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Zeta potentials of PDMS surfaces modified with poly(ethylene glycol) by physisorption

Published: Sep 13, 2019

Author(s): Yongxin Song, Angran Feng, Zhijian Liu, Dongqing Li

Journal: ELECTROPHORESIS

Abstract Controlling zeta potential of PDMS surface coated with a layer of PEG is important for electroosmosis and electrophoresis in PDMS made microfluidic chips. Here, zeta potentials of PDMS surfaces modified by simple physisorption of PEG of different concentrations in phosphate buffer solutions, pure water, and PEG solution were reported. Coating PEG on PDMS surfaces was achieved by immersing a PDMS layer into the PEG solution for 10 min and then taking it out and placing it in an oven at...

Read More thumbnail image: Zeta potentials of PDMS surfaces modified with polyethylene glycol by physisorption

3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD+

Published: Sep 13, 2019

Author(s): Tom H. Peeters, Mark J. Uden, Anne Rijpma, Tom W.J. Scheenen, Arend Heerschap

Journal: NMR in Biomedicine

31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved signal‐to‐noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual‐tuned birdcage transmit coil and a 31P eight‐channel phased‐array receive insert. To further increase...

Read More thumbnail image: 3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array An assessment of 1H decoupling T1 relaxation times 1H31P nuclear Overhauser effects and NAD

PRESS timings for resolving 13C4‐glutamate 1H signal at 9.4 T: Demonstration in rat with uniformly labelled 13C‐glucose

Published: Sep 13, 2019

Author(s): Brennen J. Dobberthien, Anthony G. Tessier, Avalyn E. Stanislaus, Michael B. Sawyer, B. Gino Fallone, Atiyah Yahya

Journal: NMR in Biomedicine

MRS of 13C4‐labelled glutamate (13C4‐Glu) during an infusion of a carbon‐13 (13C)‐labelled substrate, such as uniformly labelled glucose ([U‐13C6]‐Glc), provides a measure of Glc metabolism. The presented work provides a single‐shot indirect 13C detection technique to quantify the approximately 2.51 ppm 13C4‐Glu satellite proton (1H) peak at 9.4 T. The methodology is an optimized point‐resolved spectroscopy (PRESS) sequence that minimizes signal contamination from the strongly coupled protons...

Read More thumbnail image: PRESS timings for resolving 13C4glutamate 1H signal at 9_4 T Demonstration in rat with uniformly labelled 13Cglucose

Improved off‐resonance phase behavior using a phase‐inverted adiabatic half‐passage pulse for 13C MRS in humans at 7 T

Published: Sep 13, 2019

Author(s): Eulalia Serés Roig, Lijing Xin, Daniel Gallichan, Vladimir Mlynarik, Rolf Gruetter

Journal: NMR in Biomedicine

In vivo 13C MRS at high field benefits from an improved SNR and spectral resolution especially when using surface coils in combination with adiabatic pulses, such as the adiabatic half‐passage (AHP) pulse for 13C excitation. However, the excitation profile of the AHP pulse is asymmetric relative to the carrier frequency, which could lead to asymmetric excitation of the spectral lines relative to the center of the spectrum. In this study, a pulse‐acquire sequence was designed for adiabatic 13C...

Read More thumbnail image: Improved offresonance phase behavior using a phaseinverted adiabatic halfpassage pulse for 13C MRS in humans at 7 T

Determination of phenamacril residues in flour and rice based on Z‐Sep+ using ultra‐high‐performance liquid chromatography–tandem mass spectrometry

Published: Sep 12, 2019

Author(s): MingNa Sun, Lu Yu, Zhou Tong, Xu Dong, Yue Chu, Mei Wang, TongChun Gao, JinSheng Duan

Journal: Biomedical Chromatography

Abstract Phenamacril is a new broad‐spectrum fungicide that is commonly used for the control of fungal diseases in wheat and rice. In this study, ultra‐high‐performance liquid chromatography–tandem mass spectrometry was used to establish a method for analyzing the residual phenamacril in flour and rice based on the improved QuEChERS (quick, easy, cheap, effective, rugged and safe) method using Z‐Sep+ as the adsorbent in the pre‐treatment process. The average recovery of phenamacril in flour...

