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Electric double layer electrostatics of lipid‐bilayer‐encapsulated nanoparticles: Toward a better understanding of protocell electrostatics

Published: Jan 4, 2018

Author(s): Haoyuan Jing, Siddhartha Das

Journal: ELECTROPHORESIS

Abstract Lipid‐bilayer‐encapsulated nanoparticles (LBLENPs) or NP‐supported LBL systems, such as protocells (which are lipid bilayer encapsulated mesoporous silica nanoparticles or MSNPs) have received extensive attention for applications like targeted drug and gene deliveries, multimodal diagnostics, characterization of membrane‐geometry sensitive molecules, etc. Very often electrostatic‐mediated interactions have been hypothesized...

Read More thumbnail image: Electric double layer electrostatics of lipidbilayerencapsulated nanoparticles Toward a better understanding of protocell electrostatics

Insights into the uptake, metabolization, and translocation of four non‐steroidal anti‐inflammatory drugs in cress ( Lepidium sativum ) by HPLC‐MS 2

Published: Jan 4, 2018

Author(s): Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

Journal: ELECTROPHORESIS

Abstract The metabolization of four non‐steroidal anti‐inflammatory drugs by cress (Lepidium sativum) was investigated using a HPLC‐MS2 method. Cress was grown hydroponically in water containing 0.1 mg/L of each drug for investigations on the kinetics of drug uptake and metabolization over a growing period of 12 days. It could be shown that the parent drugs are metabolized and the abundance of both the parent drug and the metabolites...

Read More thumbnail image: Insights into the uptake metabolization and translocation of four nonsteroidal antiinflammatory drugs in cress  Lepidium sativum  by HPLCMS 2

Insights into the uptake, metabolization, and translocation of four non‐steroidal anti‐inflammatory drugs in cress ( Lepidium sativum ) by HPLC‐MS 2

Published: Jan 4, 2018

Author(s): Lisa Emhofer, Markus Himmelsbach, Wolfgang Buchberger, Christian W. Klampfl

Journal: ELECTROPHORESIS

Abstract The metabolization of four non‐steroidal anti‐inflammatory drugs by cress (Lepidium sativum) was investigated using a HPLC‐MS2 method. Cress was grown hydroponically in water containing 0.1 mg/L of each drug for investigations on the kinetics of drug uptake and metabolization over a growing period of 12 days. It could be shown that the parent drugs are metabolized and the abundance of both the parent drug and the metabolites...

Read More thumbnail image: Insights into the uptake metabolization and translocation of four nonsteroidal antiinflammatory drugs in cress  Lepidium sativum  by HPLCMS 2

Determination of telbivudine in the plasma of chronic hepatitis B patients in long‐term treatment by high‐performance liquid chromatographic–tandem mass spectrometry

Published: Jan 3, 2018

Author(s): Bicui Chen, Li Chen, Cai Cheng, Mingkang Zhong, Xiaojin Shi, Jiming Zhang, Bin Wang

Journal: Biomedical Chromatography

Abstract Creatine kinase elevation is commonly reported in telbivudine‐treated patients. However, little is known about the relationship between this adverse drug reaction and plasma concentration. In this study, a sensitive, rapid and safe quantitative bioanalytical method has been established by using LC‐MS/MS for the determination of telbivudine in a clinical study of chronic hepatitis B patients. The assay was linear in a...

Read More thumbnail image: Determination of telbivudine in the plasma of chronic hepatitis B patients in longterm treatment by highperformance liquid chromatographictandem mass spectrometry

Determination of telbivudine in the plasma of chronic hepatitis B patients in long‐term treatment by high‐performance liquid chromatographic–tandem mass spectrometry

Published: Jan 3, 2018

Author(s): Bicui Chen, Li Chen, Cai Cheng, Mingkang Zhong, Xiaojin Shi, Jiming Zhang, Bin Wang

Journal: Biomedical Chromatography

Abstract Creatine kinase elevation is commonly reported in telbivudine‐treated patients. However, little is known about the relationship between this adverse drug reaction and plasma concentration. In this study, a sensitive, rapid and safe quantitative bioanalytical method has been established by using LC‐MS/MS for the determination of telbivudine in a clinical study of chronic hepatitis B patients. The assay was linear in a...

