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Trace analysis of rimantadine in human urine after dispersive liquid liquid microextraction followed by liquid chromatography–post column derivatization

Published: Nov 18, 2019

Author(s): Constantinos K. Zacharis, Paraskevas D. Tzanavaras

Journal: Journal of Separation Science

Abstract The first dispersive liquid liquid microextraction scheme followed by liquid chromatography‐post column derivatization for the determination of the antiviral drug rimantadine in urine samples is demonstrated. The effect of the type and volume of organic extraction solvent, type and volume of disperser solvent, sample pH, ionic strength, extraction time, and centrifugation speed on the extraction efficiency were studied. Rimantadine and the internal standard (amantadine) were...

Read More thumbnail image: Trace analysis of rimantadine in human urine after dispersive liquid liquid microextraction followed by liquid chromatographypost column derivatization

Pharmacokinetics of 13 active components in a rat model of middle cerebral artery occlusion after intravenous injection of Radix Salviae miltiorrhizae‐Lignum dalbergiae odoriferae prescription

Published: Nov 18, 2019

Author(s): Baimei Shi, Qiannan Li, Ying Feng, Xufen Dai, Rui Zhao, Ye Zhao, Pu Jia, Shixiang Wang, Jie Yu, Sha Liao, Yi‐fei Li, Xiaohui Zheng

Journal: Journal of Separation Science

Abstract As a representative formulation of Radix Salviae miltiorrhizae (Danshen)‐Lignum Dalbergiae odoriferae (Jiangxiang), Xiangdan injection is widely prescribed for cardio‐ and cerebrovascular diseases in practice. This necessitates a pharmacokinetic investigation of this formulation to make it safer and more broadly applicable. We developed and validated a sensitive, selective, and reliable high‐performance liquid chromatography with tandem mass spectrometry method for the simultaneous...

Read More thumbnail image: Pharmacokinetics of 13 active components in a rat model of middle cerebral artery occlusion after intravenous injection of Radix Salviae miltiorrhizaeLignum dalbergiae odoriferae prescription

Comparative Proteomics Analysis Reveals Roles for FADD in the Regulation of Energy Metabolism and Proteolysis Pathway in Mouse Embryonic Fibroblast

Published: Nov 18, 2019

Author(s): Hongqin Zhuang, Ziyi Gan, Weiwei Jiang, Xiangyu Zhang, Zi‐Chun Hua

Journal: PROTEOMICS

Read More thumbnail image: Comparative Proteomics Analysis Reveals Roles for FADD in the Regulation of Energy Metabolism and Proteolysis Pathway in Mouse Embryonic Fibroblast

Contemporary chiral simulators for capillary zone electrophoresis

Published: Nov 18, 2019

Author(s): Jitka Caslavska, Wolfgang Thormann

Journal: ELECTROPHORESIS

Abstract For separation of enantiomers in presence of a chiral selector, data obtained with the 1D dynamic simulators SIMUL5complex and GENTRANS are compared to data predicted by PeakMaster 6, a recently released generalized model of the linear theory of electromigration. Four electrophoretic systems with stereoisomers of weak bases were investigated. They deal with the estimation of input data for complexation together with the elucidation of the origin of observed system peaks, the...

Read More thumbnail image: Contemporary chiral simulators for capillary zone electrophoresis

Development of a high‐temperature superconducting magnet for use in a cryogen‐free electron beam ion trap

Published: Nov 18, 2019

Author(s): Toshihiro Tamai, Hiroyuki A. Sakaue, Yoshiro Terazaki, Nagato Yanagi, Nobuyuki Nakamura

Journal: X-Ray Spectrometry

We present a design and test results of a high‐temperature superconducting magnet, which is under development for use in a new cryogen‐free electron beam ion trap. The magnet is designed to provide a magnetic field as high as about 3 T with a combination of six double‐pancake coils. In order to achieve such a high field, the critical current is increased by cooling the magnet down to 20 K with a refrigerator. Before the full development, a single‐pancake coil has been produced and tested.

