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Simultaneous determination of tiopronin and its primary metabolite in plasma and ocular tissues by HPLC

Published: Sep 26, 2018

Author(s): Justin Beltz, Annalise Pfaff, Nuran Ercal

Journal: Biomedical Chromatography

Abstract Tiopronin, formally 2‐mercaptopropionylglycine (MPG), is currently prescribed to treat cystinuria and rheumatoid arthritis, and its antioxidant properties have led to its investigation as a treatment for cataracts, a condition in which oxidative stress is strongly implicated. To study its accumulation in the eye, a reliable, isocratic HPLC method was developed for the determination of MPG and its primary metabolite...

Read More thumbnail image: Simultaneous determination of tiopronin and its primary metabolite in plasma and ocular tissues by HPLC

Stability of reagents used for chiral amino acid analysis during spaceflight missions in high‐radiation environments

Published: Sep 26, 2018

Author(s): Jessica S. Creamer, Maria F. Mora, Peter A. Willis

Journal: ELECTROPHORESIS

Abstract The search for biosignatures on spaceflight missions requires in situ instrumentation capable of highly selective and sensitive organic analyses. To this end, CE–LIF is a uniquely promising technique, capable of determining the type, abundance, and chirality of amino acids present in environmental samples at nanomolar concentrations. However, this type of assay requires several reagents that have not yet been used on...

Read More thumbnail image: Stability of reagents used for chiral amino acid analysis during spaceflight missions in highradiation environments

Massively parallel sequencing of 12 autosomal STRs in Cannabis sativa

Published: Sep 26, 2018

Author(s): Rachel Houston, Carrie Mayes, Jonathan L. King, Sheree Hughes‐Stamm, David Gangitano

Journal: ELECTROPHORESIS

Abstract Massively parallel sequencing (MPS) is an emerging technology in the field of forensic genetics that provides distinct advantages compared to capillary electrophoresis. This study offers a proof of concept that MPS technologies can be applied to genotype autosomal STRs in Cannabis sativa. A custom panel for MPS was designed to interrogate 12 cannabis‐specific STR loci by sequence rather than size. A simple workflow was...

Read More thumbnail image: Massively parallel sequencing of 12 autosomal STRs in Cannabis sativa

A fluorescence toolbox: A review of investigation of electrophoretic separations, process, and interfaces

Published: Sep 26, 2018

Author(s): S. Thompson, Dimitri Pappas

Journal: ELECTROPHORESIS

Abstract This review focuses on fluorescence spectroscopy techniques for the investigation of electrophoretic separations. Fluorescence has been used as a sensitive detector for capillary, gel, and microchip electrophoresis for decades. However, advanced fluorescence methods can be used to study transport, interfacial phenomena, intermolecular and affinity interactions, and other processes that occur during separation. This...

Read More thumbnail image: A fluorescence toolbox A review of investigation of electrophoretic separations process and interfaces

Zirconium(IV)‐based metal–organic frameworks (UiO‐67) as solid‐phase extraction adsorbents for extraction of phenoxyacetic acid herbicides from vegetables

Published: Sep 26, 2018

Author(s): Huixiao Duo, Yuhuan Wang, Licheng Wang, Xiaofeng Lu, Xiaojing Liang

Journal: Journal of Separation Science

Abstract A zirconium(IV)‐based metal organic framework, composed of 4,4′‐biphenyldicarboxylic acid ligands and Zr6O4(OH)4 clusters, was successfully fabricated. Characterizations were performed on fourier transform infrared spectroscopy, scanning electron microscopy, X‐ray diffraction, Brunauer‐Emmett‐Teller, and thermogravimetric analysis, which confirmed that it possessed large specific surface area, high pore volume, and strong acid...

