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A simple and selective LC‐MS/MS method for quantification of ikarisoside A in rat plasma and its application to a pharmacokinetic study

Published: Apr 23, 2018

Author(s): Yue Cong, Rui Wang, Chen Zhang, Hai Lin

Journal: Biomedical Chromatography

Abstract Ikarisoside A is a natural flavonoid isolated from Epimedium plants. To further evaluate its medicinal potential, a sensitive and robust LC–MS/MS method was developed and validated for the assay of ikarisoside A in rat plasma. Orientin was used as an internal standard. The electrospray ionization was operated in its negative ion mode while ikarisoside A and IS were measured by selected reaction monitoring using precursor‐to‐product ...

Read More thumbnail image: A simple and selective LCMSMS method for quantification of ikarisoside A in rat plasma and its application to a pharmacokinetic study

An LC–MS/MS method for quantification of demethylzeylasteral, a novel immunosuppressive agent in rat plasma and the application to a pharmacokinetic study

Published: Apr 23, 2018

Author(s): Luoluo Yang, Yan Xia, Lianhua An, Dan Zhou

Journal: Biomedical Chromatography

Abstract In this study, a sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the quantification of demethylzeylasteral in rat plasma. Electrospray ionization was operated in the negative ion mode while demethylzeylasteral and oleanolic acid (internal standard) were measured by selected reaction monitoring (demethylzeylasteral: m/z 479.2 → 436.0; oleanolic acid: m/z...

Read More thumbnail image: An LCMSMS method for quantification of demethylzeylasteral a novel immunosuppressive agent in rat plasma and the application to a pharmacokinetic study

Comparative pharmacokinetic study of the components of Jia‐Wei‐Kai‐Xin‐San in normal and vascular dementia rats by ultra‐fast liquid chromatography coupled with tandem mass spectrometry

Published: Apr 23, 2018

Author(s): Yiwei Shi, Cheng Cao, Yue Zhu, Ting Gao, Wen Yang, Mengqiu Liu Mingzhu Qi, Renjie Huang, Dawei Qian, Jin‐Ao Duan

Journal: Journal of Separation Science

Abstract A fast, sensitive, and reliable ultra‐high performance liquid chromatography coupled with tandem mass spectrometry method has been developed and validated for simultaneous quantification of geniposide, polygalaxanthone III, 3,6′‐disinapoyl sucrose, α‐asarone, β‐asarone, poricoic acid A, poricoic acid B, dehydrotumulosic acid, deoxyschizandrin, schizandrin B, and kaempferide in plasma after oral administration of extracts of...

Read More thumbnail image: Comparative pharmacokinetic study of the components of JiaWeiKaiXinSan in normal and vascular dementia rats by ultrafast liquid chromatography coupled with tandem mass spectrometry

Simultaneous determination of glycol ethers and their acetates in cosmetics by gas chromatography with mass spectrometry

Published: Apr 23, 2018

Author(s): Jinfeng Huang, Xiuying Li, Zhiqing Xun, Weifeng Du, Xindong Guo, Yanping Xian, Senyu Lin, Jianhua Tan

Journal: Journal of Separation Science

Abstract A gas chromatography with mass spectrometry method was developed for the simultaneous determination of ten kinds of glycol ethers and their acetates in cosmetics. The samples were extracted with methanol/ethyl acetate (80:20, v/v), further treated with vortex and ultrasound, and analyzed by gas chromatography with mass spectrometry. The concentration of each analyte was calibrated by the external standard method. Under the...

Read More thumbnail image: Simultaneous determination of glycol ethers and their acetates in cosmetics by gas chromatography with mass spectrometry

Determination of organophosphate flame retardants in soil and fish using ultrasound‐assisted extraction, solid‐phase clean‐up, and liquid chromatography with tandem mass spectrometry

Published: Apr 23, 2018

Author(s): María Lorenzo, Julián Campo, Yolanda Picó

Journal: Journal of Separation Science

Abstract A solid–liquid extraction method in combination with high‐performance liquid chromatography and tandem mass spectrometry was developed and optimized for extraction and analysis of organophosphorus flame retardants in soil and fish. Methanol was chosen as the optimum extraction solvent, not only in terms of extraction efficiency, but also for its broader analyte coverage. The subsequent clean‐up by solid‐phase extraction is...