Read More thumbnail image: Determination of phenamacril residues in flour and rice based on ZSep using ultrahighperformance liquid chromatographytandem mass spectrometry

Quantitative determination of artemisinin in rat hemolyzed plasma by an HPLC–HRMS method

Published: Sep 12, 2019

Author(s): Yulin Wang, Yueyue Wang, Yuming Sun

Journal: Biomedical Chromatography

Abstract Iron present in hemolyzed plasma could cause the degradation of artemisinin by reductively cleaving the peroxide bridge of artemisinin during sample preparation, which is a significant technical challenge for artemisinin determination. In this paper, this issue was resolved by using sodium nitrite as methemoglobin‐forming agent to oxidize hemoglobin to methemoglobin in the presence of acetic acid and prevent the degradation of artemisinin in hemolyzed plasma during the sample...

Read More thumbnail image: Quantitative determination of artemisinin in rat hemolyzed plasma by an HPLCHRMS method

Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer

Published: Sep 12, 2019

Author(s): Ronald C. Bruntz, Alex C. Belshoff, Yan Zhang, Jessica K. A. Macedo, Richard M. Higashi, Andrew N. Lane, Teresa W.‐M. Fan

Journal: PROTEOMICS

Abstract Large clinical trials and model systems studies suggest that the chemical form of selenium dictates chemopreventive and chemotherapeutic efficacy. Selenite induces excess ROS production, which mediates autophagy and eventual cell death in non‐small cell lung cancer adenocarcinoma A549 cells. As the mechanisms underlying these phenotypic effects are unclear, the clinical relevance of selenite for cancer therapy remains to be determined. The authors' previous stable isotope‐resolved...

Read More thumbnail image: Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer

μ‐Raman as a fundamental tool in the origin of natural or synthetic cinnabar: Preliminary data

Published: Sep 12, 2019

Author(s): Michela Botticelli, Adriana Maras, António Candeias

Journal: Journal of Raman Spectroscopy

Abstract This paper is a preliminary study on the origin of the precious red pigment cinnabar by μ‐Raman analysis. The importance of this pigment is partly due to its low availability. When the mineral was used in the Roman Age, the district of Almadén, Spain, was probably the most exploited region. However, it is still not well defined if further ores were chosen for supply. A scientific methodology has to be assessed. In the present study, samples with known provenance (Spain, Slovenia,...

Read More thumbnail image: Raman as a fundamental tool in the origin of natural or synthetic cinnabar Preliminary data

Thermal sensitivity as a quality control attribute for biotherapeutics: The L‐asparaginase case

Published: Sep 12, 2019

Author(s): Han Yao, Evelien Wynendaele, Bart De Spiegeleer

Journal: Drug Testing and Analysis

Abstract Thermal sensitivity, as a practical measure of thermostability, is an interesting quality attribute that can be used in the quality control (QC) release of biopharmaceuticals. This article investigates circular dichroism (CD) spectroscopy and nano‐differential scanning fluorimetry (nano‐DSF) to evaluate the thermal stability of E.coli L‐asparaginase (L‐ASNase) for QC purposes. In CD, molar ellipticity as a function of temperature (from 20 to 80°C) was measured at 222 nm. Different...

Read More thumbnail image: Thermal sensitivity as a quality control attribute for biotherapeutics The Lasparaginase case

Development of a mono‐specific anti‐VEGF bivalent nanobody with extended plasma half‐life for treatment of pathologic neovascularization

Published: Sep 12, 2019

Author(s): Amir Sadeghi, Mahdi Behdani, Serge Muyldermans, Mahdi Habibi‐Anbouhi, Fatemeh Kazemi‐Lomedasht

Journal: Drug Testing and Analysis

Abstract Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis within solid cancers. Thus, targeting VEGF might be part of a feasible therapy for treating pathological neovascularization, and nanobodies − derived from heavy chain‐only antibodies occurring within Camelidae − are a novel class of nanometer‐sized antibodies possessing unique properties that could be developed into a promising therapeutic. However, nanobodies have a very short half‐life in vivo due to...

