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Solid‐phase microextraction based on an agarose‐chitosan‐multiwalled carbon nanotube composite film combined with HPLC–UV for the determination of nonsteroidal anti‐inflammatory drugs in aqueous samples

Published: Jul 2, 2018

Author(s): Wan Nazihah Wan Ibrahim, Mohd Marsin Sanagi, Nor Suhaila Mohamad Hanapi, Sazlinda Kamaruzaman, Noorfatimah Yahaya, Wan Aini Wan Ibrahim

Journal: Journal of Separation Science

Abstract We describe the preparation, characterization, and application of a composite film adsorbent based on blended agarose‐chitosan‐multiwalled carbon nanotubes for the preconcentration of selected nonsteroidal anti‐inflammatory drugs in aqueous samples before determination by high performance liquid chromatography with ultraviolet detection. The composite film showed a high surface area (4.0258 m2/g) and strong hydrogen bonding...

Read More thumbnail image: Solidphase microextraction based on an agarosechitosanmultiwalled carbon nanotube composite film combined with HPLCUV for the determination of nonsteroidal antiinflammatory drugs in aqueous samples

Monolith affinity chromatography for the rapid quantification of a single‐chain variable fragment immunotoxin

Published: Jul 2, 2018

Author(s): Peter Satzer, Ralf Sommer, Johanna Paulsson, Agnes Rodler, Romana Zehetner, Klaus Hofstädter, Christoph Klade, Alois Jungbauer

Journal: Journal of Separation Science

Abstract We developed a novel analytical method for concentration determination of tandem single‐chain antibody diphtheria toxin (immunotoxin). The method is based on polymethacrylate monoliths with Protein L ligands as the binding moiety. Different buffers were tested for elution of the Protein L‐bound immunotoxin and 4.5 M guanidinium hydrochloride performed best. We optimized the elution conditions and the method sequence...

Read More thumbnail image: Monolith affinity chromatography for the rapid quantification of a singlechain variable fragment immunotoxin

Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application

Published: Jul 2, 2018

Author(s): Chandra Teja Uppuluri, Avantika V. Dalvi, Ekta Prasanthi Bommireddy, Punna Rao Ravi

Journal: Biomedical Chromatography

Abstract Simple, selective and sensitive high‐performance liquid chromatographic (HPLC) bioanalytical methods using fluorescence (FL) and photodiode array (PDA) detectors were developed and validated for determination of piribedil (PBD), an anti‐Parkinson's drug, in rat plasma and brain samples, with telmisartan as internal standard (IS). Protein precipitation technique was used to extract PBD from both biological matrices....

Read More thumbnail image: Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application

Drug–drug interaction and doping: Effect of non‐prohibited drugs on the urinary excretion profile of methandienone

Published: Jul 1, 2018

Author(s): Monica Mazzarino, Franziska L. Khevenhüller‐Metsch, Ilaria Fiacco, Maria Kristina Parr, Xavier Torre, Francesco Botrè

Journal: Drug Testing and Analysis

Abstract The potential consequences of drug–drug interactions on the excretion profile of the anabolic androgenic steroid methandienone (17β‐hydroxy‐17α‐methylandrosta‐1,4‐dien‐3‐one) are discussed. More specifically, we have evaluated by in vitro and in vivo experiments the effects of 7 non‐prohibited drugs (fluconazole, ketoconazole, itraconazole, miconazole, fluoxetine, paroxetine, and nefazodone) on the main metabolic pathways of...

Read More thumbnail image: Drugdrug interaction and doping Effect of nonprohibited drugs on the urinary excretion profile of methandienone

A novel liquid chromatography Orbitrap mass spectrometry method with full scan for simultaneous determination of multiple bioactive constituents of Shenkang injection in rat tissues: Application to tissue distribution and pharmacokinetic studies

Published: Jul 1, 2018

Author(s): Jie Yang, Zhi Sun, Duolu Li, Fei Duan, Zhuolun Li, Jingli Lu, Yingying Shi, Tanye Xu, Xiaojian Zhang

Journal: Biomedical Chromatography

Abstract Shenkang injection is a traditional Chinese formula with good curative effect on chronic renal failure. In this paper, a novel, rapid and sensitive ultra‐high‐performance liquid chromatography coupled with Q Exactive hybrid quadrupole Orbitrap high‐resolution accurate mass spectrometry was developed and validated for simultaneous determination of seven bioactive constituents of Shenkang injection in rat plasma and tissues...

