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Translating Immunopeptidomics to Immunotherapy‐Decision‐Making for Patient and Personalized Target Selection

Published: Apr 6, 2018

Author(s): Jens Fritsche, Barbara Rakitsch, Franziska Hoffgaard, Michael Römer, Heiko Schuster, Daniel J. Kowalewski, Martin Priemer, Vlatka Stos‐Zweifel, Helen Hörzer, Arun Satelli, Annika Sonntag, Valentina Goldfinger, Colette Song, Andrea Mahr, Martina Ott, Oliver Schoor, Toni Weinschenk

Journal: PROTEOMICS

Abstract Immunotherapy is revolutionizing cancer treatment and has shown success in particular for tumors with a high mutational load. These effects have been linked to neoantigens derived from patient‐specific mutations. To expand efficacious immunotherapy approaches to the vast majority of tumor types and patient populations carrying only a few mutations and maybe not a single presented neoepitope, it is necessary to expand the...

Read More thumbnail image: Translating Immunopeptidomics to ImmunotherapyDecisionMaking for Patient and Personalized Target Selection

Spectral decomposition of R aman spectra of mixed‐phase TiO2 thin films on Si and silicate substrates

Published: Apr 6, 2018

Author(s): Sebastian Schipporeit, Dieter Mergel

Journal: Journal of Raman Spectroscopy

Abstract We present a method to fit Raman spectra of TiO2 thin films on silicon wafers, fused silica, and crown glass with adjustable model spectra of the different components of the substrate and the thin film. With reasonable restrictions of the fitting parameters, the method developed in this paper allows a simultaneous fit to the measured spectra. The TiO2 thin film spectrum is split into one spectrum for the amorphous phase and spectra for...

Read More thumbnail image: Spectral decomposition of R aman spectra of mixedphase TiO2 thin films on Si and silicate substrates

Raman scattering and phase transitions in (NH4)3TiF7

Published: Apr 6, 2018

Author(s): Y.V. Gerasimova, A.S. Oreshonkov, N.M. Laptash, A.S. Krylov, A.R. Aliev, E.M. Roginskii

Journal: Journal of Raman Spectroscopy

Abstract Raman spectra of (NH4)3TiF7 within spectral range 10–3,400 cm−1 at temperatures 8–370 K are recorded, which revealed 2 phase transitions at temperatures T1 = 355 K and T2 = 283 K. First principles calculations of lattice dynamics and assignment of the observed lines to specific vibrational types are performed. The first phase transition is classified as an “order–disorder” one. Manifestation of 97 cm−1...

Read More thumbnail image: Raman scattering and phase transitions in NH43TiF7

Full‐field XRF instrument for cultural heritage: Application to the study of a Caillebotte painting

Published: Apr 6, 2018

Author(s): Philippe Walter, Philippe Sarrazin, Marc Gailhanou, Dominique Hérouard, Antoine Verney, David Blake

Journal: X-Ray Spectrometry

A novel full‐field X‐ray fluorescence spectrometer developed for cultural heritage applications is presented. Named “CartiX,” it was designed for routine deployment in the field (museum, archeological site) and uses a concept under development at NASA for planetary exploration. CartiX utilizes 2 miniature X‐ray tubes, a square pore Micro‐channel Plate X‐ray Optic, and a direct‐illumination CCD camera to collect spatially resolved X‐ray...

Read More thumbnail image: Fullfield XRF instrument for cultural heritage Application to the study of a Caillebotte painting

A validated, sensitive electrophoretic method for the detection of activin receptor type II‐Fc fusion proteins in human blood

Published: Apr 4, 2018

Author(s): L. Martin, N. Zouhiri, M. Audran, A. Marchand

Journal: Drug Testing and Analysis

Abstract New therapeutic proteins that trap circulating members of the transforming growth factor (TGF) beta superfamily (activins and growth differentiation factors) show promising effects on erythropoiesis and muscular growth. They are dimeric recombinant fusion proteins composed of the extracellular domain of a human activin receptor (ActRIIA or IIB) linked to the Fc part of human IgG1. Sotatercept (ActRIIA‐Fc) and Luspatercept...

Read More thumbnail image: A validated sensitive electrophoretic method for the detection of activin receptor type IIFc fusion proteins in human blood

Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultra‐performance liquid chromatography–tandem mass spectrometry

Published: Apr 3, 2018

Author(s): Yanqing Liu, Hongwu Wang, Su Yao, Peijie Zhu

Journal: Biomedical Chromatography

Abstract A fast and sensitive method involving ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was introduced to detect citrinin in dried orange peel. A series of extraction, purification and chromatographic conditions was also systematically examined. With the proposed method, the obtained calibration graph was linear, with an R of 0.9996 within a concentration range of 0.5–10 ng/mL. The estimated limits of...

