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Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy

Published: Jan 9, 2018

Author(s): Isaac M. Adanyeguh, Marie‐Lorraine Monin, Daisy Rinaldi, Léorah Freeman, Alexandra Durr, Stéphane Lehéricy, Pierre‐Gilles Henry, Fanny Mochel

Journal: NMR in Biomedicine

The striatum is a well‐known region affected in Huntington disease (HD). However, other regions, including the visual cortex, are implicated. We have identified previously an abnormal energy response in the visual cortex of patients at an early stage of HD using 31P magnetic resonance spectroscopy (31P MRS). We therefore sought to further characterize these metabolic alterations with 1H MRS using a well‐validated semi‐localized by adiabatic selective...

Read More thumbnail image: Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy

The effects of ageing on mouse muscle microstructure: a comparative study of time‐dependent diffusion MRI and histological assessment

Published: Jan 9, 2018

Author(s): Paola Porcari, Matt G. Hall, Chris A. Clark, Elizabeth Greally, Volker Straub, Andrew M. Blamire

Journal: NMR in Biomedicine

The investigation of age‐related changes in muscle microstructure between developmental and healthy adult mice may help us to understand the clinical features of early‐onset muscle diseases, such as Duchenne muscular dystrophy. We investigated the evolution of mouse hind‐limb muscle microstructure using diffusion imaging of in vivo and in vitro samples from both actively growing and mature mice. Mean apparent diffusion coefficients (ADCs) of the...

Read More thumbnail image: The effects of ageing on mouse muscle microstructure a comparative study of timedependent diffusion MRI and histological assessment

Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solid‐phase microextraction

Published: Jan 9, 2018

Author(s): Cuicui Cai, Pengcheng Zhang, Jiali Deng, Hongbin Zhou, Jing Cheng

Journal: Journal of Separation Science

Abstract A sensitive, accurate, and cost effective method for the quantification of trimethyl phosphate, which is highly polar and volatile, in environmental water is presented. Trimethyl phosphate was headspace solid‐phase microextracted on a molecularly imprinted polymeric fiber, and then the fiber was thermally desorbed in the gas chromatograph injector, and the compound was determined. The trimethyl phosphate imprinted polymeric...

Read More thumbnail image: Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solidphase microextraction

Fluid mixing in droplet‐based microfluidics with T junction and convergent–divergent sinusoidal microchannels

Published: Jan 9, 2018

Author(s): Li Yang, Shanshan Li, Jixiao Liu, Jingmeng Cheng

Journal: ELECTROPHORESIS

Abstract To explore and utilize the advantages of droplet‐based microfluidics, hydrodynamics, and mixing process within droplets traveling though the T junction channel and convergent–divergent sinusoidal microchannels are studied by numerical simulations and experiments, respectively. In the T junction channel, the mixing efficiency is significantly influenced by the twirling effect, which controls the initial distributions of the...

Read More thumbnail image: Fluid mixing in dropletbased microfluidics with T junction and convergentdivergent sinusoidal microchannels

Antimicrobial activity of functionalized single‐walled carbon nanotube with herbal extract of Hempedu bumi

Published: Jan 8, 2018

Author(s): Mu Ee Foo, Periasamy Anbu, Subash C. B. Gopinath, Thangavel Lakshmipriya, Choul‐Gyun Lee, Hyun Shik Yun, M. N. A. Uda, Ahmad Radi Wan Yaakub

Journal: Surface and Interface Analysis

The primary purpose of this study was to determine the antimicrobial activity of functionalized single‐walled carbon nanotube (SWNT) using an extract of the herb, Hempedu bumi. H bumi extract and H bumi extract complexed SWNT were evaluated for biological activities against Bacillus sp., (pathogen) Escherichia coli (opportunistic pathogen), and Aspergillus niger (pathogen). The formation of inhibition zones of these 3 microbes was measured to be evident for the...

Read More thumbnail image: Antimicrobial activity of functionalized singlewalled carbon nanotube with herbal extract of Hempedu bumi

Corrosion and wear resistance properties of multilayered diamond‐like carbon nanocomposite coating

Published: Jan 8, 2018

Author(s): S. Viswanathan, L. Mohan, Parthasarathi Bera, S. Shanthiswaroop, M. Muniprakash, Harish C. Barshilia, C. Anandan

Journal: Surface and Interface Analysis

Multilayered diamond‐like carbon (DLC) nanocomposite coating has been deposited on silicon and stainless steel substrates by combination of cathodic arc evaporation and magnetron sputtering. In order to make DLC coating adhered to metal substrate, a chromium interlayer has been deposited with constant bias voltage of −150 V applied to the substrate. Dense multilayered coating consists of metallic or nonmetallic and tetrahedral carbon...

