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Capillary electrophoresis with capacitively coupled contactless conductivity detection for the determination of propionate and sorbate in bread

Published: Sep 6, 2018

Author(s): Aline Guadalupe Coelho, Francielly Fernanda Souza de Jesus, Laís de Assis Pallos, José Alberto Fracassi da Silva, Dosil Pereira de Jesus

Journal: Journal of Separation Science

Abstract We propose a simple and fast method for the determination of the preservatives propionate and sorbate in bread using capillary electrophoresis with capacitively coupled contactless conductivity detection. The preservatives were quickly extracted from bread using ultra‐pure water and ultrasonic energy. The separation of the analytes, with good resolution, was achieved in about 7 min. The proposed method showed good...

Read More thumbnail image: Capillary electrophoresis with capacitively coupled contactless conductivity detection for the determination of propionate and sorbate in bread

Preparation and characterization of a novel hydrophilic interaction/ion exchange mixed‐mode chromatographic stationary phase with pyridinium‐based zwitterionic polymer‐grafted porous silica

Published: Sep 6, 2018

Author(s): Makoto Takafuji, Mohammad Shahruzzaman, Kazufusa Sasahara, Hirotaka Ihara

Journal: Journal of Separation Science

Abstract Novel zwitterionic polymer‐grafted porous silica microspheres were prepared by using sodium 2‐bromoethanesulfonate to quaternize the pyridyl side chains of the polymer, which is anchored on the surface of porous silica. The separation behavior for toluene and benzoic acid proved that the zwitterionic polymer‐grafted porous silica worked as a stationary phase in hydrophilic interaction/ion exchange mixed‐mode chromatography....

Read More thumbnail image: Preparation and characterization of a novel hydrophilic interactionion exchange mixedmode chromatographic stationary phase with pyridiniumbased zwitterionic polymergrafted porous silica

Local structural analysis of In‐doped Bi 2 Se 3 topological insulator using X‐ray fluorescence holography

Published: Sep 6, 2018

Author(s): Koji Kimura, Koichi Hayashi, Lada V. Yashina, Naohisa Happo, Takumi Nishioka, Yuta Yamamoto, Yoshihiro Ebisu, Toru Ozaki, Shinya Hosokawa, Tomohiro Matsushita, Hiroo Tajiri

Journal: Surface and Interface Analysis

We performed X‐ray fluorescence holography measurements on an In‐doped Bi2Se3 topological insulator and obtained an in‐plane atomic image in the vicinity of In. We found that atomic images at the positions of the first nearest neighbors (NNs) are very weak whereas those at the positions of the second and the third NNs are relatively strong. On the basis of the fact that In is half of the atomic number of Bi, we attributed the origin of this feature...

Read More thumbnail image: Local structural analysis of Indoped Bi 2 Se 3 topological insulator using Xray fluorescence holography

Born This Way: Using Intrinsic Disorder to Map the Connections between SLITRKs, TSHR, and Male Sexual Orientation

Published: Sep 6, 2018

Author(s): Tara Basavanhally, Renée Fonseca, Vladimir N. Uversky

Journal: PROTEOMICS

Abstract Recently, genome‐wide association study reveals a significant association between specific single nucleotide polymorphisms (SNPs) in men and their sexual orientation. These SNPs (rs9547443 and rs1035144) reside in the intergenic region between the SLITRK5 and SLITRK6 genes and in the intronic region of the TSHR gene and might affect functionality of SLITRK5, SLITRK6, and TSHR proteins that are engaged in tight control of key...

Read More thumbnail image: Born This Way Using Intrinsic Disorder to Map the Connections between SLITRKs TSHR and Male Sexual Orientation

Obituary Prof. Horst Ebel

Published: Sep 6, 2018

Author(s): Christina Streli, Peter Wobrauschek

Journal: X-Ray Spectrometry

Read More thumbnail image: Obituary Prof_ Horst Ebel

A reliable LC‐MS/MS method for the quantification of N ‐acetyl‐ p ‐benzoquinoneimine, acetaminophen glutathione and acetaminophen glucuronide in mouse plasma, liver and kidney: Method validation and application to a pharmacokinetic study

Published: Sep 6, 2018

Author(s): Xiqian Zhang, Ruina Li, Wenya Hu, Jin Zeng, Xuehua Jiang, Ling Wang

Journal: Biomedical Chromatography

Abstract A rapid, specific, and sensitive liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method has been developed and validated to simultaneously quantify N‐acetyl‐p‐benzoquinoneimine (NAPQI), acetaminophen‐glutathione (acetaminophen‐glut) and acetaminophen‐glucuronide (acetaminophen‐gluc) in mouse plasma, liver and kidney homogenates. Analytes were eluted by a binary gradient mobile phase composed of water (phase A) and...

