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Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism

Published: Jan 9, 2018

Author(s): Entai Hou, Xian Li, Zerong Liu, Fuchang Zhang, Zhongmin Tian

Journal: Biomedical Chromatography

Abstract Fumarase catalyzes the interconversion of fumarate and l‐malate in the tricarboxylic acid cycle. Fumarase insufficiencies were associated with increased levels of fumarate, decreased levels of malate and exacerbated salt‐induced hypertension. To gain insights into the metabolism profiles induced by fumarase insufficiency and identify key regulatory metabolites, we applied a GC–MS based metabolomics platform coupled with a network ...

Read More thumbnail image: Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism

Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism

Published: Jan 9, 2018

Author(s): Entai Hou, Xian Li, Zerong Liu, Fuchang Zhang, Zhongmin Tian

Journal: Biomedical Chromatography

Abstract Fumarase catalyzes the interconversion of fumarate and l‐malate in the tricarboxylic acid cycle. Fumarase insufficiencies were associated with increased levels of fumarate, decreased levels of malate and exacerbated salt‐induced hypertension. To gain insights into the metabolism profiles induced by fumarase insufficiency and identify key regulatory metabolites, we applied a GC–MS based metabolomics platform coupled with a network ...

Read More thumbnail image: Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism

Biotransformation and metabolic profile of Xian‐Ling‐Gu‐Bao capsule, a traditional Chinese medicine prescription, with rat intestinal microflora by ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry analysis

Published: Jan 9, 2018

Author(s): Meng‐xue Gao, Xi‐yang Tang, Feng‐xiang Zhang, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai

Journal: Biomedical Chromatography

Abstract Xian‐Ling‐Gu‐Bao capsule (XLGB), a well‐known traditional Chinese medicine prescription, has been used for the prevention and treatment of osteoporosis. The safety and efficacy of XLGB have been confirmed based on the principle of evidence‐based medicine. XLGB is usually administered orally, after which its multiple components are brought into contact with intestinal microflora in the alimentary tract and biotransformed....

Read More thumbnail image: Biotransformation and metabolic profile of XianLingGuBao capsule a traditional Chinese medicine prescription with rat intestinal microflora by ultraperformance liquid chromatography coupled with quadrupole timeofflight tandem mass spectrometry analysis

Biotransformation and metabolic profile of Xian‐Ling‐Gu‐Bao capsule, a traditional Chinese medicine prescription, with rat intestinal microflora by ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry analysis

Published: Jan 9, 2018

Author(s): Meng‐xue Gao, Xi‐yang Tang, Feng‐xiang Zhang, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai

Journal: Biomedical Chromatography

Abstract Xian‐Ling‐Gu‐Bao capsule (XLGB), a well‐known traditional Chinese medicine prescription, has been used for the prevention and treatment of osteoporosis. The safety and efficacy of XLGB have been confirmed based on the principle of evidence‐based medicine. XLGB is usually administered orally, after which its multiple components are brought into contact with intestinal microflora in the alimentary tract and biotransformed....

Read More thumbnail image: Biotransformation and metabolic profile of XianLingGuBao capsule a traditional Chinese medicine prescription with rat intestinal microflora by ultraperformance liquid chromatography coupled with quadrupole timeofflight tandem mass spectrometry analysis

Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki‐67, HIF‐1α and VEGF

Published: Jan 9, 2018

Author(s): Teng Ma, Shaolin Yang, Haiyan Jing, Lin Cong, Zhixin Cao, Zhiling Liu, Zhaoqin Huang

Journal: NMR in Biomedicine

Prostate cancer (PCa) is the second most common cancer in men. The Gleason score (GS) and biomarkers play important roles in the diagnosis and treatment of patients with PCa. The purpose of this study was to investigate the relationship between the apparent diffusion coefficient (ADC) and the molecular markers Ki‐67, hypoxia‐inducible factor‐1α (HIF‐1α) and vascular endothelial growth factor (VEGF) in PCa. Thirty‐nine patients with 39...

