PerkinElmer and Agena collaborate on DNA analysis

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  • Published: Aug 23, 2018
  • Source: Agena Bioscience
  • Suppliers: PerkinElmer
  • Channels: Electrophoresis / Proteomics & Genomics

Agena Bioscience has entered into a collaboration with PerkinElmer over incorporating PerkinElmer’s LabChip GX Touch nucleic acid analyzer for quality assessment and quantitation of DNA in the upfront workflow of Agena's MassARRAY system. The companies have focused on targeting ctDNA in oncology liquid biopsy, where the combined systems support a low cost, yet highly robust, single-day sample to results workflow for laboratories.

"We found the speed of Agena's MassARRAY workflow and the sensitivity of their UltraSEEK liquid biopsy assay to be an ideal pairing with the rapid quality assessment using our LabChip GX Touch system," said Mark Dupal, PerkinElmer's global portfolio manager of automation and microfluidics, applied genomics.

PerkinElmer's LabChip GX Touch nucleic acid analyzer uses automated capillary electrophoresis to provide visual quality assessment and quantitation down to 25pg/µl for DNA in as little as 30 seconds with flexible sample throughput options including 96-well and 384-well. This provides a streamlined upfront process to Agena's 96 and 384-chip systems and the UltraSEEK chemistry for liquid biopsy.

"The LabChip GX Touch system gives our customers a new option to analyze DNA quality that is consistent with the overall value proposition that we offer," said Mickie Henshall, VP of marketing at Agena Bioscience. "We look forward to working with PerkinElmer to provide this comprehensive solution with our cost effective and rapid workflows."

In evaluations performed by Agena's Scientific Affairs team, the LabChip system ensured that sufficient DNA was present in the sample to achieve the sensitivity capabilities of the UltraSEEK chemistry while efficiently identifying samples compromised by pre-analytical variables that could result in false negative results.

"Controlling pre-analytical variables is an important component of delivering robust, reproducible liquid biopsy analysis. The combination of LabChip GX Touch nucleic acid analyzer's sample qualification with UltraSEEK assay's highly sensitive, multiplexed chemistry delivers a powerful liquid biopsy sample-to-result solution," said Darryl Irwin, senior director of scientific affairs at Agena Bioscience. "We believe this collaboration will provide many benefits to customers by optimizing their liquid biopsy performance."

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