EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

T‐Cell Immunopeptidomes Reveal Cell Subtype Surface Markers Derived From Intracellular Proteins

Published: Apr 18, 2018

Author(s): Niclas Olsson, Liora M. Schultz, Lichao Zhang, Michael S. Khodadoust, Rupa Narayan, Debra K. Czerwinski, Ronald Levy, Joshua E. Elias

Journal: PROTEOMICS

Abstract Immunopeptidomes promise novel surface markers as ideal immunotherapy targets, but their characterization by mass spectrometry (MS) remains challenging. Until recently, cell numbers exceeding 109 were needed to survey thousands of HLA ligands. Such limited analytical sensitivity has historically constrained the types of clinical specimens that can be evaluated to cell cultures or bulk tissues. Measuring immunopeptidomes from purified...

Read More thumbnail image: TCell Immunopeptidomes Reveal Cell Subtype Surface Markers Derived From Intracellular Proteins

Quantitative assessment of mAb Fc glycosylation of CQA importance by capillary electrophoresis

Published: Apr 18, 2018

Author(s): Marton Szigeti, Jeff Chapman, Beata Borza, Andras Guttman

Journal: ELECTROPHORESIS

Abstract The attached carbohydrates at the highly conserved asparagine‐linked glycosylation site in the CH2 domain of the fragment crystallizable (Fc) region of monoclonal antibody therapeutics can play an essential role in their mechanism of action, including ADCC, CDC, anti‐inflammatory functions, and serum half‐life. Thus, this particular glycosylation represents one of the important critical quality attributes (CQA) of therapeutic...

Read More thumbnail image: Quantitative assessment of mAb Fc glycosylation of CQA importance by capillary electrophoresis

Use of capillary electrophoresis for characterisation of vinyl‐terminated Au nanoprisms and nanooctahedra

Published: Apr 18, 2018

Author(s): Carlos Adelantado, Manuel Algarra, Mohammed Zougagh, Ángel Ríos

Journal: ELECTROPHORESIS

Abstract It is described a simple, rapid and efficient methodology to characterise and separate gold nanoprisms and nanooctahedra by capillary electrophoresis. This technique is suitable to distinguish between morphologies and it can be used as a powerful separation tool after a customised synthesis of both structures. This synthesis was carried out by amending two parameters, temperature and pH, and a sharp decrease was found in...

Read More thumbnail image: Use of capillary electrophoresis for characterisation of vinylterminated Au nanoprisms and nanooctahedra

Determination of phenolic compounds in ancient and modern durum wheat genotypes

Published: Apr 18, 2018

Author(s): Alessandro Di Loreto, Sara Bosi, Lidia Montero, Valeria Bregola, Ilaria Marotti, Rocco Enrico Sferrazza, Giovanni Dinelli, Miguel Herrero, Alejandro Cifuentes

Journal: ELECTROPHORESIS

Abstract Due to its significant amount of antioxidants, durum wheat (Triticum turgidum ssp. durum) could potentially contribute to the protection against a number of chronic diseases, such as diabetes, cardiovascular disease, and cancer. The increasing interest toward healthy food among both consumers and scientists has moved the focus toward the phytochemical content of whole wheat grains. The aim of this study was to identify the...

Read More thumbnail image: Determination of phenolic compounds in ancient and modern durum wheat genotypes

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Published: Apr 17, 2018

Author(s): James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Journal: PROTEOMICS

Abstract Signal transduction cascades governed by kinases and GTPases are a critical component of the command and control of cellular processes, with the precise outcome partly determined by direct protein–protein interactions (PPIs). Here, we use the human ROCO proteins as a model for investigating PPI signaling events—taking advantage of the unique dual kinase/GTPase activities and scaffolding properties of these multidomain...