Read More thumbnail image: Corrosion and wear resistance properties of multilayered diamondlike carbon nanocomposite coating

Analysis of atmospheric plasma‐treated polypropylene by large area ToF‐SIMS imaging and NMF

Published: Jan 8, 2018

Author(s): Gustavo F. Trindade, David F. Williams, Marie‐Laure Abel, John F. Watts

Journal: Surface and Interface Analysis

This work combines large area time‐of‐flight secondary ion mass spectrometry imaging with multivariate analysis methods to characterise a cold atmospheric plasma treatment of the surface of an automotive grade polypropylene. Data preprocessing steps are also presented alongside their main challenges. The results enabled the investigation of the spatial distribution of the treatment for different stand‐off distances as well as the effects...

Read More thumbnail image: Analysis of atmospheric plasmatreated polypropylene by large area ToFSIMS imaging and NMF

Sub‐minute kinetics of human red cell fumarase: 1 H spin‐echo NMR spectroscopy and 13 C rapid‐dissolution dynamic nuclear polarization

Published: Jan 8, 2018

Author(s): Dmitry Shishmarev, Alan J. Wright, Tiago B. Rodrigues, Giuseppe Pileio, Gabriele Stevanato, Kevin M. Brindle, Philip W. Kuchel

Journal: NMR in Biomedicine

Fumarate is an important probe of metabolism in hyperpolarized magnetic resonance imaging and spectroscopy. It is used to detect the release of fumarase in cancer tissues, which is associated with necrosis and drug treatment. Nevertheless, there are limited reports describing the detailed kinetic studies of this enzyme in various cells and tissues. Thus, we aimed to evaluate the sub‐minute kinetics of human red blood cell fumarase using...

Read More thumbnail image: Subminute kinetics of human red cell fumarase 1 H spinecho NMR spectroscopy and 13 C rapiddissolution dynamic nuclear polarization

Proton change of parotid glands after gustatory stimulation examined by magnetic resonance imaging

Published: Jan 8, 2018

Author(s): Yi‐Jui Liu, Yi‐Hsiung Lee, Hing‐Chiu Chang, Hui‐Chu Chiu, Ta‐Wei Chiu, Kang Hsu, Cheng‐Ming Pen, Hsian‐He Hsu, Chun‐Jung Juan

Journal: NMR in Biomedicine

The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi‐quantitative parameters and an empirical mathematical model (EMM) using high‐temporal‐resolution, double‐echo, echo‐planar imaging (EPI). Approved by a local institutional review board, this study examined 20 parotid glands from 10 healthy volunteers (male:female = 6: 4; age ± standard deviation =35.1 ± 14.1 years) with...

Read More thumbnail image: Proton change of parotid glands after gustatory stimulation examined by magnetic resonance imaging

Development of HPLC with fluorescent detection using NBD‐F for the quantification of colistin sulfate in rat plasma and its pharmacokinetic applications

Published: Jan 7, 2018

Author(s): Sui Ouchi, Kazuaki Matsumoto, Maki Okubo, Yuta Yokoyama, Junko Kizu

Journal: Biomedical Chromatography

Abstract Colistin sulfate, composed of a mixture of colistin A sulfate (CLA) and colistin B sulfate (CLB), is available for treating life‐threatening infections caused by multidrug‐resistant Gram‐negative bacteria. In this study, the CLA and CLB were quantified separately. Colistin sulfate was extracted from rat plasma with a solid‐phase extraction C18 cartridge and reacted with 4‐fluoro‐7‐nitro‐2,1,3‐benzoxadiazole (NBD‐F), and the fluorescent...

Read More thumbnail image: Development of HPLC with fluorescent detection using NBDF for the quantification of colistin sulfate in rat plasma and its pharmacokinetic applications

Simultaneous determination of residues of metalaxyl, cyazofamid and a cyazofamid metabolite in tobacco leaves and soil by liquid chromatography with tandem mass spectrometry

Published: Jan 5, 2018

Author(s): Sizhuo Wu, Weiwei Yu, Caiyuan Sun, Kunming Zheng, Haizhen Zhang, Min Huang, Deyu Hu, Kankan Zhang

Journal: Biomedical Chromatography

Abstract A simple method was developed and validated for the simultaneous determination of metalaxyl, cyazofamid and the cyazofamid metabolite 4‐chloro‐5‐p‐tolylimidazole‐2‐carbonitrile (CCIM) by liquid chromatography with tandem mass spectrometry. The three target compounds were extracted from tobacco and soil with acetonitrile containing 0.1% acetic acid, and the extracts were purified using octadecylsilane. The proposed method...

