EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

Clinical Implications of Compounds Designed to Inhibit ECM‐Modifying Metalloproteinases

Published: Sep 15, 2017

Author(s): Sabrina Amar, Dmitriy Minond, Gregg B. Fields

Journal: PROTEOMICS

Abstract Remodeling of the extracellular matrix (ECM) is crucial in development and homeostasis, but also has a significant role in disease progression. Two metalloproteinase families, the matrix metalloproteinases (MMPs) and a disintegrin and metalloproteases (ADAMs), participate in the remodeling of the ECM, either directly or through the liberation of growth factors and cell surface receptors. The correlation of MMP and ADAM...

Read More thumbnail image: Clinical Implications of Compounds Designed to Inhibit ECMModifying Metalloproteinases

Aligned diphenylalanine nanotube–silver nanoparticle templates for high‐sensitivity surface‐enhanced Raman scattering

Published: Sep 15, 2017

Author(s): Sawsan Almohammed, Stefano Fedele, Brian J. Rodriguez, James H. Rice

Journal: Journal of Raman Spectroscopy

Abstract Self‐assembly offers potential routes for large‐scale, rapid, and cost‐effective surface‐enhanced Raman scattering (SERS) substrate designs. Here, a highly sensitive SERS template is reported, which utilizes aligned diphenylalanine nanotubes to form a dense packing arrangement of plasmon‐active silver nanoparticles. The template is stable under high laser illumination with a power density of ~6.25 MW/cm2 in comparison...

Read More thumbnail image: Aligned diphenylalanine nanotubesilver nanoparticle templates for highsensitivity surfaceenhanced Raman scattering

Vibrational properties of layered BiTeCl single crystal

Published: Sep 15, 2017

Author(s): Wei Zhou, Jiating Lu, Gang Xiang, Shuangchen Ruan

Journal: Journal of Raman Spectroscopy

Abstract Bismuth tellurohalides have intrigued numerous interests for their novel Rashba splitting electronic structures with potential applications in spintronics and two‐dimensional (2D) optoelectronics. In this work, we have a detailed study of bulk BiTeCl and its exfoliated flakes using ultralow wavenumber Raman spectroscopy. We observe all BiTeCl characteristic Raman modes including the lowest wavenumber rigid layer in‐plane...

Read More thumbnail image: Vibrational properties of layered BiTeCl single crystal

Raman spectroscopy as a novel method in placental research: Recognizing the pattern of placental hypoxia

Published: Sep 15, 2017

Author(s): Natalia Schlabritz‐Loutsevitch, Kushal Gandhi, Fatimah Soydemir, Paul Brownbill, Raghvendra Sengar, Gary Ventolini, Paul Bruillard, Luke Gosink

Journal: Journal of Raman Spectroscopy

Abstract Raman spectroscopy (RS) is a nonelastic photon scattering technique. We evaluated whether a specific RS pattern exists in fetal venous perfusates obtained at 30‐ to 60‐min intervals from the ex vivo human dual placental perfusion model under hypoxic (n = 6) and normoxic (n = 5) conditions. A stratified principle component and a linear support vector machine analyses showed that the separation between 2...

Read More thumbnail image: Raman spectroscopy as a novel method in placental research Recognizing the pattern of placental hypoxia

Raman‐based technique for measuring thermal conductivity of graphene and related materials

Published: Sep 15, 2017

Author(s): Hoda Malekpour, Alexander A. Balandin

Journal: Journal of Raman Spectroscopy

We describe Raman spectroscopy‐based method of measuring thermal conductivity of thin films and review significant results achieved with this technique pertinent to graphene and other two‐dimensional materials. The optothermal Raman method was instrumental for the discovery of unique heat conduction properties of graphene. In this method, Raman spectroscopy is used to determine the local temperature of the sample, while the excitation...