Read More thumbnail image: Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

Improved interfacial properties of PI composites through graphene oxide and carbon nanotubes on carbon fiber surface

Published: Apr 17, 2018

Author(s): Lv Yongqiang, Peng Chunzheng

Journal: Surface and Interface Analysis

Carbon nanotubes (CNTs) have been identified as excellent nanoreinforcements for carbon fiber (CF)–reinforced polymers regarding a wide range of engineering applications. The outstanding properties of CNTs, such as their large surface area, high mechanical strength, and low manufacturing cost bring them to be distinguished nanoreinforcements for carbon fiber–reinforced polymers to form multifunctional and multiscale composites....

Read More thumbnail image: Improved interfacial properties of PI composites through graphene oxide and carbon nanotubes on carbon fiber surface

Study of the Au‐Cr bilayer system using X‐ray reflectivity, GDOES, and ToF‐SIMS

Published: Apr 17, 2018

Author(s): Philippe Jonnard, Mohammed H. Modi, Karine Le Guen, Nargish Aneshwari, Mangalika Sinha, Mourad Idir, Patrick Chapon, Anouk Galtayries

Journal: Surface and Interface Analysis

We study a Au (25 nm)/Cr (10 nm) bilayer system as a model of mirror for the soft X‐ray energy range. The Au and Cr thin films are a few nanometer thick and are deposited on a float glass substrate. The sample is characterized by using 3 complementary techniques: soft X‐ray reflectivity, glow discharge optical emission spectrometry (GDOES), and time‐of‐flight secondary ion mass spectroscopy (ToF‐SIMS). Soft X‐ray reflectivity...

Read More thumbnail image: Study of the AuCr bilayer system using Xray reflectivity GDOES and ToFSIMS

Surface and redox characterization of new nanostructured ZrO 2 @CeO 2 systems with potential catalytic applications

Published: Apr 17, 2018

Author(s): Adrián Barroso‐Bogeat, Bernardo Núñez‐Pérez, Ginesa Blanco, José María Pintado, Juan Carlos Hernández‐Garrido, José Juan Calvino

Journal: Surface and Interface Analysis

Ceria‐zirconia mixed oxides are widely used as catalysts and catalytic supports. Nevertheless, due to economic and geo‐strategic concerns, reducing and optimizing the lanthanide content in these formulations while preserving or even improving their excellent redox and catalytic properties has become a challenge for current research. In this context, the design of core@shell nanostructures arises as a feasible alternative to achieve the...

Read More thumbnail image: Surface and redox characterization of new nanostructured ZrO 2 CeO 2 systems with potential catalytic applications

Comment on I ntensity modulation of the Shirley background of the C r3p spectra with photon energies around the C r2p edge by A H errera G omez D C abrera G erman A D D utol et al S urface I nterface A nal 2018 50 246252

Published: Apr 17, 2018

Author(s): R. Bavand, L. Chen, R. França, S. Loran, D.‐Q. Yang, A. Yelon, G.‐X. Zhang, E. Sacher

Journal: Surface and Interface Analysis

We show that, while the Shirley background lacks a theoretical basis, its use satisfies the condition for the proper modeling of all these backgrounds when properly applied. We present these four conditions of applicability, discuss their use, and indicate where their lack of use gives misleading results.

Read More thumbnail image: Comment on  I ntensity modulation of the Shirley background of the C r3p spectra with photon energies around the C r2p edge by A H errera G omez D C abrera G erman A D D utol et al S urface I nterface A nal 2018 50 246252

Electrodeposition of poly(acrylic acid) on stainless steel with enhanced adhesion properties

Published: Apr 17, 2018

Author(s): D. Meinderink, A. G. Orive, G. Grundmeier

Journal: Surface and Interface Analysis

A facile electrochemical methodology to prepare poly(acrylic acid) (PAA) thin films in mildly acid aqueous solutions onto stainless steel is presented. Together with the PAA, the codeposition of Zn species is observed. The latter can be further removed by rinsing with dilute HCl aqueous solutions. These PAA‐modified steel samples have been characterized by infrared reflection absorption spectroscopy and atomic force microscopy and exhibit...