Read More thumbnail image: ZirconiumIVbased metalorganic frameworks UiO67 as solidphase extraction adsorbents for extraction of phenoxyacetic acid herbicides from vegetables

On the Promising Role of Enzyme Activity Assay in Interpreting Comparative Proteomic Data in Plants

Published: Sep 26, 2018

Author(s): Liangjie Niu, Xiangru Xu, Hui Liu, Xiaolin Wu, Wei Wang

Journal: PROTEOMICS

Abstract Comparative proteomics is widely used to detect protein changes, especially differential abundance proteins (DAPs) that are involved in plant responses to development, disease, or environment. Once DAPs are identified, it is essential to validate any change in their abundance, and their role in the biological process under study. In addition to common confirmation by quantitative RT‐PCR, immunoblot, and multiple reaction...

Read More thumbnail image: On the Promising Role of Enzyme Activity Assay in Interpreting Comparative Proteomic Data in Plants

Activation of the Oxidative Pentose Phosphate Pathway is Critical for Photomixotrophic Growth of a hik33 ‐Deletion Mutant of Synechocystis sp. PCC 6803

Published: Sep 26, 2018

Author(s): Haitao Ge, Longfa Fang, Xiahe Huang, Jinlong Wang, Weiyang Chen, Yuanya Zhang, Xiaorong Wang, Na Sui, Wu Xu, Qingfang He, Yingchun Wang

Journal: PROTEOMICS

Abstract The histidine kinase Hik33 plays a central role in acclimation to changing environments in cyanobacteria. Deletion of hik33 induces a strong stress‐like response in Synechocystis sp. PCC 6803 (Synechocystis) as represented by repressed photoautotrophic growth and photosynthesis, and differential expression of stress‐responsive proteins. In contrast, the photomixotrophic growth of the hik33‐deletion mutant (Δhik33) with glucose as the exogenous...

Read More thumbnail image: Activation of the Oxidative Pentose Phosphate Pathway is Critical for Photomixotrophic Growth of a hik33 Deletion Mutant of Synechocystis sp_ PCC 6803

Cobalt Phthalocyanine Tetracarboxylic Acid Functionalized Polymer Monolith for Selective Enrichment of Glycopeptides and Glycans

Published: Sep 26, 2018

Author(s): Wenjuan Zhang, Naizhong Song, Haijiao Zheng, Wei Feng, Qiong Jia

Journal: PROTEOMICS

Abstract In this study, poly(glycidyl methacrylate‐ethyleneglycol dimethacrylate) monolith functionalized with cobalt phthalocyanine tetracarboxylic acid is prepared. The polymer monolithic material is used for glycopeptides enrichment coupled with MALDI–TOF MS. By taking advantage of cobalt phthalocyanine including hydrogen bonds between isoindole subunits of phthalocyanine and glycans, coordination interaction between cobalt and...

Read More thumbnail image: Cobalt Phthalocyanine Tetracarboxylic Acid Functionalized Polymer Monolith for Selective Enrichment of Glycopeptides and Glycans

Optical cleanliness measurement methods for aluminium sheet surfaces

Published: Sep 26, 2018

Author(s): Junjie Wang, Peter Andrews, Colin Butler, Eoghan McAlpine, Geoff Scamans, Xiaorong Zhou

Journal: Surface and Interface Analysis

The cleaning of rolled aluminium surfaces is of critical importance for most applications and is of particular importance in automotive applications. The cleanliness of the sheet surface is mainly determined by the residual amount of the near‐surface deformed layer on the alloy surface. This layer has nano‐sized grains with their grain boundaries decorated and pinned by oxide particles and lubricant residues. The deformed layer reduces...

Read More thumbnail image: Optical cleanliness measurement methods for aluminium sheet surfaces

A perspective view of top‐down proteomics in snake venom research

Published: Sep 26, 2018

Author(s): Parviz Ghezellou, Vannuruswamy Garikapati, Seyed Mahdi Kazemi, Kerstin Strupat, Alireza Ghassempour, Bernhard Spengler

Journal: Rapid Communications in Mass Spectrometry

The venom produced by snakes contains complex mixtures of pharmacologically active proteins and peptides which play a crucial role in the pathophysiology of snakebite diseases. The deep understanding of venom proteomes can help to improve the treatment of this “neglected tropical disease” (as expressed by the World Health Organization [WHO]) and to develop new drugs. The most widely used technique for venom analysis is liquid...

