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Hair loss laser treatment: Protein changes point to mechanism

Date: Apr 17, 2019

Author: Steve Down

A proteomic study of the hair follicles of men following low-level laser therapy to reverse the common form of hair loss known as androgenetic alopecia has highlighted the proteins involved and supported the use of this form of treatment.

Read More thumbnail image: Hair loss laser treatment Protein changes point to mechanism

Liver cancer biomarkers: SELDI MS tissue discovery

Date: Apr 4, 2019

Author: Steve Down

Several proteins that distinguish hepatocellular carcinoma from neighbouring healthy tissue have been identified by SELDI-TOF MS and their association with disease-free survival has been assessed.

Read More thumbnail image: Liver cancer biomarkers SELDI MS tissue discovery

Journal Highlight: Are formalin‐fixed and paraffin‐embedded tissues fit for proteomic analysis?

Date: Apr 2, 2019

Author: separationsNOW

Several published workflows for FFPE‐tissue have been evaluated by fit‐for‐purpose proteomics technologies, showing that many protein modifications and cross‐links remain after treatment, limiting the value of the technique.

Read More thumbnail image: Journal Highlight Are formalinfixed and paraffinembedded tissues fit for proteomic analysis

Metal nanoparticle biocoronas: Protein binding in serum

Date: Mar 20, 2019

Author: Steve Down

The identities of 200 proteins that form biocoronas around three types of metallic nanoparticles upon immersion in human serum have been determined, to assess the implications for immune safety, toxicology, and the design of novel biosensors.

Read More thumbnail image: Metal nanoparticle biocoronas Protein binding in serum

Journal Highlight: Development of a protein‐based human identification capability from a single hair

Date: Mar 6, 2019

Author: separationsNOW

A new method that completely dissolves single hairs using a combination of heat, ultrasonication and surfactants was developed for measuring genetically variant peptide profiles of proteins to help distinguish individuals in forensic contexts.

Read More thumbnail image: Journal Highlight Development of a proteinbased human identification capability from a single hair

Novel top-down protein platform: Serial SEC with FTICR mass spectrometry

Date: Mar 6, 2019

Author: Steve Down

Mixtures of intact proteins with closely related molecular masses that were extracted from heart tissue have been resolved and identified by high-resolution FT/ICR mass spectrometry following serial size exclusion chromatography.

Read More thumbnail image: Novel top-down protein platform Serial SEC with FTICR mass spectrometry

Glycopeptide enrichment for mass spectrometry: High-throughput for prostate cancer screening

Date: Feb 19, 2019

Author: Steve Down

A rapid system using titanium dioxide beads for purifying glycopeptides derived from proteins in human serum has been applied to the screening of suspected prostate cancer samples and is suitable for high-throughput analysis.

Read More thumbnail image: Glycopeptide enrichment for mass spectrometry High-throughput for prostate cancer screening

Journal Highlight: Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles

Date: Feb 7, 2019

Author: separationsNOW

This review discussed the effects of vitamin E on gene and protein expression investigated by microarray, transcriptome, and proteomics analysis.

Read More thumbnail image: Journal Highlight Vitamin E Regulatory role on gene and protein expression and metabolomics profiles

Fungi on the International Space Station: Modified proteome

Date: Feb 6, 2019

Author: Steve Down

The proteomes of two strains of the microorganism Aspergillus fumigatus, which were isolated from the International Space Station, have been analysed for the first time, revealing potential adaptations to the unique environment that might impact on the health of astronauts.

Read More thumbnail image: Fungi on the International Space Station Modified proteome

Kawasaki disease: Protein biomarker candidates

Date: Jan 17, 2019

Author: Steve Down

The rare but serious condition known as Kawasaki disease, which mainly affects children under the age of five, produces a modified urinary protein profile that could lead to the development of a diagnostic panel of proteins.

Read More thumbnail image: Kawasaki disease Protein biomarker candidates
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