Read More thumbnail image: Determination of organophosphate flame retardants in soil and fish using ultrasoundassisted extraction solidphase cleanup and liquid chromatography with tandem mass spectrometry

Quantification of metronidazole in human plasma using a highly sensitive and rugged LC–MS/MS method for a bioequivalence study

Published: Apr 23, 2018

Author(s): Pravin G. Vanol, Mallika Sanyal, Priyanka A. Shah, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract A highly sensitive, selective and rugged method has been described for the quantification of metronidazole (MTZ) in human plasma by liquid chromatography–tandem mass spectrometry using metronidazole‐d4 as the internal standard (IS). The analyte and the IS were extracted from 100 μL plasma by liquid–liquid extraction. The clear samples obtained were chromatographed on an ACE C18 (100 × 4.6 mm, 5 μm) column using acetonitrile...

Read More thumbnail image: Quantification of metronidazole in human plasma using a highly sensitive and rugged LCMSMS method for a bioequivalence study

Isolation and enrichment of Ginkgo biloba extract by a continuous chromatography system

Published: Apr 23, 2018

Author(s): Jingbo Zhu, Weibin Cui, Wei Xiao, Yan Ding, Wenzhe Huang, Pengfei Tu, Yonghua Wang

Journal: Journal of Separation Science

Abstract In this study, an effective method was developed for the isolation and enrichment of Ginkgo biloba extract by continuous chromatography system. The adsorption and desorption ratio of flavonoids as main index, the best macroporous resin was screened out from six resins by static adsorption and desorption tests. At the same time the adsorption and desorption parameters were optimized by dynamic adsorption and desorption tests. Under...

Read More thumbnail image: Isolation and enrichment of Ginkgo biloba extract by a continuous chromatography system

Integrating Proteomics and Targeted Metabolomics to Understand Global Changes in Histone Modifications

Published: Apr 20, 2018

Author(s): Johayra Simithy, Simone Sidoli, Benjamin A. Garcia

Journal: PROTEOMICS

Abstract The chromatin fiber is the control panel of eukaryotic cells. Chromatin is mostly composed of DNA, which contains the genetic instruction for cell phenotype, and histone proteins, which provide the scaffold for chromatin folding and part of the epigenetic inheritance. Histone writers/erasers “flag” chromatin regions by catalyzing/removing covalent histone post‐translational modifications (PTMs). Histone PTMs chemically...

Read More thumbnail image: Integrating Proteomics and Targeted Metabolomics to Understand Global Changes in Histone Modifications

Characterization of graphene grown on copper foil by chemical vapor deposition ( CVD ) at ambient pressure conditions

Published: Apr 20, 2018

Author(s): Enzo Cazzanelli, Oreste De Luca, Danilo Vuono, Alfonso Policicchio, Marco Castriota, Giovanni Desiderio, Maria Penelope De Santo, Alfredo Aloise, Angela Fasanella, Tania Rugiero, Raffaele Giuseppe Agostino

Journal: Journal of Raman Spectroscopy

Abstract In the aim to get high quality graphene films, with large domains and free from impurities, minimizing also the manufacturing costs, we investigate the graphene grown on copper (Cu) foil by chemical vapor deposition at ambient pressure conditions, by using methane (CH4) as carbon source, diluted in a suitable mixture of argon (Ar) and hydrogen (H2). Several graphene samples were synthesized, for variable exposure times to hydrocarbon...

Read More thumbnail image: Characterization of graphene grown on copper foil by chemical vapor deposition  CVD  at ambient pressure conditions

Field remote Stokes/anti‐Stokes Raman characterization of sulfur in hydrothermal vents

Published: Apr 20, 2018

Author(s): G. Guimbretière, S. Duraipandian, T. Ricci

Journal: Journal of Raman Spectroscopy

Abstract To study the dynamics of active volcanic environments, minerals involved in fresh lava flows are a nice probe and Raman spectroscopy is an excellent tool for their characterization. Because of the highly hostile environment linked to volcanic activity, studying lava cooling and weathering needs remote setups and specific procedures dedicated to medium‐high temperature targets. In this paper, we present the remote Raman...

