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Metabolic fate of the new synthetic cannabinoid 7’N‐5F‐ADB in rat, human, and pooled human S9 studied by means of hyphenated high‐resolution mass spectrometry

Published: Oct 9, 2018

Author(s): Lilian H.J. Richter, Hans H. Maurer, Markus R. Meyer

Journal: Drug Testing and Analysis

Abstract New psychoactive substances (NPS) are an important issue in clinical/forensic toxicology. 7’N‐5F‐ADB, a synthetic cannabinoid derived from 5F‐ADB, appeared recently on the market. Up to now, no data about its mass spectral fragmentation pattern, metabolism, and thus suitable targets for toxicological urine screenings have been available. Therefore, the aim of this study was to elucidate the metabolic fate of 7’N‐5F‐ADB in...

Read More thumbnail image: Metabolic fate of the new synthetic cannabinoid 7N5FADB in rat human and pooled human S9 studied by means of hyphenated highresolution mass spectrometry

Actuation of adaptive liquid microlens droplet in microfluidic devices: A review

Published: Oct 8, 2018

Author(s): Gui‐Ping Zhu, Jia‐Feng Yao, Shi‐Hua Wu, Xi‐Dong Zhang

Journal: ELECTROPHORESIS

Abstract A significant growth of research on adaptive liquid lens is achieved over the past decades, and the field is still attracting increasing attentions, focusing on the transition from the current stage to the commercialized stage. The challenges faced are not limited to fabrication, material, small tuning range in focal lengths, additional control systems, limitations in special actuation methods and so on. In addition, the use of external driving parts or systems induce extra problem on...

Read More thumbnail image: Actuation of adaptive liquid microlens droplet in microfluidic devices A review

The New Face of the Lipid Droplet: Lipid Droplet Proteins

Published: Oct 8, 2018

Author(s): Congyan Zhang, Pingsheng Liu

Journal: PROTEOMICS

Abstract The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types. The accumulated proteomic data are reviewed for evidence of a protein targeting mechanism for the organelle. The hypotheses for several specific localization mechanisms based on...

Read More thumbnail image: The New Face of the Lipid Droplet Lipid Droplet Proteins

On hybrid electroosmotic kinetics for field‐effect‐reconfigurable nanoparticle trapping in a four‐terminal spiral microelectrode array

Published: Oct 4, 2018

Author(s): Yukun Ren, Chunlei Song, Weiyu Liu, Tianyi Jiang, Jingni Song, Qisheng Wu, Hongyuan Jiang

Journal: ELECTROPHORESIS

Abstract Induced‐charge electroosmosis (ICEO) has attracted tremendous popularity for driving fluid motion from the microfluidic community since the last decade, while less attention has been paid to ICEO‐based nanoparticle manipulation. We propose herein a unique concept of hybrid electroosmotic kinetics (HEK) in terms of bi‐phase ICEO (BICEO) actuated in a four‐terminal spiral electrode array, for effective electrokinetic enrichment of fluorescent polystyrene nanoparticles on ideally...

Read More thumbnail image: On hybrid electroosmotic kinetics for fieldeffectreconfigurable nanoparticle trapping in a fourterminal spiral microelectrode array

New advances in microfluidic flow cytometry

Published: Oct 4, 2018

Author(s): Yanli Gong, Na Fan, Xu Yang, Bei Peng, Hai Jiang

Journal: ELECTROPHORESIS

Abstract In recent years, researchers are paying the increasing attention to the development of portable microfluidic diagnostic devices including microfluidic flow cytometry for the point‐of‐care testing. Microfluidic flow cytometry, where microfluidics and flow cytometry work together to realize novel functionalities on the microchip, provides a powerful tool for measuring the multiple characteristics of biological samples. The development of a portable, low‐cost, and compact flow cytometer...

Read More thumbnail image: New advances in microfluidic flow cytometry

Caffeine content of pre‐workout supplements commonly used by Australian consumers

Published: Oct 3, 2018

Author(s): Ben Desbrow, Susan Hall, Helen O'Connor, Gary Slater, Katelyn Barnes, Gary Grant

Journal: Drug Testing and Analysis

Abstract The stimulant properties of caffeine are often promoted in pre‐workout supplements (PWS) to assist with training, reduce the perception of fatigue, and for some brands, assist body fat loss. While manufacturers of PWS often indicate the inclusion of significant amounts of caffeine, no independent verification of the caffeine content of these products exists. The aim of this investigation was to independently assess the...

