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Separation and determination of alpha‐synuclein monomeric and oligomeric species using two electrophoretic approaches

Published: Sep 13, 2018

Author(s): Aurore Napp, Virginie Houbart, Alice Demelenne, Marie‐Paule Merville, Jacques Crommen, Mireille Dumoulin, Gaëtan Garraux, Anne‐Catherine Servais, Marianne Fillet

Journal: ELECTROPHORESIS

Abstract Parkinson's disease (PD) is a frequent degenerative disorder that is diagnosed based on clinical symptoms. When the first symptoms appear, more than 70% of the dopaminergic cells are already lost. Therefore, it is of utmost importance to have reliable biomarkers to diagnose much earlier PD. In this context, alpha‐synuclein (aSyn) is a protein of high interest because of its tendency to form oligomers and amyloid fibrils....

Read More thumbnail image: Separation and determination of alphasynuclein monomeric and oligomeric species using two electrophoretic approaches

Approach to excellent superhydrophobicity and corrosion resistance of carbon‐based films by graphene and cobalt synergism

Published: Sep 13, 2018

Author(s): Qingqing Yan, Shengguo Zhou, Liqiu Ma, Shanhong Wan, Xiaobo Zhu

Journal: Surface and Interface Analysis

A new series of carbon‐based films doped with graphene oxide and cobalt (G‐Co/a‐C:H films) were successfully prepared on Si substrate via one‐step electrochemical deposition of methanol as the carbon source and graphene oxide/cobalt as the dopant. G‐Co/a‐C:H films were fabricated at various graphene oxide concentration for comparative experiments. It can be found that the graphene oxide and cobalt were well embedded in amorphous carbon...

Read More thumbnail image: Approach to excellent superhydrophobicity and corrosion resistance of carbonbased films by graphene and cobalt synergism

Control of nitrogen doping in NaTaO 3 synthesized by hydrothermal reaction and chemical state of nitrogen

Published: Sep 13, 2018

Author(s): Akiyo Ozawa, Keita Kobayashi, Tomoko Yoshida

Journal: Surface and Interface Analysis

Nitrogen‐doped NaTaO3 was synthesized through 1‐pot reaction, hydrothermal process using Ta3N5 as precursor. Changing concentration and amount of NaOH aqueous solution influenced nitrogen content in NaTaO3. Absorption edge of nitrogen‐doped NaTaO3 was extended at 570 nm, and absorbance in visible light region depended on nitrogen content in NaTaO3. Anodic photocurrent measured under visible light irradiation became larger with increasing nitrogen content in NaTaO3‐xNy....

Read More thumbnail image: Control of nitrogen doping in NaTaO 3 synthesized by hydrothermal reaction and chemical state of nitrogen

Fluorescent molecularly imprinted nanoparticles for selective and rapid detection of ciprofloxacin in aquaculture water

Published: Sep 13, 2018

Author(s): Chunxia Wu, Rujia Cheng, Jixiang Wang, Yunyun Wang, Xuan Jing, Rongru Chen, Lin Sun, Yongsheng Yan

Journal: Journal of Separation Science

Abstract Fluorescent molecularly imprinted nanoparticles have shown great promise in the field of chemical analysis or detection because of their high stability, selectivity, and sensitivity. In this work, fluorescent molecularly imprinted nanoparticles were synthesized by precipitation polymerization employing fluorescein isothiocyanate as luminescent material, which could efficiently and rapidly detect ciprofloxacin in water...

Read More thumbnail image: Fluorescent molecularly imprinted nanoparticles for selective and rapid detection of ciprofloxacin in aquaculture water

Improving the interfacial strength of CF/PMMA composites by grafting GO

Published: Sep 13, 2018

Author(s): Zhang Shengbo, Dai Qingling

Journal: Surface and Interface Analysis

Graphene oxides (GOs) are incorporated into the carbon fiber surface to enhance the interfacial bonding of carbon fiber reinforced poly (methyl methacrylate) composite. GO nanoparticles distributed onto the fiber surface uniformly, which could increase surface polarity and roughness obviously. A large number of functional groups were introduced to the fiber surface, and the surface roughness was increased. Simultaneous increases of...