Read More thumbnail image: Ramanbased technique for measuring thermal conductivity of graphene and related materials

Applications of Raman spectroscopy in graphene‐related materials and the development of parameterized PCA for large‐scale data analysis

Published: Sep 15, 2017

Author(s): João Luiz Elias Campos, Hudson Miranda, Cassiano Rabelo, Emil Sandoz‐Rosado, Sugandha Pandey, Juha Riikonen, Abraham G. Cano‐Marquez, Ado Jorio

Journal: Journal of Raman Spectroscopy

A methodology for the structural analysis of graphene‐related materials using parameterized principal component analysis (PCA), ideal for large‐scale data treatment, is introduced. First, we review different aspects of Raman spectroscopy for structural and functional characterization of sp2‐bonded carbon materials, which are important for understanding the problem. The parameterized PCA is then introduced and applied to 2 different...

Read More thumbnail image: Applications of Raman spectroscopy in graphenerelated materials and the development of parameterized PCA for largescale data analysis

Determination of higenamine and coclaurine levels in human urine after the administration of a throat lozenge containing Nandina domestica fruit

Published: Sep 15, 2017

Author(s): Masato Okano, Mitsuhiko Sato, Shinji Kageyama

Journal: Drug Testing and Analysis

Higenamine is a key component of traditional Chinese herbal medicine. The fruit of Nandina domestica (which contains this component) is available as an ingredient in the so‐called Nanten‐nodo‐ame throat lozenge found on the Japanese market, which is an over‐the‐counter pharmaceutical and is easy to purchase for Japanese athletes. However, higenamine is a non‐selective β2‐agonist, which is exemplified in the prohibited list of the World Anti‐Doping...

Read More thumbnail image: Determination of higenamine and coclaurine levels in human urine after the administration of a throat lozenge containing Nandina domestica fruit

Introducing special issue on chemical image analysis

Published: Sep 15, 2017

Author(s): Cyril Ruckebusch

Journal: Journal of Chemometrics

Read More thumbnail image: Introducing special issue on chemical image analysis

Simultaneous determination of morphine‐6‐ d ‐glucuronide, morphine‐3‐ d ‐glucuronide and morphine in human plasma and urine by ultra‐performance liquid chromatography–tandem mass spectrometry: Application to M6G injection pharmacokinetic study

Published: Sep 15, 2017

Author(s): Wen Xu, Quankun Zhuang, Xia Chen, Ji Jiang, Pei Hu, Hongyun Wang

Journal: Biomedical Chromatography

Abstract A robust ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for the determination of morphine‐6‐d‐glucuronide (M6G), morphine‐3‐d‐glucuronide (M3G) and morphine (MOR) in human plasma and urine has been developed and validated. The analytes of interest were extracted from plasma by protein precipitation. The urine sample was prepared by dilution. Both plasma and urine samples were chromatographed on an...

Read More thumbnail image: Simultaneous determination of morphine6 d glucuronide morphine3 d glucuronide and morphine in human plasma and urine by ultraperformance liquid chromatographytandem mass spectrometry Application to M6G injection pharmacokinetic study

Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

Published: Sep 15, 2017

Author(s): Richard J. Lobb, Marcus L. Hastie, Emma L. Norris, Rosa Amerongen, Jeffrey J. Gorman, Andreas Möller

Journal: PROTEOMICS

Abstract Lung cancer is responsible for the highest rate of cancer mortality worldwide. Lung cancer patients are often ineligible for tumor biopsies due to comorbidities. As a result, patients may not have the most effective treatment regimens administered. Patients with mutations in the epidermal growth factor receptor (EGFR) have improved survival in response to EGFR tyrosine kinase inhibitors. A noninvasive method of determining...

