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X‐ray photoelectron spectroscopy study of neodymium niobate and tantalate precursors and thin films

Published: Nov 12, 2018

Author(s): Helena Brunckova, Hristo Kolev, Maria Kanuchova

Journal: Surface and Interface Analysis

Neodymium niobate NdNbO4 (NNO) and tantalate NdTaO4 (NTO) thin films (~100 nm) were prepared by sol‐gel/spin‐coating process on Al2O3 substrate with LaNbO4/PbZrO3 interlayer and annealing at 1000°C. Surface chemistry was investigated by X‐ray photoelectron spectroscopy (XPS). The core‐level XPS studies of sol‐gel NNO and NTO were performed for the first time. The binding energy differences Δ(O―Nb) and Δ(O―Ta) were used to characterize average...

Read More thumbnail image: Xray photoelectron spectroscopy study of neodymium niobate and tantalate precursors and thin films

Chemometrics in instrumental analysis of complex systems—in honor and memory of Yi‐Zeng Liang

Published: Nov 12, 2018

Author(s): Zhimin Zhang, Hongdong Li, Yonghuan Yun, Pan Ma, Lunzhao Yi, Dabing Ren, Liangxiao Zhang, Jun Yan, Naiping Dong, Baichuan Deng, Hongmei Lu

Journal: Journal of Chemometrics

Abstract A true pioneer in the fields of chemometrics and analytical chemistry was lost with the passing of Yi‐Zeng Liang in October 2016. This is an enormous loss to both the local and global community of chemometrics. Yi‐Zeng Liang is recognized as one of the major players in China in the field of chemometrics. As a professor of chemometrics and analytical chemistry in Hunan University and Central South University, he made...

Read More thumbnail image: Chemometrics in instrumental analysis of complex systemsin honor and memory of YiZeng Liang

Rembrandt's Old Woman Praying , 1629/30: A look below the surface using X‐ray fluorescence mapping

Published: Nov 11, 2018

Author(s): Katharina Uhlir, Michele Gironda, Luca Bombelli, Michael Eder, Nicola Aresi, Gabriele Groschner, Martina Griesser

Journal: X-Ray Spectrometry

Rembrandt's painting Old Woman Praying, 1629/30, is the most valuable and exceptional work of art of the Residenzgalerie Salzburg (RGS). It is painted on a gilded copper plate with dimensions of only approximately 15 × 12 cm. The painting probably belongs to a series of three small‐scale tronies, all executed on gilded copper plates. This particular picture preparation, which represents a special feature in Rembrandt's...

Read More thumbnail image: Rembrandts Old Woman Praying  162930 A look below the surface using Xray fluorescence mapping

The influence of light sources on sunitinib measurements with photoisomerization

Published: Nov 9, 2018

Author(s): Noriko Matsunaga, Takashi Kitahara, Makiko Yamada, Kayoko Sato, Yukinobu Kodama, Hitoshi Sasaki

Journal: Biomedical Chromatography

Abstract Sunitinib is an orally administered tyrosine kinase inhibitor. Therapeutic drug monitoring is an important component of the follow‐up of patients because of high interpatient variability in the pharmacokinetics of sunitinib and large variabilities in its efficacy and toxicity. The aim of the present study was to examine the light stability of sunitinib and confirm the effects of light exposure on sunitinib measurements by...

Read More thumbnail image: The influence of light sources on sunitinib measurements with photoisomerization

Human in vivo metabolism study of LGD‐4033

Published: Nov 8, 2018

Author(s): Argyro G. Fragkaki, Panagiotis Sakellariou, Polyxeni Kiousi, Nassia Kioukia‐Fougia, Maria Tsivou, Michael Petrou, Yiannis Angelis

Journal: Drug Testing and Analysis

Abstract Selective androgen receptor modulators (SARMs) are an emerging class of therapeutics targeted to cachexia, sarcopenia, and hypogonadism treatment. LGD‐4033 is a SARM which has been included on the Prohibited List annually released by the World Anti‐Doping Agency (WADA). The aim of the present work was the investigation of the metabolism of LGD‐4033 in a human excretion study after administration of an LGD‐4033 supplement,...

Read More thumbnail image: Human in vivo metabolism study of LGD4033

Recent improvements in sports drug testing concerning the initial testing for peptidic drugs (< 2 kDa) – sample preparation, mass spectrometric detection, and data review

Published: Nov 8, 2018

Author(s): Christian Görgens, Sven Guddat, Andreas Thomas, Mario Thevis

Journal: Drug Testing and Analysis

Abstract In this work, a novel initial testing assay based on liquid chromatography–mass spectrometry is presented, enabling the detection of peptidic drugs and drug candidates (< 2 kDa) prohibited in sports. The assay covers representatives and metabolites of gonadotropin releasing hormone and its analogs (GnRHs), growth hormone secretagogues (GHS), growth hormone releasing peptides (GHRPs), and the Vasopressin‐analog...

Read More thumbnail image: Recent improvements in sports drug testing concerning the initial testing for peptidic drugs  2kDa  sample preparation mass spectrometric detection and data review

Molecularly imprinted polymer solid‐phase extraction of synthetic cathinones from urine and whole blood samples

Published: Nov 8, 2018

Author(s): Takaya Murakami, Yoshiaki Iwamuro, Reiko Ishimaru, Satoshi Chinaka, Hiroshi Hasegawa

Journal: Journal of Separation Science

Abstract In forensic drug analysis, extractive pretreatment is required prior to instrumental analysis to ensure successful detection of the target compounds. However, conventional extraction methods such as hydrophilic polymer‐based solid‐phase extraction and liquid–liquid extraction are unsuitable for an emerging class of new psychoactive substances, namely, synthetic cathinones, because they exhibit a lack of class selectivity...

Read More thumbnail image: Molecularly imprinted polymer solidphase extraction of synthetic cathinones from urine and whole blood samples

Investigation of Ti/CuO interface by X‐ray photoelectron spectroscopy and atomic force microscopy

Published: Nov 8, 2018

Author(s): Dev Raj Chopra, Justin Seth Pearson, Darius Durant, Ritesh Bhakta, Anil R. Chourasia

Journal: Surface and Interface Analysis

The Ti/CuO interface has been studied by the techniques of X‐ray photoelectron spectroscopy and atomic force microscopy. Thin films of titanium were deposited on a CuO substrate at room temperature by the e‐beam technique. The photoelectron spectra of titanium and copper were found to exhibit significant chemical interaction at the interface. The titanium overlayer was observed to get oxidized to TiO2, while the CuO was observed to get...

Read More thumbnail image: Investigation of TiCuO interface by Xray photoelectron spectroscopy and atomic force microscopy

Parameter settings in a compact laser‐nitriding system for titanium composed of a focused pulsed Nd:YAG laser and nitrogen gas blow

Published: Nov 8, 2018

Author(s): Naofumi Ohtsu, Wataru Saito, Misao Yamane

Journal: Surface and Interface Analysis

The aim of the present study was to form a nitride layer on a titanium (Ti) substrate through a compact laser‐nitriding system comprising a focused pulsed Nd:YAG laser and nitrogen gas blow. To obtain a high‐quality layer, the effects of pulse frequency and gas flow rate on the surface characteristics were investigated by using plasma emission analysis as well as X‐ray analyses. Optical emission spectra from the laser‐induced plasma...

Read More thumbnail image: Parameter settings in a compact lasernitriding system for titanium composed of a focused pulsed NdYAG laser and nitrogen gas blow

Effect of low‐energy ion impact on the structure of hexagonal boron nitride films studied in surface‐wave plasma

Published: Nov 8, 2018

Author(s): M. Torigoe, Y. Kamimura, K. Teii, S. Matsumoto

Journal: Surface and Interface Analysis

A high‐density surface‐wave plasma source is used to deposit hexagonal boron nitride (hBN) films in a gas mixture of He, H2, N2, Ar, and BF3 under a high ion flux condition using low‐energy ion irradiation. The ion energy is controlled between around zero and 100 eV by applying a negative or positive bias voltage to a substrate, while the ion flux is increased by locating a substrate upstream in the diffusive plasma. For ion energies above...

Read More thumbnail image: Effect of lowenergy ion impact on the structure of hexagonal boron nitride films studied in surfacewave plasma

Effects of thermal treatment on hydrophilicity and corrosion resistance of Ti surface

Published: Nov 8, 2018

Author(s): Suwimon Boonrungsiman, Panida Prompinit, Pongtanawat Khemthong, Tuksadon Wutikhun, Alongkot Treethong, Panita Kasamechonchung, Narong Chanlek, Rawiwan Maniratanachote, Mati Horprathum, Apirak Pankiew, Suppanit Pornthreeraphat, Narathon Khemasiri, Annop Klamchuen

Journal: Surface and Interface Analysis

Surface treatment of titanium (Ti) surface has been extensively studied to improve its properties for biomedical applications, including hydrophilicity, corrosion resistance, and tissue integration. In this present work, we present the effects of thermal oxidation as surface modification method on metallic titanium (Ti). The Ti foils were oxidized at 300°C, 400°C, 500°C, and 600°C under air atmosphere for 3 hours, which formed oxide...

Read More thumbnail image: Effects of thermal treatment on hydrophilicity and corrosion resistance of Ti surface

Identification of dye content in colored BIC ballpoint pen inks by Raman spectroscopy and surface‐enhanced Raman scattering

Published: Nov 8, 2018

Author(s): Abeer Alyami, Killian Barton, Liam Lewis, Antonio Mirabile, Daniela Iacopino

Journal: Journal of Raman Spectroscopy

Abstract Raman spectroscopy and surface‐enhanced Raman scattering (SERS) were used for the elucidation of dye content in commercial BIC ballpoint pens. In contrast to the majority of studies in this field on black and blue inks of forensic interest, this paper targeted characterization of colored (red, pink, purple, and green) pen inks, increasingly used for artistic purposes. Because of its not invasive nature, the capabilities of...

Read More thumbnail image: Identification of dye content in colored BIC ballpoint pen inks by Raman spectroscopy and surfaceenhanced Raman scattering

Analysis of insulin and insulin analogs from dried blood spots by means of liquid chromatography–high resolution mass spectrometry

Published: Nov 7, 2018

Author(s): Andreas Thomas, Mario Thevis

Journal: Drug Testing and Analysis

Abstract While dried blood spot (DBS) analysis concerning low molecular mass molecules has become more and more established in various fields of analytical chemistry, the utility of DBS in determining peptides and proteins from DBS is yet comparably limited. In consideration of the fact that the apparent benefits of DBS sampling are similar for analytes of lower and higher molecular mass, dedicated (non‐generic) sample preparation...

Read More thumbnail image: Analysis of insulin and insulin analogs from dried blood spots by means of liquid chromatographyhigh resolution mass spectrometry

High‐throughput doping control analysis of 28 amphetamine‐type stimulants in equine plasma using hydrophilic interaction liquid chromatography–tandem mass spectrometry

Published: Nov 7, 2018

Author(s): Youwen You, Fuyu Guan, Robert D'Ippolito, Xiaoqing Li, Lawrence R. Soma, Mary A. Robinson

Journal: Drug Testing and Analysis

Abstract A hydrophilic interaction liquid chromatography–tandem mass spectrometry method (HILIC–MS/MS) was developed for the simultaneous determination of 28 amphetamine‐type stimulants (ATSs) in equine plasma for doping control analysis. In this method, stimulants were recovered from equine plasma by liquid–liquid extraction (LLE) at pH 9.5 using methyl tert‐butyl ether and detected on a Thermo Finnigan triple quadrupole mass spectrometer...

Read More thumbnail image: Highthroughput doping control analysis of 28 amphetaminetype stimulants in equine plasma using hydrophilic interaction liquid chromatographytandem mass spectrometry

Development of 3D printed mesofluidic devices to elute and concentrate DNA

Published: Nov 7, 2018

Author(s): Cody Masters, Jocelyn Dolphin, April Maschmann, Keegan McGill, Matthew Moore, Drew Thompson, Kristy L. Kounovsky‐Shafer

Journal: ELECTROPHORESIS

Abstract To understand structural variation for personal genomics, an extensive ensemble of large DNA molecules will be required to span large structural variations. Nanocoding, a whole‐genome analysis platform, can analyze large DNA molecules for the construction of physical restriction maps of entire genomes. However, handling of large DNA is difficult and a system is needed to concentrate large DNA molecules, while keeping the...

Read More thumbnail image: Development of 3D printed mesofluidic devices to elute and concentrate DNA

Deciphering key proteins of oil palm ( Elaeis guineensis Jacq.) fruit mesocarp development by proteomics and chemometrics

Published: Nov 7, 2018

Author(s): Hasliza Hassan, Mohd Din Amiruddin, Wolfram Weckwerth, Umi Salamah Ramli

Journal: ELECTROPHORESIS

Abstract Palm oil is an edible vegetable oil derived from lipid‐rich fleshy mesocarp tissue of oil palm (Elaeis guineensis Jacq.) fruit and is of global economic and nutritional relevance. While the understanding of oil biosynthesis in plants is improving, the fundamentals of oil biosynthesis in oil palm still require further investigations. To gain insight into the systemic mechanisms that govern oil synthesis during oil palm fruit ripening,...

Read More thumbnail image: Deciphering key proteins of oil palm  Elaeis guineensis Jacq_ fruit mesocarp development by proteomics and chemometrics

Automatic detecting and counting magnetic beads‐labeled target cells from a suspension in a microfluidic chip

Published: Nov 7, 2018

Author(s): Zhenyu Song, Mengqi Li, Bao Li, Yimo Yan, Yongxin Song

Journal: ELECTROPHORESIS

Abstract A novel microfluidic method of continually detecting and counting beads‐labeled cells from a cell mixture without fluorescence labeling was presented in this paper. The detection system is composed of a microfluidic chip (with a permanent magnet inserted along the channel), a signal amplification circuit, and a LabView® based data acquisition device. The microfluidic chip can be functionally divided into separation zone and...

Read More thumbnail image: Automatic detecting and counting magnetic beadslabeled target cells from a suspension in a microfluidic chip

Left ventricular blood flow patterns at rest and under dobutamine stress in healthy pigs

Published: Nov 7, 2018

Author(s): Nikola Cesarovic, Julia Busch, Miriam Lipiski, Maximilian Fuetterer, Thea Fleischmann, Silvia Born, Constantin Deuster, Mareike Sauer, Francesco Maisano, Sebastian Kozerke, Christian T. Stoeck

Journal: NMR in Biomedicine

Intracardiac blood flow patterns are affected by the morphology of cardiac structures and are set up to support the heart's pump function. Exercise affects contractility and chamber size as well as pre‐ and afterload. The aim of this study was to test the feasibility of four‐dimensional phase contrast cardiovascular MRI under pharmacological stress and to study left ventricular blood flow under stress. 4D flow data were successfully...

Read More thumbnail image: Left ventricular blood flow patterns at rest and under dobutamine stress in healthy pigs

Chemical profiling by LC–MS/MS and HPLC fingerprint combined with chemometrics and simultaneous determination of 16 characteristic ingredients for the quality consistency evaluation of Shaoyao‐Gancao Decoction

Published: Nov 6, 2018

Author(s): Pengfei Lu, Yong Chen, Manliang Tan, Yongjiang Wu

Journal: Biomedical Chromatography

Abstract In this paper, to evaluate the effect of the region of origin on the quality consistency of Shaoyao‐Gancao Decoction (SGD), the SGD fingerprint was developed for the first time. Chemometric methods including similarity analysis, hierarchical clustering analysis and principal component analysis were employed to study the quality consistency of SGD. Meanwhile, high‐performance liquid chromatography coupled with electrospray...

Read More thumbnail image: Chemical profiling by LCMSMS and HPLC fingerprint combined with chemometrics and simultaneous determination of 16 characteristic ingredients for the quality consistency evaluation of ShaoyaoGancao Decoction

Pharmacokinetics of monoester‐diterpenoid alkaloids in myocardial infarction and normal rats after oral administration of Sini decoction by microdialysis combined with liquid chromatography–tandem mass spectrometry

Published: Nov 6, 2018

Author(s): Qian Zhou, Ping Meng, Haibo Wang, Xin Dong, Guangguo Tan

Journal: Biomedical Chromatography

Abstract Monoester‐diterpenoid alkaloids are the main bioactive components of Sini decoction, which is a well‐known traditional Chinese medicine formula for the treatment of myocardial infarction (MI) and heart failure in China. In this work, an ultra‐high‐performance liquid chromatography–mass spectrometry combined with microdialysis method was successfully established and applied for investigating for the first time comparative...

Read More thumbnail image: Pharmacokinetics of monoesterditerpenoid alkaloids in myocardial infarction and normal rats after oral administration of Sini decoction by microdialysis combined with liquid chromatographytandem mass spectrometry
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