Read More thumbnail image: Improving the interfacial strength of CFPMMA composites by grafting GO

Identification, isolation, characterization, and UHPLC quantification of potential genotoxic impurities in linagliptin

Published: Sep 13, 2018

Author(s): Yiwen Huang, Hui Lu, Fuli Zhang, Chunyan Min

Journal: Journal of Separation Science

Abstract During the stress testing of linagliptin, one unknown degradation product (impurity I) on acidic conditions was detected by using high‐performance liquid chromatography and subsequently isolated, identified, and characterized by the spectral data (MS, MS/MS, 1D and 2D NMR spectroscopy, and IR spectroscopy) and finally subjected for mechanism analysis. The degradation product (impurity I) and another process‐related impurity...

Read More thumbnail image: Identification isolation characterization and UHPLC quantification of potential genotoxic impurities in linagliptin

Lenalidomide, a blockbuster drug for the treatment of multiple myeloma: Semipreparative separation through supercritical fluid chromatography and vibrational circular dichroism spectroscopy

Published: Sep 13, 2018

Author(s): Yilun Yan, Jun Fan, Dong Guo, Yuemei Lin, Yecai Lai, Tai Wang, Hao Gao, Xinsheng Yao, Weiguang Zhang

Journal: Journal of Separation Science

Abstract Semipreparative separation of lenalidomide has been performed through supercritical fluid chromatography. In regard to retention and resolution of lenalidomide, effects of chromatographic conditions, such as chiral stationary phases, organic co‐solvents, mobile phases, and column temperature, have been studied in detail. Amylose tris(3, 5‐dimethylphenylcarbamate)‐coated and the single‐urea‐bound β‐cyclodextrin chiral...

Read More thumbnail image: Lenalidomide a blockbuster drug for the treatment of multiple myeloma Semipreparative separation through supercritical fluid chromatography and vibrational circular dichroism spectroscopy

Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin

Published: Sep 13, 2018

Author(s): Yanan Li, Hong Chen, Yu Zhu, Tingting Zhang, Jiali Gu, Yongxia Xu, Jianrong Li

Journal: Journal of Separation Science

Abstract A technique of diffusive gradients in thin films with ciprofloxacin‐molecularly imprinted polymers as the binding agent was developed for in situ selective sampling and measurement of ciprofloxacin in water. The ciprofloxacin uptake by the method increased linearly with time (r2 = 0.998) with a recovery of 96.8% in synthetic solution. The method performance was not dependent on solution pH over the pH range of...

Read More thumbnail image: Molecularly imprinted polymer based diffusive gradients in thinfilms for in situ selective sampling and determination of ciprofloxacin

Sputtering yield for Na and Cl ions on a graphene and SiC membrane in the reverse osmosis method

Published: Sep 13, 2018

Author(s): Sanaa Rochd, Meriem El Marsi, Soufiya Mizani, Latifa Salama, Souad Lahlou, Rachida Moultif, Aouatif Dezairi

Journal: Surface and Interface Analysis

Graphene is a single layer thick consisted by honeycomb‐packed sp2 carbon atom; nanoporous graphene holds great promise in the application of filtration such as reverse osmosis method using a semipermeable membrane to remove ions, molecules, and larger particles from drinking water. The movement of molecules and ions can caused by a collision between the ions, molecules, and the graphene, so we can talk about the sputtering. In this ...

Read More thumbnail image: Sputtering yield for Na and Cl ions on a graphene and SiC membrane in the reverse osmosis method

Moment analysis for reaction kinetics of intermolecular interactions

Published: Sep 13, 2018

Author(s): Kanji Miyabe

Journal: ELECTROPHORESIS

Abstract Moment equations were developed on the basis of the principle of relativity for analyzing elution peak profiles measured by ACE to analytically determine the association (ka) and dissociation (kd) rate constants of intermolecular interactions. Basic equations representing the mass balance, mass transfer rate, and reaction kinetics in ACE system in a Galilean coordinate system S were transformed to those in another coordinate system S′,...