Read More thumbnail image: Development of a hightemperature superconducting magnet for use in a cryogenfree electron beam ion trap

MULTIOMIC patterns in body fluids: Technological challenge with a great potential to implement the advanced paradigm of 3P medicine

Published: Nov 18, 2019

Author(s): Christopher Gerner, Vincenzo Costigliola, Olga Golubnitschaja

Journal: Mass Spectrometry Reviews

Liquid biopsy (LB) is defined as a sample of any of body fluids (blood, saliva, tear fluid, urine, sweat, amniotic, cerebrospinal and pleural fluids, cervicovaginal secretion, and wound efflux, amongst others), which can be ex vivo analysed to detect and quantity the target(s) of interest. LB represents diagnostic approach relevant for organ‐specific changes and systemic health conditions including both manifested diseases and their prestages such as suboptimal health. Further, experts...

Read More thumbnail image: MULTIOMIC patterns in body fluids Technological challenge with a great potential to implement the advanced paradigm of 3P medicine

Low‐cost multi‐core inertial microfluidic centrifuge for high‐throughput cell concentration

Published: Nov 18, 2019

Author(s): Nan Xiang, Qiao Li, Zhiguo Shi, Chenguang Zhou, Fengtao Jiang, Yu Han, Zhonghua Ni

Journal: ELECTROPHORESIS

Abstract We developed a low‐cost multi‐core inertial microfluidic centrifuge (IM‐centrifuge) to achieve a continuous‐flow cell/particle concentration at a throughput of up to 20 mL/min. To lower the cost of our IM‐centrifuge, we clamped a disposable multilayer film‐based inertial microfluidic (MFIM) chip with two reusable plastic housings. The key MFIM chip was fabricated in low‐cost materials by stacking different polymer‐film channel layers and double‐sided tape. To increase processing...

Read More thumbnail image: Lowcost multicore inertial microfluidic centrifuge for highthroughput cell concentration

Aligning retention time shifts in HPLC three‐dimensional spectra by icoshift approach combined with data arrangement methods and the release of a graphical user interface

Published: Nov 18, 2019

Author(s): Xiang‐Zhi Zhang, Na Feng, Ai‐Jun Ma, Bao Qiong Li

Journal: Journal of Separation Science

Abstract High‐performance liquid chromatography coupled with photodiode array detection has been extensively applied in many fields and the peaks among the analyzed samples can be shifted due to the variations of instrumental and experimental conditions. In multivariate analysis, retention time alignment is an important pretreatment step. Hence, the shifted peaks in high‐performance liquid chromatography coupled with photodiode array detection three‐dimensional spectra should be aligned for...

Read More thumbnail image: Aligning retention time shifts in HPLC threedimensional spectra by icoshift approach combined with data arrangement methods and the release of a graphical user interface

Investigating aroma diversity combining purge‐and‐trap, comprehensive two‐dimensional gas chromatography, and mass spectrometry

Published: Nov 18, 2019

Author(s): Flavio Antonio Franchina, Delphine Zanella, Eliane Lazzari, Pierre‐Hugues Stefanuto, Jean‐François Focant

Journal: Journal of Separation Science

Abstract Headspace gas chromatography is frequently used for aroma profiling thanks to its ability to naturally exploit the volatility of aroma compounds, and also to provide chemical information on sample composition. Its main advantages rely on simplicity, no use of solvent, amenability to automation, and the cleanliness of the extract. In the present contribution, the most effective sampling (dynamic extraction), separation (multidimensional gas chromatography), and detection (mass...

Read More thumbnail image: Investigating aroma diversity combining purgeandtrap comprehensive twodimensional gas chromatography and mass spectrometry

Raman spectra of a graphite–nontronite association in marbles from Oltrek Island (Lake Baikal, Russia)

Published: Nov 18, 2019

Author(s): T.N. Moroz, H.G.M. Edwards, V.A. Ponomarchuk, A.N. Pyryaev, N.A. Palchik, S.V. Goryainov

Journal: Journal of Raman Spectroscopy

Abstract The graphite in marbles from Oltrek, an uninhabited island on Lake Baikal, has been investigated by micro‐Raman spectroscopy using visible and near‐ultraviolet wavelength excitation. All graphite samples exhibit a sharp first‐order Raman band at about 1,580 cm−1 with a width from 10 to 19 cm−1, and sometimes a D1 band with very low intensity, which is occasionally absent. Using Raman spectra data it was estimated that the temperature of graphite formation in the Oltrek marbles is...

