Lab Informatics @ separationsNOW

The Informatics channel covers data acquisition, manipulation and management.

This includes: laboratory information management systems (LIMS), chromatography data systems (CDS), and electronic lab notebooks (ELN).


Monthly Highlight

Last Month's Most Accessed Feature: Tree metabolite identification combats beetle devastation

The emerald ash borer is an invasive beetle that is currently destroying vast numbers of ash trees in North America. Scientists from Trent University, Peterborough and RB Consulting (both Ontario, Canada) used LC-MS to compare the metabolites from ash trees attacked by the insect with those from unaffected trees, thus providing a convenient method of early detection.

Read More thumbnail image: Last Month's Most Accessed Feature: Tree metabolite identification combats beetle devastation

Now available on-demand
Optimize Laboratory Productivity through System Utilization Monitoring and Business Analytics

System utilization is often recognized as the key to unlocking operational insights for effective laboratory productivity. However, the definitions of system utilization can vary greatly and can have dramatically different use models. Join us to discover the many ways to look at and interpret utilization data as well as other asset management data to build a complete picture of your lab. In this webinar, we will cover the multiple sources of utilization data, review the benefits and limitations of each...

Read More thumbnail image: <font color=red>Webinar<br/>Now available on-demand<br/></font>Optimize Laboratory Productivity through System Utilization Monitoring and Business Analytics

Advertorial Feature

Wiley Spectra Lab:
The World's Largest Spectral Database

thumbnail image: <font size=3>Wiley Spectra Lab:</font><br/>The World's Largest Spectral Database

Wiley Spectra Lab is an expert spectral data system that uses empirical spectral data and advanced software to help chemists, toxicologists, and life scientists confidently identify chemical substances. Powered by the KnowItAll® analytical platform by Bio-Rad, Wiley Spectra Lab provides researchers with access to 2.2 million MS, NMR, and IR spectra – the broadest and largest collection in the world.

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The preparative chromatography of biomolecules, such as proteins, typically requires extensive offline analysis of the fractions before fraction pooling and subsequent processing can begin. Scientists from the Austrian Centre of Industrial Biotechnology, the University of Natural Resources and Life Sciences, and Boehringer Ingelheim (Vienna) examined the output from the chromatographic purification of a protein using a large number of different online detectors and constructed suitable models for...

A simulated second‐order three‐component system (two calibrated analytes and one uncalibrated interferent in test samples) has been studied regarding the presence of rotational ambiguity in the bilinear solutions in order to quantify analytes in the presence of interferents in chromatographic systems.

Counter-current chromatography cleans up monoclonals

Ryan De Vooght-Johnson

May 8, 2019

thumbnail image: Counter-current chromatography cleans up monoclonals

The final purification step or ‘polishing’ of biotherapeutic products is typically carried out by some form of column chromatography, but the optimisation of such separations is often challenging. Researchers from ETH Zurich and Merck Biopharma (Corsier-sur-Vevey, Switzerland) optimised multi-column counter-current solvent gradient purification (MCSGP) for the separation of the main charge isoform of a monoclonal antibody from the acidic and basic isoforms. 

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Selected key technologies of the analytical science industry are discussed by Steve Down with reference to burgeoning application areas and the scope for future improvements.

We are proud to announce a new series of educational webinars run in collaboration with Chromedia, COAST, and SciMind, a product of the American Chemical Society. These webinars will build into a must-have set of tutorial materials for the analytical scientist.

This glossary of chemometrics terms is provided with the permission of Bryan Prazen of the Synovec Group, Department of Chemistry, University of Washington.

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High quality, peer-reviewed original research, reviews and short communications in the fundamental and applied aspects of chemometrics ensure that this international journal is the journal of choice for chemists, statisticians and mathematicians working with chemical data.

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