Read More thumbnail image: Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

Employment of modified Fe 3 O 4 nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

Published: Sep 14, 2017

Author(s): Saman Naghibi, Hamed Sahebi

Journal: Biomedical Chromatography

Abstract Cefexime is a useful antibiotic that can be prescribed to treat bacterial infections. Nanoparticles have been widely marketed as a universal solution among scientists. Many studies have been performed to modify nanoparticles to make them functional as extraction and pre‐concentration agents and drug carriers. Temperature‐sensitive polymers belong to a group of substances that undergo a major change in their physical...

Read More thumbnail image: Employment of modified Fe 3 O 4 nanoparticles using thermosensitive polymer for extraction and preconcentration of cefexime in biological samples

Application of HPLC‐LTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats

Published: Sep 14, 2017

Author(s): Jing Zhang, Tenghua Wang, Zhiyao Ren, Lu Gong, Juan Huang, Junqi Bai, Xiaohui Qiu, Wen Xu

Journal: Biomedical Chromatography

Abstract The root of Polygonum multiflorum (PM) is an important Chinese herbal medicine for treatment of various diseases. Extensive pharmacological studies have been conducted and demonstrated that it shows a wide range of bioactivities. Meanwhile, a considerable number of hepatotoxicity cases owing to oral administration of PM have been reported and have attracted great attention. However, the limited knowledge regarding the...

Read More thumbnail image: Application of HPLCLTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats

Qualitative analysis of Psoraleae Fructus by HPLC‐DAD/TOF‐MS fingerprint and quantitative analysis of multiple components by single marker

Published: Sep 14, 2017

Author(s): Lianjun Luan, Xiaoyu Shen, Xuesong Liu, Yongjiang Wu, Manliang Tan

Journal: Biomedical Chromatography

Abstract A variety of bioactive substances may account for the recognized efficacy and wide clinical application of Psoraleae Fructus in China. A high‐performance liquid chromatography–diode array detector (HPLC‐DAD) fingerprint method was developed to present the comprehensive phytochemical profile of the crude drug. Thirteen major compounds were separated and identified by HPLC coupled with time‐of‐flight mass spectrometry...

Read More thumbnail image: Qualitative analysis of Psoraleae Fructus by HPLCDADTOFMS fingerprint and quantitative analysis of multiple components by single marker

An upgraded external beam PIXE setup for multielemental analysis of atmospheric aerosol samples

Published: Sep 14, 2017

Author(s): M. Xu, Y.J. Chu, G.F. Wang, M.L. Qiu, L. Zheng

Journal: X-Ray Spectrometry

The external beam particle‐induced X‐ray emission (PIXE) setup has been upgraded by introducing a new silicon drift detector with the aim of obtaining better minimum detection limits (MDLs) at the 2 × 1.7 MV Tandetron accelerator of the Beijing Normal University in China. The upgraded external beam PIXE setup is equipped with two silicon drift detectors for PIXE analysis of low and high Z elements. A surface barrier...

Read More thumbnail image: An upgraded external beam PIXE setup for multielemental analysis of atmospheric aerosol samples

Study of gamma/ X ‐ray interaction in Kondo insulators

Published: Sep 14, 2017

Author(s): H.C. Manjunatha, L. Seenappa, K.N. Sridhar,  ChikkaHanumantharayappa

Journal: X-Ray Spectrometry

We have studied the gamma/X‐ray interaction parameters such as mass attenuation coefficient, mean free path (λ), half value layer, 10th value layer, energy‐absorption buildup factors, and variation of electrical conductivity with the energy of gamma/X‐ray between 1 keV and 100 GeV for Kondo insulators such as FeSi, Ce3Bi4Pt3, SmB6, YbB12, CeNiSn, CeRhSb, CeRuSn, and CeFeP. The variation of photon interaction parameters with incident energy...