Read More thumbnail image: Field remote StokesantiStokes Raman characterization of sulfur in hydrothermal vents

Regulate the coupling reaction of 4‐nitrothiophenol to 4,4′‐dimercaptoazobenzene by organic alkali

Published: Apr 20, 2018

Author(s): Caiqing Ma, Yu Liu, Jing Wang, Shiwei Wu, Qian Zhang, Peng Song, Lixin Xia

Journal: Journal of Raman Spectroscopy

Abstract The coupling reaction of 4‐nitrothiophenol to 4,4′‐dimercaptoazobenzene was investigated by surface enhancement Raman scattering method. The reaction was found to be controlled by the compatibility of organic alkalis and silver nanoparticles. The effect of hot electron–hole pairs on the reaction was evaluated. Furthermore, the mechanism of organic alkalis affecting hot electron–hole pairs to achieve regulation of the...

Read More thumbnail image: Regulate the coupling reaction of 4nitrothiophenol to 44dimercaptoazobenzene by organic alkali

Do athletes have a right to access data in their Athlete Biological Passport?

Published: Apr 20, 2018

Author(s): Thijs Devriendt, Davit Chokoshvili, Maddalena Favaretto, Pascal Borry

Journal: Drug Testing and Analysis

Abstract The Athlete Biological Passport (ABP) refers to the collection of data related to an individual athlete. The ABP contains the Haematological Module and the Steroidal Module, which are used for the longitudinal monitoring of variables in blood and urine, respectively. Based on changes in these variables, a statistical model detects outliers which indicate doping use and guide further targeted testing of the athlete....

Read More thumbnail image: Do athletes have a right to access data in their Athlete Biological Passport

Detectability of fentanyl and designer fentanyls in urine by 3 commercial fentanyl immunoassays

Published: Apr 20, 2018

Author(s): Anders Helander, Katarina Stojanovic, Tomas Villén, Olof Beck

Journal: Drug Testing and Analysis

Abstract In recent times, structural variants of fentanyl (designer fentanyls) have appeared on the recreational drug market for new psychoactive substances (NPS). These potent opioids have caused harmful intoxications and increased opioid‐related mortality in many countries. This work evaluated 3 commercial immunoassays for fentanyl screening in urine and investigated whether they are useful also for screening of designer...

Read More thumbnail image: Detectability of fentanyl and designer fentanyls in urine by 3 commercial fentanyl immunoassays

Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses

Published: Apr 20, 2018

Author(s): Heather K. Knych, Kelsey Seminoff, Dan S. McKemie

Journal: Drug Testing and Analysis

Abstract Traditional therapeutic options for the treatment of lameness associated with inflammation in performance horses include administration of cyclooxygenase enzyme inhibiting non‐steroidal anti‐inflammatory drugs (NSAID). As long‐term use of these drugs can adversely impact the health of the horse, anti‐inflammatories with a more favorable safety profile are warranted. Grapiprant is a newly approved non‐cyclooxygenase...

Read More thumbnail image: Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses

Targeted metabolomic analysis of 33 amino acids and biogenic amines in human urine by ion‐pairing HPLC‐MS/MS: Biomarkers for tacrolimus nephrotoxicity after renal transplantation

Published: Apr 19, 2018

Author(s): Tianyi Xia, Shangxi Fu, Qinghua Wang, Yan Wen, Shen‐an Chan, Sang Zhu, Shouhong Gao, Xia Tao, Feng Zhang, Wansheng Chen

Journal: Biomedical Chromatography

Abstract Calcineurin inhibitor nephrotoxicity, especially for the widely used tacrolimus, has become a major concern in post‐transplant immunosuppression. Multiparametric amino acid metabolomics is useful for biomarker identification of tacrolimus nephrotoxicity, for which specific quantitative methods are highlighted as a premise. This article presents a targeted metabolomic assay to quantify 33 amino acids and biogenic amines in...

Read More thumbnail image: Targeted metabolomic analysis of 33 amino acids and biogenic amines in human urine by ionpairing HPLCMSMS Biomarkers for tacrolimus nephrotoxicity after renal transplantation

Solid‐phase extraction based on amino‐functionalized graphene oxide nanocomposites for analysis of short‐chain perfluorinated alkyl acids in human serum by ion chromatography mass spectrometry

Published: Apr 19, 2018

Author(s): Zhixiong Zhong, Gongke Li, Lingchuan Guo, Jing Yao, Zhe Liu, Jianchao Deng

Journal: Biomedical Chromatography

Abstract A highly sensitive method was developed for the analysis of short‐chain perfluorinated alkyl acids (PFAAs) in serum samples using solid‐phase extraction (SPE) coupled with ion chromatography–electrospray ionization–mass spectrometry. The synthesized amino‐functionalized graphene oxide nanocomposites were used as an SPE sorbent for the enrichment of trace analytes and purification of samples. They exhibited high selectivity...

