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Cataloguing Casanova’s contagions with proteomics

Date: Jun 13, 2019

Author: Ryan De Vooght-Johnson

Modern analytical techniques enable information to be recovered about the diseases contracted by historical figures. A multi-centre scientific team sampled the original manuscript of Casanova’s ‘Memoirs’, extracting proteins, hydrolysing them and examining the resulting peptides by LC-MS, looking for any evidence of gonorrhoea bacteria or other harmful micro-organisms.

Read More thumbnail image: Cataloguing Casanovas contagions with proteomics

Ocean acidification: Sea urchin proteome response

Date: Jun 6, 2019

Author: Steve Down

Close examination of the immune cells of sea urchins living near carbon dioxide vents in their natural aquatic environment suggests that they will be able to adapt to life in the oceans as acidification increases due to anthropogenic impact.

Read More thumbnail image: Ocean acidification Sea urchin proteome response

Journal Highlight: Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

Date: Jun 5, 2019

Author: separationsNOW

The development of CE‐MS over the last 20 years has been reviewed by focusing on the clinical potential of proteome and peptidome analysis and highlighting some of the key technical issues and advancements that have been made towards implementation.

Read More thumbnail image: Journal Highlight Peptidomics and proteomics based on CEMS as a robust tool in clinical application The past the present and the future

Honey proteome: Novel allergens and venom-like proteins

Date: May 17, 2019

Author: Steve Down

The protein compositions of 13 different types of honey have been determined by mass spectrometry, revealing strong similarities and several novel proteins which could be associated with the food's curative properties.

Read More thumbnail image: Honey proteome Novel allergens and venom-like proteins

Hand, foot and mouth disease: Serum protein biomarkers

Date: May 2, 2019

Author: Steve Down

Two strong protein candidates for biomarkers of the childhood condition hand, foot and mouth disease have been identified in a proteomics study, opening the gates to earlier diagnosis and more timely treatment.

Read More thumbnail image: Hand foot and mouth disease Serum protein biomarkers

Journal Highlight: What did we learn from multiple omics studies in asthma?

Date: Apr 29, 2019

Author: separationsNOW

The advances in omics techniques and their application to asthma have been discussed alongside the difficulty in translating biomarker signatures into clinical practice and modifying accepted treatments.

Read More thumbnail image: Journal Highlight What did we learn from multiple omics studies in asthma

Hair loss laser treatment: Protein changes point to mechanism

Date: Apr 17, 2019

Author: Steve Down

A proteomic study of the hair follicles of men following low-level laser therapy to reverse the common form of hair loss known as androgenetic alopecia has highlighted the proteins involved and supported the use of this form of treatment.

Read More thumbnail image: Hair loss laser treatment Protein changes point to mechanism

Liver cancer biomarkers: SELDI MS tissue discovery

Date: Apr 4, 2019

Author: Steve Down

Several proteins that distinguish hepatocellular carcinoma from neighbouring healthy tissue have been identified by SELDI-TOF MS and their association with disease-free survival has been assessed.

Read More thumbnail image: Liver cancer biomarkers SELDI MS tissue discovery

Journal Highlight: Are formalin‐fixed and paraffin‐embedded tissues fit for proteomic analysis?

Date: Apr 2, 2019

Author: separationsNOW

Several published workflows for FFPE‐tissue have been evaluated by fit‐for‐purpose proteomics technologies, showing that many protein modifications and cross‐links remain after treatment, limiting the value of the technique.

Read More thumbnail image: Journal Highlight Are formalinfixed and paraffinembedded tissues fit for proteomic analysis

Metal nanoparticle biocoronas: Protein binding in serum

Date: Mar 20, 2019

Author: Steve Down

The identities of 200 proteins that form biocoronas around three types of metallic nanoparticles upon immersion in human serum have been determined, to assess the implications for immune safety, toxicology, and the design of novel biosensors.

Read More thumbnail image: Metal nanoparticle biocoronas Protein binding in serum
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