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Studies on oral bioavailability and first‐pass metabolism of withaferin A in rats using LC–MS/MS and Q‐TRAP

Published: May 26, 2019

Author(s): Tianming Dai, Weifan Jiang, Zizheng Guo, Zhenyu Wang, Mingping Huang, Guorui Zhong, Chuxin Liang, Xuzhe Pei, Renke Dai

Journal: Biomedical Chromatography

Abstract Withaferin A (WA) is one of the major bioactive steroidal lactones with extensive pharmacological activities present in the plant Withania somnifera. The absolute oral bioavailability of WA remains unknown and human‐related in vitro data are not available. Therefore, in the present study, the absolute oral bioavailability of WA in male rats and the in vitro screening of absorption factors by Q‐trap and LC–MS/MS analysis were conducted to explore possible clinical properties of WA. The...

Read More thumbnail image: Studies on oral bioavailability and firstpass metabolism of withaferin A in rats using LCMSMS and QTRAP

Identification and structural characterization of febuxostat metabolites in rat serum and urine samples using UHPLC–QTOF/MS

Published: May 26, 2019

Author(s): Liping Zhou, Hexiang Liu, Zhongyong Xu, Su Guan, Lei Zhang

Journal: Biomedical Chromatography

Abstract Febuxostat is a novel nonpurine type of highly selective xanthine oxidoreductase inhibitor. A rapid and sensitive ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry method for simultaneous separation and determination of febuxostat and its metabolites in rat serum and urine was developed at various time points after oral administration to the rats. The febuxostat metabolites were predicted by biotransformation software and transformed to a...

Read More thumbnail image: Identification and structural characterization of febuxostat metabolites in rat serum and urine samples using UHPLCQTOFMS

Identification of phenobarbital and other barbiturates in forensic drug screening using positive electrospray ionization liquid chromatography−high resolution mass spectrometry

Published: May 24, 2019

Author(s): Lars Jakobsen Høj, Christian Brinch Mollerup, Brian Schou Rasmussen, Sys Stybe Johansen, Kristian Linnet, Petur Weihe Dalsgaard

Journal: Drug Testing and Analysis

Abstract Comprehensive drug‐screening performed by liquid chromatography−high resolution mass spectrometry (LC−HRMS) enables identification of hundreds to thousands of drug compounds in a single analysis. Forensic drug screening is generally performed with positive electrospray ionization (ESI+), targeting basic drugs; however, a few toxicologically important drugs such as barbiturates, may require analysis by negative ESI. In this work, screening targets for barbiturates were determined using...

Read More thumbnail image: Identification of phenobarbital and other barbiturates in forensic drug screening using positive electrospray ionization liquid chromatographyhigh resolution mass spectrometry

Raman spectroscopic vibrational analysis of the complex iron sulfates clairite, metavoltine, and voltaite from the burning coal dump Anna I, Alsdorf, Germany

Published: May 23, 2019

Author(s): F. Košek, H.G.M. Edwards, J. Jehlička

Journal: Journal of Raman Spectroscopy

Abstract Vibrational spectroscopy has been used to characterize the three uncommon complex iron sulfates clairite, (NH4)2Fe3(SO4)4(OH)3 3H2O, metavoltine, Na6K2Fe2+Fe3+6(SO4)12O2·18H2O, and voltaite, K2Fe2+5Fe3+3Al(SO4)12 18H2O. The investigated specimens were formed at the burning coal dump Anna I (Alsdorf, Germany) due to alteration processes connected with the subsurface thermal activity. It is found that all three minerals display complex Raman spectra with an extensive proliferation of...

Read More thumbnail image: Raman spectroscopic vibrational analysis of the complex iron sulfates clairite metavoltine and voltaite from the burning coal dump Anna I Alsdorf Germany

High‐speed broadband Fourier‐transform coherent anti‐stokes Raman scattering spectral microscopy

Published: May 23, 2019

Author(s): Ryo Kinegawa, Kotaro Hiramatsu, Kazuki Hashimoto, Venkata Ramaiah Badarla, Takuro Ideguchi, Keisuke Goda

Journal: Journal of Raman Spectroscopy

Abstract We demonstrate broadband Fourier‐transform coherent anti‐Stokes Raman scattering (FT‐CARS) spectral microscopy with a pixel dwell time of 42 μs, which is ~50 times shorter than the shortest‐to‐date pixel dwell time for CARS spectral microscopy. Our broadband FT‐CARS spectral microscope is composed of an FT‐CARS spectrometer, a rapid galvanometric scanner, and a high‐speed image acquisition circuit, enabling a frame rate of 2.4 fps with a pixel resolution of 100 × 100 pixels, a...

