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Highly sensitive VOC gas sensor employing deep cooling of SERS film

Published: Apr 3, 2018

Author(s): Myoung‐Kyu Oh, Ranjit De, Sang‐Youp Yim

Journal: Journal of Raman Spectroscopy

Abstract The potential of surface‐enhanced Raman spectroscopy (SERS) as a highly sensitive and selective gas sensor was investigated experimentally. Especially, the relation between the temperature of a SERS film and gas adsorption or signal intensity was observed systemically and quantitatively, from which the enhancement of gas adsorption and signal intensity by up to 40 times was observed with the SERS film temperature of approx....

Read More thumbnail image: Highly sensitive VOC gas sensor employing deep cooling of SERS film

A sensitive LC–MS/MS method for simultaneous determination of cabozantinib and its metabolite cabozantinib N ‐oxide in rat plasma and its application in a pharmacokinetic study

Published: Apr 2, 2018

Author(s): Lian‐jie Ren, Hua‐jing Wu, Li‐han Sun, Xue Xu, Li‐ying Mo, Lei Zhang, Jun‐ying Zhang, Chun‐yong Wu

Journal: Biomedical Chromatography

Abstract Cabozantinib (CBZ) is used for the treatment of progressive, metastatic medullary thyroid cancer. Its major oxidative metabolite is cabozantinib N‐oxide (CBN), which contains a structural alert associated with mutagenicity, yet the pharmacokinetics studies lack the simultaneous investigation of CBN and dose proportionality. In the current study a simple LC–MS/MS method was developed and validated for the simultaneous...

Read More thumbnail image: A sensitive LCMSMS method for simultaneous determination of cabozantinib and its metabolite cabozantinib N oxide in rat plasma and its application in a pharmacokinetic study

Determination of metoserpate, buquinolate, and diclofenac in pork, eggs, and milk using liquid chromatography–tandem mass spectrometry

Published: Apr 2, 2018

Author(s): Jin‐A Park, A. M. Abd El‐Aty, Weijia Zheng, Seong‐Kwan Kim, Jeong‐min Choi, Ahmet Hacımüftüoğlu, Jae‐Han Shim, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract In this work, a method was developed for the simultaneous determination of residual metoserpate, buquinolate and diclofenac in pork, milk, and eggs. Samples were extracted with 0.1% formic acid in acetonitrile, defatted with n‐hexane, and filtered prior to analysis using liquid chromatography–tandem mass spectrometry. The analytes were separated on a C18 column using 0.1% acetic acid and methanol as the mobile phase. The matrix‐matched...

Read More thumbnail image: Determination of metoserpate buquinolate and diclofenac in pork eggs and milk using liquid chromatographytandem mass spectrometry

Lipophilicity evaluation of some thiazolyl‐1,3,4‐oxadiazole derivatives with antifungal activity

Published: Apr 2, 2018

Author(s): Cristina Ioana Stoica, Ioana Ionuț, Laurian Vlase, Brîndușa Tiperciuc, Gabriel Marc, Smaranda Oniga, Cătălin Araniciu, Ovidiu Oniga

Journal: Biomedical Chromatography

Abstract The chromatographic behavior of a series of thiazolyl‐1,3,4‐oxadiazoles with antifungal activity was studied by reverse‐phase thin‐layer chromatography (RP‐TLC). The lipophilicity parameters derived from RP‐TLC were correlated with the data derived from liquid‐chromatography mass‐spectrometry. Good linear relationships were observed between the chromatographic lipophilicity parameters and the theoretical lipophilicity...

Read More thumbnail image: Lipophilicity evaluation of some thiazolyl134oxadiazole derivatives with antifungal activity

Simultaneous determination of evodiamine and its four metabolites in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Published: Apr 2, 2018

Author(s): Cuiyun Wang, Fang Yue, Guangfeng Ai, Jie Yang

Journal: Biomedical Chromatography

Abstract A simple and sensitive liquid chromatography tandem mass spectrometry method was validated for simultaneous quantification of evodiamine and its metabolites 10‐hydroxyevodiamine (M1), 18‐hydroxyevodiamine (M2), 10‐hydroxyevodiamine‐glucuronide (M3) and 18‐hydroxy‐ evodiamine‐glucuronide (M4) in rat plasma for the first time. The analytes were extracted with acetonitrile and separated on a C18 column within 3 min. The...

Read More thumbnail image: Simultaneous determination of evodiamine and its four metabolites in rat plasma by LCMSMS and its application to a pharmacokinetic study

Enantioseparation and determination of dufulin enantiomers in cucumber and soil by chiral liquid chromatography–tandem mass spectrometry

Published: Apr 2, 2018

Author(s): Haizhen Zhang, Min Huang, Weiwei Yu, A'wei Zhang, Kankan Zhang, Deyu Hu

Journal: Biomedical Chromatography

Abstract A simple and rapid method for enantioselective determination of dufulin in cucumber and soil was developed by liquid chromatography with tandem mass spectrometry. The enantiomers were separated on a Superchiral S‐OD chiral cellulose tris(3,5‐dimethylphenylcarbamate) column at 20°C, with a mixture of acetonitrile and water (0.1% formic acid; 52:48, v/v) as mobile phase at a flow rate of 0.65 mL/min. The pretreatment conditions were...