Read More thumbnail image: Raman spectra of a graphitenontronite association in marbles from Oltrek Island Lake Baikal Russia

The costs and benefits of estimating T1 of tissue alongside cerebral blood flow and arterial transit time in pseudo‐continuous arterial spin labeling

Published: Nov 18, 2019

Author(s): Piet Bladt, Arnold J. Dekker, Patricia Clement, Eric Achten, Jan Sijbers

Journal: NMR in Biomedicine

Multi‐post‐labeling‐delay pseudo‐continuous arterial spin labeling (multi‐PLD PCASL) allows for absolute quantification of the cerebral blood flow (CBF) as well as the arterial transit time (ATT). Estimating these perfusion parameters from multi‐PLD PCASL data is a non‐linear inverse problem, which is commonly tackled by fitting the single‐compartment model (SCM) for PCASL, with CBF and ATT as free parameters. The longitudinal relaxation time of tissue T1t is an important parameter in this...

Read More thumbnail image: The costs and benefits of estimating T1 of tissue alongside cerebral blood flow and arterial transit time in pseudocontinuous arterial spin labeling

Feasibility of 31P spectroscopic imaging at 7 T in lung carcinoma patients

Published: Nov 18, 2019

Author(s): Quincy (.Q.). Houtum, Firdaus (.F.A.A.). Mohamed Hoesein, Joost (.J.J.C.). Verhoeff, Peter (.P.S.N.). Rossum, Anne (.A.S.R.). Lindert, Tijl (.T.A.). Velden, Wybe (.W.J.M.). Kemp, Dennis (.D.W.J.). Klomp, Catalina (.C.S.). Arteaga de Castro

Journal: NMR in Biomedicine

Currently, it is difficult to predict effective therapy response to molecular therapies for the treatment of lung cancer based solely on anatomical images. 31P MR spectroscopic imaging could provide as a non‐invasive method to monitor potential biomarkers for early therapy evaluation, a necessity to improve personalized care and reduce cost. However, surface coils limit the imaging volume in conventional 31P MRSI. High‐energetic adiabatic RF pulses are required to achieve flip angle...

Read More thumbnail image: Feasibility of 31P spectroscopic imaging at 7 T in lung carcinoma patients

Human in vivo metabolism study of LGD‐4033

Published: Nov 18, 2019

Author(s): Argyro G. Fragkaki, Panagiotis Sakellariou, Polyxeni Kiousi, Nassia Kioukia‐Fougia, Maria Tsivou, Michael Petrou, Yiannis Angelis

Journal: Drug Testing and Analysis

Read More thumbnail image: Human in vivo metabolism study of LGD4033

Phospholipids accumulation and calcification in cultured primary human aortic valve interstitial cells: New insights revealed by confocal Raman imaging

Published: Nov 18, 2019

Author(s): Krzysztof Czamara, Magdalena Kopytek, Malgorzata Szulczewska, Agnieszka Kaczor, Joanna Natorska

Journal: Journal of Raman Spectroscopy

Abstract Raman imaging was applied to investigate calcification process in situ in primary human aortic valve interstitial cells (HAVICs) isolated from patients with developed non‐rheumatic aortic stenosis (AS). To invoke calcification, cells were incubated in an osteogenic medium (OSM) in some cases supplemented with glucose. Surprisingly, upon 7 days of incubation, no calcification in the form of inorganic salts was detected, instead, the increase of lipid inclusions containing phospholipids...

Read More thumbnail image: Phospholipids accumulation and calcification in cultured primary human aortic valve interstitial cells New insights revealed by confocal Raman imaging

A novel approach to the quantification of urinary aryl‐propionamide‐derived SARMs by UHPLC–MS/MS

Published: Nov 18, 2019

Author(s): Azamat Temerdashev, Ekaterina Dmitrieva, Alice Azaryan, Elina Gashimova

Journal: Biomedical Chromatography

Abstract A simple and sensitive procedure for the quantification of two commonly abused aryl‐propionamide‐derived selective androgen receptor modulators (SARMs), namely S‐4 (GTx‐007, andarine) and S‐22 (GTx‐024, MK‐2866, ostarine, enobosarm), has been described. Urine samples were prepared for analysis by means of a dispersive liquid–liquid microextraction using methanol and chloroform as dispersive and extracting solvents, respectively. Factors that might influence the extraction process as...