Read More thumbnail image: Caffeine content of preworkout supplements commonly used by Australian consumers

Anodizing—Interplay between bath aging and oxide formation and properties

Published: Oct 1, 2018

Author(s): Uta Gierth, Kerstin Kremmer, Michael Schneider

Journal: Surface and Interface Analysis

The present study investigates the interplay between ongoing bath aging during the anodizing process and the formation and properties of the anodic formed oxide layers on AA 1050 in sulfuric acid. The change in the bath over the time of use is studied by controlling the conductivity of the bath. The pH value and the concentration of Al3+ ions in the bath are simultaneously measured. The kinetic of the oxide formation depending on the bath aging is electrochemically investigated by repetitive...

Read More thumbnail image: AnodizingInterplay between bath aging and oxide formation and properties

Synthesis and pharmacology of new psychoactive substance 5F‐CUMYL‐P7AICA, a scaffold‐ hopping analog of synthetic cannabinoid receptor agonists 5F‐CUMYL‐PICA and 5F‐CUMYL‐PINACA

Published: Oct 1, 2018

Author(s): Samuel D. Banister, Axel Adams, Richard C. Kevin, Christa Macdonald, Michelle Glass, Rochelle Boyd, Mark Connor, Iain S. McGregor, Christopher M. Havel, Stephen J. Bright, Mireia Ventura Vilamala, Cristina Gil Lladanosa, Monica J. Barratt, Roy R. Gerona

Journal: Drug Testing and Analysis

Abstract Synthetic cannabinoid receptor agonists (SCRAs) are a dynamic class of new psychoactive substances (NPS), with novel chemotypes emerging each year. Following the putative detection of 5F‐CUMYL‐P7AICA in Australia in 2016, the scaffold‐hopping SCRAs 5F‐CUMYL‐PICA, 5F‐CUMYL‐PINACA, and 5F‐CUMYL‐P7AICA were synthesized and characterized by nuclear magnetic resonance (NMR) spectroscopy, gas chromatography–mass spectrometry...

Read More thumbnail image: Synthesis and pharmacology of new psychoactive substance 5FCUMYLP7AICA a scaffold hopping analog of synthetic cannabinoid receptor agonists 5FCUMYLPICA and 5FCUMYLPINACA

Dielectrophoretic separation of microalgae cells in ballast water in a microfluidic chip

Published: Sep 30, 2018

Author(s): Yanjuan Wang, Junsheng Wang, Xudong Wu, Zong Jiang, Wei Wang

Journal: ELECTROPHORESIS

Abstract The composition of the ship's ballast water is complex and contains a large number of microalgae cells, bacteria, microplastics, and other microparticles. To increase the accuracy and efficiency of detection of the microalgae cells in ballast water, a new microfluidic chip for continuous separation of microalgae cells based on alternating current dielectrophoresis was proposed. In this microfluidic chip, one piece of 3‐dimensional electrode is embedded on one side and eight discrete...

Read More thumbnail image: Dielectrophoretic separation of microalgae cells in ballast water in a microfluidic chip

Interactions of phenethylamine‐derived psychoactive substances of the 2C‐series with human monoamine oxidases

Published: Sep 28, 2018

Author(s): Lea Wagmann, Simon D. Brandt, Alexander Stratford, Hans H. Maurer, Markus R. Meyer

Journal: Drug Testing and Analysis

Abstract Psychoactive substances of the 2C‐series (2Cs) are phenethylamine‐derived designer drugs that can induce psychostimulant and hallucinogenic effects. Chemically, the classic 2Cs contain two methoxy groups in positions 2 and 5 of the phenyl ring, whereas substances of the so‐called FLY series contain rigidified methoxy groups integrated in a 2,3,6,7‐tetrahydrobenzo[1,2‐b:4,5‐b’]difuran core. One of the pharmacological features that has not been investigated in detail is the inhibition...

