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Counter-current chromatography catches samphire compounds

Date: Apr 11, 2019

Author: Ryan De Vooght-Johnson

Salicornia species, such as marsh samphire, are becoming increasingly popular as foraged vegetables, but knowledge of their metabolites remains incomplete. Researchers from the Federal University of Rio de Janeiro and the Technical University of Brunswick (Germany) used high-speed counter-current chromatography and mass spectrometry to examine metabolites from the Brazilian species Salicornia gaudichaudiana. 

Read More thumbnail image: Counter-current chromatography catches samphire compounds

Size exclusion chromatography gives pure extracellular vesicles

Date: Mar 28, 2019

Author: Ryan De Vooght-Johnson

Extracellular vesiclesare small membrane-enclosed structures, typically containing proteins, RNA, lipids and metabolies, but their isolation is difficult. Scientists from the Germans Trias i Pujol Health Science Research Institute (Barcelona) and the Autonomous University of Barcelona have developed an improved method of isolating extracellular vesicles from biological fluids by size-exclusion chromatography.

Read More thumbnail image: Size exclusion chromatography gives pure extracellular vesicles

Journal Highlight: Isolation of individual saturated fatty acid methyl esters derived from groundwater phospholipids by preparative HPLC for compound‐specific radiocarbon analyses

Date: Mar 26, 2019

Author: separationsNOW

Large-volume groundwater filtration (up to 10,000 L) and phospholipid fatty acid purification by semipreparative HPLC have been combined for compound‐specific radiocarbon analyses to reveal the relationships between microbial and soil‐derived C, sedimentary or dissolved C sources.

Read More thumbnail image: Journal Highlight Isolation of individual saturated fatty acid methyl esters derived from groundwater phospholipids by preparative HPLC for compoundspecific radiocarbon analyses

Detox shampoo drench deceives drink test

Date: Mar 14, 2019

Author: Ryan De Vooght-Johnson

Objective proof of abstinence from alcohol can be obtained by examining hair samples for alcohol metabolites but so-called ‘detox shampoos’ claim to be able to remove these, giving misleading results. The effectiveness of four shampoos for removing alcohol metabolites from hair samples was assessed using LC-MS/MS to detect levels of ethyl glucuronide.

Read More thumbnail image: Detox shampoo drench deceives drink test

Medical metabolites made manageable by LC-MS

Date: Mar 11, 2019

Author: Ryan De Vooght-Johnson

Spironolactone is a steroid medication used for a number of conditions, including some where it is used in conjunction with glucocorticoids, but it is actually spironolactone’s metabolites that are largely responsible for its activity. Scientists from the University of Geneva, the University of Lausanne and the Geneva-based pharma company Apidel SA developed a new LC-MS method to analyse spironolactone, its main metabolites and the glucocorticoid dexamethasone.

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Journal Highlight: Development of a novel LC–MS/MS method for detection and quantification of tramadol hydrochloride in presence of some mislabeled drugs: Application to counterfeit study

Date: Feb 26, 2019

Author: separationsNOW

A highly sensitive LC–MS/MS method was developed for simultaneous determination of tramadol hydrochloride in the presence of some suspected mislabeled drugs such as alprazolam, diazepam, chlorpheniramine maleate, diphenylhydramine and paracetamol.

Read More thumbnail image: Journal Highlight Development of a novel LCMSMS method for detection and quantification of tramadol hydrochloride in presence of some mislabeled drugs Application to counterfeit study

Nano-LC determination shows up strange glycosylation

Date: Feb 14, 2019

Author: Ryan De Vooght-Johnson

Idiopathic REM sleep behaviour disorder is a condition considered to be a precursor to serious neurodegenerative diseases, such as Parkinson’s disease, so there is interest in finding biomarkers for this disorder. A multi-centre team of scientists, from Texas Tech University (Lubbock), the American University of Beirut and the Oasi Research Institute (Troina, Italy) used nano-LC/MS techniques to examine the differences in glycosylation patterns between patients with the disorder and unaffected...

Read More thumbnail image: Nano-LC determination shows up strange glycosylation

Extraction optimised with care to measure parabens in hair

Date: Jan 29, 2019

Author: Ryan De Vooght-Johnson

Parabens are commonly used preservatives found in cosmetics, personal cleaning products and pharmaceuticals, but human exposure to them needs to be monitored as they have oestrogenic properties (i.e. mimic female sex hormones). Researchers from the Korea Research Institute of Chemical Technology in Daejeon, South Korea, devised a new method to quantify five parabens in human hair using online extraction, UHPLC and MS/MS.

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Journal Highlight: Detection of plant protein in adulterated milk using nontargeted nano‐high‐performance liquid chromatography–tandem mass spectroscopy combined with principal component analysis

Date: Jan 29, 2019

Author: separationsNOW

Plant protein in adulterated in milk has been detected by nano-HPLC/MS/MS in conjunction with proteomics, using principal components to discriminate it from authentic milk.

Read More thumbnail image: Journal Highlight Detection of plant protein in adulterated milk using nontargeted nanohighperformance liquid chromatographytandem mass spectroscopy combined with principal component analysis

Fragment filters find flavonoids and saponins

Date: Jan 28, 2019

Author: Ryan De Vooght-Johnson

Liquorice and the medicinal dried root known as Bupleuri radix are used to treat liver conditions in China, but the complex mixtures of compounds present in these remedies are difficult to analyse. Scientists from the Tianjin University of Traditional Chinese Medicine, China, used mass spectral data from the literature to find particular characteristic fragments and neutral losses that aided the classification and identification of the triterpenoids present.

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