Read More thumbnail image: Enantioseparation and determination of dufulin enantiomers in cucumber and soil by chiral liquid chromatographytandem mass spectrometry

Quantification of amlodipine and atorvastatin in human plasma by UPLC–MS/MS method and its application to a bioequivalence study

Published: Apr 2, 2018

Author(s): Mamdouh R. Rezk, Kamal A. Badr

Journal: Biomedical Chromatography

Abstract A robust, rapid and sensitive UPLC–MS/MS method has been developed, optimized and validated for the determination of amlodipine (AML) and atorvastatin (ATO) in human plasma using eplerenone as an internal standard (IS). Multiple‐reaction monitoring in positive electrospray ionization mode was utilized in Xevo TQD LC–MS/MS. Double extraction was used in sample preparation using diethyl ether and ethyl acetate. The prepared...

Read More thumbnail image: Quantification of amlodipine and atorvastatin in human plasma by UPLCMSMS method and its application to a bioequivalence study

Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains

Published: Mar 30, 2018

Author(s): Dan Wu, Qiang Li, Frances J. Northington, Jiangyang Zhang

Journal: NMR in Biomedicine

Recent advances in diffusion MRI employ multiple diffusion encoding schemes with varying diffusion direction, weighting, and diffusion time to investigate specific microstructural properties in biological tissues. In this study, we examined time‐dependent diffusion kurtosis contrast in adult mouse brains and in neonatal mouse brains after hypoxic–ischemic (HI) injury. In vivo diffusion kurtosis maps were acquired with a short diffusion time using an...

Read More thumbnail image: Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains

Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia: Results from a multiple‐inflow‐time arterial spin labelling study

Published: Mar 30, 2018

Author(s): Jamie M. Kawadler, Patrick W. Hales, Simon Barker, Timothy C. S. Cox, Fenella J. Kirkham, Chris A. Clark

Journal: NMR in Biomedicine

Sickle cell anaemia (SCA) is associated with chronic anaemia and oxygen desaturation, which elevate cerebral blood flow (CBF) and increase the risk of neurocognitive complications. Arterial spin labelling (ASL) provides a methodology for measuring CBF non‐invasively; however, ASL techniques using only a single inflow time are not sufficient to fully characterize abnormal haemodynamic behaviour in SCA. This study investigated haemodynamic...

Read More thumbnail image: Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia Results from a multipleinflowtime arterial spin labelling study

Hydrogen/deuterium exchange in mass spectrometry

Published: Mar 30, 2018

Author(s): Yury Kostyukevich, Thamina Acter, Alexander Zherebker, Arif Ahmed, Sunghwan Kim, Eugene Nikolaev

Journal: Mass Spectrometry Reviews

The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of...

Read More thumbnail image: Hydrogendeuterium exchange in mass spectrometry

Electron‐ion reaction‐based dissociation: A powerful ion activation method for the elucidation of natural product structures

Published: Mar 30, 2018

Author(s): Xiangfeng Chen, Ze Wang, Y.‐L. Elaine Wong, Ri Wu, Feng Zhang, T.‐W. Dominic Chan

Journal: Mass Spectrometry Reviews

The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from...

Read More thumbnail image: Electronion reactionbased dissociation A powerful ion activation method for the elucidation of natural product structures

Molecules and elements for quantitative bioanalysis: The allure of using electrospray, MALDI, and ICP mass spectrometry side‐by‐side

Published: Mar 30, 2018

Author(s): Michael W. Linscheid

Journal: Mass Spectrometry Reviews

To understand biological processes, not only reliable identification, but quantification of constituents in biological processes play a pivotal role. This is especially true for the proteome: protein quantification must follow protein identification, since sometimes minute changes in abundance tell the real tale. To obtain quantitative data, many sophisticated strategies using electrospray and MALDI mass spectrometry...

Read More thumbnail image: Molecules and elements for quantitative bioanalysis The allure of using electrospray MALDI and ICP mass spectrometry sidebyside

Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Published: Mar 30, 2018

Author(s): Claudio A. Téllez Soto, Lázaro P. Medeiros‐Neto, Laurita Santos, André B.O. Santos, Isabelle Ferreira, Priyanka Singh, Renata A. Canevari, Aírton A. Martin

Journal: Journal of Raman Spectroscopy

Abstract Thirty thyroid samples of normal and abnormal tissues were analyzed by infrared and confocal Raman Spectroscopy. We studied the Amide I (1,720–1,580 cm−1) spectral region in order to determine different components of the proteins' secondary structure in the samples. Peak positions of the Amide I bands were determined using the second derivative and Fourier self‐deconvolution of infrared and Raman spectra. We obtained...