Read More thumbnail image: A novel approach to the quantification of urinary arylpropionamidederived SARMs by UHPLCMSMS

An NMR based panorama of the heterogeneous biology of acute respiratory distress syndrome (ARDS) from the standpoint of metabolic biomarkers

Published: Nov 16, 2019

Author(s): Akhila Viswan, Chandan Singh, Arvind M. Kayastha, Afzal Azim, Neeraj Sinha

Journal: NMR in Biomedicine

Acute respiratory distress syndrome (ARDS), manifested by intricate etiology and pathophysiology, demands careful clinical surveillance due to its high mortality and imminent life support measures. NMR based metabolomics provides an approach for ARDS which culminates from a wide spectrum of illness thereby confounding early manifestation and prognosis predictors. 1H NMR with its manifold applications in critical disease settings can unravel the biomarker of ARDS thus holding potent...

Read More thumbnail image: An NMR based panorama of the heterogeneous biology of acute respiratory distress syndrome ARDS from the standpoint of metabolic biomarkers

Extraction of methyl xanthines and their UHPLC–DAD determination in consumable beverages used in Eastern province of Saudi Arabia

Published: Nov 16, 2019

Author(s): Rizwan Ahmad, Niyaz Ahmad, Fatimah AlOthman, Haya Mohammad, Fatimah AlZahrani

Journal: Biomedical Chromatography

Abstract Coffee and tea are the most widely consumed beverages worldwide. However, the consumer may be unaware of the exact amount of methyl xanthine (MX, i.e. caffeine [C], theobromine [TB] and theophylline [TH]) consumed, as most of the products do not list the proper amounts. This may lead to serious risks including cardiovascular, kidney and stimulant effects. The aim of the study was to determine the MX amount in ready‐to‐use beverages (coffee and tea) collected from various outlets in...

Read More thumbnail image: Extraction of methyl xanthines and their UHPLCDAD determination in consumable beverages used in Eastern province of Saudi Arabia

Validation and application of a novel UHPLC–MS/MS method for the measurement of furanodienone in rat plasma

Published: Nov 16, 2019

Author(s): Zhipeng Deng, Qian Liu, Weihong Wu, Hong Wang

Journal: Biomedical Chromatography

Abstract A sensitive ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method was established to analyze furanodienone in rat plasma. In the process of chromatographic separation, selected reaction monitoring transitions for furanodienone and patchouli alcohol (internal standard, IS) were m/z 231.1 → 83.2 and m/z 205.1 → 95.1, respectively. Great linearity of furanodienone in plasma samples was found in the corresponding concentration range (r   0.995). Intra‐...

Read More thumbnail image: Validation and application of a novel UHPLCMSMS method for the measurement of furanodienone in rat plasma

Detecting liver fibrosis using a machine learning‐based approach to the quantification of the heart‐induced deformation in tagged MR images

Published: Nov 15, 2019

Author(s): Yasmine Ahmed, Rasha S. Hussein, Tamer A. Basha, Ayman M. Khalifa, Ahmed S. Ibrahim, Ahmed S. Abdelmoaty, Heba M. Abdella, Ahmed S. Fahmy

Journal: NMR in Biomedicine

Liver disease causes millions of deaths per year worldwide, and approximately half of these cases are due to cirrhosis, which is an advanced stage of liver fibrosis that can be accompanied by liver failure and portal hypertension. Early detection of liver fibrosis helps in improving its treatment and prevents its progression to cirrhosis. In this work, we present a novel noninvasive method to detect liver fibrosis from tagged MRI images using a machine learning‐based approach. Specifically,...

Read More thumbnail image: Detecting liver fibrosis using a machine learningbased approach to the quantification of the heartinduced deformation in tagged MR images

Raman spectroscopy to investigate the speciation and origin of hazardous elements associated to suspended particulate matter during a large flood event

Published: Nov 15, 2019

Author(s): Ainara Gredilla, Silvia Fdez‐Ortiz de Vallejuelo, Leticia Gomez‐Nubla, Julene Aramendia, Estilita Ruiz‐Romera, Alberto Diego, Iñaki Antigüedad, Juan Manuel Madariaga

Journal: Journal of Raman Spectroscopy

Abstract Hazardous elements are usually incorporated in natural fresh waters forming inorganic compounds or adsorbed onto organic matter as insoluble compounds in suspended particulate matters (SPMs). Considering the predominant transport of SPMs during heavy rainfalls, storms, or snow melting, such events require deep and exhaustive research to evaluate their environmental risk. The present work applies Raman spectroscopy for the analysis of SPM samples collected during a storm event...

Read More thumbnail image: Raman spectroscopy to investigate the speciation and origin of hazardous elements associated to suspended particulate matter during a large flood event
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