Read More thumbnail image: Apparent diffusion coefficients in prostate cancer correlation with molecular markers Ki67 HIF1 and VEGF

Multiband diffusion‐weighted MRI of the eye and orbit free of geometric distortions using a RARE‐EPI hybrid

Published: Jan 9, 2018

Author(s): Katharina Paul, Till Huelnhagen, Eva Oberacker, Daniel Wenz, André Kuehne, Helmar Waiczies, Sebastian Schmitter, Oliver Stachs, Thoralf Niendorf

Journal: NMR in Biomedicine

Diffusion‐weighted imaging (DWI) provides information on tissue microstructure. Single‐shot echo planar imaging (EPI) is the most common technique for DWI applications in the brain, but is prone to geometric distortions and signal voids. Rapid acquisition with relaxation enhancement [RARE, also known as fast spin echo (FSE)] imaging presents a valuable alternative to DWI with high anatomical accuracy. This work proposes a multi‐shot...

Read More thumbnail image: Multiband diffusionweighted MRI of the eye and orbit free of geometric distortions using a RAREEPI hybrid

Can T 1 w T 2 w ratio be used as a myelinspecific measure in subcortical structures Comparisons between FSEbased T 1 w T 2 w ratios GRASEbased T 1 w T 2 w ratios and multiecho GRASEbased myelin water fractions

Published: Jan 9, 2018

Author(s): Md Nasir Uddin, Teresa D. Figley, Ruth Ann Marrie, Chase R. Figley, 

Journal: NMR in Biomedicine

Given the growing popularity of T1‐weighted/T2‐weighted (T1w/T2w) ratio measurements, the objective of the current study was to evaluate the concordance between T1w/T2w ratios obtained using conventional fast spin echo (FSE) versus combined gradient and spin echo (GRASE) sequences for T2w image acquisition, and to compare the resulting T1w/T2w ratios with histologically validated myelin water fraction (MWF) measurements in several subcortical brain structures. In ...

Read More thumbnail image: Can T 1 w T 2 w ratio be used as a myelinspecific measure in subcortical structures Comparisons between FSEbased T 1 w T 2 w ratios GRASEbased T 1 w T 2 w ratios and multiecho GRASEbased myelin water fractions

Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan by a dual selector system using quality by design methodology

Published: Jan 9, 2018

Author(s): Sulaiman Krait, Matthias Heuermann, Gerhard K. E. Scriba

Journal: Journal of Separation Science

Abstract Dextromethorphan is a centrally acting antitussive drug, while its enantiomer levomethorphan is an illicit drug with opioid analgesic effects. As capillary electrophoresis has been proven as an ideal technique for enantiomer analysis, the present study was conducted in order to develop a capillary electrophoresis‐based limit test for levomethorphan. The analytical target profile was defined as a method that should be able...

Read More thumbnail image: Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan by a dual selector system using quality by design methodology

Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan by a dual selector system using quality by design methodology

Published: Jan 9, 2018

Author(s): Sulaiman Krait, Matthias Heuermann, Gerhard K. E. Scriba

Journal: Journal of Separation Science

Abstract Dextromethorphan is a centrally acting antitussive drug, while its enantiomer levomethorphan is an illicit drug with opioid analgesic effects. As capillary electrophoresis has been proven as an ideal technique for enantiomer analysis, the present study was conducted in order to develop a capillary electrophoresis‐based limit test for levomethorphan. The analytical target profile was defined as a method that should be able...

Read More thumbnail image: Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan by a dual selector system using quality by design methodology

Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy

Published: Jan 9, 2018

Author(s): Isaac M. Adanyeguh, Marie‐Lorraine Monin, Daisy Rinaldi, Léorah Freeman, Alexandra Durr, Stéphane Lehéricy, Pierre‐Gilles Henry, Fanny Mochel

Journal: NMR in Biomedicine

The striatum is a well‐known region affected in Huntington disease (HD). However, other regions, including the visual cortex, are implicated. We have identified previously an abnormal energy response in the visual cortex of patients at an early stage of HD using 31P magnetic resonance spectroscopy (31P MRS). We therefore sought to further characterize these metabolic alterations with 1H MRS using a well‐validated semi‐localized by adiabatic selective...

