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Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual‐mixed/cell membrane chromatography model

Published: Feb 6, 2018

Author(s): Shengli Han, Yanni Lv, Liyun Kong, Yueming Sun, Jia Fu, Lingjun Li, Langchong He

Journal: ELECTROPHORESIS

Abstract Traditional Chinese medicine (TCM) has been used for prevention and treatment of various diseases for many decades. TCM injection is a new dosage form, with incidence of anaphylactoid reactions increasing every year. In this study, the rat basophilic leukemia 2H3 (RBL‐2H3) and laboratory of allergic disease 2 (LAD2) dual‐mixed/CMC was established and was coupled with an HPLC‐ESI‐IT‐TOF‐MS system to identify the potential...

Read More thumbnail image: Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dualmixedcell membrane chromatography model

Identification of oxymorphone as decomposition product of the permitted drug methylnaltrexone

Published: Feb 6, 2018

Author(s): T. Sobolevsky, Y. Kucherova, B. Ahrens

Journal: Drug Testing and Analysis

Read More thumbnail image: Identification of oxymorphone as decomposition product of the permitted drug methylnaltrexone

Effect of glucocorticoid administration on the steroid profile

Published: Feb 6, 2018

Author(s): Sergi Coll, Xavier Matabosch, Lorena Garrostas, Clara Perez‐Maña, Rosa Ventura

Journal: Drug Testing and Analysis

Abstract The steroid profile (SP) is a powerful tool to detect the misuse of endogenous anabolic androgenic steroids in sports, and it is included in the Athlete Biological Passport (ABP). Glucocorticoids (GCs), which are widely prescribed in sports and only prohibited in competition by systemic routes, inhibit the hypothalamic‐pituitary‐adrenal axis. Since the metabolites monitored in the SP have a partial adrenal origin, their...

Read More thumbnail image: Effect of glucocorticoid administration on the steroid profile

Resonant broadband stimulated Raman scattering in myoglobin

Published: Feb 6, 2018

Author(s): C. Ferrante, G. Batignani, G. Fumero, E. Pontecorvo, A. Virga, L. C. Montemiglio, G. Cerullo, M. H. Vos, T. Scopigno

Journal: Journal of Raman Spectroscopy

Abstract Spontaneous Raman is a well‐established tool to probe molecular vibrations. Under resonant conditions, it is a largely used method for characterizing the structure of heme‐proteins. In recent years, advances in pulsed laser sources allowed to explore vibrational features with complex techniques based on nonlinear optical interactions, among which is stimulated Raman scattering (SRS). Building on its combined...

Read More thumbnail image: Resonant broadband stimulated Raman scattering in myoglobin

On the SERS quantitative determination of organic dyes

Published: Feb 6, 2018

Author(s): Marilena Ricci, Elisa Trombetta, Emilio Castellucci, Maurizio Becucci

Journal: Journal of Raman Spectroscopy

Abstract The use of surface‐enhanced Raman scattering methods for the quantitative determination of different molecular species is not trivial as many parameters seriously affect the outcome of any experiment. In this work, we use as a case study the quantitative analysis of ionic organics dyes. We report on the role of different molecular properties to the modulation of the surface‐enhanced Raman scattering signal, the useful...

Read More thumbnail image: On the SERS quantitative determination of organic dyes

A validated liquid chromatography‐high resolution‐tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma

Published: Feb 5, 2018

Author(s): Kathrin Arnhard, Florian Pitterl, Barbara Sperner‐Unterweger, Dietmar Fuchs, Therese Koal, Herbert Oberacher

Journal: ELECTROPHORESIS

Abstract Tryptophan (TRP) catabolism via the kynurenine pathway is considered to represent a major link between inflammation and various diseases, including neurodegenerative disorders, depression, schizophrenia, multiple sclerosis, cardiovascular disease, and cancer. The kynurenine pathway and levels of TRP and its metabolites kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) are well regulated under physiological...

