber liquidphase microextraction based on deep eutectic solvent as acceptor phase for extraction and preconcentration of main active compounds in a traditional Chinese medicinal formula

Screening the anti‐allergic components in Saposhnikoviae Radix using high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry

Published: May 15, 2019

Author(s): Qianqian Jia, Wei Sun, Liyang Zhang, Jia Fu, Yanni Lv, Yuanyuan Lin, Shengli Han

Journal: Journal of Separation Science

Abstract Saposhnikoviae Radix, the dried root of Saposhnikoviae divaricata, is commonly used in the traditional Chinese anti‐allergic preparations, like Bofutsusho‐san and Yupingfeng granules. A high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography coupled online with high‐performance liquid chromatography combined with an ion trap time‐of‐flight multistage mass spectrometry system was established and used for screening and identifying the anti‐allergic...

Read More thumbnail image: Screening the antiallergic components in Saposhnikoviae Radix using highexpression Masrelated G proteincoupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry

Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra‐performance liquid chromatography−tandem mass spectrometry

Published: May 15, 2019

Author(s): Abhisheak Sharma, Shyam H. Kamble, Francisco León, Nelson J.‐Y. Chear, Tamara I. King, Erin C. Berthold, Surash Ramanathan, Christopher R. McCurdy, Bonnie A. Avery

Journal: Drug Testing and Analysis

Abstract Kratom (Mitragyna speciosa) is a psychoactive plant popular in the United States for the self‐treatment of pain and opioid addiction. For standardization and quality control of raw and commercial kratom products, an ultra‐performance liquid chromatography−tandem mass spectrometry (UPLC−MS/MS) method was developed and validated for the quantification of ten key alkaloids, namely: corynantheidine, corynoxine, corynoxine B, 7‐hydroxymitragynine, isocorynantheidine, mitragynine,...

Read More thumbnail image: Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultraperformance liquid chromatographytandem mass spectrometry

Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018 – A potential risk to users?

Published: May 15, 2019

Author(s): Lewis Couchman, Anca Frinculescu, Catarina Sobreira, Trevor Shine, John Ramsey, Max Hecht, Karin Kipper, David Holt, Atholl Johnston

Journal: Drug Testing and Analysis

Abstract 3,4‐Methylenedioxymethamphetamine (MDMA, Ecstasy) tablets are widely used recreationally, and not only vary in appearance, but also in MDMA content. Recently, the prevalence of high‐content tablets is of concern to public health authorities. To compare UK data with other countries, we evaluated MDMA content of 412 tablets collected from the UK, 2001–2018, and investigated within‐batch content variability for a sub‐set of these samples. In addition, we investigated dissolution profiles...

Read More thumbnail image: Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018  A potential risk to users

Gas chromatography−mass spectrometry analysis of non‐hydrolyzed sulfated steroids by degradation product formation

Published: May 15, 2019

Author(s): Michael Polet, Wim Van Gansbeke, Aðalheiður Dóra Albertsdóttir, Gilles Coppieters, Koen Deventer, Peter Van Eenoo

Journal: Drug Testing and Analysis

Abstract Steroid detection and identification remain key issues in toxicology, drug testing, medical diagnostics, food safety control, and doping control. In this study, we evaluate the capabilities and usefulness of analyzing non‐hydrolyzed sulfated steroids with gas chromatography−mass spectrometry (GC–MS) instead of the conventionally applied liquid chromatography−mass spectrometry (LC–MS) approach. Sulfates of 31 steroids were synthesized and their MS and chromatographic behavior studied...

Read More thumbnail image: Gas chromatographymass spectrometry analysis of nonhydrolyzed sulfated steroids by degradation product formation

Argon matrix Raman spectroscopic and aggregation model density function theoretical study of methyl isothiocyanate

Published: May 15, 2019

Author(s): Maozhu Liu, Yanying Zhao, Fengqi Wu, Huigang Wang, Xuming Zheng

Journal: Journal of Raman Spectroscopy

Abstract The Raman spectra for methyl isothiocyanate (MTC) isolated in an argon matrix at different annealing temperatures and MTC in carbon tetrachloride at different concentrations were collected separately. Concentration‐dependent properties were characterized, and no noncoincidence effect (NCE) was observed. Argon matrix isolated Raman spectra shows that, the SCNC stretching at 6K presents as one distinct peak, it separates into two peaks at 25–35 K and merges as one peak again above...

Read More thumbnail image: Argon matrix Raman spectroscopic and aggregation model density function theoretical study of methyl isothiocyanate

A review of Raman spectroscopy of vanadium oxides

Published: May 15, 2019

Author(s): Petr Shvets, Olga Dikaya, Ksenia Maksimova, Alexander Goikhman

Journal: Journal of Raman Spectroscopy

Abstract This review summarizes Raman scattering data for different stable and metastable phases of vanadium oxides. We analyze literature data on crystal structures existing in the binary vanadium‐oxygen system. If available, we combine these data with experimental Raman spectra and relations of vibrational modes with the atomic arrangements and motions in crystals. Further, we employ arc sputtering to produce vanadium oxide films, including α and β‐vanadium, V14O6, VO, V2O3, V3O5, several...