Read More thumbnail image: Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy

The effects of ageing on mouse muscle microstructure: a comparative study of time‐dependent diffusion MRI and histological assessment

Published: Jan 9, 2018

Author(s): Paola Porcari, Matt G. Hall, Chris A. Clark, Elizabeth Greally, Volker Straub, Andrew M. Blamire

Journal: NMR in Biomedicine

The investigation of age‐related changes in muscle microstructure between developmental and healthy adult mice may help us to understand the clinical features of early‐onset muscle diseases, such as Duchenne muscular dystrophy. We investigated the evolution of mouse hind‐limb muscle microstructure using diffusion imaging of in vivo and in vitro samples from both actively growing and mature mice. Mean apparent diffusion coefficients (ADCs) of the...

Read More thumbnail image: The effects of ageing on mouse muscle microstructure a comparative study of timedependent diffusion MRI and histological assessment

Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solid‐phase microextraction

Published: Jan 9, 2018

Author(s): Cuicui Cai, Pengcheng Zhang, Jiali Deng, Hongbin Zhou, Jing Cheng

Journal: Journal of Separation Science

Abstract A sensitive, accurate, and cost effective method for the quantification of trimethyl phosphate, which is highly polar and volatile, in environmental water is presented. Trimethyl phosphate was headspace solid‐phase microextracted on a molecularly imprinted polymeric fiber, and then the fiber was thermally desorbed in the gas chromatograph injector, and the compound was determined. The trimethyl phosphate imprinted polymeric...

Read More thumbnail image: Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solidphase microextraction

Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solid‐phase microextraction

Published: Jan 9, 2018

Author(s): Cuicui Cai, Pengcheng Zhang, Jiali Deng, Hongbin Zhou, Jing Cheng

Journal: Journal of Separation Science

Abstract A sensitive, accurate, and cost effective method for the quantification of trimethyl phosphate, which is highly polar and volatile, in environmental water is presented. Trimethyl phosphate was headspace solid‐phase microextracted on a molecularly imprinted polymeric fiber, and then the fiber was thermally desorbed in the gas chromatograph injector, and the compound was determined. The trimethyl phosphate imprinted polymeric...

Read More thumbnail image: Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solidphase microextraction

Fluid mixing in droplet‐based microfluidics with T junction and convergent–divergent sinusoidal microchannels

Published: Jan 9, 2018

Author(s): Li Yang, Shanshan Li, Jixiao Liu, Jingmeng Cheng

Journal: ELECTROPHORESIS

Abstract To explore and utilize the advantages of droplet‐based microfluidics, hydrodynamics, and mixing process within droplets traveling though the T junction channel and convergent–divergent sinusoidal microchannels are studied by numerical simulations and experiments, respectively. In the T junction channel, the mixing efficiency is significantly influenced by the twirling effect, which controls the initial distributions of the...

Read More thumbnail image: Fluid mixing in dropletbased microfluidics with T junction and convergentdivergent sinusoidal microchannels

Antimicrobial activity of functionalized single‐walled carbon nanotube with herbal extract of Hempedu bumi

Published: Jan 8, 2018

Author(s): Mu Ee Foo, Periasamy Anbu, Subash C. B. Gopinath, Thangavel Lakshmipriya, Choul‐Gyun Lee, Hyun Shik Yun, M. N. A. Uda, Ahmad Radi Wan Yaakub

Journal: Surface and Interface Analysis

The primary purpose of this study was to determine the antimicrobial activity of functionalized single‐walled carbon nanotube (SWNT) using an extract of the herb, Hempedu bumi. H bumi extract and H bumi extract complexed SWNT were evaluated for biological activities against Bacillus sp., (pathogen) Escherichia coli (opportunistic pathogen), and Aspergillus niger (pathogen). The formation of inhibition zones of these 3 microbes was measured to be evident for the...

