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Isotope‐like effect in YVO4:Eu3+ nanopowders: Raman spectroscopy

Published: Feb 26, 2019

Author(s): Jelena Mitrić, Uroš Ralević, Miodrag Mitrić, Jovana Ćirković, Gregor Križan, Maja Romčević, Martina Gilić, Nebojsa Romčević

Journal: Journal of Raman Spectroscopy

Abstract In this paper, we describe synthesis and characterization of YVO4 and Eu3+‐doped YVO4 nanopowders. Two methods of preparation were used—solution combustion synthesis (SCS) and classical ceramic method (CCM)—and compared. Morphology and structure of all samples were characterized with atomic‐force microscopy (AFM), X‐ray diffraction (XRD), and field‐emission scanning electron microscopy (SEM). Raman spectroscopy was used to discuss the isotope‐like effect. It is confirmed that doping...

Read More thumbnail image: Isotopelike effect in YVO4Eu3 nanopowders Raman spectroscopy

Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

Published: Feb 26, 2019

Author(s): Xiang Cui, Yu‐meng Shen, Shu Jiang, Da‐wei Qian, Er‐xin Shang, Zhen‐hua Zhu, Jin‐ao Duan

Journal: Journal of Separation Science

Abstract In this study, a rapid and highly sensitive ultra high performance liquid chromatography with triple quadrupole mass spectrometry method with the mobile phase of acetonitrile and 0.1% aqueous formic acid was established and successfully applied to comparatively analyze main active components after their compatibility. Besides, the effects of Scutellariae Radix, Coptidis Rhizoma and combined extracts on type 2 diabetic rats induced by high‐fat diet along with low dose of streptozocin...

Read More thumbnail image: Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

A hierarchical screening method for detection of illegal adulterants in Fur seal ginseng pills by profiling analysis of HPLC multi‐dimensional fingerprints

Published: Feb 26, 2019

Author(s): Ke Wang, Huiyun Zeng, Yi Zhang, Xiujuan Xie, Zhenfeng Yue, Wei Zhang, Chujun Fu, Laicheng Luo, Huajun Fan

Journal: Journal of Separation Science

Abstract A novel method for hierarchical screening of illegal adulterants in Fur seal ginseng pills products was developed by multi‐dimensional fingerprint profiling analysis. Fingerprint feature of the samples was acquired by high‐performance liquid chromatography analysis of 11 batches of samples with diode array detector and fluorescence detector, and then potential illegal adulterants including phosphodiesterase type‐5 inhibitors, androgens, α receptor antagonists and yohimbine, were...

Read More thumbnail image: A hierarchical screening method for detection of illegal adulterants in Fur seal ginseng pills by profiling analysis of HPLC multidimensional fingerprints

Comparative Proteomic Analysis Reveals the Upregulation of Ketogenesis in Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells

Published: Feb 26, 2019

Author(s): Sunjoo Kim, Ju Mi Jeon, Oh Kwang Kwon, Mu Seog Choe, Han Cheol Yeo, Xiaojun Peng, Zhongyi Cheng, Min Young Lee, Sangkyu Lee

Journal: PROTEOMICS

Abstract Diverse metabolic pathways, such as the tricarboxylic acid cycle, pyruvate metabolism, and oxidative phosphorylation, regulate the differentiation of induced pluripotent stem cells (iPSCs) to cells of specific lineages and organs. Here, the protein dynamics during cardiac differentiation of human iPSCs into cardiomyocytes (CMs) are characterized. The differentiation is induced by...

Read More thumbnail image: Comparative Proteomic Analysis Reveals the Upregulation of Ketogenesis in Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells

Breast Cancer‐Derived Exosomes Reflect the Cell‐of‐Origin Phenotype

Published: Feb 26, 2019

Author(s): Shu Wen Wen, Luize G Lima, Richard J Lobb, Emma L Norris, Marcus L Hastie, Sophie Krumeich, Andreas Möller

Journal: PROTEOMICS

Abstract A manner in which cells can communicate with each other is via secreted nanoparticles termed exosomes. These vesicles contain lipids, nucleic acids, and proteins, and are said to reflect the cell‐of‐origin. However, for the exosomal protein content, there is limited evidence in the literature to verify this statement. Here, proteomic assessment combined with pathway‐enrichment analysis is used to demonstrate that the protein cargo of exosomes reflects the epithelial/mesenchymal...

