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Streamlined microfluidic analysis of phosphopeptides using stable isotope‐labeled synthetic peptides and MRM‐MS detection

Published: Oct 1, 2018

Author(s): Jingren Deng, Fumio Ikenishi, Nicole Smith, Iulia M. Lazar

Journal: ELECTROPHORESIS

Abstract Modern high‐throughput and high‐content biological research is performed with advanced instrumentation and complex and time‐consuming protocols, which, as a whole, pose a challenge for routine implementation in a research laboratory. In support of a “bioanalytical toolbox” with potential utility for exploring cellular functions mediated via protein phosphorylation‐a post‐translational modification (PTM) with essential...

Read More thumbnail image: Streamlined microfluidic analysis of phosphopeptides using stable isotopelabeled synthetic peptides and MRMMS detection

Electrokinetics with blood

Published: Oct 1, 2018

Author(s): Suman Chakraborty

Journal: ELECTROPHORESIS

Abstract Microfluidics based lab‐on‐a‐chip technology holds tremendous promises towards point‐of‐care diagnosis of diseases as well as for developing engineered devices aimed towards replicating the intrinsic functionalities of human bodies as mediated by blood vessel mimicking circulatory networks. While the analysis of transport of blood including its unique cellular constituents has remained to be the focus of many reported...

Read More thumbnail image: Electrokinetics with blood

Study of aldehyde oxidase by micellar electrokinetic chromatography separation of O 6 ‐benzylguanine and 8‐oxo‐O 6 ‐benzylguanine

Published: Oct 1, 2018

Author(s): Shengyun Huang, Erwin Adams, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract A separation method for O6‐benzylguanine (O6‐BG) and 8‐oxo‐O6‐benzylguanine (8‐oxo‐O6‐BG) is developed by using MEKC. This study includes the optimization of separation and incubation parameters for both off‐line and on‐line procedures. The BGE consisted of 25 mM sodium phosphate buffer‐methanol (70:30, v/v), apparent pH 7.4, in which SDS and methyl‐β‐cyclodextrin were dissolved yielding final concentrations of 50 and 15 mM,...

Read More thumbnail image: Study of aldehyde oxidase by micellar electrokinetic chromatography separation of O 6 benzylguanine and 8oxoO 6 benzylguanine

Dielectrophoretic separation of microalgae cells in ballast water in a microfluidic chip

Published: Oct 1, 2018

Author(s): Yanjuan Wang, Junsheng Wang, Xudong Wu, Zong Jiang, Wei Wang

Journal: ELECTROPHORESIS

Abstract The composition of the ship's ballast water is complex and contains a large number of microalgae cells, bacteria, microplastics, and other microparticles. To increase the accuracy and efficiency of detection of the microalgae cells in ballast water, a new microfluidic chip for continuous separation of microalgae cells based on alternating current dielectrophoresis was proposed. In this microfluidic chip, one piece of...

Read More thumbnail image: Dielectrophoretic separation of microalgae cells in ballast water in a microfluidic chip

Brain metabolism under different anesthetic conditions using hyperpolarized [1‐ 13 C]pyruvate and [2‐ 13 C]pyruvate

Published: Oct 1, 2018

Author(s): Małgorzata Marjańska, Alexander A. Shestov, Dinesh K. Deelchand, Emily Kittelson, Pierre‐Gilles Henry

Journal: NMR in Biomedicine

Carbon‐13 NMR spectroscopy (13C MRS) offers the unique capability to measure brain metabolic rates in vivo. Hyperpolarized 13C reduces the time required to assess brain metabolism from hours to minutes when compared with conventional 13C MRS. This study investigates metabolism of hyperpolarized [1‐13C]pyruvate and [2‐13C]pyruvate in the rat brain in vivo under various anesthetics: pentobarbital, isoflurane, α‐chloralose, and morphine. The apparent metabolic rate...