Read More thumbnail image: Development of a monospecific antiVEGF bivalent nanobody with extended plasma halflife for treatment of pathologic neovascularization

Pharmacokinetics and absolute oral bioavailability of stemazole by UPLC–MS/MS and its bio‐distribution through tritium labeling

Published: Sep 12, 2019

Author(s): Huajun Li, Qi Tan, Yubo Zhang, Jing Zhang, Chaoran Zhao, Shuai Lu, Jinping Qiao, Mei Han

Journal: Drug Testing and Analysis

Abstract The small molecule, stemazole, has significant therapeutic effects on neurodegenerative diseases, such as Alzheimer's disease (AD), due to its neuroprotective effects and remarkable survival‐promoting activity in stem cells. However, pharmacokinetic properties of stemazole were unclear. In this study, a rapid and effective ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC−MS/MS) method was developed to detect stemazole. The detector was operated in the...

Read More thumbnail image: Pharmacokinetics and absolute oral bioavailability of stemazole by UPLCMSMS and its biodistribution through tritium labeling

Meet the contributors: Nicolas Leuenberger Swiss Laboratory for Doping Analyses, Epalinges, Switzerland

Published: Sep 12, 2019

Author(s): Paul Trevorrow

Journal: Drug Testing and Analysis

Read More thumbnail image: Meet the contributors Nicolas Leuenberger Swiss Laboratory for Doping Analyses Epalinges Switzerland

SIMS accurate determination of matrix composition of topological crystalline insulator material Pb1 − xSnxSe

Published: Sep 11, 2019

Author(s): Rafał Jakieła, Marta Galicka, Piotr Dziawa, Gunther Springholz, Adam Barcz

Journal: Surface and Interface Analysis

Substitutional alloy Pb1 − xSnxSe is a new class of electronic materials called topological crystalline insulators, which at the temperature range from 0 K to 300 K exhibit topological state at compositions in the range 0.18 

Read More thumbnail image: SIMS accurate determination of matrix composition of topological crystalline insulator material Pb1  xSnxSe

Surfactant‐mediated formation of alginate layers at the water‐air interface

Published: Sep 11, 2019

Author(s): Patrick Degen, Michael Paulus, Elena Zwar, Victoria Jakobi, Susanne Dogan, Metin Tolan, Heinz Rehage

Journal: Surface and Interface Analysis

The self‐organization process of polysaccharide alginate with different cationic surfactants at the water‐air interface was investigated over a wide concentration regime. The changes of surface properties determined by surface tension measurements, surface rheology, and X‐ray reflectivity are correlated with changes of bulk properties measured by turbidity, light scattering, and zeta potential measurements. We demonstrate that the interactions between the alginate and cationic surfactants...

Read More thumbnail image: Surfactantmediated formation of alginate layers at the waterair interface

Molecularly imprinted polymer solid‐phase microextraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine

Published: Sep 11, 2019

Author(s): Qiang Fu, Aiguo Zeng, Chun Chang, Xia Cui, Hua Shu, Lu Wang, Xuan Li, Guoning Chen, Zhimin Luo

Journal: Journal of Separation Science

Abstract Pyrrolizidine alkaloids are the most widely distributed natural toxins, and pyrrolizidine alkaloid‐containing herbal medicines are probably the most common poisonous plants affecting humans. We reported pyrrolizidine alkaloid‐molecularly imprinted polymer solid‐phase microextraction for the selective adsorption of toxic pyrrolizidine alkaloids from herbal medicine. A sulfonic compound, sodium allylsulfonate, was chosen as the functional monomer to interact with pyrrolizidine alkaloids...

Read More thumbnail image: Molecularly imprinted polymer solidphase microextraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine

Molecularly imprinted polymer coating on metal‐organic frameworks for solid‐phase extraction of fluoroquinolones from water

Published: Sep 11, 2019

Author(s): Shanwen Zhao, Zhian Sun, Huachun Liu, Yanqiang Zhou, Jianmin Li, Xiaoxiao Wang, Bolin Gong

Journal: Journal of Separation Science

Abstract In this work, a novel surface molecularly imprinted polymer with high adsorption capacity, high adsorption rate, and high selectivity for fluoroquinolones was prepared on the surface of UiO‐66‐NH2, which is a kind of metal‐organic framework. The surface morphology and adsorption properties of this molecularly imprinted polymer were investigated. The maximum adsorption capacity was 99.19 mg/g, and adsorption equilibrium was achieved within 65 s. Combined with reversed‐phase...