Read More thumbnail image: A novel liquid chromatography Orbitrap mass spectrometry method with full scan for simultaneous determination of multiple bioactive constituents of Shenkang injection in rat tissues Application to tissue distribution and pharmacokinetic studies

Precise control of distance between plasmonic surface‐enhanced Raman scattering substrate and analyte molecules with polyelectrolyte layers

Published: Jul 1, 2018

Author(s): Ekaterina S. Prikhozhdenko, Daniil N. Bratashov, Vsevolod S. Atkin, Roman A. Kamyshinsky, Alexander L. Vasiliev, Boris N. Khlebtsov, Dmitry A. Gorin, Helmuth Möhwald, Alexey M. Yashchenok

Journal: Journal of Raman Spectroscopy

Abstract The dependence of the surface‐enhanced Raman scattering (SERS) activity of small and large molecules on the number of polyelectrolyte monolayers covering the surface of gold nanocages (AuNCs) is investigated. The linkage of AuNCs to silica microparticles and the covering of its surface with additional polyelectrolyte layers are performed via layer‐by‐layer self‐assembly. Either three‐dimensional core–shell composite...

Read More thumbnail image: Precise control of distance between plasmonic surfaceenhanced Raman scattering substrate and analyte molecules with polyelectrolyte layers

Raman spectroscopy of neutron irradiated silicon carbide: C orrelation among R aman spectra, swelling, and irradiation temperature

Published: Jul 1, 2018

Author(s): Takaaki Koyanagi, Yutai Katoh, Michael J. Lance

Journal: Journal of Raman Spectroscopy

Abstract The effects of neutron irradiation on microstructural evolution and the resultant changes in physical and mechanical properties are of critical importance for the development of silicon carbide (SiC) materials for nuclear applications. This study neutron‐irradiated β‐SiC under a wide range of conditions at temperatures between 235 and 750°C and neutron doses of 0.01–11.8 displacements per atom, and then evaluated the...

Read More thumbnail image: Raman spectroscopy of neutron irradiated silicon carbide C orrelation among R aman spectra swelling and irradiation temperature

Multivariate calibration in TXRF analysis of water

Published: Jul 1, 2018

Author(s): A. Shulyumova, A. Maltsev, N. Umarova

Journal: X-Ray Spectrometry

The aim of this paper is the application of multivariate linear calibration for quantitative determination of elements (K, Cd, Co, Hg, As, Pb, Ni, and Al) in water by using Total Reflection X‐ray Fluorescence Analysis with partial least squares (PLS) as a regression method to improve a result of common univariate method. In purpose of elimination of matrix effects in X‐ray fluorescence analysis, experimental design was applied. As a set...

Read More thumbnail image: Multivariate calibration in TXRF analysis of water

The analytical challenges of cyclopropylfentanyl and crotonylfentanyl: An approach for toxicological analysis

Published: Jun 29, 2018

Author(s): Shane Maher, Simon P. Elliott, Steve George

Journal: Drug Testing and Analysis

Abstract New psychoactive substances (NPS) are increasingly being seen in forensic casework globally and encompass a number of types of drugs including “designer opioids”, especially fentanyl analogues, which are of particular concern due to their high potency and significant risk of toxicity. They are often sold as heroin or mixed with other illicit drugs and therefore users may be unaware they are taking such hazardous compounds....

Read More thumbnail image: The analytical challenges of cyclopropylfentanyl and crotonylfentanyl An approach for toxicological analysis

Analysis of cis and trans 3‐methylfentanyl by liquid chromatography–high resolution mass spectrometry and findings in forensic toxicology casework

Published: Jun 29, 2018

Author(s): Melissa F. Fogarty, Donna M. Papsun, Barry K. Logan

Journal: Drug Testing and Analysis

Abstract 3‐methylfentanyl (3‐MF), N‐(3‐methyl‐1‐phenethyl‐4‐piperidyl)‐N‐phenyl‐propanamide, has reappeared on the US illicit drug market since its disappearance after a series of overdose deaths in 1988. 3‐MF presents an analytical challenge, due to presence of cis and trans stereoisomers, each with different potencies, and ultimately very low concentrations in the blood after use. A method was developed using liquid...