Read More thumbnail image: Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Theoretical methods for calculations of optical phonons in BiOBr: Analysis and correction of propagated errors

Published: Mar 30, 2018

Author(s): Mateus M. Ferrer, João Elias F.S. Rodrigues, Marcio A.P. Almeida, Francisco Moura, Elson Longo, Paulo S. Pizani, Julio R. Sambrano

Journal: Journal of Raman Spectroscopy

Abstract Theoretical and experimental methods were employed to investigate the vibrational modes of BiOBr. Wavenumber prediction and assignments of the infrared and Raman modes were performed using density functional theory and lattice dynamics calculations. The theoretical models were directly compared with the experimental results of particles fabricated using the microwave‐assisted hydrothermal method and results reported in...

Read More thumbnail image: Theoretical methods for calculations of optical phonons in BiOBr Analysis and correction of propagated errors

Formation of cyanide compounds during preparation of gold surfaces evidenced by surface‐enhanced R aman spectroscopy

Published: Mar 30, 2018

Author(s): A. Merlen, C. Pardanaud, S. Coussan, C. Panagiotopoulos, O. Grauby, Carmen M. Ruiz

Journal: Journal of Raman Spectroscopy

Abstract We report surface‐enhanced Raman spectroscopy (SERS) measurements on nanostructured gold surfaces prepared using a primary vacuum sputtering technique. Even if no molecules have been deposited on the metallic surface, a clear Raman signal is observed. A very intense and sharp peak around 2,100 cm−1 together with low‐wavenumber modes are visible. The comparison between the experimental spectra and those obtained using ...

Read More thumbnail image: Formation of cyanide compounds during preparation of gold surfaces evidenced by surfaceenhanced R aman spectroscopy

Specific glycine to alanine mutation eliminates dynamic interaction of polymeric GlyT1a N‐terminus with Coomassie Brilliant Blue G‐250

Published: Mar 29, 2018

Author(s): Martina Baliova, Frantisek Jursky

Journal: ELECTROPHORESIS

Abstract We previously found that multimeric GlyT1aN16 protein exhibits increased diffusion in a polyacrylamide gel and shows an unusual time‐dependent absorbance rearrangement, as revealed by the Bradford assay. Here, we find that glycine to alanine mutation eliminates the absorbance shift, but not the altered diffusion properties of GlyT1aN16, indicating that these two phenomena are not interconnected. The absorbance shift is...

Read More thumbnail image: Specific glycine to alanine mutation eliminates dynamic interaction of polymeric GlyT1a Nterminus with Coomassie Brilliant Blue G250

Study of the enantiomeric separation of the anticholinergic drugs on two immobilized polysaccharide‐based chiral stationary phases by HPLC and the possible chiral recognition mechanisms

Published: Mar 29, 2018

Author(s): Meng Li, Yu Zhao, Li Zhou, Jia Yu, Jian Wang, Xingjie Guo

Journal: ELECTROPHORESIS

Abstract In this work, the enantiomeric separation of ten anticholinergic drugs was first examined on two derivative polysaccharide chiral stationary phases (CSPs), i.e., Chiralpak ID and Chiralpak IA in the normal phase mode. Except for scopolamine hydrobromide, the remaining nine analytes could be completely separated with good resolutions using both columns under the optimized mobile phase conditions. And the enantiomeric...

Read More thumbnail image: Study of the enantiomeric separation of the anticholinergic drugs on two immobilized polysaccharidebased chiral stationary phases by HPLC and the possible chiral recognition mechanisms

Investigation of pumping mechanism for non‐Newtonian blood flow with AC electrothermal forces in a microchannel by hybrid boundary element method and immersed boundary‐lattice Boltzmann method

Published: Mar 29, 2018

Author(s): Qinlong Ren

Journal: ELECTROPHORESIS

Abstract Efficient pumping of blood flow in a microfluidic device is essential for rapid detection of bacterial bloodstream infections (BSI) using alternating current (AC) electrokinetics. Compared with AC electro‐osmosis (ACEO) phenomenon, the advantage of AC electrothermal (ACET) mechanism is its capability of pumping biofluids with high electrical conductivities at a relatively high AC voltage frequency. In the current work, the...

Read More thumbnail image: Investigation of pumping mechanism for nonNewtonian blood flow with AC electrothermal forces in a microchannel by hybrid boundary element method and immersed boundarylattice Boltzmann method

Combined AC‐electrokinetic effects: Theoretical considerations on a three‐axial ellipsoidal model

Published: Mar 29, 2018

Author(s): Jan Gimsa

Journal: ELECTROPHORESIS

Abstract AC fields induce charges at the structural interfaces of particles or biological cells. The interaction of these charges with the field generates frequency‐dependent forces that are the basis for AC‐electrokinetic effects such as dielectrophoresis (DEP), electrorotation (ROT), electro‐orientation, and electro‐deformation. The effects can be used for the manipulation or dielectric single‐particle spectroscopy. The...

Read More thumbnail image: Combined ACelectrokinetic effects Theoretical considerations on a threeaxial ellipsoidal model

Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection

Published: Mar 29, 2018

Author(s): Maria Guirro, Andrea Costa, Andreu Gual‐Grau, Jordi Mayneris‐Perxachs, Helena Torrell, Pol Herrero, Núria Canela, Lluís Arola

Journal: ELECTROPHORESIS

Abstract Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several...

Read More thumbnail image: Multiomics approach to elucidate the gut microbiota activity Metaproteomics and metagenomics connection
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