Read More thumbnail image: Electrodeposition of polyacrylic acid on stainless steel with enhanced adhesion properties

Investigation of work function and chemical composition of thin films of borides and nitrides

Published: Apr 17, 2018

Author(s): A. Mezzi, P. Soltani, S. Kaciulis, A. Bellucci, M. Girolami, M. Mastellone, D. M. Trucchi

Journal: Surface and Interface Analysis

Thin films of various borides, nitrides, and barium fluorides were tentatively deposited by pulsed laser deposition and by magnetron sputtering in order to develop the components of thermionic‐photovoltaic devices for the high‐temperature thermal to electrical conversion by solid state. To improve the device performance, the materials characterized by a low work function were selected. In the present work, the chemical composition and...

Read More thumbnail image: Investigation of work function and chemical composition of thin films of borides and nitrides

Depth analysis of Al/ZrC interfaces using SIMS and x‐ray reflectivity

Published: Apr 17, 2018

Author(s): Mohammed H. Modi, Mangalika Sinha, Aniruddha Bose, Amol Singh, Philippe Jonnard

Journal: Surface and Interface Analysis

Al/ZrC/Al/W multilayer structure is suitable for waveguide applications in the hard X‐ray region in order to confine the wave field in a nanometer‐thick layer. Intermixing of Al at the interfaces is a serious problem to achieve the expected performances from an experimentally grown multilayer. In the present study, the effect of a carbon capping layer in a C/Al/ZrC/Al/W waveguide structure is determined using time of flight secondary ion...

Read More thumbnail image: Depth analysis of AlZrC interfaces using SIMS and xray reflectivity

Raman spectroscopy of the photosensitive pigment Prussian blue

Published: Apr 17, 2018

Author(s): Giulia Moretti, Claire Gervais

Journal: Journal of Raman Spectroscopy

Abstract Prussian blue is a pigment highly sensitive to electromagnetic radiation, visible light included. This photosensitivity, associated with a complex redox behavior, causes a vulnerability even to Raman lasers, with the possibility of sample alteration or irreversible damage. In this study, we systematically explored the influence of the laser wavelength and laser power on different types of Prussian blue pigments, soluble and...

Read More thumbnail image: Raman spectroscopy of the photosensitive pigment Prussian blue

Cascade Mi (i = 1–5) subshell X ‐ray emission at incident photon energies across the Lj (j = 1–3) subshell absorption edges of 66Dy

Published: Apr 17, 2018

Author(s): Rajnish Kaur, Anil Kumar, Mateusz Czyzycki, Alessandro Migliori, Andreas G. Karydas, Sanjiv Puri

Journal: X-Ray Spectrometry

The total M shell and the Mk (k = ξ, αβ, γ, m) X‐ray production cross sections for 66Dy have been measured at incident photon energies across its Lj (j = 1–3) subshell absorption edge energies, ranging 7.8–9.2 keV. This study aims to investigate the evolution of the probability for cascade decay of Lj subshell vacancies as the tunable incident energy ionizes progressively different 66Dy Lj subshells. The experimental X‐ray production...

Read More thumbnail image: Cascade Mi i15 subshell X ray emission at incident photon energies across the Lj j13 subshell absorption edges of 66Dy

A microscale HPLC‐UV method for the determination of latamoxef in plasma: An adapted method for therapeutic drug monitoring in neonates

Published: Apr 16, 2018

Author(s): Qian Dong, Hai‐Yan Shi, Chen Kou, Xin Huang, A‐Dong Shen, Wei Zhao

Journal: Biomedical Chromatography

Abstract Latamoxef, a broad‐spectrum anti‐bacterial agent of the β‐lactam antibiotics, is used off‐label in treatment of neonatal sepsis. Large inter‐individual variability and uncertainty of treatment make therapeutic drug monitoring (TDM) useful to optimize antimicrobial therapy. The objective of this study was to develop and validate a simple, selective and reliable HPLC method for the determination of latamoxef in small volumes ...