Read More thumbnail image: Antimicrobial activity of functionalized singlewalled carbon nanotube with herbal extract of Hempedu bumi

Corrosion and wear resistance properties of multilayered diamond‐like carbon nanocomposite coating

Published: Jan 8, 2018

Author(s): S. Viswanathan, L. Mohan, Parthasarathi Bera, S. Shanthiswaroop, M. Muniprakash, Harish C. Barshilia, C. Anandan

Journal: Surface and Interface Analysis

Multilayered diamond‐like carbon (DLC) nanocomposite coating has been deposited on silicon and stainless steel substrates by combination of cathodic arc evaporation and magnetron sputtering. In order to make DLC coating adhered to metal substrate, a chromium interlayer has been deposited with constant bias voltage of −150 V applied to the substrate. Dense multilayered coating consists of metallic or nonmetallic and tetrahedral carbon...

Read More thumbnail image: Corrosion and wear resistance properties of multilayered diamondlike carbon nanocomposite coating

Analysis of atmospheric plasma‐treated polypropylene by large area ToF‐SIMS imaging and NMF

Published: Jan 8, 2018

Author(s): Gustavo F. Trindade, David F. Williams, Marie‐Laure Abel, John F. Watts

Journal: Surface and Interface Analysis

This work combines large area time‐of‐flight secondary ion mass spectrometry imaging with multivariate analysis methods to characterise a cold atmospheric plasma treatment of the surface of an automotive grade polypropylene. Data preprocessing steps are also presented alongside their main challenges. The results enabled the investigation of the spatial distribution of the treatment for different stand‐off distances as well as the effects...

Read More thumbnail image: Analysis of atmospheric plasmatreated polypropylene by large area ToFSIMS imaging and NMF

Analysis of atmospheric plasma‐treated polypropylene by large area ToF‐SIMS imaging and NMF

Published: Jan 8, 2018

Author(s): Gustavo F. Trindade, David F. Williams, Marie‐Laure Abel, John F. Watts

Journal: Surface and Interface Analysis

This work combines large area time‐of‐flight secondary ion mass spectrometry imaging with multivariate analysis methods to characterise a cold atmospheric plasma treatment of the surface of an automotive grade polypropylene. Data preprocessing steps are also presented alongside their main challenges. The results enabled the investigation of the spatial distribution of the treatment for different stand‐off distances as well as the effects...

Read More thumbnail image: Analysis of atmospheric plasmatreated polypropylene by large area ToFSIMS imaging and NMF

Sub‐minute kinetics of human red cell fumarase: 1 H spin‐echo NMR spectroscopy and 13 C rapid‐dissolution dynamic nuclear polarization

Published: Jan 8, 2018

Author(s): Dmitry Shishmarev, Alan J. Wright, Tiago B. Rodrigues, Giuseppe Pileio, Gabriele Stevanato, Kevin M. Brindle, Philip W. Kuchel

Journal: NMR in Biomedicine

Fumarate is an important probe of metabolism in hyperpolarized magnetic resonance imaging and spectroscopy. It is used to detect the release of fumarase in cancer tissues, which is associated with necrosis and drug treatment. Nevertheless, there are limited reports describing the detailed kinetic studies of this enzyme in various cells and tissues. Thus, we aimed to evaluate the sub‐minute kinetics of human red blood cell fumarase using...

Read More thumbnail image: Subminute kinetics of human red cell fumarase 1 H spinecho NMR spectroscopy and 13 C rapiddissolution dynamic nuclear polarization

Proton change of parotid glands after gustatory stimulation examined by magnetic resonance imaging

Published: Jan 8, 2018

Author(s): Yi‐Jui Liu, Yi‐Hsiung Lee, Hing‐Chiu Chang, Hui‐Chu Chiu, Ta‐Wei Chiu, Kang Hsu, Cheng‐Ming Pen, Hsian‐He Hsu, Chun‐Jung Juan

Journal: NMR in Biomedicine

The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi‐quantitative parameters and an empirical mathematical model (EMM) using high‐temporal‐resolution, double‐echo, echo‐planar imaging (EPI). Approved by a local institutional review board, this study examined 20 parotid glands from 10 healthy volunteers (male:female = 6: 4; age ± standard deviation =35.1 ± 14.1 years) with...

Read More thumbnail image: Proton change of parotid glands after gustatory stimulation examined by magnetic resonance imaging
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