Read More thumbnail image: Breast CancerDerived Exosomes Reflect the CellofOrigin Phenotype

Screening and isolation of cyclooxygenase‐2 inhibitors from Trifolium pratense L. via ultrafiltration, enzyme‐immobilized magnetic beads, semi‐preparative high‐performance liquid chromatography and high‐speed counter‐current chromatography

Published: Feb 25, 2019

Author(s): Wanchao Hou, Senlin Li, Sainan Li, Dongfang Shi, Chunming Liu

Journal: Journal of Separation Science

Abstract Nonsteroidal anti‐inflammatory drugs reportedly reduce the risk of developing cancer. One mechanism by which they reduce carcinogenesis involves the inhibition of the activity of cyclooxygenase‐2, an enzyme that is overexpressed in various cancer tissues. Its overexpression increases cell proliferation and inhibits apoptosis. However, selected cyclooxygenase‐2 inhibitors can also act through cyclooxygenase‐independent mechanisms. In this study, using ultrafiltration,...

Read More thumbnail image: Screening and isolation of cyclooxygenase2 inhibitors from Trifolium pratense L_ via ultrafiltration enzymeimmobilized magnetic beads semipreparative highperformance liquid chromatography and highspeed countercurrent chromatography

Magnetic digital microfluidics on a bioinspired surface for point‐of‐care diagnostics of infectious disease

Published: Feb 25, 2019

Author(s): Pojchanun Kanitthamniyom, Yi Zhang

Journal: ELECTROPHORESIS

Abstract Magnetic digital microfluidics uses magnetic force to manipulate droplets on a Teflon‐coated substrate through the added magnetic particles. To achieve a wide range of droplet manipulation, hydrophilic patterns, known as surface energy traps, are introduced onto the Teflon‐coated hydrophobic substrate. However, the Teflon‐coated substrate is difficult to modify because it is nonwettable, and existing techniques for patterning surface energy traps have many limitations. Inspired by the...

Read More thumbnail image: Magnetic digital microfluidics on a bioinspired surface for pointofcare diagnostics of infectious disease

Analysis and interpretation of mixture DNA using AS‐PCR of mtDNA

Published: Feb 25, 2019

Author(s): Feng‐ling Xu, Mei Ding, Xi Xia, Xue Wu, Jing‐jing Zhang, Jia‐xin Xing, Jin‐feng Xuan, Jun Yao, Bao‐jie Wang

Journal: ELECTROPHORESIS

Abstract Semi‐nested PCR with allele‐specific (AS) primers and sequencing of mitochondrial DNA (mtDNA) were performed to analyze and interpret DNA mixtures, especially when biological materials were degraded or contained a limited amount of DNA. SNP‐STR markers were available to identify the minor DNA component using AS‐PCR; moreover, SNPs in mtDNA could be used when the degraded or limited amounts of DNA mixtures were not successful with SNP‐STR markers. Five pairs of allele‐specific primers...

Read More thumbnail image: Analysis and interpretation of mixture DNA using ASPCR of mtDNA

On the design of deterministic dielectrophoresis for continuous separation of circulating tumor cells from peripheral blood cells

Published: Feb 25, 2019

Author(s): Mohammad Aghaamoo, Arian Aghilinejad, Xiaolin Chen, Jie Xu

Journal: ELECTROPHORESIS

Abstract Detection and analysis of circulating tumor cells (CTCs) have emerged as a promising way to diagnose cancer, study its cellular mechanism, and test or develop potential treatments. However, the rarity of CTCs among peripheral blood cells is a big challenge toward CTC detection. In addition, in cases where there is similar size range between certain types of CTCs (e.g. breast cancer cells) and white blood cells (WBCs), high‐resolution techniques are needed. In the present work, we...

Read More thumbnail image: On the design of deterministic dielectrophoresis for continuous separation of circulating tumor cells from peripheral blood cells

Quantitative analysis of different batches of raw, wine‐processed, and vinegar‐processed Paeoniae Alba Radix using ultra‐performance convergence chromatography coupled with photo diode array detection

Published: Feb 25, 2019

Author(s): Liu Yang, Hai Jiang, Xinyue Guo, Ajiao Hou, Wenjing Man, Xudong Xing, Meiling Yan, Bingyou Yang, Qiuhong Wang, Haixue Kuang

Journal: Biomedical Chromatography

Abstract Supercritical fluid chromatography is a safe and ecofriendly analytical technique that has not been fully applied to the analysis of traditional Chinese medicine. This is the first study on the separation of six quality markers—paeoniflorin, albiflorin, benzoyl paeoniflorin, oxypaeoniflorin, gallic acid and benzoic acid—from raw, wine‐baked and vinegar‐baked Paeoniae Alba Radix (PAR) by Supercritical fluid chromatography. Optimum separation was achieved on an HSS C18 SB column...

