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Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC–MS/MS assay

Published: Nov 21, 2018

Author(s): Kai Niu, Huiyu Yan, Chunjie Guo, Sixi Zhang, Wei Zhu, Shiyong Teng

Journal: Biomedical Chromatography

Abstract A highly sensitive LC–MS/MS method was developed to measure oroxin B in rat plasma and tissue homogenates. The analyte and IS were isolated from biological matrices by a simple protein precipitation followed by centrifugation. Detection was conducted by electrospray negative‐ionization mass spectrometry in selected‐reaction monitoring mode. The assay was linear in the concentration range 4.52–904 ng/mL with intra‐ and...

Read More thumbnail image: Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LCMSMS assay

Assessment of quality consistency in traditional Chinese medicine using multi‐wavelength fusion profiling by integrated quantitative fingerprint method: Niuhuang Jiedu pill as an example

Published: Nov 21, 2018

Author(s): Jing Zhang, Guoxiang Sun

Journal: Journal of Separation Science

Abstract Under the wave of the revival of traditional Chinese medicine, there is a quite imperative duty to study an integrated and comprehensive method of fingerprint data processing and analysis on the quality consistency of traditional Chinese medicine. So, we proposed six parameters from two aspects (qualitative and quantitative), three levels (biased to strong peaks, biased to weak peaks, no obvious bias), to comprehensively...

Read More thumbnail image: Assessment of quality consistency in traditional Chinese medicine using multiwavelength fusion profiling by integrated quantitative fingerprint method Niuhuang Jiedu pill as an example

Mapping tissue water T 1 in the liver using the MOLLI T 1 method in the presence of fat, iron and B 0 inhomogeneity

Published: Nov 21, 2018

Author(s): Ferenc E. Mozes, Elizabeth M. Tunnicliffe, Ahmad Moolla, Thomas Marjot, Christina K. Levick, Michael Pavlides, Matthew D. Robson

Journal: NMR in Biomedicine

Modified Look‐Locker inversion recovery (MOLLI) T1 mapping sequences can be useful in cardiac and liver tissue characterization, but determining underlying water T1 is confounded by iron, fat and frequency offsets. This article proposes an algorithm that provides an independent water MOLLI T1 (referred to as on‐resonance water T1) that would have been measured if a subject had no fat and normal iron, and imaging had been done on resonance. Fifteen NiCl2‐doped...

Read More thumbnail image: Mapping tissue water T 1 in the liver using the MOLLI T 1 method in the presence of fat iron and B 0 inhomogeneity

Sulfate metabolites improve retrospectivity after oral testosterone administration

Published: Nov 20, 2018

Author(s): Argitxu Esquivel, Élida Alechaga, Nuria Monfort, Rosa Ventura

Journal: Drug Testing and Analysis

Abstract The detection of testosterone (T) misuse is performed using the steroid profile that includes concentrations of T and related metabolites excreted free and glucuronoconjugated, and the ratios between them. In this work, the usefulness of 14 endogenous steroid sulfates to improve the detection capabilities of oral T administration has been evaluated. Quantitation of the sulfate metabolites was performed using solid‐phase...

Read More thumbnail image: Sulfate metabolites improve retrospectivity after oral testosterone administration

Metabolomics‐based parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology

Published: Nov 20, 2018

Author(s): Chang Chen, Ziquan Fan, Hui Xu, Xiaojie Tan, Mingshe Zhu

Journal: Biomedical Chromatography

Abstract Intoxication by xenobiotics triggers the perturbation of metabolic fingerprints in biofluids, including the accumulation of xenobiotic compounds and the dysregulation of endogenous metabolites. In this work, an untargeted metabolomics workflow was developed to simultaneously profile both xenobiotic and endogenous metabolites for the identification of the xenobiotic origin and an in‐depth understanding of the intoxication...

Read More thumbnail image: Metabolomicsbased parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology

Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets

Published: Nov 20, 2018

Author(s): Chang‐Shun Liu, Xiao Liang, Xiao‐Han Wei, Fei‐Long Chen, Qing‐Fa Tang, Xiao‐Mei Tan

Journal: Biomedical Chromatography

Abstract Diarrhoeal diseases alter the composition of intestinal flora, thereby affecting the efficacy of herbal medicinal formulations. Gegen Qinlian decoction (GQD), a Chinese traditional herbal formulation, is widely used to treat infectious diarrhoea. However, little is known about the microbial disposition of GQD in the diarrhoeal state. In this study, the comparative metabolism of components of GQD by diarrhoeal and normal...

Read More thumbnail image: Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets

Isolation and determination of saponin hydrolysis products from Medicago sativa using supercritical fluid extraction, solid‐phase extraction and liquid chromatography with evaporative light scattering detection

Published: Nov 20, 2018

Author(s): Anna Kiełbasa, Aneta Krakowska, Katarzyna Rafińska, Bogusław Buszewski

Journal: Journal of Separation Science

Abstract Saponins are widespread secondary metabolites with various beneficial properties: fungicidal, antibacterial, antiviral, and anticancer. Alfalfa saponin molecules contain mainly: medicagenic acid, hederagenin, bayogenin, and soyasapogenol B. Structural diversity of saponins makes their determination in Medicago sativa extracts very difficult. The most popular determination technique is high‐performance liquid chromatography applied...