Read More thumbnail image: Determination of telbivudine in the plasma of chronic hepatitis B patients in longterm treatment by highperformance liquid chromatographictandem mass spectrometry

A novel fast method for aqueous derivatization of THC, OH‐THC and THC‐COOH in human whole blood and urine samples for routine forensic analyses

Published: Jan 3, 2018

Author(s): Fabio Stefanelli, Federica Giorgia Pesci, Mario Giusiani, Silvio Chericoni

Journal: Biomedical Chromatography

Abstract A novel aqueous in situ derivatization procedure with propyl chloroformate (PCF) for the simultaneous, quantitative analysis of Δ9‐tetrahydrocannabinol (THC), 11‐hydroxy‐Δ9‐tetrahydrocannabinol (OH‐THC) and 11‐nor‐Δ9‐tetrahydrocannabinol‐carboxylic acid (THC‐COOH) in human blood and urine is proposed. Unlike current methods based on the silylating agent [N,O‐bis(trimethylsilyl)trifluoroacetamide] added in an anhydrous environment, this new...

Read More thumbnail image: A novel fast method for aqueous derivatization of THC OHTHC and THCCOOH in human whole blood and urine samples for routine forensic analyses

A novel fast method for aqueous derivatization of THC, OH‐THC and THC‐COOH in human whole blood and urine samples for routine forensic analyses

Published: Jan 3, 2018

Author(s): Fabio Stefanelli, Federica Giorgia Pesci, Mario Giusiani, Silvio Chericoni

Journal: Biomedical Chromatography

Abstract A novel aqueous in situ derivatization procedure with propyl chloroformate (PCF) for the simultaneous, quantitative analysis of Δ9‐tetrahydrocannabinol (THC), 11‐hydroxy‐Δ9‐tetrahydrocannabinol (OH‐THC) and 11‐nor‐Δ9‐tetrahydrocannabinol‐carboxylic acid (THC‐COOH) in human blood and urine is proposed. Unlike current methods based on the silylating agent [N,O‐bis(trimethylsilyl)trifluoroacetamide] added in an anhydrous environment, this new...

Read More thumbnail image: A novel fast method for aqueous derivatization of THC OHTHC and THCCOOH in human whole blood and urine samples for routine forensic analyses

Qualitative analysis of flavors and fragrances added to tea by using GC–MS

Published: Jan 3, 2018

Author(s): Jianwu Wang, Yuanxin Hang, Tingting Yan, Jiahui Liang, Zhiqiang Huang, Huilan Xu

Journal: Journal of Separation Science

Abstract A precise identification method was developed to identify the flavors and fragrances added to tea matrix artificially using gas chromatography with mass spectrometry and gas chromatography with quadrupole time‐of‐flight mass spectrometry. The proposed method was based on the corresponding “three‐column retention indices, two exact mass numbers, one mass spectrum matching degree” database of 40 kinds of common flavors and...

Read More thumbnail image: Qualitative analysis of flavors and fragrances added to tea by using GCMS

Surfactant‐assisted electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the separation and quantification of Tranylcypromine enantiomers in biological samples

Published: Jan 3, 2018

Author(s): Ali Reza Fakhari, Hasan Mohammadi Kosalar, Sajad Asadi, Kobra Sadat Hasheminasab

Journal: Journal of Separation Science

Abstract Surfactant‐assisted electromembrane extraction coupled with cyclodextrin‐modified capillary electrophoresis was developed for the separation and determination of Tranylcypromine enantiomers in biological samples. This combination would provide a new strategy for selective and sensitive determination of target analytes. The addition of surfactant in the donor solution improved the analyte transport into the lumen of hollow...

Read More thumbnail image: Surfactantassisted electromembrane extraction combined with cyclodextrinmodified capillary electrophoresis for the separation and quantification of Tranylcypromine enantiomers in biological samples

Isolation and purification of food‐grade C‐phycocyanin from Arthrospira platensis and its determination in confectionery by HPLC with diode array detection

Published: Jan 3, 2018

Author(s): Maria Kissoudi, Ioannis Sarakatsianos, Victoria Samanidou

Journal: Journal of Separation Science

Abstract C‐Phycocyanin is the major phycobiliprotein in Arthrospira platensis, also known as Spirulina, which is a cyanobacterium used as a dietary supplement because of its powerful effects on body and brain. C‐phycocyanin is a blue‐colored accessory photosynthetic pigment with multiple applications in food industry as natural dye or additive, and in pharmaceuticals. This study presents a simple protocol for the extraction and purification of...

