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Development of a novel LC–MS/MS method for detection and quantification of tramadol hydrochloride in presence of some mislabeled drugs: Application to counterfeit study

Published: Feb 20, 2019

Author(s): Ahmed M. Abdel‐Megied, Khalid M. Badr El‐din

Journal: Biomedical Chromatography

Abstract Counterfeiting of pharmaceuticals has become a serious problem all over the world, particularly in developing countries. In the present work, a highly sensitive LC–MS/MS method was developed for simultaneous determination of tramadol hydrochloride in the presence of some suspected mislabeled drugs such as alprazolam, diazepam, chlorpheniramine maleate, diphenylhydramine and paracetamol. The prepared samples were analyzed on an API 4000 mass spectrometer using an Eclipse C18 column...

Read More thumbnail image: Development of a novel LCMSMS method for detection and quantification of tramadol hydrochloride in presence of some mislabeled drugs Application to counterfeit study

A study of FTIR and XPS analysis of alkaline‐based cleaning agent for removing Cu‐BTA residue on Cu wafer

Published: Feb 20, 2019

Author(s): Baohong Gao, Baimei Tan, Yuling Liu, Chenwei Wang, Yangang He, Yanyan Huang

Journal: Surface and Interface Analysis

This study is to focus on the benzotriazole (BTA) residue problem in the postchemical mechanical planarization (post‐CMP) cleaning process. The adsorption of BTA on copper surface was studied by analyzing the FTIR spectra; it indicates that the oxidation of the copper surface could affect the adsorption of BTA on the wafer surface. It used an alkaline‐based chelating agent, ethylenediamine tetra acetic acid with four equivalents of 3,4‐diaminobutane‐1,1,2,2‐tetraol, to deal with Cu‐BTA film,...

Read More thumbnail image: A study of FTIR and XPS analysis of alkalinebased cleaning agent for removing CuBTA residue on Cu wafer

Application of surface analysis in study on removal mechanism and abrasive selection during fused silica chemical mechanical polishing

Published: Feb 20, 2019

Author(s): Gaopan Chen, Haimei Luo, Chengxi Kang, Guihai Luo, Yan Zhou, Guoshun Pan

Journal: Surface and Interface Analysis

In this work, surface analysis technology is employed to investigate the removal mechanism and the selection of abrasive during fused silica chemical mechanical polishing (CMP). Morphology of abrasives is inspected by scanning electron microscope (SEM). The atomic force microscope (AFM) is used to determine the surface roughness (Rq) and undulating (PV) of the polished fused silica surface. The results show that abrasive morphology has a tremendous influence on removal rate (MRR) and PV but...

Read More thumbnail image: Application of surface analysis in study on removal mechanism and abrasive selection during fused silica chemical mechanical polishing

Surface characterisation of TiCxN1 − x coatings processed by cathodic arc physical vapour deposition: XPS and XRD analysis

Published: Feb 20, 2019

Author(s): Ping Chuan Siow, Jaharah A. Ghani, Muhammad Rizal, Talib Ria Jaafar, Mariyam Jameelah Ghazali, Che Hassan Che Haron

Journal: Surface and Interface Analysis

The properties of titanium carbonitride (TiCN) can be controlled by maintaining the C―N ratio within the coating to a certain level. An experimental study was carried out to vary the composition and properties of TiCN using cathodic arc physical vapour deposition (CAPVD). The substrate used was tungsten carbide (WC‐6Co), which was prepared in‐house through a powder metallurgy process. In order to form the TiCxN1 − x coatings, titanium (Ti) was used as the cathode, while methane (CH4) and...

Read More thumbnail image: Surface characterisation of TiCxN1x coatings processed by cathodic arc physical vapour deposition XPS and XRD analysis

Surface oxide development on aluminum alloy 6063 during heat treatment

Published: Feb 20, 2019

Author(s): Lisa Rullik, Jonas Evertsson, Niclas Johansson, Florian Bertram, Jan‐Olov Nilsson, Alexei A. Zakharov, Anders Mikkelsen, Edvin Lundgren, Watts John

Journal: Surface and Interface Analysis

We report on the influence of oxygen partial pressure for the development of surface oxides covering the industrial aluminum alloy standard 6063 at temperatures ranging from room temperature to 500° C. Using an array of synchrotron‐based techniques, we followed the change in oxide thickness, chemical composition, and the lateral distribution of alloying elements. The impact of the oxygen chemical potential is most visible at high temperatures where the oxide composition changes from mostly Al...