Read More thumbnail image: Highspeed broadband Fouriertransform coherent antistokes Raman scattering spectral microscopy

Raman band widths of anhydrite II reveal the burning history of high‐fired medieval gypsum mortars

Published: May 23, 2019

Author(s): Thomas Schmid, Robert Jungnickel, Petra Dariz

Journal: Journal of Raman Spectroscopy

Abstract When used as a mineral binder, gypsum is thermally dehydrated and mixed with water, resulting in a paste hardening in the backreaction to calcium sulphate dihydrate (CaSO4 · 2 H2O). Although nowadays mainly hemihydrate‐based (CaSO4 · ½ H2O) binders are employed, higher firing temperatures in medieval kilns yielded anhydrite II (CaSO4). Except for the discrimination of the metastable phases anhydrite III and I due to different crystal structures, variations within the production...

Read More thumbnail image: Raman band widths of anhydrite II reveal the burning history of highfired medieval gypsum mortars

Rapid characterization of structural and functional similarity for a candidate bevacizumab (Avastin) biosimilar using a multipronged mass‐spectrometry‐based approach

Published: May 23, 2019

Author(s): Kerene A. Brown, Shanthi Rajendran, Jason Dowd, Derek J. Wilson

Journal: Drug Testing and Analysis

Abstract The ongoing shift from small molecule drugs to protein therapeutics in the pharmaceuticals industry presents a considerable challenge to generic drug developers who are increasingly required to demonstrate biosimilarity for biological macromolecules, a task that is decidedly more complex than doing the same for small molecule drugs. In this work, we demonstrate a multipronged mass‐spectrometry‐based workflow that allows rapid and facile molecular characterization of antibody‐based...

Read More thumbnail image: Rapid characterization of structural and functional similarity for a candidate bevacizumab Avastin biosimilar using a multipronged massspectrometrybased approach

Screening potential antagonists of epidermal growth factor receptor from Marsdenia tenacissima via cell membrane chromatography model assisted by HPLC–ESI–IT–TOF–MS

Published: May 23, 2019

Author(s): Yanni Lv, Xianpeng Shi, Jia Fu, Qianqian Jia, Yuanyuan Lin, Hongying Wang, Xin Yang, Shengli Han

Journal: Biomedical Chromatography

Abstract Marsdenia tenacissima, or Tongguanteng in Chinese, is a traditional Chinese herb and has a broad application in clinical practice for its pharmacological effects of treating asthma, pneumonia, tonsillitis, pharyngitis tumors, etc. However, few studies have reported the screening of the active components of this medicine for tumor therapy. In this work, a two‐dimensional analytical system was developed to screen antagonists of epidermal growth factor receptor (EGFR) from M....

Read More thumbnail image: Screening potential antagonists of epidermal growth factor receptor from Marsdenia tenacissima via cell membrane chromatography model assisted by HPLCESIITTOFMS

Matrix‐assisted ionization mass spectrometry in targeted protein analysis – An initial evaluation

Published: May 23, 2019

Author(s): Øystein Skjærvø, Sarah Trimpin, Trine Grønhaug Halvorsen

Journal: Rapid Communications in Mass Spectrometry

Rationale Matrix‐assisted ionization (MAI) is a relatively new ionization technique for analysis by mass spectrometry (MS). The technique is simple and has been shown to be less influenced by matrix effects than e.g. electrospray ionization (ESI). These features are of interest in the targeted analysis of proteins from biological samples. Methods Targeted protein determination by MAI‐MS was evaluated using a triple quadrupole mass analyzer equipped with a stripped nanoESI source in selected...

Read More thumbnail image: Matrixassisted ionization mass spectrometry in targeted protein analysis  An initial evaluation

Interaction of highly charged ions with carbon‐based materials using Kobe EBIS

Published: May 23, 2019

Author(s): Naofumi Nishida, Yuki Hori, Akane Yamauchi, Hazuki Fujiwara, Makoto Sakurai, Yuya Fujiwara, Shin‐ichi Honda, Shunjiro Fujii, Hiroyuki A. Sakaue, Daiji Kato, Tomohiro Yamaguchi, Koji Ishibashi, Toshifumi Terui, Kuei‐Yi Lee

Journal: X-Ray Spectrometry

Interaction of highly charged ions (HCIs) with surfaces produce various specific phenomena as a consequence of the potential energy that HCI possesses. In the present study, we have observed photon emission, structural, magnetic, and electronic modification on various carbon‐based materials such as carbon nanotube by the impact of HCIs using an electron beam ion source named Kobe EBIS installed at the Kobe University. In order to study the potential effect, HCIs of Arq+ (q = 6–16) with the...