Read More thumbnail image: Moment analysis for reaction kinetics of intermolecular interactions

Surface chemical states of gold nanoparticles prepared using the solution‐plasma method in a CsCl aqueous solution

Published: Sep 13, 2018

Author(s): Chie Tsukada, Hikaru Yoshida, Satoshi Ogawa, Akitaka Yoshigoe, Shinya Yagi, Tsuyoshi Yaita

Journal: Surface and Interface Analysis

In this study, gold nanoparticles (AuNPs) prepared in a 5 mM CsCl aqueous solution using the solution‐plasma method are characterized via transmission electron microscopy (TEM) and X‐ray photoelectron spectroscopy with synchrotron radiation (SR‐XPS). The particle diameter is measured over the process time via TEM. During the solution‐plasma process, small particles of 2.1 to 2.2‐nm diameter are generated in the CsCl aqueous solution;...

Read More thumbnail image: Surface chemical states of gold nanoparticles prepared using the solutionplasma method in a CsCl aqueous solution

Recent advances of online coupling of sample preparation techniques with ultra high performance liquid chromatography and supercritical fluid chromatography

Published: Sep 13, 2018

Author(s): Yanshan Liang, Ting Zhou

Journal: Journal of Separation Science

Abstract Ultra high performance liquid chromatography and supercritical fluid chromatography techniques are favored because of their high efficiency and fast analysis speed. Although many sample preparation techniques have been coupled with common liquid chromatography online, the online coupling of sample preparation with the two popular chromatography techniques have gained increasing attention owing to the increasing requirements...

Read More thumbnail image: Recent advances of online coupling of sample preparation techniques with ultra high performance liquid chromatography and supercritical fluid chromatography

LC–MS/MS glycomics of idiopathic rapid eye movement sleep behavior disorder

Published: Sep 13, 2018

Author(s): Xue Dong, Stefania Mondello, Firas Kobeissy, Farid Talih, Raffaele Ferri, Yehia Mechref

Journal: ELECTROPHORESIS

Abstract Idiopathic REM sleep behavior disorder (iRBD) is now considered a prodromal stage of an α‑synucleinopathy‐related to neurodegenerative disease such as Parkinson's diseases. Emerging evidence has shown that post‐translational modification or glycosylation are implicated in dynamic disease mechanisms and the onset of many pathological conditions. We hypothesized that the characterization of the glycosylation pattern of...

Read More thumbnail image: LCMSMS glycomics of idiopathic rapid eye movement sleep behavior disorder

A simple gradient equilibrium method for better separation in countercurrent chromatography

Published: Sep 13, 2018

Author(s): Kai‐Jun Quan, Xing‐jun Xi, Xin‐Yi Huang, Wen‐Da Duan, Dong Pei, Duo‐Long Di

Journal: Journal of Separation Science

Abstract The stationary phase retention is one of the most important parameters in countercurrent chromatography. In this work, a simple gradient equilibrium method was developed to further improve the stationary phase retention based on the optimized condition in the traditional equilibrium model. Meanwhile, this novel gradient equilibrium method was used to separate three flavone model compounds and compared with the conventional...

Read More thumbnail image: A simple gradient equilibrium method for better separation in countercurrent chromatography

Covalent triazine‐based frameworks/iron oxide for highly sensitive magnetic solid‐phase extraction of phenolic pollutants in water samples

Published: Sep 13, 2018

Author(s): Jin‐Qing Ma, Ji‐Yun Ren, Lei‐Lei Wang, Xia Wang, Jin‐Ming Lin, Ru‐Song Zhao

Journal: Journal of Separation Science

Abstract This study demonstrates for the first time the enrichment potential of covalent triazine‐based frameworks/iron oxide for the magnetic solid‐phase extraction of seven typical polar phenolic pollutants. Important parameters, such as the eluant and its volume, adsorbent amounts, sample pH, extraction time, and ionic strength, were optimized in detail. Under the optimal conditions, low limits of detection...