Read More thumbnail image: A microscale HPLCUV method for the determination of latamoxef in plasma An adapted method for therapeutic drug monitoring in neonates

Site‐Specific Systematic Analysis of Lysine Modification Crosstalk

Published: Apr 16, 2018

Author(s): Hao‐Dong Xu, Li‐Na Wang, Ping‐Ping Wen, Shao‐Ping Shi, Jian‐Ding Qiu

Journal: PROTEOMICS

Abstract Research has revealed that post‐translational modifications (PTMs) that occur at lysine (PLMs) can cooperatively regulate various biological processes by crosstalk. However, the trend of the crosstalk between multiple PLMs and the properties of PLM crosstalk require additional investigation. Here, the crosstalk among acetylation, succinylation, and SUMOylation is systematically studied in a site‐specific waz. First,...

Read More thumbnail image: SiteSpecific Systematic Analysis of Lysine Modification Crosstalk

Applications of liquid‐based separation in conjunction with mass spectrometry to the analysis of forensic evidence

Published: Apr 16, 2018

Author(s): Mehdi Moini

Journal: ELECTROPHORESIS

Abstract In the past few years, there has been a significant effort by the forensic science community to develop new scientific techniques for the analysis of forensic evidence. Forensic chemists have been spearheaded to develop information‐rich confirmatory technologies and techniques and apply them to a broad array of forensic challenges. The purpose of these confirmatory techniques is to provide alternatives to presumptive...

Read More thumbnail image: Applications of liquidbased separation in conjunction with mass spectrometry to the analysis of forensic evidence

Quinine‐modified polymer monolithic column with reversed‐phase /strong anion‐exchange mixed‐mode for pressurized capillary electrochromatography

Published: Apr 16, 2018

Author(s): Jiabin Wang, Changying Ding, Jianhua Xiao, Wenchao Jia, Yongxuan Chen, Xucong Lin, Zenghong Xie

Journal: ELECTROPHORESIS

Abstract Via the facile ring‐opening reaction of epoxy groups with quinine, a novel polymer monolith with quaternary ammonium for reversed‐phase/strong anion‐exchange mixed‐mode has been fabricated for pressurized capillary electrochromatography (pCEC). Optimization on the preparation of quinine‐modified monoliths has been investigated, and characteristics including morphology, permeability, mechanical stability, reproducibility,...

Read More thumbnail image: Quininemodified polymer monolithic column with reversedphase strong anionexchange mixedmode for pressurized capillary electrochromatography

Effect of solvent on the extraction of phenolic compounds and antioxidant capacity of hazelnut kernel

Published: Apr 16, 2018

Author(s): Chiara Fanali, Giusy Tripodo, Marina Russo, Susanna Della Posta, Valentina Pasqualetti, Laura Gara

Journal: ELECTROPHORESIS

Abstract Hazelnut kernel phenolic compounds were recovered applying two different extraction approaches, namely ultrasound‐assisted solid/liquid extraction (UA‐SLE) and solid‐phase extraction (SPE). Different solvents were tested evaluating total phenolic compounds and total flavonoids contents together to antioxidant activity. The optimum extraction conditions, in terms of the highest value of total phenolic compounds extracted...

Read More thumbnail image: Effect of solvent on the extraction of phenolic compounds and antioxidant capacity of hazelnut kernel

Three‐dimensional microfluidic chip with twin‐layer herringbone structure for high efficient tumor cell capture and release via antibody‐conjugated magnetic microbeads

Published: Apr 16, 2018

Author(s): Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue

Journal: ELECTROPHORESIS

Abstract Harvesting rare circulating tumor cells (CTCs) from human blood is distinctly substantial to monitor tumor stage and evaluate therapeutic efficacy. As a proof‐of‐concept study, a microfluidic chip with twin‐layer herringbone grooves was developed to isolate and recover tumor cells with high efficiency based on the immunoreaction between cells and antibody‐conjugated microbeads (MBs) under local magnetic field. Functional...

Read More thumbnail image: Threedimensional microfluidic chip with twinlayer herringbone structure for high efficient tumor cell capture and release via antibodyconjugated magnetic microbeads
Page:   Prev 1 2 3 4 5 6 7 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in spectroscopy? Visit our sister site spectroscopyNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved