Developments in Analysis of Drugs and Metabolites in Skeletal Remains

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  • Date: Dec 6, 2016 - 15:00 - 16:00 (local time)
  • Presenter: James WattersonWaters
  • Categories: HPLC / Base Peak
thumbnail image: Developments in Analysis of Drugs and Metabolites in Skeletal Remains

Developments in Analysis of Drugs and Metabolites in Skeletal Remains

Broadcast on December 6, 2016
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Bone remains are one of the least characterized and most challenging matrices for forensic toxicological analysis. Before the forensic utility of the matrix may be fully realized, we must understand the time course of drugs and metabolites, both distribution into and elimination from bone; dose-concentration relationships; and the interpretive value of drug detection or non-detection in a given sample.

The understanding of these phenomena requires controlled experiments—experiments where analysis of drugs and metabolites in bone elements throughout the skeleton follow known drug exposure conditions. Furthermore, bone is typically a forensically-relevant matrix only in cases where conventional matrices are unavailable; for example, where severe decomposition has rendered them as the sole choice for toxicological analysis.

This presentation will highlight the value that UPLC-based approaches have brought to the drug analysis of bone samples. In addition, we will discuss the most recent findings in analytical developments using UPLC-QTof mass spectrometry, including: dramatic enhancements in sensitivity, the concomitant reduction in sample masses required, and the number of metabolites that may be detected and/or identified. These developments have led to reductions in the amount of sample preparation required, thereby providing both reduced costs and significant increases in sample throughput.

What will I learn?

  • How drug and metabolite analysis from bone is challenging, but achievable
  • How UPLC-QTOF methods help to identify drugs and metabolites in a skeletal remains
  • How SPE clean up plays an important role in the analysis of bone

Who should attend?

  • Forensic toxicology laboratories
  • Drug testing laboratories
  • Institutes of legal medicine
  • Police forensic laboratories
  • State crime laboratories
  • Medical Examiners or Pathologists
  • People involved in toxicology research
  • People interested in alternative sample matrices

   Your Presenter

James Watterson

Dr James Watterson

Associate Professor of Forensic Science
Forensic Toxicology Research Laboratory,
Laurentian University,
Ontario, Canada

James Watterson: Biography

Dr. James Watterson is Associate Professor of Forensic Science and the Principal Investigator in the FTRL. He completed graduate studies at the University of Toronto under Prof. Ulrich Krull, with a focus on analytical performance of nucleic acid sensors as a function of interfacial chemistry. He then worked in the biotechnology industry at FONA Technologies, as Analytical Research Supervisor, continuing the focus of development and characterization of nucleic acid sensor technology. Dr. Watterson then worked as a forensic toxicologist at the Centre of Forensic Sciences in Toronto before joining the faculty at Laurentian University. He is a consulting forensic toxicologist and a Fellow of the American Board of Forensic Toxicology (F-ABFT). He is cross­‐appointed to the Department of Chemistry & Biochemistry and to the Biomolecular Sciences Program at Laurentian University.

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