Read More thumbnail image: Interactions of phenethylaminederived psychoactive substances of the 2Cseries with human monoamine oxidases

Dielectric relaxation spectroscopy of aqueous micellar electrolyte solutions: A novel application to infer Dukhin number and zeta potential of a micelle

Published: Sep 27, 2018

Author(s): Mahmoud Khademi, Dominik P. J. Barz

Journal: ELECTROPHORESIS

Abstract The complex permittivities of aqueous SDS solutions, with and without the addition of sodium chloride (NaCl), are measured in the frequency range from 200 MHz to 14 GHz. The SDS concentrations are chosen such that the SDS molecules aggregate to micelles. In this frequency range, the measured spectra allow for the identification of two different relaxation processes. That is, the relaxation of the water molecules at frequencies above 1 GHz and the micellar relaxation at frequencies...

Read More thumbnail image: Dielectric relaxation spectroscopy of aqueous micellar electrolyte solutions A novel application to infer Dukhin number and zeta potential of a micelle

Localization of double‐bond positions in lipids by tandem mass spectrometry succeeding high‐performance liquid chromatography with post‐column derivatization

Published: Sep 27, 2018

Author(s): Heiko Hayen, Christian Vosse, Ansgar Korf, Viola Jeck

Journal: Rapid Communications in Mass Spectrometry

Rationale Lipids are a group of biomolecules known for their importance in a broad variety of biological tasks, which is attributed to the diversity of their molecular structures. The exact position of the double bond in a lipid affects its biological properties. Therefore, the determination of its position is highly important. Nevertheless, the unambiguous assignment is still a challenging task and requires the development of new approaches. Methods A novel method for pinpointing double‐bond...

Read More thumbnail image: Localization of doublebond positions in lipids by tandem mass spectrometry succeeding highperformance liquid chromatography with postcolumn derivatization

A perspective view of top‐down proteomics in snake venom research

Published: Sep 26, 2018

Author(s): Parviz Ghezellou, Vannuruswamy Garikapati, Seyed Mahdi Kazemi, Kerstin Strupat, Alireza Ghassempour, Bernhard Spengler

Journal: Rapid Communications in Mass Spectrometry

The venom produced by snakes contains complex mixtures of pharmacologically active proteins and peptides which play a crucial role in the pathophysiology of snakebite diseases. The deep understanding of venom proteomes can help to improve the treatment of this “neglected tropical disease” (as expressed by the World Health Organization [WHO]) and to develop new drugs. The most widely used technique for venom analysis is liquid chromatography/tandem mass spectrometry (LC/MS/MS)‐based bottom‐up...

Read More thumbnail image: A perspective view of topdown proteomics in snake venom research

Optical cleanliness measurement methods for aluminium sheet surfaces

Published: Sep 26, 2018

Author(s): Xiaorong Zhou, Geoff Scamans, Eoghan McAlpine, Colin Butler, Peter Andrews, Junjie Wang

Journal: Surface and Interface Analysis

The cleaning of rolled aluminium surfaces is of critical importance for most applications and is of particular importance in automotive applications. The cleanliness of the sheet surface is mainly determined by the residual amount of the near‐surface deformed layer on the alloy surface. This layer has nano‐sized grains with their grain boundaries decorated and pinned by oxide particles and lubricant residues. The deformed layer reduces the reflectivity of the sheet or strip surface to visible...

Read More thumbnail image: Optical cleanliness measurement methods for aluminium sheet surfaces

A fluorescence toolbox: A review of investigation of electrophoretic separations, process, and interfaces

Published: Sep 25, 2018

Author(s): S. Thompson, Dimitri Pappas

Journal: ELECTROPHORESIS

Abstract This review focuses on fluorescence spectroscopy techniques for the investigation of electrophoretic separations. Fluorescence has been used as a sensitive detector for capillary, gel, and microchip electrophoresis for decades. However, advanced fluorescence methods can be used to study transport, interfacial phenomena, intermolecular and affinity interactions, and other processes that occur during separation. This so‐called spectroscopic toolkit can be implemented to understand...