Read More thumbnail image: Isolation and purification of foodgrade Cphycocyanin from Arthrospira platensis and its determination in confectionery by HPLC with diode array detection

Isolation and purification of food‐grade C‐phycocyanin from Arthrospira platensis and its determination in confectionery by HPLC with diode array detection

Published: Jan 3, 2018

Author(s): Maria Kissoudi, Ioannis Sarakatsianos, Victoria Samanidou

Journal: Journal of Separation Science

Abstract C‐Phycocyanin is the major phycobiliprotein in Arthrospira platensis, also known as Spirulina, which is a cyanobacterium used as a dietary supplement because of its powerful effects on body and brain. C‐phycocyanin is a blue‐colored accessory photosynthetic pigment with multiple applications in food industry as natural dye or additive, and in pharmaceuticals. This study presents a simple protocol for the extraction and purification of...

Read More thumbnail image: Isolation and purification of foodgrade Cphycocyanin from Arthrospira platensis and its determination in confectionery by HPLC with diode array detection

Liquid chromatographic resolution of proline and pipecolic acid derivatives on chiral stationary phases based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid

Published: Jan 2, 2018

Author(s): Eun Sol Cho, Ji Yeong Sung, Jong Sung Jin, Myung Ho Hyun

Journal: Journal of Separation Science

Abstract Two liquid chromatographic chiral stationary phases based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid were applied to the resolution of the amide derivatives of cyclic α‐amino acids including proline and pipecolic acid. Among the five amide derivatives of proline, aniline amide was resolved best on the first chiral stationary phase, which contains two N–H tethering amide groups, with the separation factor of 1.31 and...

Read More thumbnail image: Liquid chromatographic resolution of proline and pipecolic acid derivatives on chiral stationary phases based on 18crown6231112tetracarboxylic acid

Liquid chromatographic resolution of proline and pipecolic acid derivatives on chiral stationary phases based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid

Published: Jan 2, 2018

Author(s): Eun Sol Cho, Ji Yeong Sung, Jong Sung Jin, Myung Ho Hyun

Journal: Journal of Separation Science

Abstract Two liquid chromatographic chiral stationary phases based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid were applied to the resolution of the amide derivatives of cyclic α‐amino acids including proline and pipecolic acid. Among the five amide derivatives of proline, aniline amide was resolved best on the first chiral stationary phase, which contains two N–H tethering amide groups, with the separation factor of 1.31 and...

Read More thumbnail image: Liquid chromatographic resolution of proline and pipecolic acid derivatives on chiral stationary phases based on 18crown6231112tetracarboxylic acid

Determination of the transformation of ginsenosides in Ginseng Radix et Rhizoma during decoction with water using ultra‐fast liquid chromatography coupled with tandem mass spectrometry

Published: Jan 2, 2018

Author(s): Lei Zhang, Qi‐Le Zhou, Xiu‐Wei Yang

Journal: Journal of Separation Science

Abstract This study was conducted to determine the variations of ginsenosides in Ginseng Radix et Rhizoma when using different preparation solvents and explore the major factors for changes. With an established ultra‐fast liquid chromatography coupled with tandem mass spectrometry method which could quantify 52 ginsenosides, the extraction differences were characterized and compared using different solvents (water, 70% aqueous...

Read More thumbnail image: Determination of the transformation of ginsenosides in Ginseng Radix et Rhizoma during decoction with water using ultrafast liquid chromatography coupled with tandem mass spectrometry

Determination of the transformation of ginsenosides in Ginseng Radix et Rhizoma during decoction with water using ultra‐fast liquid chromatography coupled with tandem mass spectrometry

Published: Jan 2, 2018

Author(s): Lei Zhang, Qi‐Le Zhou, Xiu‐Wei Yang

Journal: Journal of Separation Science

Abstract This study was conducted to determine the variations of ginsenosides in Ginseng Radix et Rhizoma when using different preparation solvents and explore the major factors for changes. With an established ultra‐fast liquid chromatography coupled with tandem mass spectrometry method which could quantify 52 ginsenosides, the extraction differences were characterized and compared using different solvents (water, 70% aqueous...