Read More thumbnail image: Quantitative analysis of different batches of raw wineprocessed and vinegarprocessed Paeoniae Alba Radix using ultraperformance convergence chromatography coupled with photo diode array detection

Imaging of the region of the osteochondral junction (OCJ) using a 3D adiabatic inversion recovery prepared ultrashort echo time cones (3D IR‐UTE‐cones) sequence at 3 T

Published: Feb 22, 2019

Author(s): Ya‐Jun Ma, Saeed Jerban, Michael Carl, Lidi Wan, Tan Guo, Hyungseok Jang, Graeme M. Bydder, Eric Y. Chang, Jiang Du

Journal: NMR in Biomedicine

The purpose of this study is to develop a 3D adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR‐UTE‐Cones) sequence for high resolution and contrast imaging of the region of osteochondral junction (OCJ) of human knee joint using a clinical 3 T scanner. A feasibility study on direct imaging of the OCJ region was performed on a human patellar cartilage sample and on eight cadaveric knee joints using T1‐weighted, proton density (PD)‐weighted and short‐T2‐weighted 3D...

Read More thumbnail image: Imaging of the region of the osteochondral junction OCJ using a 3D adiabatic inversion recovery prepared ultrashort echo time cones 3D IRUTEcones sequence at 3T

Geographic origin identification and rapid determination of four constituents of Gentiana rigescens by FTIR combined with chemometrics

Published: Feb 21, 2019

Author(s): Yanli Zhao, Tianjun Yuan, Ji Zhang, Yuanzhong Wang

Journal: Journal of Chemometrics

Highlights The characteristic Fourier‐transform infrared (FTIR) spectra of Gentiana rigescens were selected by Monte Carlo uninformative variable elimination and 93 common peaks were selected and interpreted. The identification model for G. rigescens from different geographic origins was built by partial least squares discriminant analysis. On the basis of the correlation between characteristic spectral points and content of swertiamarin, gentiopicroside, sweroside, and loganic acid, the...

Read More thumbnail image: Geographic origin identification and rapid determination of four constituents of Gentiana rigescens by FTIR combined with chemometrics

Effect of chemical surface modification on dendritic gold in surface‐enhanced Raman scattering‐active substrates

Published: Feb 21, 2019

Author(s): Chia‐Yu Chang, Yun‐Ching Hsieh, Yung‐Yi Huang, Yun‐Jie Wang, Yu‐Mei Chen, Yu‐Bin Huang, Wei‐Hsiu Hung, Ying‐Huang Lai

Journal: Journal of Raman Spectroscopy

Abstract We fabricate crystalline dendritic gold (Au‐D) via a simple electrochemical method and characterize it using several techniques. Chemical modification by self‐assembled thiol molecules on the Au‐D is used to adjust the chemical environment of the substrate surface and to improve surface‐enhanced Raman scattering (SERS) performance. First, the Au‐D modified with different length chains of n‐alkyl thiols cause an enhancement of SERS, which follows a relationship of normalized intensity,...

Read More thumbnail image: Effect of chemical surface modification on dendritic gold in surfaceenhanced Raman scatteringactive substrates

Investigation of the enantioselectivity of tetramethylammonium‐lactobionate chiral ionic liquid based dual selector systems toward basic drugs in capillary electrophoresis

Published: Feb 21, 2019

Author(s): Xiaodong Sun, Kang Liu, Yingxiang Du, Jie Liu, Xiaofei Ma

Journal: ELECTROPHORESIS

Abstract Recently, chiral ionic liquids (CILs) have received increasing interest in chiral separation by CE. Nevertheless, the lack of deep perception of the specific mechanism about CILs in CE for enantioseparation still perplexes a legion of researchers, despite the strenuous efforts. In this paper, a lactobionic acid based ionic liquid, tetramethylammonium‐lactobionate (TMA‐LA) was applied for the first time in CE to establish dual selector system with clindamycin phosphate (CP) for...