Read More thumbnail image: Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultraperformance liquid chromatographytandem mass spectrometry

Separation of positional isomers of nine 2‐phenethylamine‐derived designer drugs by liquid chromatography–tandem mass spectrometry

Published: Apr 3, 2018

Author(s): Christina Grumann, Volker Auwärter

Journal: Drug Testing and Analysis

Abstract The synthesis of positional isomers of designer drugs is a common way of bypassing legal restrictions. For forensic case work, and especially for the legal assessment of cases, there is a need for screening methods capable of the unequivocal identification of positional isomers. The presented liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) method facilitates separation of positional...

Read More thumbnail image: Separation of positional isomers of nine 2phenethylaminederived designer drugs by liquid chromatographytandem mass spectrometry

Validation of a blood marker for plasma volume in endurance athletes during a live‐high train‐low altitude training camp

Published: Apr 3, 2018

Author(s): Louisa M. Lobigs, Laura A. Garvican‐Lewis, Victor L. Vuong, Nicolin Tee, Christopher J. Gore, Peter Peeling, Brian Dawson, Yorck O. Schumacher

Journal: Drug Testing and Analysis

Abstract Altitude is a confounding factor within the Athlete Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; haemoglobin concentration ([Hb]) and the OFF‐score. Endurance athletes (n=34) completed a 21‐night simulated live‐high train‐low (LHTL) protocol...

Read More thumbnail image: Validation of a blood marker for plasma volume in endurance athletes during a livehigh trainlow altitude training camp

Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Published: Mar 30, 2018

Author(s): Claudio A. Téllez Soto, Lázaro P. Medeiros‐Neto, Laurita Santos, André B.O. Santos, Isabelle Ferreira, Priyanka Singh, Renata A. Canevari, Aírton A. Martin

Journal: Journal of Raman Spectroscopy

Abstract Thirty thyroid samples of normal and abnormal tissues were analyzed by infrared and confocal Raman Spectroscopy. We studied the Amide I (1,720–1,580 cm−1) spectral region in order to determine different components of the proteins' secondary structure in the samples. Peak positions of the Amide I bands were determined using the second derivative and Fourier self‐deconvolution of infrared and Raman spectra. We obtained...

Read More thumbnail image: Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Formation of cyanide compounds during preparation of gold surfaces evidenced by surface‐enhanced R aman spectroscopy

Published: Mar 30, 2018

Author(s): A. Merlen, C. Pardanaud, S. Coussan, C. Panagiotopoulos, O. Grauby, Carmen M. Ruiz

Journal: Journal of Raman Spectroscopy

Abstract We report surface‐enhanced Raman spectroscopy (SERS) measurements on nanostructured gold surfaces prepared using a primary vacuum sputtering technique. Even if no molecules have been deposited on the metallic surface, a clear Raman signal is observed. A very intense and sharp peak around 2,100 cm−1 together with low‐wavenumber modes are visible. The comparison between the experimental spectra and those obtained using ...

Read More thumbnail image: Formation of cyanide compounds during preparation of gold surfaces evidenced by surfaceenhanced R aman spectroscopy

Theoretical methods for calculations of optical phonons in BiOBr: Analysis and correction of propagated errors

Published: Mar 30, 2018

Author(s): Mateus M. Ferrer, João Elias F.S. Rodrigues, Marcio A.P. Almeida, Francisco Moura, Elson Longo, Paulo S. Pizani, Julio R. Sambrano

Journal: Journal of Raman Spectroscopy

Abstract Theoretical and experimental methods were employed to investigate the vibrational modes of BiOBr. Wavenumber prediction and assignments of the infrared and Raman modes were performed using density functional theory and lattice dynamics calculations. The theoretical models were directly compared with the experimental results of particles fabricated using the microwave‐assisted hydrothermal method and results reported in...

Read More thumbnail image: Theoretical methods for calculations of optical phonons in BiOBr Analysis and correction of propagated errors

Hydrogen/deuterium exchange in mass spectrometry

Published: Mar 30, 2018

Author(s): Yury Kostyukevich, Thamina Acter, Alexander Zherebker, Arif Ahmed, Sunghwan Kim, Eugene Nikolaev

Journal: Mass Spectrometry Reviews

The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of...

Read More thumbnail image: Hydrogendeuterium exchange in mass spectrometry

Electron‐ion reaction‐based dissociation: A powerful ion activation method for the elucidation of natural product structures

Published: Mar 30, 2018

Author(s): Xiangfeng Chen, Ze Wang, Y.‐L. Elaine Wong, Ri Wu, Feng Zhang, T.‐W. Dominic Chan

Journal: Mass Spectrometry Reviews

The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from...

Read More thumbnail image: Electronion reactionbased dissociation A powerful ion activation method for the elucidation of natural product structures

Molecules and elements for quantitative bioanalysis: The allure of using electrospray, MALDI, and ICP mass spectrometry side‐by‐side

Published: Mar 30, 2018

Author(s): Michael W. Linscheid

Journal: Mass Spectrometry Reviews

To understand biological processes, not only reliable identification, but quantification of constituents in biological processes play a pivotal role. This is especially true for the proteome: protein quantification must follow protein identification, since sometimes minute changes in abundance tell the real tale. To obtain quantitative data, many sophisticated strategies using electrospray and MALDI mass spectrometry...