Read More thumbnail image: Brain metabolism under different anesthetic conditions using hyperpolarized 1 13 Cpyruvate and 2 13 Cpyruvate

Anodizing—Interplay between bath aging and oxide formation and properties

Published: Oct 1, 2018

Author(s): Michael Schneider, Kerstin Kremmer, Uta Gierth

Journal: Surface and Interface Analysis

The present study investigates the interplay between ongoing bath aging during the anodizing process and the formation and properties of the anodic formed oxide layers on AA 1050 in sulfuric acid. The change in the bath over the time of use is studied by controlling the conductivity of the bath. The pH value and the concentration of Al3+ ions in the bath are simultaneously measured. The kinetic of the oxide formation depending on the bath aging is...

Read More thumbnail image: AnodizingInterplay between bath aging and oxide formation and properties

The surface modification of carbon fiber for thermoplastic HDPE composites

Published: Oct 1, 2018

Author(s): Zhang Shengbo, Dai Qingling

Journal: Surface and Interface Analysis

The interfacial adhesion strength between the fiber and the matrix greatly affects the properties of the carbon fiber (CF)–reinforced composite. The presence of surface functional groups on the fiber and changes in surface roughness were determined by X‐ray photoelectron spectroscopy, scanning electron microscopy (SEM), and Raman spectroscopy. The effect of surface modification of CF on the mechanical properties and tribological...

Read More thumbnail image: The surface modification of carbon fiber for thermoplastic HDPE composites

Effects of the crystalline structure of Ga 2 O 3 on the photocatalytic activity for CO production from CO 2

Published: Oct 1, 2018

Author(s): Yu Kawaguchi, Muneaki Yamamoto, Akiyo Ozawa, Yuma Kato, Tomoko Yoshida

Journal: Surface and Interface Analysis

Ga2O3 samples with different crystalline structures were prepared by calcination of a gallium nitrate powder around 800 K. Ga2O3 samples with mixed phases of γ and β showed high photocatalytic activity for CO production from CO2 reduction with water, and the activity was even higher than that for an Ag‐loaded β‐Ga2O3. The photocatalytic activity increased with time. The increase was attributed to the appearance of GaOOH resulting from the interaction of...

Read More thumbnail image: Effects of the crystalline structure of Ga 2 O 3 on the photocatalytic activity for CO production from CO 2

Electrospun TiO 2 nanofibers coated with polydopamine for enhanced sunlight‐driven photocatalytic degradation of cationic dyes

Published: Oct 1, 2018

Author(s): Xuebin Hou, Yibing Cai, Xiaofei Song, Yue Wu, Junhao Zhang, Qufu Wei

Journal: Surface and Interface Analysis

Controlled polydopamine (PDA)‐coated TiO2 composite nanofibers (NFs) were successfully fabricated via a facile electrospinning process and exposing TiO2 NFs into a slightly alkaline dopamine solution. Chemical composition, structural morphology, and photocatalytic degradation property of as‐prepared TiO2 NFs and PDA‐coated TiO2 composite NFs were characterized by Fourier transfer infrared, X‐ray photoelectron spectra, transmission electron microscopy, ...

Read More thumbnail image: Electrospun TiO 2 nanofibers coated with polydopamine for enhanced sunlightdriven photocatalytic degradation of cationic dyes

On the effect of TiO2 nanocrystallites over the plasmonic photodegradation by Au nanoparticles

Published: Oct 1, 2018

Author(s): Jiale Wang, Eduardo C.M. Barbosa, Zebo Fang, André L.A. Parussulo, Flavia V.E. Reis, Rômulo A. Ando, Koiti Araki, Henrique E. Toma, Pedro H.C. Camargo

Journal: Journal of Raman Spectroscopy

Abstract In this paper, we aimed at investigating the effect of the presence of small TiO2 crystallites over the transfer of hot electrons from Au nanoparticles (NPs) mediated by the surface plasmon resonance (SPR) excitation and its subsequent photocatalytic activities. To this end, we employed TiO2 colloidal spheres composed of TiO2 crystallites of 8.5 nm in size decorated with Au NPs (TiO2–Au) of 17 nm in size over the TiO2 surface as model...

Read More thumbnail image: On the effect of TiO2 nanocrystallites over the plasmonic photodegradation by Au nanoparticles

Drop coating deposition Raman spectroscopy of dipicolinic acid

Published: Oct 1, 2018

Author(s): Eva Kočišová, Marek Procházka

Journal: Journal of Raman Spectroscopy

Abstract Dipicolinic acid (DPA) is an important spore biomarker for Bacillus anthracis (anthrax). Drop coating deposition Raman (DCDR) spectroscopy on a commercial hydrophobic SpectRIM™ plate allowed DPA to be detected at 5 × 10−7‐M deposited concentration, equivalent to approximately 90 spores, significantly below the infective dose (104 spores). The DCDR spectra of DPA differ from Raman spectrum of DPA powder, crystalline state, and aqueous...

Read More thumbnail image: Drop coating deposition Raman spectroscopy of dipicolinic acid

Spectroscopic characterization of adsorbate confined in small mesopores: Distinction of first surface‐adsorbed layer, polymolecular layers, and liquid clusters

Published: Oct 1, 2018

Author(s): Vladimir G. Arakcheev, Alexey N. Bekin, Viacheslav B. Morozov

Journal: Journal of Raman Spectroscopy

Abstract Coherent anti‐Stokes Raman scattering is applied to distinguish dense phases of carbon dioxide adsorbed in mesoporous glass Vycor with pores of 2 nm in radius. Each of the phases is identified by their Raman shifts corresponding to the CO2 band at 1388 cm−1. The results show that the first layer adsorbed on the pore wall and the polymolecular layers adsorbed upon it can be spectroscopically distinguished from each other....

Read More thumbnail image: Spectroscopic characterization of adsorbate confined in small mesopores Distinction of first surfaceadsorbed layer polymolecular layers and liquid clusters

Updated protocols for the detection of Sotatercept and Luspatercept in human serum

Published: Oct 1, 2018

Author(s): Christian Reichel, Günter Gmeiner, Katja Walpurgis, Mario Thevis

Journal: Drug Testing and Analysis

Abstract We recently published two protocols for the detection of Sotatercept (ACE‐011, ACVR2A‐Fc) and Luspatercept (ACE‐536, ACVR2B‐Fc) in human serum. Both methods used covalently immobilized antibodies on agarose beads for immunoprecipitation and SAR‐PAGE/Western blotting for detection. Disadvantages were the relatively high amount of antibody required per sample (10 μg) and the need of a secondary antibody for the final...

Read More thumbnail image: Updated protocols for the detection of Sotatercept and Luspatercept in human serum

Synthesis and pharmacology of new psychoactive substance 5F‐CUMYL‐P7AICA, a scaffold‐ hopping analog of synthetic cannabinoid receptor agonists 5F‐CUMYL‐PICA and 5F‐CUMYL‐PINACA

Published: Oct 1, 2018

Author(s): Samuel D. Banister, Axel Adams, Richard C. Kevin, Christa Macdonald, Michelle Glass, Rochelle Boyd, Mark Connor, Iain S. McGregor, Christopher M. Havel, Stephen J. Bright, Mireia Ventura Vilamala, Cristina Gil Lladanosa, Monica J. Barratt, Roy R. Gerona

Journal: Drug Testing and Analysis

Abstract Synthetic cannabinoid receptor agonists (SCRAs) are a dynamic class of new psychoactive substances (NPS), with novel chemotypes emerging each year. Following the putative detection of 5F‐CUMYL‐P7AICA in Australia in 2016, the scaffold‐hopping SCRAs 5F‐CUMYL‐PICA, 5F‐CUMYL‐PINACA, and 5F‐CUMYL‐P7AICA were synthesized and characterized by nuclear magnetic resonance (NMR) spectroscopy, gas chromatography–mass spectrometry...

Read More thumbnail image: Synthesis and pharmacology of new psychoactive substance 5FCUMYLP7AICA a scaffold hopping analog of synthetic cannabinoid receptor agonists 5FCUMYLPICA and 5FCUMYLPINACA

Sample and feature augmentation strategies for calibration updating

Published: Oct 1, 2018

Author(s): Erik Andries, John H. Kalivas, Anit Gurung

Journal: Journal of Chemometrics

Calibration updating—transfer and/or maintenance—has historically been implemented using a simple but effective technique: in addition to primary samples, include a small number of secondary samples and weight them. It would be beneficial if these classical weighting techniques could be enhanced. Moreover, it would be ideal if we could only use secondary spectra without reference measurements. In this paper, we examine multiple...