Read More thumbnail image: Interaction of highly charged ions with carbonbased materials using Kobe EBIS

Optimization of a primary X‐ray filter for X‐ray fluorescence analysis of uranium and plutonium

Published: May 22, 2019

Author(s): Kota Ishii, Yukie Izumoto, Tsugufumi Matsuyama, Kumiko Fukutsu, Yasuhiro Sakai, Yoshiyuki Oguri, Hiroshi Yoshii

Journal: X-Ray Spectrometry

When workers are wounded at a nuclear fuel handling facility, it is difficult to quantify actinide contamination through α‐particle counting because these particles are shielded by blood. To overcome this problem, we used X‐ray fluorescence (XRF) analysis with a handheld‐type device that is useful in cases where sampling is not allowed, such as in this study. In XRF analysis, a primary X‐ray filter made of metal foil is generally inserted between the X‐ray tube and the sample to attenuate the...

Read More thumbnail image: Optimization of a primary Xray filter for Xray fluorescence analysis of uranium and plutonium

Characteristics of highly charged ions produced at Kobe EBIS under modulated operation

Published: May 22, 2019

Author(s): Naofumi Nishida, Yuuki Hori, Akane Yamauchi, Makoto Sakurai, Hiroyuki A. Sakaue, Daiji Kato

Journal: X-Ray Spectrometry

The electron beam ion source (Kobe EBIS) has been developed to perform modification of surfaces using highly charged ions (HCIs) at the Kobe University, Japan. Recent study revealed that periodic intermission of electron beam improves charge state distribution of extracted ions. The period of intermission is in the order of 100 ms, and the width of beam‐off time is 1 ms or less. This operational mode (pulse mode) makes it possible to produce Ar15+ to Ar17+ effectively, whereas the charge is...

Read More thumbnail image: Characteristics of highly charged ions produced at Kobe EBIS under modulated operation

Fractal characterizations of energetic Si ions irradiated amorphized‐Si surfaces

Published: May 22, 2019

Author(s): G. Maity, Sunil Ojha, I. Sulania, K. Devrani, Shiv P. Patel

Journal: Surface and Interface Analysis

The fractal characterizations of amorphized‐silicon (a‐Si) surfaces under low‐energy ion irradiations are presented. The crystalline Si surfaces have been irradiated with Si ions having different energy of 35, 50, 75, and 100 keV at a fixed fluence of 2 × 1015 ions‐cm−2. The samples have been characterized by means of using Raman spectroscopy, Channeling‐Rutherford backscattering spectrometry (C‐RBS), and atomic force microscopy (AFM) techniques. The ion irradiation leads to the amorphization...

Read More thumbnail image: Fractal characterizations of energetic Si ions irradiated amorphizedSi surfaces

Autoionization in the evolution process of dense Rb Rydberg atoms in nP states

Published: May 22, 2019

Author(s): Y. F. Li, D. M. Zhao, X. Ma, J. Yang

Journal: X-Ray Spectrometry

The autoionization mechanisms of dense nP3/2 (n = 20–97) Rydberg gases of 87Rb atoms in the spontaneous evolution were investigated for the first time. By observing the characteristic time of the electrons generated through autoionization process, the dependence of autoionization mechanisms (black‐body radiation, electron–Rydberg collision, and Penning ionization) on the principal quantum number n of initial nP states was demonstrated. The dependence on the number n in nP Rydberg atoms is...

Read More thumbnail image: Autoionization in the evolution process of dense Rb Rydberg atoms in nP states

An insight into chiral monolithic stationary phases for enantioselective high‐performance liquid chromatography applications

Published: May 22, 2019

Author(s): Ali Fouad, Diana Ibrahim, Frady G. Adly, Ashraf Ghanem

Journal: Journal of Separation Science

Abstract In this review, three main classes of chiral monolithic stationary phases, namely silica‐, organic polymer‐, and hybrid‐based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional‐packed and open‐tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization,...