Read More thumbnail image: A validated liquid chromatographyhigh resolutiontandem mass spectrometry method for the simultaneous quantitation of tryptophan kynurenine kynurenic acid and quinolinic acid in human plasma

Determination of isoorientin levels in rat plasma after oral administration of Vaccinum bracteatum Thunb. methanol extract by high‐performance liquid chromatography‐tandem mass spectrometry

Published: Feb 2, 2018

Author(s): Min‐Ji Kim, Seung‐Hwan Kwon, Choon‐Gon Jang, Han‐Joo Maeng

Journal: Biomedical Chromatography

Abstract A simple, sensitive and rapid liquid chromatography tandem mass spectrometry method (LC‐MS/MS) was developed and validated for the determination of plasma isoorientin levels in rats. After simple protein precipitation using methanol, chromatographic analysis was performed using a Synergi 4μ polar‐RP 80A column (150 × 2.0 mm, 4μm) under isocratic conditions and a mobile phase consisting of 0.1% formic acid in water and...

Read More thumbnail image: Determination of isoorientin levels in rat plasma after oral administration of Vaccinum bracteatum Thunb_ methanol extract by highperformance liquid chromatographytandem mass spectrometry

External RBS analysis setup at U niversity of G öttingen: RBS analysis for liquid samples

Published: Feb 2, 2018

Author(s): M. Saito, K. Holm, F. L. Bregolin, H. Hofsäss

Journal: Surface and Interface Analysis

In this work, we describe new developments in the external analysis setup at University of Göttingen. The aim of this work is to expand the ability of the setup for performing Rutherford backscattering spectrometry (RBS) in atmospheric condition. This work presents the detail of the developed device for external RBS, as well as the initial result of RBS analysis for a volatile liquid sample. We also made an electrochemical cell with a...

Read More thumbnail image: External RBS analysis setup at U niversity of G ottingen RBS analysis for liquid samples

All‐dielectric core/shell resonators: From plasmon‐free SERS to multimodal analysis

Published: Feb 2, 2018

Author(s): Nicolò Bontempi, Irene Vassalini, Ivano Alessandri

Journal: Journal of Raman Spectroscopy

Abstract All‐dielectric materials are emerging as a new class of substrates for enhanced Raman scattering. As ohmic losses are reduced in the absence of plasmonic metals, Raman data obtained with dielectrics are very reproducible and reliable. This mini‐review summarizes our recent work in the field of core/shell dielectric resonators designed for Raman purposes, with a special focus on SiO2/TiO2 (T‐rex) core/shell beads. These...

Read More thumbnail image: Alldielectric coreshell resonators From plasmonfree SERS to multimodal analysis

Simultaneous analysis of oral anticancer drugs for renal cell carcinoma in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry

Published: Feb 1, 2018

Author(s): Shinya Takasaki, Masaki Tanaka, Masafumi Kikuchi, Masamitsu Maekawa, Yoshihide Kawasaki, Akihiro Ito, Yoichi Arai, Hiroaki Yamaguchi, Nariyasu Mano

Journal: Biomedical Chromatography

Abstract An analytical method using high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry has been developed and validated for simultaneous measurement of four tyrosine kinase inhibitors used for renal cell carcinoma and their metabolites in human plasma. Despite their similar structures, it is difficult to measure plasma levels of these compounds simultaneously using optimal MS parameters for each...

Read More thumbnail image: Simultaneous analysis of oral anticancer drugs for renal cell carcinoma in human plasma using liquid chromatographyelectrospray ionization tandem mass spectrometry

Ensemble learning model based on selected diverse principal component analysis models for process monitoring

Published: Feb 1, 2018

Author(s): Zhichao Li, Xuefeng Yan

Journal: Journal of Chemometrics

Abstract Principal component analysis (PCA) is extensively applied in industrial process monitoring. For optimal performance monitoring, different faults may require different principal components (PCs). However, at present, it only selects PCs of the highest variance to create a single PCA model, thereby leading to information loss and poor monitoring performance. For the solution of this problem, a method based on ensemble...

