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Developments in Analysis of Drugs and Metabolites in Skeletal Remains

Bone remains are one of the least characterized and most challenging matrices for forensic toxicological analysis. Before the forensic utility of the matrix may be fully realized, controlled experiments must be carried out. This presentation will highlight the value that UPLC-based approaches have brought to the drug analysis of bone samples. In addition, we will discuss the most recent findings in analytical developments using UPLC-QTof mass spectrometry, including: dramatic enhancements in sensitivity,...

Read More thumbnail image: <font color=red>Webinar<br/>Now available on-demand</font><br/>Developments in Analysis of Drugs and Metabolites in Skeletal Remains

Webinar
Now available on-demand

Peptide Hormones in Sports Drug Testing: Detection of Emerging Protein/Peptide Based Drugs by Means of LC-MS

Therapeutic proteins and peptides have emerged as one of the most important classes of new pharmaceuticals. Several drug candidates with potential performance-enhancing properties are currently in preclinical or clinical development. The current version of the WADA Prohibited List includes a variety of protein/peptide-based doping agents, some of which can be detected in biological samples by using immunological and mass spectrometry-based approaches.

Read More thumbnail image: <font color=red>Webinar<br/>Now available on-demand</font><br/>Peptide Hormones in Sports Drug Testing: Detection of Emerging Protein/Peptide Based Drugs by Means of LC-MS

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JMS Special Feature Collections

thumbnail image: <font size=3>JMS Special Feature Collections</font>

For over 20 years, each issue of the Journal of Mass Spectrometry has contained a Special Feature article. These are highly regarded in the mass spectrometry community and extremely popular with researchers around the globe. These features are freely available to the entire mass spec community.

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Ezines

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The expression of many proteins in the hippocampi of mice are modified by dominant and submissive behaviour, say scientists in Israel in the first study of its kind which will help to decode the molecular mechanisms of psychiatric disorders and lead to therapeutic solutions.

Fast GC’s rapidity gives greater productivity

Ryan De Vooght-Johnson

Aug 15, 2017

thumbnail image: Fast GCs rapidity gives greater productivity

GC-MS run times can now be much shorter than with traditional methods due to a number of recent developments. Scientists from Tel Aviv University applied a combination of open probe fast GC and mass spectrometry to obtain rapid results from a wide variety of different analytes.

No standards involved, but are all problems solved?

Ryan De Vooght-Johnson

Aug 15, 2017

thumbnail image: No standards involved but are all problems solved

Modern analytical techniques, such as HRMS (high-resolution mass spectrometry), enable the simultaneous detection of a large number of compounds, but normally rely on analytical standards of all the compounds being available, which may not be the case. Researchers from the Zurich Official Food Control Authority have developed an LC-HRMS method that identifies compounds without the use of standards, demonstrating its efficiency by identifying veterinary compounds spiked into meat and fish extracts.

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Education

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Selected key technologies of the analytical science industry are discussed by Steve Down with reference to burgeoning application areas and the scope for future improvements.

Ion source pressure plays a significant role in the process of ionization and the subsequent ion transmission inside a mass spectrometer. Pressurizing the ion source to a gas pressure greater than atmospheric pressure is a relatively new approach that aims to further improve the performance of atmospheric pressure ionization sources. A brief review on the development of super-atmospheric pressure ion sources, including high-pressure electrospray, field desorption and superheated ESI, and the strategies to...

In the current context of international conflicts and localized terrorist actions, there is unfortunately a permanent threat of attacks with unconventional warfare agents. Among these, biological agents such as toxins, microorganisms, and viruses deserve particular attention owing to their ease of production and dissemination. Mass spectrometry-based techniques for the detection and quantification of biological agents have a decisive role to play for countermeasures in a scenario of biological attacks.

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Radiation and Health is a specialty section of Frontiers in Public Health.

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