Read More thumbnail image: A reliable LCMSMS method for the quantification of N acetyl p benzoquinoneimine acetaminophen glutathione and acetaminophen glucuronide in mouse plasma liver and kidney Method validation and application to a pharmacokinetic study

A metabolomics research based on UHPLC‐ESI‐Q‐TOF‐MS coupled with metabolic pathway analysis: Treatment effects of stir‐frying Xanthii Fructus on allergic rhinitis in mice model

Published: Sep 6, 2018

Author(s): Yanshuang Zhuang, Kunming Qin, Beibei Yu, Xiao Liu, Baochang Cai, Hao Cai

Journal: Biomedical Chromatography

Abstract Xanthii Fructus (XF), a well‐known herb in traditional Chinese medicine, has been frequently used for the treatment of allergic rhinitis in the clinic. Its therapeutic metabolic mechanism, however, remains undetermined. In this work, a metabolomics research coupled with metabolic pathway analysis has been employed to screen out the potential mechanism in its effects on allergic rhinitis. Specifically, mouse serum samples...

Read More thumbnail image: A metabolomics research based on UHPLCESIQTOFMS coupled with metabolic pathway analysis Treatment effects of stirfrying Xanthii Fructus on allergic rhinitis in mice model

In vitro and in vivo evaluation of a posaconazole‐sulfobutyl ether‐ β ‐cyclodextrin inclusion complex

Published: Sep 5, 2018

Author(s): Miao Wang, Juan Jiang, Yi Cai, Min Zhao, Qijuan Wu, Yannan Cui, Chunjie Zhao

Journal: Biomedical Chromatography

Abstract Posaconazole (PCZ) is a triazole antifungal agent with an extended spectrum of antifungal activity. It is approved for the prophylaxis of invasive fungal infections in patients with neutropenia or in hematopoietic stem cell transplant recipients undergoing high‐dose immunosuppressive therapy for graft‐vs‐host disease, and for the treatment of fungal infections. However, its pharmacological effects are severely limited owing...

Read More thumbnail image: In vitro and in vivo evaluation of a posaconazolesulfobutyl ether  cyclodextrin inclusion complex

Optimization of extraction and analytical protocol for mass spectrometry‐based metabolomics analysis of hepatotoxicity

Published: Sep 5, 2018

Author(s): Rui Yang, Qi Zhao, Dan‐Dan Hu, Xue‐Rong Xiao, Fei Li

Journal: Biomedical Chromatography

Abstract Drug‐induced liver injury is a clinically leading side‐effect of drugs. In the present study, a liquid chromatography mass spectrometry‐based metabolomics protocol was optimized for extraction and analysis of endogenous metabolites from liver tissue during hepatotoxicity. Various extraction solutions, resuspension solutions, extraction folds and dissolution methods for the supernatant were compared using the number of...

Read More thumbnail image: Optimization of extraction and analytical protocol for mass spectrometrybased metabolomics analysis of hepatotoxicity

Pharmacokinetic, metabolic profiling and elimination of brusatol in rats

Published: Sep 5, 2018

Author(s): Nan Guo, Xin Xu, Guiyan Yuan, Xuwang Chen, Qing Wen, Ruichen Guo

Journal: Biomedical Chromatography

Abstract Brusatol, a quassinoid isolated from the traditional Chinese medicine Brucea javanica, has been reported to be an inhibitor of Nrf2 pathway and has great potential to be developed into a novel chemotherapeutic adjuvant. However, the in vivo process of brusatol has not been comprehensively explained yet. Therefore, this paper focused on the pharmacokinetic metabolism and excretion of brusatol in rats using a simple and reproducible...

Read More thumbnail image: Pharmacokinetic metabolic profiling and elimination of brusatol in rats

Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism

Published: Sep 5, 2018

Author(s): Alice Ameline, Camille Richeval, Jean‐Michel Gaulier, Jean‐Sébastien Raul, Pascal Kintz

Journal: Drug Testing and Analysis

Abstract Designer benzodiazepines have emerged as recreational drugs. They are available via the Internet without control and are found in the form of falsified (fake) medicines. For some of them, limited information concerning their effects, their toxicity, and their detection in bio fluids is available in the literature. For others, nothing has been published, as in the case of flunitrazolam (FNTZ). To gain preliminary data on its...

Read More thumbnail image: Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism

HPLC‐MS/MS combined with membrane‐protected molecularly imprinted polymer micro‐solid‐phase extraction for synthetic cathinones monitoring in urine

Published: Sep 5, 2018

Author(s): Juan Sánchez‐González, Sara Odoardi, Ana María Bermejo, Pilar Bermejo–Barrera, Francesco Saverio Romolo, Antonio Moreda–Piñeiro, Sabina Strano‐Rossi

Journal: Drug Testing and Analysis

Abstract Synthetic cathinones are a type of drug belonging to group of new psychoactive substances (NPSs). The illicit market for these substances is characterized by the continuous introduction to the market of new analogs to evade legislation and to avoid detection. New screening and confirmation assays are therefore needed, mainly in forensic/clinical samples. In the current development, a porous membrane‐protected,...

Read More thumbnail image: HPLCMSMS combined with membraneprotected molecularly imprinted polymer microsolidphase extraction for synthetic cathinones monitoring in urine

The Microstructure, Proteomics and Crystallization of the Limpet Teeth

Published: Sep 5, 2018

Author(s): Yadong Wang, Chuang Liu, Jinzhe Du, Jingliang Huang, Shuce Zhang, Rongqing Zhang

Journal: PROTEOMICS

Abstract Limpets are marine mollusks that use mineralized teeth, one of the hardest and strongest biomaterials, to feed on algae on intertidal rocks. However, most of studies only focus on the ultrastructure and chemical composition of the teeth while the molecular information is largely unknown, limiting our understanding of this unique and fundamental biomineralization process. The study investigates the microstructure,...

Read More thumbnail image: The Microstructure Proteomics and Crystallization of the Limpet Teeth

Preparative separation of phloridzin from apple leaves using macroporous resins followed by preparative high‐performance liquid chromatography

Published: Sep 5, 2018

Author(s): Hongjuan Li, Guige Hou, Yuanyuan Li, Feng Zhao, Wei Cong, Chunhua Wang

Journal: Journal of Separation Science

Abstract Phloridzin is one of the major phenolic compounds in apple and has been widely used in medicine for a long time due to its significant biomedical activities. In this article, macroporous resin was used for purification of phloridzin from apple leaves. The HPD‐300 resin was selected for the enrichement of phloridzin according to its high adsorption and desorption capacities. The adsorption kinetics and isotherms were...

Read More thumbnail image: Preparative separation of phloridzin from apple leaves using macroporous resins followed by preparative highperformance liquid chromatography

Quantitative Analysis of the Global Proteome in Peripheral Blood Mononuclear Cells from Patients with New‐Onset Psoriasis

Published: Sep 5, 2018

Author(s): Fengdi Li, Yacui Wang, Yu Li, Hongpu Yang, Hongmei Wang

Journal: PROTEOMICS

Abstract Psoriasis is a common chronic autoimmune skin disease involving the activation of T cells. To explore the proteomic signature of peripheral blood mononuclear cells, a quantitative analysis of their global proteome was conducted in samples from Chinese patients with new‐onset psoriasis (n = 31) and healthy controls (n = 32) using an integrated quantitative approach with tandem mass tag labeling and LC–MS/MS. Protein annotation,...

