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Quantitative determination of meloxicam in dog plasma by high performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study

Published: Apr 4, 2018

Author(s): Yongzhi Tian, Xiao Wu, Mingjie Zhang, Longshan Zhao, Zhili Xiong, Feng Qin

Journal: Biomedical Chromatography

Abstract A rapid, selective and sensitive high‐performance liquid chromatography–tandem mass spectrometry (HPLC‐MS/MS) method was developed to determine meloxicam in beagle dog plasma. Sample pretreatment involved a one‐step protein precipitation with methanol of 0.1 mL plasma. Analysis was performed on a Venusil ASB‐C18 column with mobile phase consisting of methanol–water (containing 0.1% formic acid) (75:25, v/v). The detection was performed...

Read More thumbnail image: Quantitative determination of meloxicam in dog plasma by high performance liquid chromatographytandem mass spectrometry and its application in a pharmacokinetic study

A validated, sensitive electrophoretic method for the detection of activin receptor type II‐Fc fusion proteins in human blood

Published: Apr 4, 2018

Author(s): L. Martin, N. Zouhiri, M. Audran, A. Marchand

Journal: Drug Testing and Analysis

Abstract New therapeutic proteins that trap circulating members of the transforming growth factor (TGF) beta superfamily (activins and growth differentiation factors) show promising effects on erythropoiesis and muscular growth. They are dimeric recombinant fusion proteins composed of the extracellular domain of a human activin receptor (ActRIIA or IIB) linked to the Fc part of human IgG1. Sotatercept (ActRIIA‐Fc) and Luspatercept...

Read More thumbnail image: A validated sensitive electrophoretic method for the detection of activin receptor type IIFc fusion proteins in human blood

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple ( Acer rubrum ) leaves

Published: Apr 4, 2018

Author(s): Chunting Li, Navindra P. Seeram

Journal: Journal of Separation Science

Abstract The red maple (Acer rubrum) species is economically important to North America because of its sap, which is used to produce maple syrup. In addition, various other red maple plant parts, including leaves, were used as a traditional medicine by the Native Americans. Currently, red maple leaves are being used for nutraceutical and cosmetic applications but there are no published analytical methods for comprehensive...

Read More thumbnail image: Ultrafast liquid chromatography coupled with electrospray ionization timeofflight mass spectrometry for the rapid phenolic profiling of red maple  Acer rubrum  leaves

High‐throughput multipesticides residue analysis in earthworms by the improvement of purification method: Development and application of magnetic Fe 3 O 4 ‐SiO 2 nanoparticles based dispersive solid‐phase extraction

Published: Apr 4, 2018

Author(s): Yuhan Sun, Peipei Qi, Tao Cang, Zhiwei Wang, Xiangyun Wang, Xuewei Yang, Lidong Wang, Xiahong Xu, Qiang Wang, Xinquan Wang, Changshan Zhao

Journal: Journal of Separation Science

Abstract As a key representative organism, earthworms can directly illustrate the influence of pesticides on environmental organisms in soil ecosystems. The present work aimed to develop a high‐throughput multipesticides residue analytical method for earthworms using solid–liquid extraction with acetonitrile as the solvent and magnetic material‐based dispersive solid‐phase extraction for purification. Magnetic Fe3O4 nanoparticles...

Read More thumbnail image: Highthroughput multipesticides residue analysis in earthworms by the improvement of purification method Development and application of magnetic Fe 3 O 4 SiO 2 nanoparticles based dispersive solidphase extraction

Characterization of imatinib mesylate formulations distributed in South American countries: Determination of genotoxic impurities by UHPLC–MS/MS and dissolution profile

Published: Apr 3, 2018

Author(s): Fernanda Caroline Wolff, Thaís Luise Dillenburg, Marina Venzon Antunes, Rafael Linden, Sandrine Comparsi Wagner, Simone G. Verza

Journal: Biomedical Chromatography

Abstract Imatinib mesylate (IM) is an anti‐neoplasic drug used for the treatment of cancer. Recent new guidelines specify daily doses and concentration limits for genotoxic impurities (GTIs) in pharmaceutical final products. Therefore, in this work an analytical method using UHPLC–MS/MS was developed, validated and applied to characterize IM tablets for two GTIs: N‐(2‐methyl‐5‐aminophenyl)‐4‐(3‐pyridyl)‐2‐pyrimidine amine (Imp. 1), and...

Read More thumbnail image: Characterization of imatinib mesylate formulations distributed in South American countries Determination of genotoxic impurities by UHPLCMSMS and dissolution profile

Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultra‐performance liquid chromatography–tandem mass spectrometry

Published: Apr 3, 2018

Author(s): Yanqing Liu, Hongwu Wang, Su Yao, Peijie Zhu

Journal: Biomedical Chromatography

Abstract A fast and sensitive method involving ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was introduced to detect citrinin in dried orange peel. A series of extraction, purification and chromatographic conditions was also systematically examined. With the proposed method, the obtained calibration graph was linear, with an R of 0.9996 within a concentration range of 0.5–10 ng/mL. The estimated limits of...

Read More thumbnail image: Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultraperformance liquid chromatographytandem mass spectrometry

Rapid and sensitive detection of the phenoxy acid herbicides in environmental water samples by magnetic solid‐phase extraction combined with liquid chromatography–tandem mass spectrometry

Published: Apr 3, 2018

Author(s): Mao‐Min Peng, Ya‐Quan Han, Hong Xia, Xi‐Zhou Hu, You‐Xiang Zhou, Li‐Jun Peng, Xi‐Tian Peng

Journal: Journal of Separation Science

Abstract Phenoxy acid herbicides are widely used herbicides that play an important role in improving the yield and quality of crops. However, some research has shown that this kind of herbicide is poisonous to human and animals. In this study, a rapid and sensitive method was developed for the detection of seven phenoxy acid herbicides in water samples based on magnetic solid‐phase extraction followed by liquid chromatography and...

Read More thumbnail image: Rapid and sensitive detection of the phenoxy acid herbicides in environmental water samples by magnetic solidphase extraction combined with liquid chromatographytandem mass spectrometry

Automated solid‐phase extraction of phenolic acids using layered double hydroxide–alumina–polymer disks

Published: Apr 3, 2018

Author(s): Milad Ghani, Carlos Palomino Cabello, Mohammad Saraji, Jose Manuel Estela, Víctor Cerdà, Gemma Turnes Palomino, Fernando Maya

Journal: Journal of Separation Science

Abstract The application of layered double hydroxide–Al2O3–polymer mixed‐matrix disks for solid‐phase extraction is reported for the first time. Al2O3 is embedded in a polymer matrix followed by an in situ metal‐exchange process to obtain a layered double hydroxide–Al2O3–polymer mixed‐matrix disk with excellent flow‐through properties. The extraction performance of the prepared disks is evaluated as a proof of concept for the automated extraction using...

Read More thumbnail image: Automated solidphase extraction of phenolic acids using layered double hydroxidealuminapolymer disks

Simple, low‐cost fabrication of semi‐circular channel using the surface tension of solder paste and its application to microfluidic valves

Published: Apr 3, 2018

Author(s): Sheng Yan, Yuxing Li, Yuanqing Zhu, Minsu Liu, Qianbin Zhao, Dan Yuan, Guolin Yun, Shiwu Zhang, Weijia Wen, Shi‐Yang Tang, Weihua Li

Journal: ELECTROPHORESIS

Abstract This work presents a simple, low‐cost method to fabricate semi‐circular channels using solder paste, which can amalgamate the cooper surface to form a half‐cylinder mold using the surface tension of Sn–Pd alloy (the main component in solder paste). This technique enables semi‐circular channels to be manufactured with different dimensions. These semi‐circular channels will then be integrated with a polymethylmethacrylate...

Read More thumbnail image: Simple lowcost fabrication of semicircular channel using the surface tension of solder paste and its application to microfluidic valves

Evaluation of ionic liquids supported on silica as a sorbent for fully automated online solid‐phase extraction with LC–MS determination of sulfonamides in bovine milk samples

Published: Apr 3, 2018

Author(s): Meire Ribeiro da Silva, Fernando Mauro Lanças

Journal: Journal of Separation Science

Abstract Sulfonamides are antibiotics widely used in the treatment of diseases in dairy cattle. However, their indiscriminate use for disease control may lead to their presence in tissues and milk and their determination requires a sample preparation step as part of an analytical approach. Among the several sample preparation techniques available, those based upon the use of sorptive materials have been widely employed. Recently,...

Read More thumbnail image: Evaluation of ionic liquids supported on silica as a sorbent for fully automated online solidphase extraction with LCMS determination of sulfonamides in bovine milk samples

Risk assessment, dissipation behavior and persistence of quinalphos in/on green pea by gas chromatography with electron capture detector

Published: Apr 3, 2018

Author(s): Alamgir A. Dar, Ishrat Jan, Ashraf A. Wani, Sofi Mubashir, Khurshid A. Sofi, Javid A. Sofi, Irshad H. Dar

Journal: Journal of Separation Science

Abstract Chemical investigation was carried out to examine the risk assessment, dissipation behavior, persistence, and half‐life period of quinalphos in/on green pea fruit by spraying quinalphos at fruiting stage followed by another application after 10‐day interval. The samples were extracted by using the quick, easy, cheap, effective, rugged, and safe method, and the residues of quinalphos were analyzed by gas chromatography with...

Read More thumbnail image: Risk assessment dissipation behavior and persistence of quinalphos inon green pea by gas chromatography with electron capture detector

Simultaneous identification of three pseudoallergic components in Danshen injection by using high‐expression Mas‐related G protein coupled receptor X2 cell membrane chromatography coupled online to HPLC–ESI‐MS/MS

Published: Apr 3, 2018

Author(s): Yuanyuan Lin, Cheng Wang, Yajing Hou, Wei Sun, Delu Che, Liu Yang, Tao Zhang, Meng Sun, Huaizhen He, Langchong He

Journal: Journal of Separation Science

Abstract Adverse drug reactions of Danshen injection mainly manifested as pseudoallergic reactions. In the present study, salvianolic acid A and a pair of geometric isomers (isosalvianolic acid C and salvianolic acid C) were identified as pseudoallergic components in Danshen injection by a high‐expression Mas‐related G protein coupled receptor X2 cell membrane chromatography coupled online with high‐performance liquid chromatography...

Read More thumbnail image: Simultaneous identification of three pseudoallergic components in Danshen injection by using highexpression Masrelated G protein coupled receptor X2 cell membrane chromatography coupled online to HPLCESIMSMS

Separation of positional isomers of nine 2‐phenethylamine‐derived designer drugs by liquid chromatography–tandem mass spectrometry

Published: Apr 3, 2018

Author(s): Christina Grumann, Volker Auwärter

Journal: Drug Testing and Analysis

Abstract The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) method facilitates separation of positional...

Read More thumbnail image: Separation of positional isomers of nine 2phenethylaminederived designer drugs by liquid chromatographytandem mass spectrometry

Validation of a blood marker for plasma volume in endurance athletes during a live‐high train‐low altitude training camp

Published: Apr 3, 2018

Author(s): Louisa M. Lobigs, Laura A. Garvican‐Lewis, Victor L. Vuong, Nicolin Tee, Christopher J. Gore, Peter Peeling, Brian Dawson, Yorck O. Schumacher

Journal: Drug Testing and Analysis

Abstract Altitude is a confounding factor within the Athlete Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; haemoglobin concentration ([Hb]) and the OFF‐score. Endurance athletes (n=34) completed a 21‐night simulated live‐high train‐low (LHTL) protocol...

Read More thumbnail image: Validation of a blood marker for plasma volume in endurance athletes during a livehigh trainlow altitude training camp

Determination of 15 polycyclic aromatic hydrocarbons in aquatic products by solid‐phase extraction and GC–MS

Published: Apr 3, 2018

Author(s): Qiying Liu, Yuanming Guo, Xiumei Sun, Qing Hao, Xin Cheng, Lu Zhang

Journal: Journal of Separation Science

Abstract We propose a method for the simultaneous determination of 15 kinds of polycyclic aromatic hydrocarbons in marine samples (muscle) employing gas chromatography with mass spectrometry after saponification with ultrasound‐assisted extraction and solid‐phase extraction. The experimental conditions were optimized by the response surface method. In addition, the effects of different lyes and extractants on polycyclic aromatic...