Read More thumbnail image: Determination of the transformation of ginsenosides in Ginseng Radix et Rhizoma during decoction with water using ultrafast liquid chromatography coupled with tandem mass spectrometry

Direct HPLC separation of carnosine enantiomers with two chiral stationary phases based on penicillamine and teicoplanin derivatives

Published: Jan 2, 2018

Author(s): Laura Fumagalli, Lucia Pucciarini, Luca Regazzoni, Ettore Gilardoni, Marina Carini, Giulio Vistoli, Giancarlo Aldini, Roccardo Sardella

Journal: Journal of Separation Science

Abstract Carnosine is present in high concentrations in specific human tissues such as the skeletal muscle, and among its biological functions, the remarkable scavenging activity toward reactive carbonyl species is noteworthy. Although the two enantiomers show almost identical scavenging reactivity toward reactive carbonyl species, only d‐carnosine is poorly adsorbed at the gastrointestinal level and is stable in human plasma. Direct methods...

Read More thumbnail image: Direct HPLC separation of carnosine enantiomers with two chiral stationary phases based on penicillamine and teicoplanin derivatives

Direct HPLC separation of carnosine enantiomers with two chiral stationary phases based on penicillamine and teicoplanin derivatives

Published: Jan 2, 2018

Author(s): Laura Fumagalli, Lucia Pucciarini, Luca Regazzoni, Ettore Gilardoni, Marina Carini, Giulio Vistoli, Giancarlo Aldini, Roccardo Sardella

Journal: Journal of Separation Science

Abstract Carnosine is present in high concentrations in specific human tissues such as the skeletal muscle, and among its biological functions, the remarkable scavenging activity toward reactive carbonyl species is noteworthy. Although the two enantiomers show almost identical scavenging reactivity toward reactive carbonyl species, only d‐carnosine is poorly adsorbed at the gastrointestinal level and is stable in human plasma. Direct methods...

Read More thumbnail image: Direct HPLC separation of carnosine enantiomers with two chiral stationary phases based on penicillamine and teicoplanin derivatives

Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent

Published: Jan 2, 2018

Author(s): Efthimia Papastavros, Rachael A. Remmers, Daniel D. Snow, David A. Cassada, David S. Hage

Journal: Journal of Separation Science

Abstract Affinity sorbents using bovine serum albumin as a binding agent were developed and tested for the extraction of environmental contaminants from water. Computer simulations based on a countercurrent distribution model were also used to study the behavior of these sorbents. Several model drugs, pesticides, and hormones of interest as emerging contaminants were considered in this work, with carbamazepine being used as a...

Read More thumbnail image: Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent

Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent

Published: Jan 2, 2018

Author(s): Efthimia Papastavros, Rachael A. Remmers, Daniel D. Snow, David A. Cassada, David S. Hage

Journal: Journal of Separation Science

Abstract Affinity sorbents using bovine serum albumin as a binding agent were developed and tested for the extraction of environmental contaminants from water. Computer simulations based on a countercurrent distribution model were also used to study the behavior of these sorbents. Several model drugs, pesticides, and hormones of interest as emerging contaminants were considered in this work, with carbamazepine being used as a...

Read More thumbnail image: Affinity extraction of emerging contaminants from water based on bovine serum albumin as a binding agent

Development of a precolumn derivatization HPLC method with diode‐array detection for the determination of amino sugars in peat and soil humic acids

Published: Jan 2, 2018

Author(s): Erik Beňo, Róbert Góra, Milan Hutta

Journal: Journal of Separation Science

Abstract The work is focused on the development of a high‐performance liquid chromatography method with diode‐array detection for the separation and quantitation of the three most abundant amino sugars; d‐glucosamine, d‐galactosamine, and d‐mannosamine. The high‐performance liquid chromatography separation was carried out by reversed‐phase chromatography on Chromolith Performance RP‐18e monolithic column after acid hydrolysis (5 M HCl) and...

Read More thumbnail image: Development of a precolumn derivatization HPLC method with diodearray detection for the determination of amino sugars in peat and soil humic acids
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