Read More thumbnail image: A perspective view of topdown proteomics in snake venom research

Characterization of disulfide linkages at the hinge region of IgG antibodies by HPLC mass spectrometry

Published: Sep 25, 2018

Author(s): Jia You, Ying Shi, Wenli Zhu, Zhigang Wu, Jingyuan Xiong

Journal: Biomedical Chromatography

Abstract There are two types of disulfide linkages in IgG antibodies at the hinge region: intra‐ and inter‐disulfide linkages. Characterization of intra‐disulfide linked isomer will provide important information on the stability of the antibodies and better understanding of the mechanism of Fab‐arm exchange. In this report, HPLC coupled with high‐resolution mass spectrometry was applied for characterization of disulfide linkages in...

Read More thumbnail image: Characterization of disulfide linkages at the hinge region of IgG antibodies by HPLC mass spectrometry

Simultaneous quantification of THC‐COOH, OH‐THC, and further cannabinoids in human hair by gas chromatography–tandem mass spectrometry with electron ionization applying automated sample preparation

Published: Sep 25, 2018

Author(s): Tobias Kieliba, Oliver Lerch, Hilke Andresen‐Streichert, Markus A. Rothschild, Justus Beike

Journal: Drug Testing and Analysis

Abstract The detection of Δ9‐tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in hair, for the purpose of identifying cannabis consumption, is conducted in many forensic laboratories. Since external contamination of hair with these cannabis components cannot be excluded, even after hair decontamination, only the detection of THC metabolites such as 11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol (THC‐COOH) or...

Read More thumbnail image: Simultaneous quantification of THCCOOH OHTHC and further cannabinoids in human hair by gas chromatographytandem mass spectrometry with electron ionization applying automated sample preparation

Synthetic isoflavones and doping: A novel class of aromatase inhibitors?

Published: Sep 25, 2018

Author(s): Michele Iannone, Francesco Botrè, Nicoletta Cardillo, Xavier Torre

Journal: Drug Testing and Analysis

Abstract Anectodical information suggests that flavonoids may be widely used among athletes for their multiple biochemical and pharmacological effects. We have evaluated in vitro the effects of two synthetic isoflavones, methoxyisoflavone and ipriflavone, on the catalytic activity of human aromatase (CYP19), the enzyme catalyzing the conversion of androgens (ie, testosterone or androstenedione) to estrogens (ie, estradiol and...

Read More thumbnail image: Synthetic isoflavones and doping A novel class of aromatase inhibitors

Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry

Published: Sep 25, 2018

Author(s): Mirjam Kummer, Nela Šestáková, Regula Theurillat, Uyen Huynh‐Do, Andrea Endimiani, Parham Sendi, Wolfgang Thormann

Journal: Journal of Separation Science

Abstract Cefepime monitoring in urine by micellar electrokinetic capillary chromatography with UV detection and liquid chromatography coupled to mass spectrometry via electrospray ionization is described. For micellar electrokinetic capillary chromatography, sample preparation comprised urine dilution and dodecyl‐sulfate protein precipitation at pH 4.5, whereas diluted urines were analyzed in the other assay. Both approaches...

Read More thumbnail image: Monitoring of cefepime in urine by micellar electrokinetic capillary chromatography with ultraviolet detection and liquid chromatography coupled to mass spectrometry

Lattice dynamics study of cubic Tb 2 O 3

Published: Sep 25, 2018

Author(s): Jordi Ibáñez, Oriol Blázquez, Sergi Hernández, Blas Garrido, Plácida Rodríguez‐Hernández, Alfonso Muñoz, Matias Velázquez, Philippe Veber, Francisco Javier Manjón

Journal: Journal of Raman Spectroscopy

Abstract We report a joint experimental and theoretical study of the lattice dynamics of cubic Tb2O3. Up to 16 optical Raman‐active modes have been observed with polarized and unpolarized Raman scattering measurements on a high‐quality Tb2O3 single crystal. The measured wavenumbers have been compared with those of other rare‐earth (RE) and related sesquioxides with cubic (C‐type or bixbyite) structure. First‐principles calculations have allowed...