Read More thumbnail image: An insight into chiral monolithic stationary phases for enantioselective highperformance liquid chromatography applications

Determination of GL‐V9, a derivative of wogonin, in rat plasma by UPLC–MS/MS and its application to a pharmacokinetic study after oral and pulmonary administration

Published: May 22, 2019

Author(s): Han Xing, Chang Ren, Ying Kong, Qi Ni, Zeyu Wang, Di Zhao, Ning Li, Xijing Chen, Yang Lu

Journal: Biomedical Chromatography

Abstract GL‐V9, a derivative of wogonin, shows much more potent anticancer properties than wogonin. In this study, a selective, sensitive and rapid ultra‐high‐performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) method was developed and validated for the determination of GL‐V9 in rat plasma. Plasma samples were processed using methanol to precipitate protein. Chromatographic separation of analytes was achieved on a C18 column using gradient elution within 4.5 min. The mobile...

Read More thumbnail image: Determination of GLV9 a derivative of wogonin in rat plasma by UPLCMSMS and its application to a pharmacokinetic study after oral and pulmonary administration

A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study

Published: May 22, 2019

Author(s): Yi Tao, Surun Huang, Jizhong Yan, Baochang Cai

Journal: Biomedical Chromatography

Abstract A simple and reliable liquid chromatography–mass spectrometry (LC–MS) method was developed for simultaneous determination of saikosaponin A, saikosaponin B1, saikosaponin C, saikosaponin D and saikosaponin F in rat plasma using glycyrrhetinic acid as an internal standard (IS). The separation was operated on a Waters BEH C18 column. The mobile phases of gradient elution consisted of acetonitrile (A) and 0.1% aqueous acetic acid (B). The mass spectrometric detection was accomplished in...

Read More thumbnail image: A reliable LCMSMS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study

Single and double electron capture associated with target K‐shell ionization for F7 + ,8 + ,9++Ar

Published: May 22, 2019

Author(s): David La Mantia, P. N. S. Kumara, Asghar Kayani, John Tanis

Journal: X-Ray Spectrometry

Ratios for target Ar K‐shell ionization associated with single and double electron capture, as well as the ratios corresponding to total capture and the projectile K x rays, were determined for 1.8‐ to 2.2‐MeV/u F7 + ,8 + ,9+ projectiles. This work was performed at Western Michigan University with the tandem Van de Graaff accelerator. Coincidences between emitted K‐shell X‐rays (both target and projectile) and the corresponding charge‐changed particles were observed. The F9+ Ar K X‐ray...

Read More thumbnail image: Single and double electron capture associated with target Kshell ionization for F789Ar

State‐selective single‐electron capture in 30‐keV N3+–He collisions

Published: May 21, 2019

Author(s): Jiawei Xu, Xiaolong Zhu, Wentian Feng, Dongmei Zhao, Weizhe Huang, Dalong Guo, Yong Gao, Shaofeng Zhang, Xu Shan, Xiangjun Chen, Xinwen Ma

Journal: X-Ray Spectrometry

The cold‐target recoil‐ion momentum spectroscopy has been employed to study the single‐electron‐capture processes in collisions of N3+ ions with He atoms at an impact energy of 30 keV. From the longitudinal momentum spectrum of recoil ions, the different electronic configuration was identified, and the metastable projectile ions were distinguished. For the ground‐state N3+(2s2 1S) projectile, the single‐electron capture into the N2+(2s22p 2P) state is the dominant reaction channel, whereas for...

Read More thumbnail image: Stateselective singleelectron capture in 30keV N3He collisions

Dielectronic recombination at low energy range with Boron‐like Ar13+at the CSRm

Published: May 21, 2019

Author(s): Z.K. Huang, S.X. Wang, W.Q. Wen, X. Xu, H.B. Wang, S. Li, L.J. Dou, N. Khan, S. Mahmood, X.L. Zhu, D.M. Zhao, L.J. Mao, X.M. Ma, J. Li, R.S. Mao, J.C. Yang, D.Y. Yin, Y.J. Yuan, C.Y. Chen, L.F. Zhu, X. Ma

Journal: X-Ray Spectrometry

In order to extend the dielectronic recombination (DR) experiments from the main cooler storage ring CSRm with intermediate charge state ions to the experimental cooler storage ring CSRe with highly charged ions and even radioactive ions, a test electron‐ion recombination experiment of B‐like Ar13+ ions was performed with a section of the new electron beam energy detuning system, which will be installed at the CSRe. We present the measured and also the calculated DR spectra for the ∆n = 0...

Read More thumbnail image: Dielectronic recombination at low energy range with Boronlike Ar13at the CSRm
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