Read More thumbnail image: Surface oxide development on aluminum alloy 6063 during heat treatment

The effect of trace additions of copper and pretreatment conditions on the filiform corrosion of powder‐coated aluminium alloy AA6060

Published: Feb 20, 2019

Author(s): Malgorzata Halseid, Jan Tore B. Gundersen, Øystein Bauger, Thomas Hentschel

Journal: Surface and Interface Analysis

This paper presents a short review of the literature data and the newest studies of filiform corrosion (FFC) testing of profiles extruded using a recycling‐friendly AA 6xxx aluminium alloy, with Cu content up to 0.09 wt%. As the pretreatment plays a significant role in avoiding FFC on powder‐coated aluminium profiles, the profiles were pretreated and coated at three different production sites. They have been tested at 40°C, 82% RH for 1000 hours (according to modified ISO 4623‐2). It was...

Read More thumbnail image: The effect of trace additions of copper and pretreatment conditions on the filiform corrosion of powdercoated aluminium alloy AA6060

Tuning parameter identification for variable selection algorithm using the sum of ranking differences algorithm

Published: Feb 19, 2019

Author(s): Mingpeng Nie, Liuwei Meng, Xiaojing Chen, Xinyu Hu, Limin Li, Leimin Yuan, Wen Shi

Journal: Journal of Chemometrics

The sum of ranking differences (SRD) coupled with partial least squares‐variable importance in projection (PLS‐VIP‐SRD) and partial least squares‐uninformative variable elimination (PLS‐UVE‐SRD) algorithms was applied to objectively identify the latent variable of the PLS model and the threshold value of VIP and UVE. And the final results show that the PLS‐VIP (UVE) ‐SRD model can more effectively and objectively determine the optimal parameter. Moreover, the selected variables are easier to...

Read More thumbnail image: Tuning parameter identification for variable selection algorithm using the sum of ranking differences algorithm

Energy dispersive X‐ray fluorescence determination of Fe in solid powder samples: A quality improvement perspective

Published: Feb 19, 2019

Author(s): Trupti A. Chavan, Nicy Ajith, Remya Devi Periyamana Sankaran nampoothiri, Kallola Kumar Swain

Journal: X-Ray Spectrometry

The various factors affecting energy dispersive X‐ray fluorescence determination of iron in solid powder samples were evaluated, to improve the quality of these measurements. Influence of samples/standards preparation and instrumental parameters such as applied voltage to the X‐ray tube, tube output current, and duration of acquisition were assessed, and the optimized instrumental parameters were 12 kV, 200 μA, and 200 s, respectively. Linear dynamic range of the spectrometer was found to be...

Read More thumbnail image: Energy dispersive Xray fluorescence determination of Fe in solid powder samples A quality improvement perspective

Application of X‐ray fluorescence spectroscopy to provenance studies of Algerian archaeological pottery

Published: Feb 19, 2019

Author(s): Lynda Idjouadiene, Toufik A. Mostefaoui, Hocine Djermoune, Letizia Bonizzoni

Journal: X-Ray Spectrometry

The North African regions boast a multimillenary tradition of pottery production that represents a decisive progress in all societies. In this paper, we present the analysis of several fragments of pottery dating from the Middle Ages and collected in the archaeological site of Gouraya in Béjaïa (Algeria). Energy‐dispersive X‐ray fluorescence measurements were performed to obtain the elemental composition of the clays and to attempt a classification of the samples through multivariate analysis...

Read More thumbnail image: Application of Xray fluorescence spectroscopy to provenance studies of Algerian archaeological pottery

VERDICT MRI validation in fresh and fixed prostate specimens using patient‐specific moulds for histological and MR alignment

Published: Feb 19, 2019

Author(s): Colleen Bailey, Roger M. Bourne, Bernard Siow, Edward W. Johnston, Mrishta Brizmohun Appayya, Hayley Pye, Susan Heavey, Thomy Mertzanidou, Hayley Whitaker, Alex Freeman, Dominic Patel, Greg L. Shaw, Ashwin Sridhar, David J. Hawkes, Shonit Punwani, Daniel C. Alexander, Eleftheria Panagiotaki

Journal: NMR in Biomedicine

The VERDICT framework for modelling diffusion MRI data aims to relate parameters from a biophysical model to histological features used for tumour grading in prostate cancer. Validation of the VERDICT model is necessary for clinical use. This study compared VERDICT parameters obtained ex vivo with histology in five specimens from radical prostatectomy. A patient‐specific 3D‐printed mould was used to investigate the effects of fixation on VERDICT parameters and to aid registration to histology....

Read More thumbnail image: VERDICT MRI validation in fresh and fixed prostate specimens using patientspecific moulds for histological and MR alignment

Dielectrophoresis‐assisted creation of cell aggregates under flow conditions using planar electrodes

Published: Feb 19, 2019

Author(s): Jonathan Cottet, Alexandre Kehren, Soufian Lasli, Harald Lintel, François Buret, Marie Frénéa‐Robin, Philippe Renaud

Journal: ELECTROPHORESIS

Abstract We present a microfluidic platform allowing dielectrophoresis‐assisted formation of cell aggregates of controlled size and composition under flow conditions. When specific experimental conditions are met, negative dielectrophoresis allows efficient concentration of cells towards electric field minima and subsequent aggregation. This bottom‐up assembly strategy offers several advantages with respect to the targeted application: first, dielectrophoresis offers precise control of spatial...

Read More thumbnail image: Dielectrophoresisassisted creation of cell aggregates under flow conditions using planar electrodes

Development and validation of a solid‐phase extraction method coupled with LC–MS/MS for the simultaneous determination of 16 antibiotic residues in duck meat

Published: Feb 19, 2019

Author(s): Weijia Zheng, A. M. Abd El‐Aty, Seong‐Kwan Kim, Jeong‐Min Choi, Da‐Hee Park, Kyung‐Hee Yoo, Young‐Sun Kang, Jong‐Sup Jeon, Ahmet Hacımüftüoğlu, Jae‐Han Shim, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract The present study was carried out to determine 16 antibiotics belonging to seven different groups (tetracyclines, sulfonamides, penicillins, fluoroquinolones, macrolides, lincosamides and trimethoprims) in duck meat. A solid‐phase extraction method based on Oasis HLB cartridges coupled with liquid chromatography–electrospray ionization tandem mass spectrometry was developed. Solutions of 0.1 m ethylenediaminetetraacetic acid disodium salt and 2% trifluoroacetic acid were used for the...

Read More thumbnail image: Development and validation of a solidphase extraction method coupled with LCMSMS for the simultaneous determination of 16 antibiotic residues in duck meat

Simultaneous determination of spinosad, temephos, and piperonyl butoxide in animal‐derived foods using LC–MS/MS

Published: Feb 18, 2019

Author(s): Weijia Zheng, Jeong‐Min Choi, A. M. Abd El‐Aty, Kyung‐Hee Yoo, Da‐Hee Park, Seong‐Kwan Kim, Young‐Sun Kang, Ahmet Hacımüftüoğlu, Jing Wang, Jae‐Han Shim, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract Pesticides, which are used as plant protection products, can enter the food chain, and exposure to these xenobiotics can cause a wide array of health problems in humans. Therefore, the objective of the present study was to develop an analytical method for the simultaneous determination of residual spinosad (sum of spinosyn A and D), temephos and piperonyl butoxide in porcine muscle, egg, milk, eel, flatfish and shrimp (sampling period: February to June 2018) using liquid...

Read More thumbnail image: Simultaneous determination of spinosad temephos and piperonyl butoxide in animalderived foods using LCMSMS

Raman study of Ming porcelain dark spots: Probing Mn‐rich spinels

Published: Feb 18, 2019

Author(s): Ariane Pinto, Philippe Sciau, Tiequan Zhu, Bing Zhao, Jesse Groenen

Journal: Journal of Raman Spectroscopy

Abstract We report on the analysis of dendritic crystals present in the dark spot areas of blue‐and‐white Ming porcelains. Using Raman spectroscopy and scanning electron microscopy equipped with energy dispersive spectrometer, we were able to evidence Mn‐rich spinels. Small Mn‐based spinel crystals being highly sensitive to laser‐induced heating, we identified proper working conditions, avoiding excessive heating and damage. Local temperatures during Raman measurements were deduced from...

Read More thumbnail image: Raman study of Ming porcelain dark spots Probing Mnrich spinels

Strong Raman yield enhancement in large Si nanocrystals from ultraviolet to infrared: Density and shape dependence

Published: Feb 18, 2019

Author(s): Giuseppe Faraci, Markus Italia, Rosa Ruggeri, Grazia Litrico, Giovanni Mannino

Journal: Journal of Raman Spectroscopy

Abstract Silicon nanocrystals, few hundred nanometers in size, demonstrate impressive Raman yield enhancement. We report, first, the enormous Raman yield enhancement obtained with octahedral‐shaped nanocrystals in a wide wavelength range going from the ultraviolet, through the visible, to the infrared. We observed, along with the main Si peak amplification at 521 cm−1, also the amplification of the 480 cm−1 broad peak of a thin amorphous Si layer embedded between the nanocrystals, together...