Read More thumbnail image: Quantitative Analysis of the Global Proteome in Peripheral Blood Mononuclear Cells from Patients with NewOnset Psoriasis

Separation and determination of microRNAs by high‐speed capillary sieving electrophoresis

Published: Sep 5, 2018

Author(s): Wei Wang, Xiaoyu Cai, Ping Lin, Ruiguang Bai

Journal: Journal of Separation Science

Abstract In this work, high‐speed capillary sieving electrophoresis with laser‐induced fluorescence detection was applied to simultaneously determine three microRNAs. A developed manual sample introduction device for the high‐speed capillary electrophoresis system was applied to perform sample injection. Strategies, including field‐amplified sample injection and electrokinetic injection, were studied to improve the detection...

Read More thumbnail image: Separation and determination of microRNAs by highspeed capillary sieving electrophoresis

Quantitative Global Proteome and Lysine Succinylome Analyses Reveal the Effects of Energy Metabolism in Renal Cell Carcinoma

Published: Sep 5, 2018

Author(s): Naiwen Zhang, Ruxu Gao, Jianyu Yang, Yuyan Zhu, Zhe Zhang, Xiaolong Xu, Jianfeng Wang, Xiankui Liu, Zeliang Li, Zhenhua Li, Daxin Gong, Jun Li, Jianbin Bi, Chuize Kong

Journal: PROTEOMICS

Abstract In light of the increasing incidence of renal cell carcinoma (RCC), its molecular mechanisms have been comprehensively explored in numerous recent studies. However, few studies focus on the influence of multi‐factor interactions during the occurrence and development of RCC. This study aims to investigate the quantitative global proteome and the changes in lysine succinylation in related proteins, seeking to facilitate a...

Read More thumbnail image: Quantitative Global Proteome and Lysine Succinylome Analyses Reveal the Effects of Energy Metabolism in Renal Cell Carcinoma

CEST‐MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

Published: Sep 5, 2018

Author(s): Giuseppe Ferrauto, Enza Di Gregorio, Vincent Auboiroux, Manuel Petit, François Berger, Silvio Aime, Hana Lahrech

Journal: NMR in Biomedicine

In glioma, the acidification of the extracellular tumor microenvironment drives proliferation, angiogenesis, immunosuppression, invasion and chemoresistance. Therefore, quantification of glioma extracellular pH (pHe) is of crucial importance. This study is focused on the application of the YbHPDO3A (ytterbium 1,4,7‐triscarboxymethyl‐1,4,7,10‐tetraazacyclododecane) probe for in vivo glioma pHe quantification using chemical exchange...

Read More thumbnail image: CESTMRI for glioma pH quantification in mouse model Validation by immunohistochemistry

Plant‐wide optimization for gold hydrometallurgy based on the fuzzy qualitative model and interval number

Published: Sep 5, 2018

Author(s): Yadong Liu, Yuqing Chang, Dapeng Niu, Fuli Wang

Journal: Journal of Chemometrics

Abstract Since the difficulty of obtaining accurate online‐measurement of some key variables in hydrometallurgy plant‐wide production process causes that the quantitative models of some procedures are difficult to establish and the plant‐wide optimization based on quantitative model is difficult to realize, a plant‐wide optimization method based on interval numbers is proposed in this work. First, based on the information of expert...

Read More thumbnail image: Plantwide optimization for gold hydrometallurgy based on the fuzzy qualitative model and interval number

Application of X‐ray fluorescence holography to the analysis of the interior and surface of an yttrium oxide thin film

Published: Sep 5, 2018

Author(s): Jens R. Stellhorn, Shinya Hosokawa, Naohisa Happo, Hiroo Tajiri, Tomohiro Matsushita, Kenichi Kaminaga, Tomoteru Fukumura, Tetsuya Hasegawa, Koji Kimura, Kouichi Hayashi

Journal: Surface and Interface Analysis

We report on the characterization of a thin film of yttrium oxide by X‐ray fluorescence holography. The sample has a layered structure with an YO base layer and an oxidized Y2O3 surface. Both layers are clearly observed in the atomic image reconstructions, and their local structure is analyzed. We show that by using incident energies close to the absorption edge of the fluorescing atom, it becomes possible to observe the thin surface...

Read More thumbnail image: Application of Xray fluorescence holography to the analysis of the interior and surface of an yttrium oxide thin film
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