Read More thumbnail image: Molecules and elements for quantitative bioanalysis The allure of using electrospray MALDI and ICP mass spectrometry sidebyside

Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection

Published: Mar 29, 2018

Author(s): Maria Guirro, Andrea Costa, Andreu Gual‐Grau, Jordi Mayneris‐Perxachs, Helena Torrell, Pol Herrero, Núria Canela, Lluís Arola

Journal: ELECTROPHORESIS

Abstract Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several...

Read More thumbnail image: Multiomics approach to elucidate the gut microbiota activity Metaproteomics and metagenomics connection

Detection of prohibited substances in equine hair by ultra‐high performance liquid chromatography–triple quadrupole mass spectrometry – application to doping control samples

Published: Mar 28, 2018

Author(s): B. Gray, M. Viljanto, E. Menzies, L. Vanhaecke

Journal: Drug Testing and Analysis

Abstract The detection of drugs in human hair samples has been performed by laboratories around the world for many years and the matrix is popular in disciplines, such as workplace drug testing. To date, however, hair has not become a routinely utilised matrix in sports drug detection. The analysis of hair samples offers several potential advantages to doping control laboratories, not least of which are the greatly extended...

Read More thumbnail image: Detection of prohibited substances in equine hair by ultrahigh performance liquid chromatographytriple quadrupole mass spectrometry  application to doping control samples

Prediction of designer drugs: Synthesis and spectroscopic analysis of synthetic cathinone analogs that may appear on the Swedish drug market

Published: Mar 28, 2018

Author(s): Andreas Carlsson, Veronica Sandgren, Stefan Svensson, Peter Konradsson, Simon Dunne, Martin Josefsson, Johan Dahlén

Journal: Drug Testing and Analysis

Abstract The use of hyphenated analytical techniques in forensic drug screening enables simultaneous identification of a wide range of different compounds. However, the appearance of drug seizures containing new substances, mainly new psychoactive substances (NPS), is steadily increasing. These new and other already known substances often possess structural similarities and consequently they exhibit spectral data with slight...

Read More thumbnail image: Prediction of designer drugs Synthesis and spectroscopic analysis of synthetic cathinone analogs that may appear on the Swedish drug market

Pharmacokinetics, tissue distribution, and excretion of FGF‐21 following subcutaneous administration in rats

Published: Mar 28, 2018

Author(s): Yufei He, Yazhuo Li, Zihong Wei, Xingyan Zhang, Jing Gao, Xiaojie Wang, Xiaokun Li, Weidang Wu, Wei Li, Xiulin Yi, Yong Zeng, Changxiao Liu

Journal: Drug Testing and Analysis

Abstract As one of the fibroblast growth factor (FGF) superfamily, FGF‐21 has been extensively investigated for its functions and roles since its discovery. It has been demonstrated to be one of the key regulators for glucose and lipid metabolism, and exhibits beneficial effects on cardiovascular disease. However, studies focusing on its pharmacokinetic behavior in vivo as a novel therapeutic agent have not been reported. In the...

Read More thumbnail image: Pharmacokinetics tissue distribution and excretion of FGF21 following subcutaneous administration in rats

Suitable simple and fast methods for selective isolation of phospholipids as a tool for their analysis

Published: Mar 28, 2018

Author(s): Lígia Pimentel, Ana Luiza Fontes, Sofia Salsinha, Manuela Machado, Inês Correia, Ana Maria Gomes, Manuela Pintado, Luís Miguel Rodríguez‐Alcalá

Journal: ELECTROPHORESIS

Abstract Lipids are gaining relevance over the last 20 years, as our knowledge about their role has changed from merely energy/structural molecules to compounds also involved in several biological processes. This led to the creation in 2003 of a new emerging research field: lipidomics. In particular the phospholipids have pharmacological/food applications, participate in cell signalling/homeostatic pathways while their analysis...

Read More thumbnail image: Suitable simple and fast methods for selective isolation of phospholipids as a tool for their analysis

Quantitative separation of hesperidin, chrysin, epicatechin, epigallocatechin gallate, and morin using ionic liquid as a buffer additive in capillary electrophoresis

Published: Mar 28, 2018

Author(s): Almas F. Memon, Amber R. Solangi, Saima Q. Memon, Arfana Mallah, Najma Memon

Journal: ELECTROPHORESIS

Abstract Recently, an increasing interest has been observed in ionic liquids (ILs) due to their potentialities in various chemical processes. ILs have some unique properties making them excellent additives in CE. In this work a simple, rapid, and reliable CZE method has been developed and validated using 1‐butyl‐3‐methyl imidazolium hexafluorophosphate (BMIM‐PF6) ionic liquid as a buffer additive for the determination/separation of five...

Read More thumbnail image: Quantitative separation of hesperidin chrysin epicatechin epigallocatechin gallate and morin using ionic liquid as a buffer additive in capillary electrophoresis
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