Read More thumbnail image: Ensemble learning model based on selected diverse principal component analysis models for process monitoring

Interview with David A. Case: On force fields, biomolecular modeling, and NMR

Published: Feb 1, 2018

Author(s): David A. Case, Nikolai R. Skrynnikov

Journal: Concepts in Magnetic Resonance Part A

Abstract Prof. David Case is based in the Department of Chemistry and Chemical Biology at Rutgers University. In this interview he speaks about force field development and validation, predictive power of MD models, combining physics‐based force fields with empirical scoring functions, MD modeling of disordered proteins and RNA, synergies between MD simulations and NMR measurements, and chemical shift calculations. The video of this...

Read More thumbnail image: Interview with David A_ Case On force fields biomolecular modeling and NMR

Development of an immunochromatographic strip incorporating anti‐mitragynine monoclonal antibody conjugated to colloidal gold for kratom alkaloids detection

Published: Jan 30, 2018

Author(s): Supattra Limsuwanchote, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto, Niwat Keawpradub, Juraithip Wungsintaweekul

Journal: Drug Testing and Analysis

Abstract A lateral flow‐based immunochromatographic strip was developed for the rapid detection of mitragynine (MG), a dominant alkaloid found in the leaves of kratom. Monoclonal antibody (mAb) against MG (anti‐MG mAb) was conjugated to colloidal gold and used as a recognition probe. MG‐ovalbumin conjugate (MG‐OVA) and goat anti‐mouse IgG were immobilized on the strip to produce a test zone and control zone, respectively. Based on...

Read More thumbnail image: Development of an immunochromatographic strip incorporating antimitragynine monoclonal antibody conjugated to colloidal gold for kratom alkaloids detection

Phase I metabolism of the recently emerged synthetic cannabinoid CUMYL‐PEGACLONE and detection in human urine samples

Published: Jan 30, 2018

Author(s): Lukas Mogler, Maurice Wilde, Laura M. Huppertz, Georg Weinfurtner, Florian Franz, Volker Auwärter

Journal: Drug Testing and Analysis

Abstract Indole‐, indazole‐, or azaindole‐based synthetic cannabinoids (SCs), bearing a cumyl substituent are a widespread, recreationally used subgroup of new psychoactive substances (NPS). The latest cumyl‐derivative, CUMYL‐PEGACLONE, emerged in December 2016 on the German drug market. The substance features a novel γ‐carboline core structure, which is most likely synthesized to bypass generic legislative approaches to control SCs by...

Read More thumbnail image: Phase I metabolism of the recently emerged synthetic cannabinoid CUMYLPEGACLONE and detection in human urine samples

The quality is in the eye of the beholder: The perspective of FTIR and UV resonant Raman spectroscopies on extracted nucleic acids

Published: Jan 30, 2018

Author(s): P. Zucchiatti, K. Latella, G. Birarda, L. Vaccari, B. Rossi, A. Gessini, C. Masciovecchio, F. D'Amico

Journal: Journal of Raman Spectroscopy

Abstract The quality of a sample has always to be considered with respect to its purposes and to the technique used for assessing it. The aim of this work is to point out the most common interfering agents that vibrational spectroscopists may find when analyzing nucleic acids extracted from cellular cultures. Fourier transformed infrared and ultraviolet‐resonant Raman measurements have been carried out on DNA and RNA samples...

Read More thumbnail image: The quality is in the eye of the beholder The perspective of FTIR and UV resonant Raman spectroscopies on extracted nucleic acids

Performance of the Early Access AmpliSeq™ Mitochondrial Panel with degraded DNA samples using the Ion Torrent™ platform

Published: Jan 30, 2018

Author(s): Ka Tak Wai, Mark Barash, Peter Gunn

Journal: ELECTROPHORESIS

Abstract The Early Access AmpliSeq™ Mitochondrial Panel amplifies whole mitochondrial genomes for phylogenetic and kinship identifications, using Ion Torrent™ technology. There is currently limited information on its performance with degraded DNA, a common occurrence in forensic samples. This study evaluated the performance of the Panel with DNA samples degraded in vitro, to mimic conditions commonly found in forensic...