Read More thumbnail image: Analysis of cis and trans 3methylfentanyl by liquid chromatographyhigh resolution mass spectrometry and findings in forensic toxicology casework

Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis

Published: Jun 29, 2018

Author(s): Jesús Marín‐Sáez, Roberto Romero‐González, Antonia Garrido Frenich, Francisco Javier Egea‐González

Journal: Drug Testing and Analysis

Abstract Homeopathic products are still a controversial issue in modern medicine, understood as complementary or alternative medicine (CAM). In this particular case, homeopathic products prepared from Atropa belladonna extracts may present specific problems due to the effects derived from its components. This article applies a simple, rapid, reliable method to the analysis of different homeopathic products obtained from Atropa belladonna; drugs...

Read More thumbnail image: Screening of drugs and homeopathic products from Atropa belladonna seed extracts Tropane alkaloids determination and untargeted analysis

Development of a low flow‐resistive charged nanoporous membrane in a microchip for fast electropreconcentration

Published: Jun 29, 2018

Author(s): Honggu Chun

Journal: ELECTROPHORESIS

Abstract A nanoporous poly‐(styrene sulfonate) (poly‐SS) membrane was developed for fast and selective ion transport in a microfluidic chip. The poly‐SS membrane can be photopolymerized in‐situ at arbitrary location of a microchannel, enabling integrated fluidics design in the microfluidic chip. The membrane is characterized by a low hydraulic resistance and a high surface charge to maximize the electroosmotic flow and charge...

Read More thumbnail image: Development of a low flowresistive charged nanoporous membrane in a microchip for fast electropreconcentration

Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestry‐informative SNPs

Published: Jun 29, 2018

Author(s): Guanglin He, Zheng Wang, Mengge Wang, Tao Luo, Jing Liu, You Zhou, Bo Gao, Yiping Hou

Journal: ELECTROPHORESIS

Abstract Ancestry inference based on SNPs with marked allele frequency differences in diverse populations (called ancestry‐informative SNP (AISNP)) is rapidly developed with the technology advancements of massively parallel sequencing. Despite the decade of exploration and broad public interest in the peopling of East‐Asians, the genetic landscape of Chinese Silk Road populations based on the AISNPs is still little known. In this...

Read More thumbnail image: Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestryinformative SNPs

Silica‐based magnetic hybrid nanocomposite for the extraction and preconcentration of some organophosphorus pesticides before gas chromatography

Published: Jun 29, 2018

Author(s): Somayeh Koupaei Malek, Hamid Rashidi Nodeh, Behrouz Akbari‐Adergani

Journal: Journal of Separation Science

Abstract The precise control of pesticide residues in foodstuffs depends significantly on the clean extraction of analytes using specifically designed separation methods. In this study, a one‐pot sol–gel process was used for the preparation of a magnetic hybrid silica gel tetraethylortho silicate‐cyanopropyltriethoxy silane nanocomposite. The prepared material was characterized using energy dispersive X‐ray spectroscopy, Fourier...

Read More thumbnail image: Silicabased magnetic hybrid nanocomposite for the extraction and preconcentration of some organophosphorus pesticides before gas chromatography

Discovering cellular protein‐protein interactions: Technological strategies and opportunities

Published: Jun 29, 2018

Author(s): Kevin Titeca, Irma Lemmens, Jan Tavernier, Sven Eyckerman

Journal: Mass Spectrometry Reviews

The analysis of protein interaction networks is one of the key challenges in the study of biology. It connects genotypes to phenotypes, and disruption often leads to diseases. Hence, many technologies have been developed to study protein‐protein interactions (PPIs) in a cellular context. The expansion of the PPI technology toolbox however complicates the selection of optimal approaches for diverse biological...