Read More thumbnail image: Sample and feature augmentation strategies for calibration updating

Methods and approaches for determination and enantioseparation of ( RS )‐propranolol

Published: Sep 30, 2018

Author(s): Sonika Batra, Ravi Bhushan

Journal: Biomedical Chromatography

Abstract Propranolol, a β‐adrenergic receptor antagonist, is a chiral compound that is marketed as a racemate, but only the (S)‐(−)‐enantiomer is responsible for the β‐adrenoceptor blocking activity. Different chromatographic methods have been applied for separation and determination of enantiomers of (RS)‐propranolol. In this article a review is presented on different liquid chromatographic methods used for enantioseparation of...

Read More thumbnail image: Methods and approaches for determination and enantioseparation of  RS propranolol

Interactions of phenethylamine‐derived psychoactive substances of the 2C‐series with human monoamine oxidases

Published: Sep 28, 2018

Author(s): Lea Wagmann, Simon D. Brandt, Alexander Stratford, Hans H. Maurer, Markus R. Meyer

Journal: Drug Testing and Analysis

Abstract Psychoactive substances of the 2C‐series (2Cs) are phenethylamine‐derived designer drugs that can induce psychostimulant and hallucinogenic effects. Chemically, the classic 2Cs contain two methoxy groups in positions 2 and 5 of the phenyl ring, whereas substances of the so‐called FLY series contain rigidified methoxy groups integrated in a 2,3,6,7‐tetrahydrobenzo[1,2‐b:4,5‐b’]difuran core. One of the pharmacological...

Read More thumbnail image: Interactions of phenethylaminederived psychoactive substances of the 2Cseries with human monoamine oxidases

Postharvest metabolomic changes in Pyrus ussuriensis Maxim. wild accession ‘Zaoshu Shanli’

Published: Sep 28, 2018

Author(s): Jiayu Xu, Ying Zhang, Dan Qi, Hongliang Huo, Xingguang Dong, Luming Tian, Xiaoshuang Zhang, Chao Liu, Yufen Cao

Journal: Journal of Separation Science

Abstract There are strong economic drivers for understanding the process of fruit post‐harvest softening. In this study, liquid chromatography with electrospray ionization tandem mass spectrometry was used to analyze metabolite changes in ‘Zaoshu Shanli’ fruit after different storage periods; this wild accession of Pyrus ussuriensis presents good fruit quality and relatively low flesh firmness after fruit storage. The lipid metabolites in...

Read More thumbnail image: Postharvest metabolomic changes in Pyrus ussuriensis Maxim_ wild accession Zaoshu Shanli

MaSS‐Simulator: A Highly Configurable Simulator for Generating MS/MS Datasets for Benchmarking of Proteomics Algorithms

Published: Sep 28, 2018

Author(s): Muaaz Gul Awan, Fahad Saeed

Journal: PROTEOMICS

Abstract Mass Spectrometry (MS)‐based proteomics has become an essential tool in the study of proteins. With the advent of modern MS machines huge amounts of data is being generated, which can only be processed by novel algorithmic tools. However, in the absence of data benchmarks and ground truth datasets algorithmic integrity testing and reproducibility is a challenging problem. To this end, MaSS‐Simulator has been presented,...

Read More thumbnail image: MaSSSimulator A Highly Configurable Simulator for Generating MSMS Datasets for Benchmarking of Proteomics Algorithms

Sample preparation for the analysis of fire debris – Past and present

Published: Sep 28, 2018

Author(s): Tanya J. Kerr

Journal: Journal of Separation Science

Abstract Identification of ignitable liquids from fire debris is such a major part of an arson investigation that much time and effort has gone into advancing sample preparation techniques to capture complicated and unexpected hydrocarbon compounds. Advancements in sample preparation have been made in order to account for biodegradation of commonly used accelerants, rarely encountered compounds, such as vegetable oils, biodiesel,...

Read More thumbnail image: Sample preparation for the analysis of fire debris  Past and present
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