Read More thumbnail image: Solidphase extraction based on aminofunctionalized graphene oxide nanocomposites for analysis of shortchain perfluorinated alkyl acids in human serum by ion chromatography mass spectrometry

A validated LC–MS/MS method for the simultaneous determination of thalidomide and its two metabolites in human plasma: Application to a pharmacokinetic assay

Published: Apr 19, 2018

Author(s): Fulin Jiang, Xiang Peng, Dake Cai, Dingsheng Wen, Yao Liu, Min Zhi, Jiangying Chen, Pinjin Hu, Xueding Wang, Yujie Gao, Min Huang, Xiang Gao, Guoping Zhong

Journal: Biomedical Chromatography

Abstract An accurate and sensitive LC–MS/MS method for determining thalidomide, 5‐hydroxy thalidomide and 5′‐hydroxy thalidomide in human plasma was developed and validated using umbelliferone as an internal standard. The analytes were extracted from plasma (100 μL) by liquid–liquid extraction with ethyl acetate and then separated on a BETASIL C18 column (4.6 × 150 mm, 5 μm) with mobile phase composed of methanol–water containing 0.1% formic...

Read More thumbnail image: A validated LCMSMS method for the simultaneous determination of thalidomide and its two metabolites in human plasma Application to a pharmacokinetic assay

Quantification of liver function by linearization of a two‐compartment model of gadoxetic acid uptake using dynamic contrast‐enhanced magnetic resonance imaging

Published: Apr 19, 2018

Author(s): Josiah Simeth, Adam Johansson, Dawn Owen, Kyle Cuneo, Michelle Mierzwa, Mary Feng, Theodore S. Lawrence, Yue Cao

Journal: NMR in Biomedicine

Dynamic gadoxetic acid‐enhanced magnetic resonance imaging (MRI) allows the investigation of liver function through the observation of the perfusion and uptake of contrast agent in the parenchyma. Voxel‐by‐voxel quantification of the contrast uptake rate (k1) from dynamic gadoxetic acid‐enhanced MRI through the standard dual‐input, two‐compartment model could be susceptible to overfitting of variance in the data. The aim of this study was...

Read More thumbnail image: Quantification of liver function by linearization of a twocompartment model of gadoxetic acid uptake using dynamic contrastenhanced magnetic resonance imaging

Dual‐frequency irradiation CEST‐MRI of endogenous bulk mobile proteins

Published: Apr 19, 2018

Author(s): Steffen Goerke, Johannes Breitling, Moritz Zaiss, Johannes Windschuh, Patrick Kunz, Patrick Schuenke, Daniel Paech, Dario L. Longo, Karel D. Klika, Mark E. Ladd, Peter Bachert

Journal: NMR in Biomedicine

A novel MRI contrast is proposed which enables the selective detection of endogenous bulk mobile proteins in vivo. Such a non‐invasive imaging technique may be of particular interest for many diseases associated with pathological alterations of protein expression, such as cancer and neurodegenerative disorders. Specificity to mobile proteins was achieved by the selective measurement of intramolecular spin diffusion and the removal of semi‐solid...

Read More thumbnail image: Dualfrequency irradiation CESTMRI of endogenous bulk mobile proteins

Measurement of large strain properties in calf muscles in vivo using magnetic resonance elastography and spatial modulation of magnetization

Published: Apr 19, 2018

Author(s): Kristy Tan, Lauriane Jugé, Alice Hatt, Shaokoon Cheng, Lynne E. Bilston

Journal: NMR in Biomedicine

It is important to measure the large deformation properties of skeletal muscle in vivo in order to understand and model movement and the force‐producing capabilities of muscle. As muscle properties are non‐linear, an understanding of how the deformation state affects the measured shear moduli is also useful for clinical applications of magnetic resonance elastography (MRE) to muscle disorders. MRE has so far only been used to measure the linear...

Read More thumbnail image: Measurement of large strain properties in calf muscles in vivo using magnetic resonance elastography and spatial modulation of magnetization
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