Read More thumbnail image: Simultaneous determination of residues of metalaxyl cyazofamid and a cyazofamid metabolite in tobacco leaves and soil by liquid chromatography with tandem mass spectrometry

A comparison of 2‐hydroxyglutarate detection at 3 and 7 T with long‐TE semi‐LASER

Published: Jan 5, 2018

Author(s): Adam Berrington, Natalie L. Voets, Sarah J. Larkin, Nick Pennington, James Mccullagh, Richard Stacey, Christopher J. Schofield, Peter Jezzard, Stuart Clare, Tom Cadoux‐Hudson, Puneet Plaha, Olaf Ansorge, Uzay E. Emir

Journal: NMR in Biomedicine

Abnormally high levels of the ‘oncometabolite’ 2‐hydroxyglutarate (2‐HG) occur in many grade II and III gliomas, and correlate with mutations in the genes of isocitrate dehydrogenase (IDH) isoforms. In vivo measurement of 2‐HG in patients, using magnetic resonance spectroscopy (MRS), has largely been carried out at 3 T, yet signal overlap continues to pose a challenge for 2‐HG detection. To combat this, several groups have proposed MRS methods...

Read More thumbnail image: A comparison of 2hydroxyglutarate detection at 3 and 7T with longTE semiLASER

Simultaneous determination of isochamaejasmin, neochamaejasmin A and aphnoretinin rat plasma by UPLC‐MS/MS and its application to a pharmacokinetic study of Stellera chamaejasme L. extract

Published: Jan 5, 2018

Author(s): Ludi Wang, Wei Yang, Siyang Wu, Shuyao Wang, Chen Kang, Xiaoli Ma, Yingfei Li, Chuan Li

Journal: Biomedical Chromatography

Abstract Isochamaejasmin, neochamaejasmin A and daphnoretin derived from Stellera chamaejasme L. are important because of their reported anticancer properties. In this study, a sensitive UPLC‐MS/MS method for the determination of isochamaejasmin, neochamaejasmin A and daphnoretin in rat plasma was developed. The analyte and IS were separated on an Acquity UPLC HSS T3 column (100 × 2.1 mm, 1.8 μm) using gradient elution with the mobile phase of...

Read More thumbnail image: Simultaneous determination of isochamaejasmin neochamaejasmin A and aphnoretinin rat plasma by UPLCMSMS and its application to a pharmacokinetic study of Stellera chamaejasme L_ extract

Cryogenic modulation fast GC × GC–MS using a 10 m microbore column combination: Concept, method optimization, and application

Published: Jan 5, 2018

Author(s): Barbara Giocastro, Marco Piparo, Peter Q. Tranchida, Luigi Mondello

Journal: Journal of Separation Science

Abstract The present research is based on the concept of using a 10 m × 0.1 mm id column for cryogenic‐modulation fast comprehensive two‐dimensional gas chromatography with quadrupole mass spectrometry. Specifically, an 8.9 m × 0.1 mm id low‐polarity column was used as the first dimension, and a 1.1 m × 0.1 mm id medium‐polarity column was used as the second dimension. The main scope of the...

Read More thumbnail image: Cryogenic modulation fast GC  GCMS using a 10m microbore column combination Concept method optimization and application

Chiral separation of helical chromenes with chloromethyl phenylcarbamate polysaccharide‐based stationary phases

Published: Jan 5, 2018

Author(s): Federica Ianni, Stefania Scorzoni, Pier Luigi Gentili, Alessandro Di Michele, Michel Frigoli, Emidio Camaioni, Fausto Ortica, Roccaldo Sardella

Journal: Journal of Separation Science

Abstract Two chloromethyl phenylcarbamate‐based chiral stationary phases, one containing an amylose‐type chiral selector (Lux Amylose 2, from Phenomenex) and the other a cellulose‐type one (Lux Cellulose‐4, from Phenomenex), were successfully used for the chiral resolution of three helical chromenes featuring a helicene‐like structure. The compound bearing a phenyl substituent on the helicene‐like structure was enantioresolved at...

Read More thumbnail image: Chiral separation of helical chromenes with chloromethyl phenylcarbamate polysaccharidebased stationary phases

Chiral separation of lenalidomide by liquid chromatography on polysaccharide‐type stationary phases and by capillary electrophoresis using cyclodextrin selectors

Published: Jan 5, 2018

Author(s): Zoltán‐István Szabó, Mohammadhassan Foroughbakhshfasaei, Réka Gál, Péter Horváth, Balázs Komjáti, Béla Noszál, Gergő Tóth

Journal: Journal of Separation Science

Abstract Complementary techniques were applied for the investigation of the chiral recognition and enantiomeric resolution of lenalidomide using various cyclodextrins and polysaccharides as chiral selectors. The high‐performance liquid chromatography enantioseparation of the anticancer drug was achieved using polysaccharide‐type chiral stationary phases in polar organic mode. Elution order and absolute configuration were elucidated...

Read More thumbnail image: Chiral separation of lenalidomide by liquid chromatography on polysaccharidetype stationary phases and by capillary electrophoresis using cyclodextrin selectors

Simultaneous determination of polysaccharides and 21 nucleosides and amino acids in different tissues of Salvia miltiorrhiza from different areas by UV–visible spectrophotometry and UHPLC with triple quadrupole MS/MS

Published: Jan 5, 2018

Author(s): Xiang Xiang, Xiuxiu Sha, Shulan Su, Zhenhua Zhu, Sheng Guo, Hui Yan, Dawei Qian, Jin‐ao Duan

Journal: Journal of Separation Science

Abstract Salvia miltiorrhiza, a traditional Chinese medicine, is a widely used herbal medicine to treat cardiovascular and cerebrovascular diseases. In this study, ultraviolet (UV)–visible spectrophotometry and ultra‐high performance liquid chromatography with triple quadrupole tandem mass spectrometry analytical methods were used for rapid quantification of polysaccharides and 21 nucleosides and amino acids in S. miltiorrhiza to...

Read More thumbnail image: Simultaneous determination of polysaccharides and 21 nucleosides and amino acids in different tissues of Salvia miltiorrhiza from different areas by UVvisible spectrophotometry and UHPLC with triple quadrupole MSMS

Investigation of cadmium accumulation mechanism in hepatopancreas of Patinopecten yessoensis by synchrotron radiation X‐ray absorption fine structure and synchrotron radiation X‐ray fluorescence analyses

Published: Jan 4, 2018

Author(s): Kenji Terada, Yoshinari Abe, Izumi Nakai, Shingo Maruhashi, Shigetoshi Miura, Kotaro Honda, Yasuhiro Tomooka

Journal: X-Ray Spectrometry

Chemical state of cadmium in a hepatopancreas of a scallop (Patinopecten yessoensis) was studied by means of synchrotron radiation‐based X‐ray analytical techniques. X‐ray absorption fine structure (XAFS) and X‐ray fluorescence (XRF) imaging were used to identify the chemical state and the distribution of cadmium in the hepatopancreas, respectively. The results of in vivo Cd K‐edge XAFS suggested that the neighboring atoms of the cadmium in the...

Read More thumbnail image: Investigation of cadmium accumulation mechanism in hepatopancreas of Patinopecten yessoensis by synchrotron radiation Xray absorption fine structure and synchrotron radiation Xray fluorescence analyses

Electrochromatographic performance of graphene and graphene oxide modified silica particles packed capillary columns

Published: Jan 4, 2018

Author(s): Hongyan Zhao, Yizhou Wang, Danyu Zhang, Heyong Cheng, Yuanchao Wang

Journal: ELECTROPHORESIS

Abstract Graphene oxide functionalized silica microspheres (GO@SiO2) were synthesized based on condensation reaction between amino from aminosilica particles and carboxyl groups from GO. Reduction of GO@SiO2 with hydrazinium hydroxide generated graphene modified silica particles (G@SiO2). GO@SiO2 and G@SiO2 packed capillary columns for capillary electrochromatography were thereafter fabricated by pressure slurry packing with single‐particle ...

Read More thumbnail image: Electrochromatographic performance of graphene and graphene oxide modified silica particles packed capillary columns

Direct determination of amino acids in brewery worts produced by different processes by capillary zone electrophoresis

Published: Jan 4, 2018

Author(s): Renata Corrêa de Carvalho, Thiago Rocha dos Santos Mathias, Annibal Duarte Pereira Netto, Flávia Ferreira de Carvalho Marques

Journal: ELECTROPHORESIS

Abstract The direct and simultaneous determination of cysteine, histidine, phenylalanine, lysine, tryptophan and arginine in brewery worts by capillary zone electrophoresis (CZE) was applied to evaluate the effects of temperature control and protease supplementation during mashing on the changes of these amino acids (AAs) wort composition. A cation exchange resin was used for AAs extraction from wort samples prior to CZE...

Read More thumbnail image: Direct determination of amino acids in brewery worts produced by different processes by capillary zone electrophoresis
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