Read More thumbnail image: A fluorescence toolbox A review of investigation of electrophoretic separations process and interfaces

Synthetic isoflavones and doping: A novel class of aromatase inhibitors?

Published: Sep 25, 2018

Author(s): Michele Iannone, Francesco Botrè, Nicoletta Cardillo, Xavier Torre

Journal: Drug Testing and Analysis

Abstract Anectodical information suggests that flavonoids may be widely used among athletes for their multiple biochemical and pharmacological effects. We have evaluated in vitro the effects of two synthetic isoflavones, methoxyisoflavone and ipriflavone, on the catalytic activity of human aromatase (CYP19), the enzyme catalyzing the conversion of androgens (ie, testosterone or androstenedione) to estrogens (ie, estradiol and...

Read More thumbnail image: Synthetic isoflavones and doping A novel class of aromatase inhibitors

Simultaneous quantification of THC‐COOH, OH‐THC, and further cannabinoids in human hair by gas chromatography–tandem mass spectrometry with electron ionization applying automated sample preparation

Published: Sep 25, 2018

Author(s): Tobias Kieliba, Oliver Lerch, Hilke Andresen‐Streichert, Markus A. Rothschild, Justus Beike

Journal: Drug Testing and Analysis

Abstract The detection of Δ9‐tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in hair, for the purpose of identifying cannabis consumption, is conducted in many forensic laboratories. Since external contamination of hair with these cannabis components cannot be excluded, even after hair decontamination, only the detection of THC metabolites such as 11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol (THC‐COOH) or 11‐hydroxy‐Δ9‐tetrahydrocannabinol (OH‐THC), is considered to prove...

Read More thumbnail image: Simultaneous quantification of THCCOOH OHTHC and further cannabinoids in human hair by gas chromatographytandem mass spectrometry with electron ionization applying automated sample preparation

Rapid mass spectral fingerprinting of complex mixtures of decomposed lignin: Data‐processing methods for high‐resolution full‐scan mass spectra

Published: Sep 23, 2018

Author(s): Yulin Qi, Dietrich A. Volmer

Journal: Rapid Communications in Mass Spectrometry

Lignin is the second most abundant natural biopolymer and its wastes are significant sources for renewable chemicals as an alternative to conventional fossil fuels. Consequently, chemical characterization methods are required to assess the content of valuable chemicals contained in these complex lignin wastes. This short overview summarizes rapid data‐processing methods developed in our laboratory for application to full‐scan raw data from high‐resolution mass spectrometry experiments of...

Read More thumbnail image: Rapid mass spectral fingerprinting of complex mixtures of decomposed lignin Dataprocessing methods for highresolution fullscan mass spectra

Revealing the potential of capillary electrophoresis/mass spectrometry: the tipping point

Published: Sep 23, 2018

Author(s): Rabah Gahoual, Emmanuelle Leize‐Wagner, Pascal Houzé, Yannis‐Nicolas François

Journal: Rapid Communications in Mass Spectrometry

The hyphenation of capillary electrophoresis and mass spectrometry (CE/MS) remains a minor technique compared with liquid chromatography/mass spectrometry (LC/MS), which represents nowadays the standard instrumentation, regardless of its introduction thirty years ago. However, from a theoretical point of view, CE coupling should be quite favorable especially with electrospray ionization mass spectrometry (ESI‐MS). At the time, the sensitivity provided by CE/MS was often limited, due to...

Read More thumbnail image: Revealing the potential of capillary electrophoresismass spectrometry the tipping point

Effects of electrode size and surface morphology on electrode polarization in physiological buffers

Published: Sep 21, 2018

Author(s): Anil Koklu, Amin Mansoorifar, Ali Beskok

Journal: ELECTROPHORESIS

Abstract Electrode polarization (EP) is inevitable in high conductivity buffers at low AC frequencies due to the accumulation of free charges at the electrode/electrolyte interface. Electrode miniaturization increases EP effect on impedance measurements. In this paper, six gold planar (GP) electrodes having different diameters () were used to investigate the size effect on EP with parallel plate electrode geometry. GP electrode surface was electrochemically deposited with gold nanostructures...

Read More thumbnail image: Effects of electrode size and surface morphology on electrode polarization in physiological buffers
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