Read More thumbnail image: Molecularly imprinted polymer coating on metalorganic frameworks for solidphase extraction of fluoroquinolones from water

Detection of Δ9 THC in oral fluid following vaporized cannabis with varied cannabidiol (CBD) content: An evaluation of two point‐of‐collection testing devices

Published: Sep 10, 2019

Author(s): Thomas R. Arkell, Richard C. Kevin, Jordyn Stuart, Nicholas Lintzeris, Paul S. Haber, Johannes G. Ramaekers, Iain S. McGregor

Journal: Drug Testing and Analysis

Abstract Point‐of‐collection testing (POCT) for Δ9‐tetrahydrocannabinol (THC) in oral fluid is increasingly used to detect driving under the influence of cannabis (DUIC). However, previous studies have questioned the reliability and accuracy of two commonly used POCT devices, the Securetec DrugWipe® 5 s (DW5s) and Dräger DrugTest® 5000 (DT5000). In the current placebo controlled, double‐blind, crossover study we used liquid chromatography‐tandem mass spectrometry (LC–MS/MS) to accurately...

Read More thumbnail image: Detection of 9 THC in oral fluid following vaporized cannabis with varied cannabidiol CBD content An evaluation of two pointofcollection testing devices

In situ conversion monitoring of styrene emulsion polymerization by deconvolution of a single reference band near 1,000 cm−1

Published: Sep 10, 2019

Author(s): E. Dropsit, S. Hoppe, D. Chapron, A. Durand, P. Bourson

Journal: Journal of Raman Spectroscopy

Abstract Styrene emulsion polymerization was performed in batch reactor using Raman spectroscopy for in situ monitoring of styrene conversion. The variation of the band of trigonal aromatic ring breathing at 1,000 cm−1 was analyzed in detail as a function of monomer conversion (wavenumber, integrated intensity, and half‐width at half‐maximum). The observed variation was described both qualitatively and quantitatively by a model assuming that the overall signal resulted from the addition of two...

Read More thumbnail image: In situ conversion monitoring of styrene emulsion polymerization by deconvolution of a single reference band near 1000 cm1

Toxicokinetics and analytical toxicology of the abused opioid U‐48800 — in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding

Published: Sep 10, 2019

Author(s): Tanja M. Gampfer, Lilian H.J. Richter, Jan Schäper, Lea Wagmann, Markus R. Meyer

Journal: Drug Testing and Analysis

Abstract Due to the risk of new synthetic opioids (NSOs) for human health, the knowledge of their toxicokinetic characteristics is important for clinical and forensic toxicology. U‐48800 is an NSO structurally non‐related to classical opioids such as morphine or fentanyl and offered for abuse. As toxicokinetic data of U‐48800 is not currently available, the aims of this study were to identify the in vitro metabolites of U‐48800 in pooled human liver S9 fraction (pS9), to map the isozymes...

Read More thumbnail image: Toxicokinetics and analytical toxicology of the abused opioid U48800  in vitro metabolism metabolic stability isozyme mapping and plasma protein binding

Determination, residue and risk assessment of trifloxystrobin, trifloxystrobin acid and tebuconazole in Chinese rice consumption

Published: Sep 10, 2019

Author(s): Xiaoshuang Luo, Xinxian Qin, Zhengyi Liu, Dan Chen, Weiwei Yu, Kankan Zhang, Deyu Hu

Journal: Biomedical Chromatography

Abstract A simple and rapid analytical method for the detection of trifloxystrobin, trifloxystrobin acid and tebuconazole in soil, brown rice, paddy plants and rice hulls was established and validated by liquid chromatography with tandem mass spectrometry. Acceptable linearity (R2   0.99), accuracy (average recoveries of 74.3–108.5%) and precision (intra‐ and inter‐day relative standard deviations of 0.9–8.8%) were obtained using the developed determination approach. In the field trial, the...

Read More thumbnail image: Determination residue and risk assessment of trifloxystrobin trifloxystrobin acid and tebuconazole in Chinese rice consumption
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