Read More thumbnail image: Performance of the Early Access AmpliSeq Mitochondrial Panel with degraded DNA samples using the Ion Torrent platform

Determination of cycloserine in microdialysis samples using liquid chromatography–tandem mass spectrometry with benzoyl chloride derivatization

Published: Jan 29, 2018

Author(s): Wenjing Zhang, Sihui Wan, Lizhi Chen, Xuebin Wang, Zhuo Wang, Yi Huang

Journal: Biomedical Chromatography

Abstract A new method for the analysis of cycloserine (4‐amino‐3‐isoxazolidinone, CYC) in rat microdialysis samples has been developed. This method consists of derivatizing the CYC with benzoyl chloride, which transforms primary amines into highly stable derivatives. An attractive feature of this method was that the derivatization reaction is straightforward and can be completed within 10 min. The formed derivative, in contrast to...

Read More thumbnail image: Determination of cycloserine in microdialysis samples using liquid chromatographytandem mass spectrometry with benzoyl chloride derivatization

Development and validation of LC‐MS/MS method for simultaneous determination of sofosbuvir and daclatasvir in human Plasma: Application to pharmacokinetic study

Published: Jan 29, 2018

Author(s): Ola M. Abdallah, Ahmed M. Abdel‐Megied, Amira S. Gouda

Journal: Biomedical Chromatography

Abstract A simple and highly sensitive liquid chromatography–tandem mass spectrometry (LC‐MS/MS) bioanalytical method was developed and fully validated for the first time for the simultaneous determination of newly discovered antiviral drugs, namely sofosbuvir (SOF) and daclatasvir (DAC) in human plasma. Tadalafil (TAD) was used as internal standard (IS). SOF, DAC and TAD (IS) were extracted from plasma using liquid–liquid...

Read More thumbnail image: Development and validation of LCMSMS method for simultaneous determination of sofosbuvir and daclatasvir in human Plasma Application to pharmacokinetic study

Simultaneous quantification of T4, T3, rT3, 3,5‐T2 and 3,3′‐T2 in larval zebrafish ( Danio rerio ) as a model to study exposure to polychlorinated biphenyls

Published: Jan 29, 2018

Author(s): Xiaopeng Chen, Kyla M. Walter, Galen W. Miller, Pamela J. Lein, Birgit Puschner

Journal: Biomedical Chromatography

Abstract Environmental toxicants that interfere with thyroid hormone (TH) signaling can impact growth and development in animals and humans. Zebrafish represent a model to study chemically induced TH disruption, prompting the need for sensitive detection of THs. Simultaneous quantification of 3,3′,5‐triiodo‐l‐thyronine (T3), thyroxine (T4), 3,3′,5′‐triiodo‐l‐thyronine (rT3), 3,5‐diiodo‐l‐thyronine (3,5‐T2) and 3,3′‐diiodo‐l‐thyronine (3,3′‐T2)...

Read More thumbnail image: Simultaneous quantification of T4 T3 rT3 35T2 and 33T2 in larval zebrafish  Danio rerio  as a model to study exposure to polychlorinated biphenyls

GC‐MS/MS detects potential pregabalin abuse in susceptible subjects’ hair

Published: Jan 25, 2018

Author(s): Federica Ianni, Kyriaki Aroni, Alessio Gili, Roccaldo Sardella, Mauro Bacci, Massimo Lancia, Benedetto Natalini, Cristiana Gambelunghe

Journal: Drug Testing and Analysis

Abstract Pregabalin, a GABA analogue, binds to the alpha 2 delta subunit of voltage‐dependent calcium channels. It is recognised as efficacious in pathologies such as epilepsy, neuropathic pain, and anxiety disorders. Since pregabalin prescriptions have increased worldwide, reports of its abuse have been accumulating, mainly in patients with opioid abuse disorders. The present study investigated potential pregabalin abuse by means...

Read More thumbnail image: GCMSMS detects potential pregabalin abuse in susceptible subjects hair
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