Read More thumbnail image: A review of Raman spectroscopy of vanadium oxides

Time‐gated Raman and laser‐induced breakdown spectroscopy in mapping of eudialyte and catapleiite

Published: May 15, 2019

Author(s): Sari Romppanen, Heikki Häkkänen, Jere Kekkonen, Jan Nissinen, Ilkka Nissinen, Juha Kostamovaara, Saara Kaski

Journal: Journal of Raman Spectroscopy

Abstract Raman analysis of rock samples containing rare earth elements (REEs) is challenging due to the strong fluorescence, which may mask the weaker Raman signal. In this research, time‐gated (TG) Raman has been applied to the construction of the mineral distribution map from REE‐bearing rock. With TG Raman, material is excited with a short subnanosecond laser pulse, and the Raman signal is collected within a picosecond‐scale time window prior to the formation of a strong fluorescent signal...

Read More thumbnail image: Timegated Raman and laserinduced breakdown spectroscopy in mapping of eudialyte and catapleiite

Universal detection of body fluid traces in situ with Raman hyperspectroscopy for forensic purposes: Evaluation of a new detection algorithm (HAMAND) using semen samples

Published: May 15, 2019

Author(s): Gregory McLaughlin, Marisia A. Fikiet, Masahiro Ando, Hiro‐o Hamaguchi, Igor K. Lednev

Journal: Journal of Raman Spectroscopy

Abstract Towards closing the technological gaps in forensic science, Raman spectroscopy has been a boon to the field. One area that this technique shows exceptional promise is in body fluid identification and characterization, but substrate interference remains a major impediment to its practical implementation. Here, we present an approach for the universal detection of body fluids regardless of the substrate. This approach, which is based on Raman hyperspectroscopy and multivariate curve...

Read More thumbnail image: Universal detection of body fluid traces in situ with Raman hyperspectroscopy for forensic purposes Evaluation of a new detection algorithm HAMAND using semen samples

Formulation of Raman scattering revisited

Published: May 15, 2019

Author(s): Reiko Morita, Hayato Morita, Mitsuo Tasumi

Journal: Journal of Raman Spectroscopy

Abstract In Raman scattering, photons are scattered by electrons in a molecule. Its mechanism was elucidated early after the development of quantum mechanics. If the frequencies of incident and scattered photons are denoted respectively by ν0 and νs, the differential scattering cross section of a Raman band is proportional to . The differential scattering cross section of Rayleigh scattering is proportional to , as is known as the ν4 rule. This article reconfirms these points from a tutorial...

Read More thumbnail image: Formulation of Raman scattering revisited

Ballpoint connector‐protected salt‐oil‐salt liquid phase microextraction for concentration and enrichment of trace anthraquinone compounds in rhubarb

Published: May 15, 2019

Author(s): Xuan Chen, Zhuo‐yi Li, Xin Ge, Shuang Hu, Run‐qin Wang, Li Yang, Zhi‐hui Yu, Xiao‐hong Bai

Journal: Journal of Separation Science

Abstract This study proposed a new ballpoint connector‐protected salt‐oil‐salt liquid phase microextraction for extraction and enrichment of trace rhein and chrysophanol in rhubarb prior to determination of the analytes by high performance liquid chromatography. In this study, a handy ballpoint connector (between ballpoint tip and ink chamber) was used as extraction device, in which its cavity was filled with n‐octanol, and the bare n‐octanol in its two opening ends was covered with a thin...

Read More thumbnail image: Ballpoint connectorprotected saltoilsalt liquid phase microextraction for concentration and enrichment of trace anthraquinone compounds in rhubarb

Affinity capillary electrophoresis employed for determination of stability constants of antamanide complexes with univalent and divalent cations in methanol

Published: May 14, 2019

Author(s): Sachin Pangavhane, Emanuel Makrlík, Paolo Ruzza, Václav Kašička

Journal: ELECTROPHORESIS

Abstract Affinity capillary electrophoresis (ACE) and pressure‐assisted ACE were employed to study the noncovalent molecular interactions of antamanide (AA), cyclic decapeptide from the deadly poisonous fungus Amanita phalloides, with univalent (Li+, Na+, K+, and NH4+) and divalent (Mg2+ and Ca2+) cations in methanol. The strength of these interactions was quantified by the apparent stability constants of the appropriate AA‐cation complexes. The stability constants were calculated using the...

Read More thumbnail image: Affinity capillary electrophoresis employed for determination of stability constants of antamanide complexes with univalent and divalent cations in methanol

Lifetime measurements of ultrashort‐lived excited states in Be‐like ions

Published: May 14, 2019

Author(s): J. Rothhardt, M. Bilal, R. Beerwerth, A.V. Volotka, V. Hilbert, T. Stöhlker, S. Fritzsche, J. Limpert

Journal: X-Ray Spectrometry

We propose to measure the lifetime of short‐lived excited states in highly charged ions by pump‐probe experiments. Utilizing two synchronized and delayed Femtosecond pulses allows accessing these lifetimes with Femtosecond precision. Such measurements could provide sensitive tests of state‐of‐the art atomic structure calculations beyond the capabilities of established methods.

Read More thumbnail image: Lifetime measurements of ultrashortlived excited states in Belike ions

An approach for visualizing the spatial metabolome of an entire plant root system inspired by the Swiss‐rolling technique

Published: May 14, 2019

Author(s): Dušan Veličković, Rosalie K. Chu, Gabriel L. Myers, Amir H. Ahkami, Christopher R. Anderton

Journal: Journal of Mass Spectrometry

Abstract The spatial configuration and morphology of roots are commonly monitored for a better understanding of plant health and development. However, this approach provides minimal details about the biochemistry regulating the observable traits. Therefore, the ability to metabolically map the entire root structure would be of major value. Here, we developed a sample preparation approach that enables imaging of the entire root within a restricted space (width of microscope slide), which was...

Read More thumbnail image: An approach for visualizing the spatial metabolome of an entire plant root system inspired by the Swissrolling technique

Precise measurement and control of the pressure‐driven flows for microfluidic systems

Published: May 14, 2019

Author(s): Wen Zeng, Hai Fu

Journal: ELECTROPHORESIS

Abstract The pressure‐driven device is designed and the flow rates of the microfluidic systems can be supplied by the pressure‐driven flows, which can significantly reduce the flow‐rate fluctuations coming from the pump source. For pressure‐driven flows, the flow rates of the fluids can be predicted by measuring the pressure drop along a polytetrafluoroethylene (PTFE) tubing. Especially, by varying the geometrical parameters of the PTFE tubing, the predicted flow rates of the fluids are...

Read More thumbnail image: Precise measurement and control of the pressuredriven flows for microfluidic systems

Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

Published: May 14, 2019

Author(s): Agnieszka Latosinska, Justyna Siwy, Harald Mischak, Maria Frantzi

Journal: ELECTROPHORESIS

Abstract Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for several years for the investigation of proteins and peptides as biomarkers for diagnosis and prognosis of diseases. In addition, the technology has recently been introduced to support the stratification of patients in clinical trials and in large clinical studies. In this review, we aim at presenting the development of CE‐MS over the last 20 years, by focusing on the clinical potential of proteome and...

Read More thumbnail image: Peptidomics and proteomics based on CEMS as a robust tool in clinical application The past the present and the future

Comparative proteomic analysis of plasma of children with congenital heart disease

Published: May 14, 2019

Author(s): Qiong Huang, Zhi Geng, Tao Chen, Xiangjun Cheng, Haitao Gu, Qingguo Li, Dianfu Li, Rui Liu

Journal: ELECTROPHORESIS

Abstract Congenital heart disease is one of the largest class of birth defects. Eight subjects with ventricular septal defect (VSD, a kind of congenital heart disease) and 11 health children were enrolled in tandem mass tags label‐based quantitative proteomic analysis to compare plasma proteins differentially abundance. A total of 66 proteins were significantly upregulated or downregulated in VSD patients compared with healthy children. These proteins were involved in pathways linked to...

Read More thumbnail image: Comparative proteomic analysis of plasma of children with congenital heart disease

Simultaneous determination of nine trace concentration angiotensin peptides in human serum using ultra high performance liquid chromatography with tandem mass spectrometry with sephadex LH‐20 gel solid‐phase extraction

Published: May 13, 2019

Author(s): Yue Shen, Mingyang Liu, Mingyue Xu, Zhanling Xu, Yue Na, Ning Zhang, Fang Geng

Journal: Journal of Separation Science

Abstract The renin–angiotensin system is a highly complex enzymatic system consisting of multiple peptide hormones, enzymes, and receptors. Here, an assay to simultaneously quantify eight angiotensin peptides and bradykinin in human serum was developed and validated, using ultra high performance liquid chromatography coupled with tandem mass spectrometry. A pre‐concentration method of Sephadex LH‐20 gel solid‐phase extraction was first applied for analysis of angiotensin peptides from serum...

Read More thumbnail image: Simultaneous determination of nine trace concentration angiotensin peptides in human serum using ultra high performance liquid chromatography with tandem mass spectrometry with sephadex LH20 gel solidphase extraction

Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response

Published: May 13, 2019

Author(s): Coralie Petit, Jordan Guillon, Bertrand Toutain, Alice Boissard, Anne Patsouris, Eric Lelièvre, Catherine Guette, Olivier Coqueret

Journal: PROTEOMICS

Abstract In primary cells, senescence induces a permanent proliferative arrest to prevent the propagation of malignant cells. However, the outcome of senescence is more complex in advanced cancer cells where senescent states are heterogeneous. Here, this heterogeneity is discussed and it is proposed that proteomic analysis should be used to identify specific signatures of cancer cells that use this pathway as an adaptive mechanism. Since senescent cells produce an inflammatory secretome, MRM...

Read More thumbnail image: Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response
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