Read More thumbnail image: Investigation of the enantioselectivity of tetramethylammoniumlactobionate chiral ionic liquid based dual selector systems toward basic drugs in capillary electrophoresis

Chiral separation of rasagiline using sulfobutylether‐β‐cyclodextrin: capillary electrophoresis, NMR and molecular modeling study

Published: Feb 21, 2019

Author(s): Zoltán‐István Szabó, Róbert Ludmerczki, Béla Fiser, Béla Noszál, Gergő Tóth

Journal: ELECTROPHORESIS

Abstract Pressure‐assisted stereospecific capillary electrophoresis method was developed for the determination of enantiomeric purity of the antiparkinsonian agent (R)‐rasagiline. The optimized method, 50 mM glycine‐HCl buffer pH 2, supplied with 30 mM sulfobutylether‐β‐cyclodextrin, at 35°C, applying 12 kV in reversed polarity, and –8 mbar pressure (vacuum), short‐end injection with ‐25 mbar × 2 s, was successful for baseline separation of rasagiline enantiomers (Rs = 3.5 ± 0.1) in a short...

Read More thumbnail image: Chiral separation of rasagiline using sulfobutylethercyclodextrin capillary electrophoresis NMR and molecular modeling study

On/off resonance Raman optical activity of human serum transferrin

Published: Feb 20, 2019

Author(s): Jonathan Bogaerts, Christian Johannessen

Journal: Journal of Raman Spectroscopy

Abstract The transferrin proteins exhibit two high affinity Fe(III) binding pockets and are responsible for the iron transport into cells of higher order organisms. Previously, transferrins have been studied as possible transporter molecules for drugs delivery. In this study, Raman optical activity (ROA) was employed to investigate human serum transferrin. Due to the presence of Fe(III) in the holo form of the protein, it is in resonance with the the laser excitation wavelength (of 532 nm)...

Read More thumbnail image: Onoff resonance Raman optical activity of human serum transferrin

Assessing serum albumin concentration following exercise‐induced fluid shifts in the context of the athlete biological passport

Published: Feb 20, 2019

Author(s): Geoffrey D. Miller, Masaru Teramoto, Stacy J. Smeal, Dan Cushman, Daniel Eichner

Journal: Drug Testing and Analysis

Abstract Purpose The hydration status of an athlete at the time of a doping control sample collection is an important factor to consider when reviewing athlete biological passports (ABPs). Dehydration results in a reduction of the circulating plasma volume (PV), which may lead to artificially high values of some blood parameters. This study aimed to identify whether serum albumin could serve as a single marker of fluid shifts, which are not currently accounted for in the hematological...

Read More thumbnail image: Assessing serum albumin concentration following exerciseinduced fluid shifts in the context of the athlete biological passport

Identification of interactions between multiple components in Socheongryong‐tang using a plant profiling approach

Published: Feb 20, 2019

Author(s): Hyun‐A Oh, Hyunbeom Lee, Keon Wook Kang, Ji Hye Im, Donghak Kim, Hyun Ok Yang, Byung Hwa Jung

Journal: Biomedical Chromatography

Abstract Traditional herbal medicine consists of multiple components. There are interactions among the components, which affect both potency and toxicity. The preparation of herbal medicines can be a cause of interactions between multicomponents in herbs. To demonstrate the differences in multiherb interactions based on the preparation methods, the changes in the active components in the different preparations of Socheongryong‐tang (SCRT) were evaluated using metabolomics profiling. We...

Read More thumbnail image: Identification of interactions between multiple components in Socheongryongtang using a plant profiling approach

Analysis of membrane transport mechanisms of endogenous substrates using chromatographic techniques

Published: Feb 20, 2019

Author(s): Hiroaki Yamaguchi, Nariyasu Mano

Journal: Biomedical Chromatography

Abstract Membrane transporters are expressed in various bodily tissues and play essential roles in the homeostasis of endogenous substances and the absortion, distribution and/or excretion of xenobiotics. For transporter assays, radioisotope‐labeled compounds have been mainly used. However, commercially available radioisotope‐labeled compounds are limited in number and relatively expensive. Chromatographic analyses such as high‐performance liquid chromatography with ultraviolet absorptiometry...

Read More thumbnail image: Analysis of membrane transport mechanisms of endogenous substrates using chromatographic techniques
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