Read More thumbnail image: Covalent triazinebased frameworksiron oxide for highly sensitive magnetic solidphase extraction of phenolic pollutants in water samples

Recent development trends for chiral stationary phases based on chitosan derivatives, cyclofructan derivatives and chiral porous materials in high performance liquid chromatography

Published: Sep 13, 2018

Author(s): Sheng‐Ming Xie, Li‐Ming Yuan

Journal: Journal of Separation Science

Abstract The separation of enantiomers by chromatographic methods, such as gas chromatography, high‐performance liquid chromatography and capillary electrochromatography, has become an increasingly significant challenge over the past few decades due to the demand of pharmaceutical, agrochemical, and food analysis. Among these chromatographic resolution methods, high‐performance liquid chromatography based on chiral stationary phases...

Read More thumbnail image: Recent development trends for chiral stationary phases based on chitosan derivatives cyclofructan derivatives and chiral porous materials in high performance liquid chromatography

Applications of polydopamine modifications in capillary electrophoretic analysis

Published: Sep 13, 2018

Author(s): Hao Zhang, Feng‐Qing Yang

Journal: Journal of Separation Science

Abstract Mussel‐inspired polydopamine has been widely used in capillary electrophoresis as a facile and universal tool for the surface modification of capillary, mainly due to its versatility, stability, strong adhesiveness, and biocompatibility properties. In this review, the recent development of mussel‐inspired surface chemistry with rapid deposition of polydopamine was introduced, and the recent applications of polydopamine in...

Read More thumbnail image: Applications of polydopamine modifications in capillary electrophoretic analysis

Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix‐assisted laser desorption/ionization mass spectrometry

Published: Sep 13, 2018

Author(s): Oliver J. Hale, Pavel Ryumin, Jeffery M. Brown, Michael Morris, Rainer Cramer

Journal: Rapid Communications in Mass Spectrometry

Rationale Liquid atmospheric pressure matrix‐assisted laser desorption/ionisation (AP‐MALDI) has been shown to enable the production of electrospray ionisation (ESI)‐like multiply charged analyte ions with little sample consumption and long‐lasting, robust ion yield for sensitive analysis by mass spectrometry (MS). Previous reports have focused on positive ion production. Here, we report an initial...

Read More thumbnail image: Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrixassisted laser desorptionionization mass spectrometry

Recent advances in the preparation of adsorbent layers for thin‐layer chromatography combined with matrix‐assisted laser desorption/ionization mass‐spectrometric detection

Published: Sep 13, 2018

Author(s): Elizaveta Kucherenko, Anastasiia Kanateva, Andrey Pirogov, Alexander Kurganov

Journal: Journal of Separation Science

Abstract This review is focused on planar chromatography hyphenated with mass‐spectrometric detection for analysis of low‐molecular‐mass solutes. Various kinds of hyphenations are discussed with attention paid to the preparation of thin layer plates suited both for the mass‐spectrometric detection of the resolved solutes direct from thin‐layer plates and for indirect mass‐spectrometric detection of the resolved solutes, performed by...

Read More thumbnail image: Recent advances in the preparation of adsorbent layers for thinlayer chromatography combined with matrixassisted laser desorptionionization massspectrometric detection

Last ten years (2008–2018) of chiral ligand‐exchange chromatography in HPLC: An updated review

Published: Sep 13, 2018

Author(s): Federica Ianni, Lucia Pucciarini, Andrea Carotti, Serena Natalini, Gulnara Z. Raskildina, Roccaldo Sardella, Benedetto Natalini

Journal: Journal of Separation Science

Abstract Chiral ligand‐exchange chromatography is one of the elective strategies for the direct enantioresolution of small chelating compounds: amino acids, diamines, amino alcohols, diols, small peptides, etc. Unlike other methods, the interaction between chiral selector and analyte enantiomers is mediated by a cation, thus producing diastereomeric ternary complexes. Two main approaches are conventionally applied in chiral...

Read More thumbnail image: Last ten years 20082018 of chiral ligandexchange chromatography in HPLC An updated review
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