Read More thumbnail image: Study of gamma X ray interaction in Kondo insulators

Poly ( N ‐acryloxysuccinimide‐co‐ethylene glycol dimethacrylate) precursor monolith and its post polymerization modification with alkyl ligands, trypsin and lectins for reversed‐phase chromatography, miniaturized enzyme reactors and lectin affinity chromatography, respectively

Published: Sep 14, 2017

Author(s): Murthy Jonnada, Ziad El Rassi

Journal: ELECTROPHORESIS

This investigation was aimed at introducing a monolithic precursor that can be conveniently grafted with the desired chromatographic ligand via the process of post polymerization modification (PPM). The precursor was obtained by the in‐situ polymerization of N‐acryloxysuccinimide (NAS) and ethylene glycol dimethacrylate (EDMA) in a narrow bore stainless steel column of 1 mm i.d. yielding a poly(NAS‐co‐EDMA) monolithic column...

Read More thumbnail image: Poly  N acryloxysuccinimidecoethylene glycol dimethacrylate precursor monolith and its post polymerization modification with alkyl ligands trypsin and lectins for reversedphase chromatography miniaturized enzyme reactors and lectin affinity chromatography respectively

Fast separation of enantiomers by capillary electrophoresis using a combination of two capillaries with different internal diameters

Published: Sep 14, 2017

Author(s): Andrea Šebestová, Jan Petr

Journal: ELECTROPHORESIS

Abstract The combination of capillaries with different internal diameters was used to accelerate the separation of enantiomers in capillary electrophoresis. Separation of R,S‐1,1′‐binaphthalene‐2,2′‐diyl hydrogen phosphate using isopropyl derivative of cyclofructan 6 was studied as a model system. The best separation conditions included 500 mM sodium borate pH 9.5 with 60 mM concentration of the chiral selector. Separation ...

Read More thumbnail image: Fast separation of enantiomers by capillary electrophoresis using a combination of two capillaries with different internal diameters

Preparation and evaluation of tert ‐leucine derivative functionalized polymeric monoliths for micro‐liquid chromatography

Published: Sep 14, 2017

Author(s): Meng Ruan, Qiqin Wang, Huihui Wu, Yuqiang Wang, Hai Han, Zhengjin Jiang

Journal: ELECTROPHORESIS

In this study, a novel functional monomer N‐[1‐(α‐naphthyl)ethylaminocarbonyl]‐D‐tert‐leucine‐[2‐(methacryloyloxy)ethyl] amide (NA‐D‐tert‐Leu‐MA) was synthesized, and then employed to prepare polymeric monoliths (240 mm × 100 μm id) functionalized with tert‐leucine derivative through a single step thermo‐initiated co‐polymerization approach or a multi‐step post‐modification approach. The multi‐step approach involves the post‐modification of a...

Read More thumbnail image: Preparation and evaluation of tert leucine derivative functionalized polymeric monoliths for microliquid chromatography

High concentration measurements of U and Pu with nondestructive and standardless K ‐edge densitometer device

Published: Sep 14, 2017

Author(s): E. Esbelin, C. Rivier, G. Duhamel

Journal: X-Ray Spectrometry

In nuclear activities such as reprocessing plants, safeguard laboratories, or research centers, U and Pu are regularly analyzed. Fast and accurate analytical devices are favored such as K‐edge densitometer. This paper presents the results obtained by this device from assay samples with high U and Pu concentrations. Two processing methods without calibration (except energy calibration) are compared and discussed. Despite literature...

Read More thumbnail image: High concentration measurements of U and Pu with nondestructive and standardless K edge densitometer device

Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows

Published: Sep 13, 2017

Author(s): Kenneth Verheggen, Helge Ræder, Frode S. Berven, Lennart Martens, Harald Barsnes, Marc Vaudel

Journal: Mass Spectrometry Reviews

Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass spectrometry, have provided scientists with more than 30 published search engines, each with its own properties. In this review, we present the common paradigm behind the different implementations, and...

Read More thumbnail image: Anatomy and evolution of database search enginesa central component of mass spectrometry based proteomic workflows
Page:   Prev 12 13 14 15 16 17 18 19 20 21 22 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in spectroscopy? Visit our sister site spectroscopyNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved