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Doping control analysis of four JWH‐250 metabolites in equine urine by liquid chromatography–tandem mass spectrometry

Published: Dec 9, 2018

Author(s): Youwen You, Rachel M. Proctor, Eric D. Vasilko, Mary A. Robinson

Journal: Drug Testing and Analysis

Abstract JWH‐250 is a synthetic cannabinoid. Its use is prohibited in equine sport according to the Association of Racing Commissioners International (ARCI) and the Fédération Équestre Internationale (FEI). A doping control method to confirm the presence of four JWH‐250 metabolites (JWH‐250 4‐OH‐pentyl, JWH‐250 5‐OH‐pentyl, JWH‐250 5‐OH‐indole, and JWH‐250 N‐pentanoic acid) in equine urine was developed and validated. Urine...

Read More thumbnail image: Doping control analysis of four JWH250 metabolites in equine urine by liquid chromatographytandem mass spectrometry

Two‐dimensional quantitative imaging of multicomponent samples using polychromatic X‐rays

Published: Dec 9, 2018

Author(s): Aileen Eyou, Bao Thanh Pham, Tony Kirk, Benedicta D. Arhatari, Chanh Quoc Tran

Journal: X-Ray Spectrometry

We present the theoretical formalism and an experimental demonstration of a technique for two‐dimensional quantitative imaging of two‐component samples using polychromatic X‐rays. The technique takes into account the full spectral information of the incident polychromatic beam to quantify the total X‐ray attenuation, due to each component presented in the sample, as functions of both energy and thickness. As a result, this technique is...

Read More thumbnail image: Twodimensional quantitative imaging of multicomponent samples using polychromatic Xrays

Characterization of 20th century art materials from the Lasar Segall Museum

Published: Dec 9, 2018

Author(s): Isolda de Castro Mendes, Juliana Alves Santos Oliveira, Maria Sylvia Silva Dantas

Journal: Journal of Raman Spectroscopy

Abstract This article describes the first results of a study of the collection of art materials, painted works, and techniques, belonging to the Lasar Segall Museum in Brazil, using materials and documents of the early 20th century. The paint materials from the museum's collection consist of over a hundred glass vases, tubes, and packets containing powdered pigments, inks, oils, and varnishes. Powdered and dried ink (labeled “ink...

Read More thumbnail image: Characterization of 20th century art materials from the Lasar Segall Museum

Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time‐of‐flight mass spectrometry

Published: Dec 6, 2018

Author(s): Yining Liu, Canhui Chen, Jiuwen Qiu, Zongbao Fang, Haibo Wu, Xingxian Zhang, Shufang Wang

Journal: Biomedical Chromatography

Abstract Hongjingtian injection is made from Rhodiola wallichiana and used in the treatment of stable angina pectoris associated with coronary heart disease. In this study, the chemical constituents in Hongjingtian injection were comprehensively studied using liquid chromatography quadrupole time‐of‐flight mass spectrometry. A total of 49 compounds were identified or assumed, including 10 organic acids, nine phenylethanoids, 10...

Read More thumbnail image: Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole timeofflight mass spectrometry

Incurred sample reanalysis in drug discovery bioanalysis

Published: Dec 6, 2018

Author(s): Poonam Giri, Nirmal Patel, Vipul Joshi, Shyamkumar Giri, Nuggehally R. Srinivas

Journal: Biomedical Chromatography

Abstract Bioanalysis plays a key role during the drug discovery process to generate the pharmacokinetic data to facilitate unbiased evaluation of leads, optimized leads and drug candidates. Such pharmacokinetic data are used to enable key decisions in the drug discovery process. The aim of the work is to put forward a new strategy of performing the incurred sample reanalysis for select small molecule novel chemical entities at...