Read More thumbnail image: Strong Raman yield enhancement in large Si nanocrystals from ultraviolet to infrared Density and shape dependence

Three‐color coherent anti‐Stokes Raman scattering with optical nonresonant background removal

Published: Feb 18, 2019

Author(s): Brad Littleton, Priyank Shah, Thomas Kavanagh, David Richards

Journal: Journal of Raman Spectroscopy

Abstract Broadband coherent anti‐Stokes Raman scattering (B‐CARS), excited through intrapulse three‐color processes in which both the pump and Stokes photons are derived from a broadband beam, enable diffraction‐limited hyperspectral Raman imaging over the entire fingerprint spectral region with a speed and sensitivity far superior to that possible with conventional spontaneous Raman confocal microspectroscopy. We extend the theory of spectral interferometric polarization coherent anti‐Stokes...

Read More thumbnail image: Threecolor coherent antiStokes Raman scattering with optical nonresonant background removal

Dual‐probe polarization spectroscopy as a concept for combustion diagnostics

Published: Feb 18, 2019

Author(s): Johannes Kiefer

Journal: Journal of Raman Spectroscopy

Abstract Studying the line‐broadening effects of combustion intermediates in flames is the key to derive quantitative information via spectroscopic techniques. In this communication, an extension to polarization spectroscopy via employing two probe beams, one of which is copropagating whereas the other one is counterpropagating to the pump beam, is proposed. This gives rise to dual‐probe polarization spectroscopy, which enables recording a Doppler‐broadened and a Doppler‐free signal...

Read More thumbnail image: Dualprobe polarization spectroscopy as a concept for combustion diagnostics

Investigations into the performance of travelling wave enabled conventional and cyclic ion mobility systems to characterise protomers of fluoroquinolone antibiotic residues

Published: Feb 18, 2019

Author(s): Michael McCullagh, Kevin Giles, Keith Richardson, Sara Stead, Martin Palmer

Journal: Rapid Communications in Mass Spectrometry

Rationale Fluoroquinolones (FLQs) have been shown to form protomers with distinctive fragment profiles. Experimental parameters affect protomer formation, impacting observed conventional tandem mass spectrometric (MS/MS) dissociation and multiple reaction monitoring (MRM) transition reproducibility. Collision cross section (CCS) measurement can provide an additional identification metric and improved ion mobility (IM) separation strategies could provide further understanding of fluctuations in...

Read More thumbnail image: Investigations into the performance of travelling wave enabled conventional and cyclic ion mobility systems to characterise protomers of fluoroquinolone antibiotic residues

Single‐stranded DNA structural diversity: TAGGGT from monomers to dimers to tetramer formation

Published: Feb 18, 2019

Author(s): Jacob E. Porter, Prem Chapagain, Francisco Fernandez‐Lima

Journal: Rapid Communications in Mass Spectrometry

Rationale DNA quadruplex structures have emerged as novel drug targets due to their role in preventing abnormal gene transcription and maintaining telomere stability. Trapped Ion Mobility Spectrometry–Mass Spectrometry (TIMS–MS), combined with theoretical modeling, is a powerful tool for studying the kinetic intermediates of DNA complexes formed in solution and interrogated in the gas phase after desolvation. Methods A TAGGGT ssDNA sequence was purchased and studied in 10 mM ammonium acetate...

Read More thumbnail image: Singlestranded DNA structural diversity TAGGGT from monomers to dimers to tetramer formation

A novel, rapid and sensitive UPLC–MS/MS method for the determination of macitentan in patients with pulmonary arterial hypertension

Published: Feb 18, 2019

Author(s): Mevlut Albayrak, Alptug Atıla, Elif Yılmazel Ucar, Omer Araz, Yucel Kadıoglu

Journal: Biomedical Chromatography

Abstract Macitentan is an endothelin receptor antagonist commonly used in the treatment of pulmonary arterial hypertension (PAH). A novel, rapid, simple and sensitive UPLC–MS/MS method was developed and validated for pharmacokinetic study and the determination of macitentan in PAH patients. Macitentan and bosentan, which are used as internal standards, were detected using atmospheric pressure chemical ionization in positive ion and multiple reaction monitoring mode by monitoring the mass...

Read More thumbnail image: A novel rapid and sensitive UPLCMSMS method for the determination of macitentan in patients with pulmonary arterial hypertension
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