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Can a threshold for 11‐nor‐9‐carboxy‐Δ 9 ‐tetrahydrocannabinol in hair be derived when its respective concentration in blood serum indicates regular use?

Published: Oct 11, 2018

Author(s): Bettina Zinka, Sabine Epple, Sylvia Schick, Gisela Skopp, Matthias Graw, Frank Musshoff

Journal: Drug Testing and Analysis

Abstract A 100 μg/L or higher concentration of 11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol (THC‐COOH) in blood serum is generally assumed to be associated with regular and/or heavy use of cannabis. At present, determination of the extent of cannabis use by means of the concentration of THC‐COOH in hair has not been assessed. Therefore, we aimed at establishing a threshold for THC‐COOH concentrations in hair to prove frequent...

Read More thumbnail image: Can a threshold for 11nor9carboxy 9 tetrahydrocannabinol in hair be derived when its respective concentration in blood serum indicates regular use

GC–MS analysis of terpenes from Sicilian Pistacia vera L. oleoresin. A source of biologically active compounds

Published: Oct 11, 2018

Author(s): Edoardo Napoli, Davide Gentile, Giuseppe Ruberto

Journal: Biomedical Chromatography

Abstract The genus Pistacia includes different species diffused worldwide able to produce oleoresins used in several folk medicines. Oleoresins are phytocomplexes exudate from the trunk of plants and possess several biological properties thanks to the simultaneous presence of essential oils, di‐ and triterpenes and phenols. Pistacia vera L. oleoresin chemical composition is not well known owing a lack of studies compared with other Pistacia...

Read More thumbnail image: GCMS analysis of terpenes from Sicilian Pistacia vera L_ oleoresin_ A source of biologically active compounds

Development of sample preparation technique to characterize chemical structure of humin by synchrotron‐radiation–based X‐ray photoelectron spectroscopy

Published: Oct 11, 2018

Author(s): Duyen Minh Pham, Yasushi Miyata, Takanori Awata, Masashi Nakatake, Chung Fang Zhang, Keiji Kanda, Satoshi Ogawa, Shozo Ohta, Shinya Yagi, Arata Katayama

Journal: Surface and Interface Analysis

Carbon‐binding state of humin (HM, a non‐conductive insoluble organo‐mineral humic substance) was successfully characterized for the first time by synchrotron‐radiation–based X‐ray photoelectron spectroscopy (XPS). Four sample preparation techniques—HM on double‐sided carbon tape, indium sheet, copper mesh, and in pellet formed from the mixture of HM and copper powder (Cu) at different mixing ratios (1:1, 1:2, and 1:6 v/v)—were...

Read More thumbnail image: Development of sample preparation technique to characterize chemical structure of humin by synchrotronradiationbased Xray photoelectron spectroscopy

Nanoscale imaging of hydrogen and sodium in alteration layers of corroded glass using ToF‐SIMS: Is an auxiliary sputtering ion beam necessary?

Published: Oct 11, 2018

Author(s): Jiandong Zhang, Yanyan Zhang, Marie Collin, Stephane Gin, James J. Neeway, Tieshan Wang, Zihua Zhu

Journal: Surface and Interface Analysis

The hydrogen (H)/sodium (Na) interface is of great interest in glass corrosion research. Time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) is one of the few techniques that can provide nanoscale H and Na imaging simultaneously. However, the optimized condition for ToF‐SIMS imaging of H in glass is still unclear. In H depth profiling using ToF‐SIMS, H background control is a key, in which an analysis ion beam and a sputtering ion...

Read More thumbnail image: Nanoscale imaging of hydrogen and sodium in alteration layers of corroded glass using ToFSIMS Is an auxiliary sputtering ion beam necessary

Site‐sensitive X‐ray photoelectron spectroscopy of Fe 3 O 4 by photoelectron diffraction

Published: Oct 11, 2018

Author(s): Yusuke Hashimoto, Munetaka Taguchi, Shun Fukami, Hiroki Momono, Tomohiro Matsushita, Hiroyuki Matsuda, Fumihiko Matsui, Hiroshi Daimon

Journal: Surface and Interface Analysis

Fe 2p core‐level photoelectron spectra of magnetite were measured using soft X‐ray and hard X‐ray, and its emission angle dependence was investigated. The photoelectron diffraction pattern from different atomic sites differs because the atomic arrangement surrounding each site is different. By selecting the forward‐focusing‐peak (FFP) directions characteristic to each atomic site and measuring the kinetic energy dependence of the FFP...

Read More thumbnail image: Sitesensitive Xray photoelectron spectroscopy of Fe 3 O 4 by photoelectron diffraction

Moving window partial least squares after orthogonal signal correction as a coupling method for determination of uranium and thorium by ultrasound‐assisted emulsification microextraction

Published: Oct 11, 2018

Author(s): Neda Khorshidi, Ali Niazi

Journal: Journal of Chemometrics

Abstract This study, a fast, simple, and efficient ultrasound‐assisted emulsification microextraction coupled with orthogonal signal correction‐moving window partial least squares (OSC‐MWPLS) was successfully used to preconcentration and simultaneous spectrophotometric determination of uranium and thorium in water samples. Response surface methodology based on a Box‐Behnken design was used to optimize the extraction conditions. The...

Read More thumbnail image: Moving window partial least squares after orthogonal signal correction as a coupling method for determination of uranium and thorium by ultrasoundassisted emulsification microextraction

Tri‐icosahedral Au 37 cluster as a carrier/detector for anti‐cancer cisplatin drug

Published: Oct 11, 2018

Author(s): Omar Palacios‐Álvarez, Alfredo Tlahuice‐Flores

Journal: Journal of Raman Spectroscopy

Abstract In this work, DFT studies devoted to the adsorption of anti‐cancer cisplatin drug and one cationic tri‐icosahedral Au37 cluster are addressed, which are aiming to explore the application of thiolate/phosphine protected gold clusters as carriers/detectors for cisplatin molecules. The Au37 cluster is able to adsorb up to four cisplatin molecules, and the cisplatin4/Au37 complex holds a 1.71 eV adsorption energy value. Further atomic population...

Read More thumbnail image: Triicosahedral Au 37 cluster as a carrierdetector for anticancer cisplatin drug

Quantifying alkyl chain disorder in crystalline models of lipid bilayers using Raman spectroscopy

Published: Oct 11, 2018

Author(s): Anne M. Rich, Saroj Bhattacharyya, Vina R. Aldilla, Jonathon E. Beves, Mohan Bhadbhade, Naresh Kumar, Ena T. Luis, Christopher E. Marjo

Journal: Journal of Raman Spectroscopy

Abstract Crystalline bis‐N‐alkyl‐chlorotriazines 2–6 can be considered multilayers of lipid bilayers comprising a rigid hydrogen‐bonded tape in the polar layer separated by a lipid region of small to medium‐length alkyl chains. The persistent ordering of these tapes acts as a scaffold in the solid state enabling measurement of temperature‐induced conformational changes in the “lipid phase” using X‐ray crystallography. The alkyl...

Read More thumbnail image: Quantifying alkyl chain disorder in crystalline models of lipid bilayers using Raman spectroscopy

Surface‐enhanced resonance Raman scattering for the sensitive detection of a tuberculosis biomarker in human serum

Published: Oct 11, 2018

Author(s): Nicholas A. Owens, Abraham Pinter, Marc D. Porter

Journal: Journal of Raman Spectroscopy

Abstract Improvements in the detection of biomarkers indicative of disease continue to be vital to human health. Toward this end, this paper presents (a) the development and characterization of a biomarker detection strategy based on the inherently stronger signals generated by surface‐enhanced resonance Raman scattering (SERRS), as opposed to surface‐enhanced Raman scattering (SERS); (b) the application of this approach to the...

Read More thumbnail image: Surfaceenhanced resonance Raman scattering for the sensitive detection of a tuberculosis biomarker in human serum

Investigating Raman spectra and density functional theory calculations on SrAl 2 O 4 polymorphs

Published: Oct 11, 2018

Author(s): Rocío Estefanía Rojas‐Hernandez, Wilfredo More, Fernando Rubio‐Marcos, José Francisco Fernandez

Journal: Journal of Raman Spectroscopy

Abstract SrAl2O4 is a long‐lasting material that combines several favorable attributes in comparison with their inorganic luminescent predecessor. In addition, it is an intriguing material combining a structural polymorphism with potential application such as in solar cells, biological labeling and imaging, and security encode. Here, we unambiguously determinate the Raman spectra for hexagonal and monoclinic polymorphs....

Read More thumbnail image: Investigating Raman spectra and density functional theory calculations on SrAl 2 O 4 polymorphs

Trapping DNA with a high throughput microfluidic device

Published: Oct 10, 2018

Author(s): Ryan J. Montes, Jason E. Butler, Anthony J. C. Ladd

Journal: ELECTROPHORESIS

Abstract Long strands of DNA can be trapped and concentrated near the inlet of a microfluidic channel by applying a pressure gradient and an opposing electric field. The mechanism for trapping involves a migration of DNA perpendicular to both the fluid flow and the electric field. Migration leads to a highly nonuniform distribution of DNA within a cross section of the channel, with the bulk of the DNA concentrated in a thin (10 μm)...

Read More thumbnail image: Trapping DNA with a high throughput microfluidic device

Resolving power in liquid chromatography: A trade‐off between efficiency and analysis time

Published: Oct 10, 2018

Author(s): José Luís Dores‐Sousa, Jelle Vos, Sebastiaan Eeltink

Journal: Journal of Separation Science

Abstract This review describes chromatographic dispersion and different plate‐height models frequently used to assess the chromatographic performance of ultra‐high‐pressure liquid chromatography column technology. Furthermore, different performance indices, including the resolution, the separation impedance, and kinetic plots are discussed allowing to quantify and visualize the resolving power in liquid chromatography. The...

Read More thumbnail image: Resolving power in liquid chromatography A tradeoff between efficiency and analysis time

Sum frequency generation study of immobilized 3‐aminopropyltriethoxysilane self‐assembled layer on Si(111) substrates

Published: Oct 10, 2018

Author(s): Thi Thu Hien Khuat, Lin Liang, Trong Tue Phan, Goro Mizutani, Harvey N. Rutt

Journal: Surface and Interface Analysis

Distribution and orientation of 3‐aminopropyltriethoxysilane (APTES) on a sensing surface play critical role on biosensor, but have not been fully investigated. In this work, the quality of APTES SAM immobilized on the Si(111) substrate was studied by observing sum frequency generation (SFG) response. The polarization, azimuthal angle, and position‐dependent SFG spectra of APTES coverage were obtained. In ppp and psp‐SFG spectra, the CH2...

Read More thumbnail image: Sum frequency generation study of immobilized 3aminopropyltriethoxysilane selfassembled layer on Si111 substrates

Metabolic fate of the new synthetic cannabinoid 7’N‐5F‐ADB in rat, human, and pooled human S9 studied by means of hyphenated high‐resolution mass spectrometry

Published: Oct 9, 2018

Author(s): Lilian H.J. Richter, Hans H. Maurer, Markus R. Meyer

Journal: Drug Testing and Analysis

Abstract New psychoactive substances (NPS) are an important issue in clinical/forensic toxicology. 7’N‐5F‐ADB, a synthetic cannabinoid derived from 5F‐ADB, appeared recently on the market. Up to now, no data about its mass spectral fragmentation pattern, metabolism, and thus suitable targets for toxicological urine screenings have been available. Therefore, the aim of this study was to elucidate the metabolic fate of 7’N‐5F‐ADB in...

Read More thumbnail image: Metabolic fate of the new synthetic cannabinoid 7N5FADB in rat human and pooled human S9 studied by means of hyphenated highresolution mass spectrometry

Development and validation of LC–MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Published: Oct 9, 2018

Author(s): Pavan Kumar Prathipati, Subhra Mandal, Christopher J. Destache

Journal: Biomedical Chromatography

Abstract A sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for quantification of bictegravir in human plasma. A small volume of only 50 μL aliquot of plasma was precipitated with acetonitrile containing an internal standard (IS). Chromatographic separation was performed on a Kinetex EVO C18 column, 50 × 3.0 mm, 5 μm using an isocratic mobile phase containing 80:20 acetonitrile–water with...

Read More thumbnail image: Development and validation of LCMSMS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Quantitative determination of six steroid alkaloids by sensitive hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats

Published: Oct 9, 2018

Author(s): Jianbo Chen, Lixue Chen, Meijia Li, Yinshi Sun

Journal: Biomedical Chromatography

Abstract In this study, a sensitive hydrophilic interaction liquid chromatography (HILIC) method was developed to determine pseudojervine (PJV), veratrosine (VTS), jervine (JV), veratramine (VTM), veramarine (VA) and veratroylzygadenine (VTG) in rat plasma. Separations were carried out using LC–MS/MS with a Chrom Matrix HP amide column (5 m, 10 cm × 3.0 mm i.d.). The mobile phases were (A) 0.01 mm formic acid and (B) acetonitrile....

Read More thumbnail image: Quantitative determination of six steroid alkaloids by sensitive hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats

Enantiomers separation by capillary electrochromatography using polysaccharide‐based stationary phases

Published: Oct 9, 2018

Author(s): Giovanni D’ Orazio, María Asensio‐Ramos, Chiara Fanali

Journal: Journal of Separation Science

Abstract The separation of chiral compounds is an interesting and important topic of research because these compounds are involved in some biological processes, fundamentally in human health. Among the various application fields where enantiomers are remarkable, drug analysis has to be considered. Most of the drugs contain enantiomers and very often one of the two isomers could be pharmacologically more active or even dangerous....

Read More thumbnail image: Enantiomers separation by capillary electrochromatography using polysaccharidebased stationary phases

The New Face of the Lipid Droplet: Lipid Droplet Proteins

Published: Oct 9, 2018

Author(s): Congyan Zhang, Pingsheng Liu

Journal: PROTEOMICS

Abstract The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types. The accumulated proteomic data are reviewed for evidence of a protein targeting mechanism for the organelle. The...

Read More thumbnail image: The New Face of the Lipid Droplet Lipid Droplet Proteins

PHOTOIONIZATION AND PHOTOFRAGMENTATION IN MASS SPECTROMETRY WITH VISIBLE AND UV LASERS

Published: Oct 9, 2018

Author(s): Frank Gunzer, Sascha Krüger, Jürgen Grotemeyer

Journal: Mass Spectrometry Reviews

Ever since the introduction of laser technology to the field of mass spectrometry, several disciplines evolved providing solutions to challenging scientific and analytical tasks in research and industry. Among these are techniques involving multiphoton ionization such as Resonance‐Enhanced Multiphoton Ionization (REMPI, R2PI) and Mass‐Analyzed Threshold Ionization (MATI) spectroscopy, a variant of Zero Kinetic Energy...

Read More thumbnail image: PHOTOIONIZATION AND PHOTOFRAGMENTATION IN MASS SPECTROMETRY WITH VISIBLE AND UV LASERS

A method for improvement of mass resolution and isotope accuracy for laser ablation time‐of‐flight mass spectrometers

Published: Oct 9, 2018

Author(s): Reto Wiesendanger, Marek Tulej, Valentine Grimaudo, Alena Cedeño‐López, Rustam Lukmanov, Andreas Riedo, Peter Wurz

Journal: Journal of Chemometrics

Abstract Accumulation of spectra is a common approach for improvement of the signal‐to‐noise ratio (SNR) in mass spectrometry. However, severe degradation of the overall spectrum can occur if some individual mass spectra, affected by peak broadening, are included in the accumulation process. In this contribution, we discuss potential sources and effects of spectral distortions by using examples from mass spectra acquired by our...

Read More thumbnail image: A method for improvement of mass resolution and isotope accuracy for laser ablation timeofflight mass spectrometers
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