Read More thumbnail image: Lattice dynamics study of cubic Tb 2 O 3

Fast UHPLC–MS/MS method for analysis of furanylfentanyl in different seized blotter papers

Published: Sep 24, 2018

Author(s): Lilian de Melo Barbosa, Jandyson Machado Santos, Damila Rodrigues Morais, Alessandra Valério Nimtz, Marcos Nogueira Eberlin, Marcelo Firmino Oliveira, Jose Luiz Costa

Journal: Drug Testing and Analysis

Read More thumbnail image: Fast UHPLCMSMS method for analysis of furanylfentanyl in different seized blotter papers

Simultaneous TLC–densitometric determination of tamoxifen citrate and medroxyprogesterone acetate and UV‐degradation kinetic study of medroxyprogesterone acetate

Published: Sep 24, 2018

Author(s): Gamal A. Saleh, Fatma A.M. Abdel‐aal, Noha S. Abbas

Journal: Biomedical Chromatography

Abstract Coadministration of tamoxifen citrate (TMC) and medroxyprogesterone acetate (MPA) is preferred to increase the response rate and the percentage recovery in patients with endometrial carcinoma. Administration of TMC and MPA and their combination affects estrogen and progestin receptor concentrations in advanced endometrium carcinoma by affecting 17β‐hydroxyl steroid dehydrogenase activity and serum hormone concentrations. A sensitive,...

Read More thumbnail image: Simultaneous TLCdensitometric determination of tamoxifen citrate and medroxyprogesterone acetate and UVdegradation kinetic study of medroxyprogesterone acetate

Quantitative susceptibility mapping (QSM) with an extended physical model for MRI frequency contrast in the brain: a proof‐of‐concept of quantitative susceptibility and residual (QUASAR) mapping

Published: Sep 24, 2018

Author(s): Ferdinand Schweser, Robert Zivadinov

Journal: NMR in Biomedicine

Quantitative susceptibility mapping (QSM) aims to calculate the tissue's magnetic susceptibility distribution from its perturbing effect on the MRI static main magnetic field. The method is increasingly being applied to study iron and myelin in clinical and preclinical settings. However, recent experimental and theoretical findings have challenged the fundamental theoretical assumptions that form the basis of current numerical...

Read More thumbnail image: Quantitative susceptibility mapping QSM with an extended physical model for MRI frequency contrast in the brain a proofofconcept of quantitative susceptibility and residual QUASAR mapping

Development, validation and application to real samples of a liquid chromatography with tandem mass spectrometry method for the determination of tetracyclines in beeswax

Published: Sep 24, 2018

Author(s): Anna Gajda, Maja Antczak, Kamila Mitrowska, Andrzej Posyniak

Journal: Journal of Separation Science

Abstract Beeswax is a valuable honeybee product, which finds applications in the food and pharmaceutical industries, as well as in cosmetic production. However, some substances used in apiculture, like tetracyclines, can be delivered to hives where they cause contamination of honeybee products such as beeswax. Tetracyclines are commonly used for the treatment of American and European foulbrood diseases, but in the European Union...

Read More thumbnail image: Development validation and application to real samples of a liquid chromatography with tandem mass spectrometry method for the determination of tetracyclines in beeswax

Rapid mass spectral fingerprinting of complex mixtures of decomposed lignin: Data‐processing methods for high‐resolution full‐scan mass spectra

Published: Sep 24, 2018

Author(s): Yulin Qi, Dietrich A. Volmer

Journal: Rapid Communications in Mass Spectrometry

Lignin is the second most abundant natural biopolymer and its wastes are significant sources for renewable chemicals as an alternative to conventional fossil fuels. Consequently, chemical characterization methods are required to assess the content of valuable chemicals contained in these complex lignin wastes. This short overview summarizes rapid data‐processing methods developed in our laboratory for application to full‐scan raw data...

Read More thumbnail image: Rapid mass spectral fingerprinting of complex mixtures of decomposed lignin Dataprocessing methods for highresolution fullscan mass spectra
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