Read More thumbnail image: Determination of 15 polycyclic aromatic hydrocarbons in aquatic products by solidphase extraction and GCMS

Fiber‐in‐tube solid‐phase microextraction of caffeine as a molecular tracer in wastewater by electrochemically deposited layered double hydroxide

Published: Apr 3, 2018

Author(s): Maryam Lashgari, Yadollah Yamini

Journal: Journal of Separation Science

Abstract Modified stainless‐steel wires with a layer of polyaniline conductive polymer were coated by electrochemical deposition with Zn/Al layered double hydroxide to make solid‐phase microextraction fibers. The coating layer was also electrochemically deposited on the inner surface of a stainless‐steel tube. Then, ten prepared fibers were put inside the inner coated tube to make a fiber‐in‐tube solid phase microextraction device....

Read More thumbnail image: Fiberintube solidphase microextraction of caffeine as a molecular tracer in wastewater by electrochemically deposited layered double hydroxide

Temperature‐controlled liquid–liquid microextraction combined with high‐performance liquid chromatography for the simultaneous determination of diazinon and fenitrothion in water and fruit juice samples

Published: Apr 3, 2018

Author(s): Alireza Bazmandegan‐Shamili, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani, Masoud Rohani Moghadam, Mahboubeh Saeidi

Journal: Journal of Separation Science

Abstract A simple, environmentally benign, and rapid method based on temperature‐controlled liquid–liquid microextraction using a deep eutectic solvent was developed for the simultaneous extraction/preconcentration of diazinon and fenitrothion. The method involved the addition of deep eutectic solvent to the aqueous sample followed by heating the mixture in a 75°C water bath until the solvent was completely dissolved in the aqueous...

Read More thumbnail image: Temperaturecontrolled liquidliquid microextraction combined with highperformance liquid chromatography for the simultaneous determination of diazinon and fenitrothion in water and fruit juice samples

Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro

Published: Apr 3, 2018

Author(s): Friederike A. Sandbaumhüter, Wolfgang Thormann

Journal: ELECTROPHORESIS

Abstract Glucuronidation catalyzed by uridine‐5′‐diphospho‐glucuronosyl‐transferases (UGTs) is the most important reaction in phase II metabolism of drugs and other compounds. O‐glucuronidation is more common than N‐glucuronidation. The anesthetic, analgesic and antidepressive drug ketamine is metabolized in phase I by cytochrome P450 enzymes to norketamine, hydroxynorketamine (HNK) diastereomers and dehydronorketamine (DHNK)....

Read More thumbnail image: Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro

DNA translocation through polyelectrolyte‐modified nanopores: An analytical approximation

Published: Apr 3, 2018

Author(s): Pradipta Kr. Das

Journal: ELECTROPHORESIS

Abstract An analytical model for the electrophoretic speed of DNA translocating through nanopore functionalized with polyelectrolyte (PE) brush is developed for the first time. The electrophoretic speed depends on DNA surface potential, applied electric field, viscosity, and permittivity of solution along with velocity and electrostatic potential at liquid–polyelectrolyte layer (PEL) interface where the interface seemed to behave...

Read More thumbnail image: DNA translocation through polyelectrolytemodified nanopores An analytical approximation

Method for the simultaneous determination of monoaromatic and polycyclic aromatic hydrocarbons in industrial effluents using dispersive liquid–liquid microextraction with gas chromatography–mass spectrometry

Published: Apr 3, 2018

Author(s): Patrycja Makoś, André Fernandes, Grzegorz Boczkaj

Journal: Journal of Separation Science

Abstract We present a new method for simultaneous determination of 22 monoaromatic and polycyclic aromatic hydrocarbons in postoxidative effluents from the production of petroleum bitumen using dispersive liquid–liquid microextraction coupled to gas chromatography and mass spectrometry. The eight extraction parameters including the type and volume of extraction and disperser solvent, pH, salting out effect, extraction, and...

Read More thumbnail image: Method for the simultaneous determination of monoaromatic and polycyclic aromatic hydrocarbons in industrial effluents using dispersive liquidliquid microextraction with gas chromatographymass spectrometry
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