Read More thumbnail image: Isolation and determination of saponin hydrolysis products from Medicago sativa using supercritical fluid extraction solidphase extraction and liquid chromatography with evaporative light scattering detection

Application of in vivo MR methods in the study of breast cancer metabolism

Published: Nov 20, 2018

Author(s): Naranamangalam R. Jagannathan

Journal: NMR in Biomedicine

In the last two decades, various in vivo MR methodologies have been evaluated for their potential in the study of cancer metabolism. During malignant transformation, metabolic alterations occur, leading to morphological and functional changes. Among various MR methods, in vivo MRS has been extensively used in breast cancer to study the metabolism of cells, tissues or whole organs. It provides biochemical information at the metabolite...

Read More thumbnail image: Application of in vivo MR methods in the study of breast cancer metabolism

Rapid and sensitive surface‐enhanced resonance Raman spectroscopy detection for norepinephrine in biofluids

Published: Nov 20, 2018

Author(s): Xia Zhou, Miao Qin, Jun Zhu, Cong Wang, Guang Zhu, Hongyan Wang, Liangbao Yang

Journal: Journal of Raman Spectroscopy

Abstract Norepinephrine (NE) is a kind of catecholamine neurotransmitter that participates significant function in living organism. Rapid and sensitive detection target in complex system is crucial in analytical science. A facile ferric citrate (CA‐Fe (III)) sensor was designed successfully for sensitive detection of NE by surface‐enhanced resonance Raman spectroscopy (SERRS) method. This CA‐Fe (III) sensor was prepared by modifying...

Read More thumbnail image: Rapid and sensitive surfaceenhanced resonance Raman spectroscopy detection for norepinephrine in biofluids

Si quantum dots enhancement stimulated Raman scattering of water molecules

Published: Nov 20, 2018

Author(s): Fabing Li, Ying Wang, Zhanlong Li, Wenhui Fang, Yeqiu Li, Chenglin Sun, Zhiwei Men

Journal: Journal of Raman Spectroscopy

Abstract Stimulated Raman scattering (SRS) spectra of the OH stretching vibrations of pure water and 2‐nm Si quantum dots (Si QDs) water solution have been investigated under different pump laser energies. Simultaneously, we have studied the spontaneous Raman spectra of pure water and Si QDs water solution at room temperature and atmospheric pressure. The results show that SRS intensity of Si QDs water solution is an order of...

Read More thumbnail image: Si quantum dots enhancement stimulated Raman scattering of water molecules

Preprocessing of spectral data in the extended multiplicative signal correction framework using multiple reference spectra

Published: Nov 20, 2018

Author(s): Joakim Skogholt, Kristian Hovde Liland, Ulf Geir Indahl

Journal: Journal of Raman Spectroscopy

Abstract Extended multiplicative signal correction (EMSC) is a widely used framework for preprocessing spectral data. In the EMSC framework, spectra are scaled according to a given reference spectrum. Spectra that are far from collinear with the selected reference spectrum may not be scaled appropriately. An extension of the EMSC framework that allows for the incorporation of multiple reference spectra in the EMSC model is proposed...

Read More thumbnail image: Preprocessing of spectral data in the extended multiplicative signal correction framework using multiple reference spectra

Preface for the special issue of ALC'17

Published: Nov 20, 2018

Author(s): Yahachi Saito

Journal: Surface and Interface Analysis

Read More thumbnail image: Preface for the special issue of ALC17

Tribological properties of Ti‐doped diamond‐like carbon coatings under dry friction and PAO oil lubrication

Published: Nov 20, 2018

Author(s): Youzhi Guo, Peng Guo, Lili Sun, Xiaowei Li, Peiling Ke, Qiang Li, Aiying Wang

Journal: Surface and Interface Analysis

Titanium‐doped diamond‐like carbon (Ti‐DLC) coatings with Ti concentration of 4 at.% (Ti4at.%‐DLC) and 27 at.% (Ti27at.%‐DLC) were prepared by a hybrid ion beam deposition system for comparison. The tribological behaviors of Ti‐DLC coatings under dry friction and boundary lubrication conditions were systematically investigated. Results showed that, under dry friction, the Ti4at.%‐DLC coating displayed lower friction coefficient (0.07) and...

Read More thumbnail image: Tribological properties of Tidoped diamondlike carbon coatings under dry friction and PAO oil lubrication

The effect of surface pretreatment on the corrosion behaviour of silanated AA2198‐T851 Al‐Cu‐Li alloy

Published: Nov 20, 2018

Author(s): Uyime Donatus, Rafael Emil Klumpp, Naga Vishnu Vardan Mogili, Renato Aletobelli Antunees, Mariana Xavier Milagre, Isolda Costa

Journal: Surface and Interface Analysis

The corrosion behaviour of silanated AA2198‐T851 alloy substrates with and with no manufacturing‐process induced near‐surface deformed layer (MPI‐NSDL) has been investigated. Two methods (alkaline etching + desmutting and mechanical polishing) were employed in removing the MPI‐NSDL. Silanization was performed using 2‐bis‐triethoxysilylethane. Electrochemical impedance spectroscopy (EIS), salt spray test, and microscopy techniques were...

Read More thumbnail image: The effect of surface pretreatment on the corrosion behaviour of silanated AA2198T851 AlCuLi alloy

Applying facilely synthesized CuO/CeO 2 photocatalyst to accelerate methylene blue degradation in hypersaline wastewater

Published: Nov 20, 2018

Author(s): Zhendong Li, Dongfang Liu, Wenli Huang, Yanmei Sun, Songrong Li, Xiaocheng Wei

Journal: Surface and Interface Analysis

Textile and dye effluents have strong color, unstable pH and COD, a lot of inorganic salt, and high biotoxicity. It is difficult and inefficient to remove dyes from high‐saline wastewater by traditional methods. In this study, a simple synthetic CuO/CeO2 photocatalyst is used to achieve high efficiency photodegradation of methylene blue in high salt wastewater. The p‐type CuO/n‐type CeO2 heterojunction photocatalyst is synthesized by a modified...

Read More thumbnail image: Applying facilely synthesized CuOCeO 2 photocatalyst to accelerate methylene blue degradation in hypersaline wastewater

Metabolomic analysis of raw Pinelliae Rhizoma and its alum‐processed products via UPLC–MS and their cytotoxicity

Published: Nov 19, 2018

Author(s): Li‐Ming Sun, Bo Zhang, Yu‐Chen Wang, Hao‐Ke He, Xiao‐Guang Chen, Su‐Juan Wang

Journal: Biomedical Chromatography

Abstract Alum‐processing is a traditional method to attenuate the toxicity of Pinelliae Rhizoma (tubers of Pinellia ternate, PT). The present study aimed at investigating the chemical and cytotoxic changes during alum processing. Metabolomic profiles of raw and alum‐processed PT were studied based on ultra‐performance liquid chromatography coupled with Orbitrap mass spectrometry. More than 80 chemicals in positive MS mode and 40 chemicals in...

Read More thumbnail image: Metabolomic analysis of raw Pinelliae Rhizoma and its alumprocessed products via UPLCMS and their cytotoxicity

A hydrophobic deep eutectic solvent‐based vortex‐assisted dispersive liquid–liquid microextraction combined with HPLC for the determination of nitrite in water and biological samples

Published: Nov 19, 2018

Author(s): Kaige Zhang, Shuangying Li, Chuang Liu, Qi Wang, Yunhe Wang, Jing Fan

Journal: Journal of Separation Science

Abstract In recent years, hydrophobic deep eutectic solvents as new generation of green solvents have attracted wide attention in liquid microextraction technique. In this article, four hydrophobic deep eutectic solvents composed of trioctylmethylammonium chloride and oleic acid were designed and prepared firstly. Combined with high‐performance liquid chromatography, these deep eutectic solvents were used as an extraction solvent in...

Read More thumbnail image: A hydrophobic deep eutectic solventbased vortexassisted dispersive liquidliquid microextraction combined with HPLC for the determination of nitrite in water and biological samples

Use of high‐pH (basic/alkaline) mobile phases for LC–MS or LC–MS/MS bioanalysis

Published: Nov 18, 2018

Author(s): Aimin Tan, John C. Fanaras

Journal: Biomedical Chromatography

Abstract High‐pH or basic/alkaline mobile phases are not commonly used in LC–MS or LC–MS/MS bioanalysis because of the deeply rooted concern with column instability and reduced detection sensitivity for basic compounds in high‐pH mobile phases owing to charge neutralization. With the advancement of LC column technology and the wide recognition of the “wrong‐way‐round” phenomena, high‐pH mobile phases are more and more used in LC–MS...

Read More thumbnail image: Use of highpH basicalkaline mobile phases for LCMS or LCMSMS bioanalysis

Development of a simple and rapid HPLC‐MS/MS method for quantification of streptomycin in mice and its application to plasma pharmacokinetic studies

Published: Nov 18, 2018

Author(s): Zhijun Wang, Chen Xie, Steven Yeung, Jeffrey Wang, Moses S.S. Chow

Journal: Biomedical Chromatography

Abstract Streptomycin was the first discovered aminoglycoside antibiotic. It has been widely applied in veterinary medicine for the prevention and treatment of bacterial infection. However, the current detection methods are not satisfactory in terms of sensitivity and sample process, which makes them unsuitable for a pharmacokinetic study. A high‐performance liquid chromatography–mass spectrometric method employing positive...

Read More thumbnail image: Development of a simple and rapid HPLCMSMS method for quantification of streptomycin in mice and its application to plasma pharmacokinetic studies

New psychoactive substances detected at the New Zealand border, 2014–2018

Published: Nov 18, 2018

Author(s): Cameron S. Johnson, Brent R. Copp, Aaron Lewis

Journal: Drug Testing and Analysis

Read More thumbnail image: New psychoactive substances detected at the New Zealand border 20142018
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