Read More thumbnail image: Incurred sample reanalysis in drug discovery bioanalysis

Detection of erythropoiesis stimulating agents in urine samples using a capillary Western system

Published: Dec 6, 2018

Author(s): Philippe Desharnais, Jean‐François Naud, Christiane Ayotte

Journal: Drug Testing and Analysis

Abstract The presence of erythropoiesis stimulating agents (ESAs) in the urine samples collected from athletes is detected using traditional Western blotting following either size‐based separation (SDS/SAR‐PAGE) or isoelectric focusing (IEF). Although there is an important testing effort, there is little doubt that ESAs are still abused in sports and that reducing the costs of the tests might increase the number of tests and improve...

Read More thumbnail image: Detection of erythropoiesis stimulating agents in urine samples using a capillary Western system

Estimating the Reliability of Low‐Abundant Signals and Limited Replicate Measurements through MS2 Peak Area in SWATH

Published: Dec 6, 2018

Author(s): Franck Limonier, Sander Willems, Geneviève Waeterloos, Myriam Sneyers, Maarten Dhaenens, Dieter Deforce

Journal: PROTEOMICS

Abstract Sequential windows acquisition of all theoretical fragment ions mass spectrometry (SWATH‐MS) provides large‐scale protein quantification with high accuracy and selectivity. Nevertheless, reliable quantification of low‐abundant signals in complex samples remains challenging, as recently illustrated in a multicenter benchmark study of different label‐free software tools. Here, the SWATH Replicates Analysis 2.0 template from...

Read More thumbnail image: Estimating the Reliability of LowAbundant Signals and Limited Replicate Measurements through MS2 Peak Area in SWATH

Frontal Cortex Proteome Perturbation after Juvenile Rat Secondhand Smoke Exposure

Published: Dec 6, 2018

Author(s): Liam S. C. Lewis, Pretal P. Muldoon, Pallavi P. Pilaka, Andrew K. Ottens

Journal: PROTEOMICS

Abstract Secondhand smoke remains a global concern for children's health. Epidemiological studies implicate exposure to secondhand smoke as a major risk factor for behavioral disorders, yet biological causation remains unclear. Model studies have mainly focused on secondhand smoke impacts to prenatal neurodevelopment, yet juvenile exposure represents a separate risk. Using ion mobility–enhanced data‐independent mass spectrometry,...

Read More thumbnail image: Frontal Cortex Proteome Perturbation after Juvenile Rat Secondhand Smoke Exposure

Counter‐current chromatography melamine‐modified column and its separation mechanism

Published: Dec 6, 2018

Author(s): Kai‐Jun Quan, Xin‐Yi Huang, Yuan Gong, Dong Pei, Wen‐Da Duan, Duo‐Long Di

Journal: Journal of Separation Science

Abstract In this work, to further verify and develop the novel counter‐current chromatography modified column separate mode, a melamine modified counter‐current chromatography column was prepared. Meanwhile, the modified counter‐current chromatography column was used to separate stevioside and rebaudioside A with the same partition coefficient in chosen solvent system to evaluate its separation efficiency. The results show that...

Read More thumbnail image: Countercurrent chromatography melaminemodified column and its separation mechanism

A rapid and sensitive reversed phase‐HPLC method for simultaneous determination of ibuprofen and paracetamol in drug samples and their behaviors in simulated gastric conditions

Published: Dec 6, 2018

Author(s): Tülay Borahan, Tuğçe Unutkan, Ayşe Şahin, Sezgin Bakırdere

Journal: Journal of Separation Science

Abstract Paracetamol is a widely used drug for fever and pain relief. Ibuprofen is a common nonsteroidal anti‐inflammatory drug. In this study, a sensitive and accurate reversed phase high performance liquid chromatography method was developed for the simultaneous determination of ibuprofen and paracetamol. The chromatographic separation was achieved on a Phenomenex C18 (250 mm, 4.6 mm, 5 μm) column. Fifty milli molar...

Read More thumbnail image: A rapid and sensitive reversed phaseHPLC method for simultaneous determination of ibuprofen and paracetamol in drug samples and their behaviors in simulated gastric conditions

A passive microfluidic device for continuous microparticle enrichment

Published: Dec 6, 2018

Author(s): Liang‐Liang Fan, Xiao‐Liang Zhu, Qing Yan, Jiang Zhe, Liang Zhao

Journal: ELECTROPHORESIS

Abstract A passive microfluidic device is reported for continuous microparticle enrichment. The microparticle is enriched based on the inertial effect in a microchannel with contracting‐expanding structures on one side where microparticles/cells are subjected to the inertial lift force and the momentum‐change‐induced inertial force induced by highly curved streamlines. Under the combined effect of the two forces, yeast cells and...

Read More thumbnail image: A passive microfluidic device for continuous microparticle enrichment

Use of spinning band distillation equipment for fractionation of volatile compounds of Copaifera oleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity

Published: Dec 6, 2018

Author(s): Victor Pena Ribeiro, Caroline Arruda, Jonas Joaquim Mangabeira Silva, Jennyfer Andrea Aldana Mejia, Niege Araçari Jacometti Cardoso Furtado, Jairo Kenupp Bastos

Journal: Biomedical Chromatography

Abstract Copaifera is a tree that produces an oleoresin that has great historical and economic importance. These oleoresins display several pharmacological properties, such as anti‐inflammatory and antimicrobial, among others. The commercialization of Copaifera oleoresin occurs, in many cases, without any quality control, which facilitates its adulteration. Validated analytical methods can provide a safe quality control. In this work, the 800...

Read More thumbnail image: Use of spinning band distillation equipment for fractionation of volatile compounds of Copaifera oleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity

Absorption and distribution of lupeol in CD‐1 mice evaluated by UPLC–APCI + –MS/MS

Published: Dec 6, 2018

Author(s): Manuel Humberto Cháirez‐Ramírez, Jose Alberto Gallegos‐Infante, Martha Rocio Moreno‐Jiménez, Ruben Francisco González‐Laredo, Nuria Elizabeth Rocha‐Guzmán

Journal: Biomedical Chromatography

Abstract Lupeol is a dietary triterpene that shows limited water solubility, which affects its bioavailability. It is well known that poor oral bioavailability is one of the major causes of therapeutic variability. Lupeol has been reported to have multiple biological activities; however, there are no reports about its bioavailability. Therefore, the objective of this research was to evaluate the systemic bioavailability of lupeol....

Read More thumbnail image: Absorption and distribution of lupeol in CD1 mice evaluated by UPLCAPCI  MSMS

A quantitative evaluation of inorganic boundary films formed in engine oils by TOF‐SIMS depth profiling with low energy Cs sputtering

Published: Dec 6, 2018

Author(s): Atsushi Murase, Yuichi Kato, Eiichi Sudo

Journal: Surface and Interface Analysis

Quantitative evaluation of lubrication boundary films was investigated by time‐of‐flight secondary ion mass spectrometry depth profiling with low energy Cs sputtering. Relative sensitivity correction coefficient (RSC) for calcium phosphate, calcium carbonate, or calcium sulfate was determined by measuring the pellets of the mixture of these compounds. The RSCs for the three calcium salts varied with measurement conditions such as sputter...

Read More thumbnail image: A quantitative evaluation of inorganic boundary films formed in engine oils by TOFSIMS depth profiling with low energy Cs sputtering

Pattern formation using polystyrene benzaldimine self‐assembled monolayer by soft X‐ray

Published: Dec 6, 2018

Author(s): Chandrashekhar Channapura Halappa, So‐Jin Park

Journal: Surface and Interface Analysis

A nanopatterning fabrication by soft X‐ray generated chemical construction of a polystyrene benzaldehydeimine monolayer has been carried out from the polystyrenebezaldehyde resin with (3‐aminopropyl) triethoxysilane for the first time. The molecular layer was exposed to soft X‐rays; the involved chemical modification on the monolayer was analyzed by using Fourier transform infrared spectroscopy‐attenuated total internal reflectance and...

Read More thumbnail image: Pattern formation using polystyrene benzaldimine selfassembled monolayer by soft Xray

Advances in the measurements of the mass attenuation coefficients

Published: Dec 6, 2018

Author(s): Yves Ménesguen, Christophe Dulieu, Marie‐Christine Lépy

Journal: X-Ray Spectrometry

The knowledge of atomic fundamental parameters, such as mass attenuation coefficients or fluorescence yields with low uncertainties, is of decisive importance in elemental quantification involving X‐ray fluorescence analysis techniques. Several databases providing the mass attenuation coefficients are accessible and frequently used within a large community of users. These compilations are most often in good agreement for photon energies...

Read More thumbnail image: Advances in the measurements of the mass attenuation coefficients

Quantitative analysis of stibnite content in raw ore by Raman spectroscopy and chemometric tools

Published: Dec 6, 2018

Author(s): Yaoyi Cai, Chunhua Yang, Degang Xu, Weihua Gui

Journal: Journal of Raman Spectroscopy

Abstract This paper presents a non‐destructive and fast methodology to quantify the stibnite content in raw ore samples using Raman spectroscopy. A total of 120 raw ore reference samples were obtained from a froth flotation process, and multipoint collection and averaging were used to obtain Raman spectra from the raw ore samples. Our aim was to create the best multivariate calibration model for the quantitative analysis of stibnite...

Read More thumbnail image: Quantitative analysis of stibnite content in raw ore by Raman spectroscopy and chemometric tools

Quantitation of cobalt in Chinese tea by surface‐enhanced Raman spectroscopy in combination with the spectral shape deformation quantitative theory

Published: Dec 6, 2018

Author(s): Qing Liu, Zeng‐Ping Chen, Cai‐Xia Shi, Yao Chen, Ru‐Qin Yu

Journal: Journal of Raman Spectroscopy

Abstract A surface‐enhanced Raman spectroscopy (SERS) method for the quantification of Co2+ in Chinese tea was developed in this contribution. SERS‐enhancing substrates with a high selectivity for Co2+ were prepared by attaching 2‐(bis (pyridin‐2‐ylmethyl)amino)ethane‐1‐thiol onto the surfaces of Ag nanoparticles. A calibration model based on the spectral shape deformation quantitative theory was derived to address the poor reproducibility problem ...

Read More thumbnail image: Quantitation of cobalt in Chinese tea by surfaceenhanced Raman spectroscopy in combination with the spectral shape deformation quantitative theory

IRMS delta values ( 13 C) of nandrolone and testosterone products available in the UK: Implications for anti‐doping

Published: Dec 4, 2018

Author(s): Alan D. Brailsford, Wan Noor Mahirah Majidin, Nick Wojek, David A. Cowan, Christopher Walker

Journal: Drug Testing and Analysis

Abstract Anabolic androgenic steroids (AAS) are the most widely abused class of drugs by athletes and thus represent a significant problem to the anti‐doping community. Confirmation of a doping violation for AAS cannot always be based on their presence alone due to the endogenous production of some steroids. Both testosterone (and its metabolites) and the major diagnostic metabolite of nandrolone (19‐norandrosterone) are produced...

Read More thumbnail image: IRMS delta values  13 C of nandrolone and testosterone products available in the UK Implications for antidoping

Metabolism and elimination of the catechol‐ o ‐methyltransferase inhibitor tolcapone in the horse

Published: Dec 4, 2018

Author(s): Shawn Stanley, Koos Van den Berg, Hsiao Ching Foo, Derek Deng

Journal: Drug Testing and Analysis

Abstract The metabolism of the masking agent tolcapone in the horse has been investigated. This substance was found to have undergone various chemical transformations that produced a large variety of phase I metabolites, as well as glucuronide and sulfate conjugation. Confirmation of the presence of tolcapone and the 3‐O‐methylated metabolite in the blood samples collected up to 240 minutes and in urine obtained up to...

Read More thumbnail image: Metabolism and elimination of the catechol o methyltransferase inhibitor tolcapone in the horse
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