Read More thumbnail image: Discovering cellular proteinprotein interactions Technological strategies and opportunities

Raman vibrational spectral characteristics and quantitative analysis of H 2 up to 400°C and 40 MPa

Published: Jun 29, 2018

Author(s): Lianfu Li, Xin Zhang, Zhendong Luan, Zengfeng Du, Shichuan Xi, Bing Wang, Lei Cao, Chao Lian, Jun Yan

Journal: Journal of Raman Spectroscopy

Abstract In situ Raman detection is an ideal method to determine the concentration of dissolved H2 in deep‐sea high temperature hydrothermal fluids, but studies on in situ Raman qualitative and quantitative analyses of H2 that are suitable for detection in high temperature hydrothermal fluids are lacking. In this study, the Raman characteristics of gaseous and dissolved H2 were researched at 0–400°C and 0–40 MPa in detail, which cover most deep‐sea...

Read More thumbnail image: Raman vibrational spectral characteristics and quantitative analysis of H 2 up to 400C and 40MPa

Compatibility effects of herb pair Phellodendri chinensis cortex and Anemarrhenae rhizoma on benign prostatic hyperplasia using targeted metabolomics

Published: Jun 28, 2018

Author(s): Xiaoning Zhao, Yiran Li, Jiaxin Huai, Congcong Cheng, Teng Zhang, Linlin Xie, Siqi Wang, Meng Zhang, Ronghua Dai

Journal: Biomedical Chromatography

Abstract Phellodendri chinensis cortex (P. C. cortex) and Anemarrhenae rhizoma (A. rhizoma) herb pair is a core component of traditional Chinese medicines used to treat inflammation and benign prostatic hyperplasia (BPH). The present study was designed to profile the arachidonic acid (AA) metabolomic characteristics in rat plasma and prostate after being treated with P. C. cortex and A. rhizoma as well as their combination. Plasma and prostate ...

Read More thumbnail image: Compatibility effects of herb pair Phellodendri chinensis cortex and Anemarrhenae rhizoma on benign prostatic hyperplasia using targeted metabolomics

Syringe cleanup with UHPLC–MS/MS for nitroimidazoles and steroids detection in manure‐based fertilizers

Published: Jun 28, 2018

Author(s): Huizhen Wu, Jianying Tong, Jianmei Wang, Xiaofeng Ji, Zuguang Li, Mingrong Qian

Journal: Journal of Separation Science

Abstract A syringe‐dispersive solid‐phase extraction method was developed for the determination of seven nitroimidazoles and nine steroids in manure‐based fertilizers by ultra‐high performance liquid chromatography with tandem mass spectrometry. Methanol and acetonitrile were used to extract the sample, and mixed dispersive sorbents dispersed in the syringe were used for purification. The extract was separated with an HSS‐T3 column...

Read More thumbnail image: Syringe cleanup with UHPLCMSMS for nitroimidazoles and steroids detection in manurebased fertilizers

Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis

Published: Jun 28, 2018

Author(s): Hanna Wolling, Sarah A. Konze, Anne Höfer, Jelena Erdmann, Andreas Pich, Robert Zweigerdt, Falk F. R. Buettner

Journal: PROTEOMICS

Abstract Human pluripotent stem cells can be differentiated in vitro into cardiomyocytes (CMs) but the molecular mechanisms behind this process are still not fully understood. In particular, the identification of morphogens remained elusive because the mass spectrometry–based identification of secreted proteins from cell culture supernatants is impeded by high levels of albumin present in common differentiation media. An...

Read More thumbnail image: Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis

Perspectives in the Use of Peptidomics in Ham

Published: Jun 28, 2018

Author(s): Marta Gallego, Leticia Mora, Fidel Toldrá

Journal: PROTEOMICS

Abstract The use of proteomics in food science has permitted both a better characterization of the food products and the control of their final quality despite the fact that food systems are under continuous changes during processing and consumption. Ham is a very popular meat product frequently consumed in Mediterranean countries after a dry‐curing processing that results in the generation of large amounts of peptides that...

Read More thumbnail image: Perspectives in the Use of Peptidomics in Ham
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