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Resolution of R‐(−) and S‐(+)‐ enantiomers of clenbuterol in pharmaceutical preparations and black‐market products using liquid chromatography–tandem mass spectrometry

Published: Oct 23, 2017

Author(s): Benjamín Velasco‐Bejarano, Jahir Bautista, Ma. Olivia Noguez, Evangelina Camacho, Martha E. Rodríguez, Leonardo Rodríguez

Journal: Drug Testing and Analysis

Several banned substances are illegally used by athletes in racemic mixtures for performance enhancement. These include clenbuterol, methyl hexaneamine, methamphetamines, and amphetamines. Clenbuterol is present in a large number of doping samples from Olympic and non‐Olympic athletes that have adverse analytical findings (AAFs). In some cases, the presence of these substances could be the result of consumption of meat contaminated with...

Read More thumbnail image: Resolution of R and S enantiomers of clenbuterol in pharmaceutical preparations and blackmarket products using liquid chromatographytandem mass spectrometry

Hybrid central composite design for simultaneous optimization of removal of methylene blue and alizarin red S from aqueous solutions using Vitis tree leaves

Published: Oct 23, 2017

Author(s): Maryam Bagtash, Javad Zolgharnein

Journal: Journal of Chemometrics

Abstract Vitis tree leaves powder was used for efficient removal of dyes (eg, alizarin red and methylene blue) from water samples in binary batch systems. The influence of various parameters such as initial pH, initial dye concentration, and sorbent mass on the biosorption process was investigated. Statistical experimental design was utilized to optimize this biosorption process. A regression model was derived using a response...

Read More thumbnail image: Hybrid central composite design for simultaneous optimization of removal of methylene blue and alizarin red S from aqueous solutions using Vitis tree leaves

Exploring the mechanism of Jieduquyuziyin prescription on systemic lupus erythematosus by GC–MS‐based urine metabolomics

Published: Oct 19, 2017

Author(s): Jing Wei, Jun Gao, Xinghong Ding

Journal: Biomedical Chromatography

Abstract A urine metabolomics method based on gas chromatography–mass spectrometry was developed in order to investigate the metabolite characteristics of systemic lupus erythematosus (SLE) and the therapeutic effects of Jieduquyuziyin prescription. The urinary metabolic profiles in urine specimens of the SLE model mice (MRL/lpr) group, prednisone acetate‐treated SLE mouse group, Jieduquyuziyin prescription‐treated SLE mouse group,...

Read More thumbnail image: Exploring the mechanism of Jieduquyuziyin prescription on systemic lupus erythematosus by GCMSbased urine metabolomics

Density‐weighted concentric rings k ‐space trajectory for 1 H magnetic resonance spectroscopic imaging at 7 T

Published: Oct 18, 2017

Author(s): Mark Chiew, Wenwen Jiang, Brian Burns, Peder Larson, Adam Steel, Peter Jezzard, M. Albert Thomas, Uzay E. Emir

Journal: NMR in Biomedicine

It has been shown that density‐weighted (DW) k‐space sampling with spiral and conventional phase encoding trajectories reduces spatial side lobes in magnetic resonance spectroscopic imaging (MRSI). In this study, we propose a new concentric ring trajectory (CRT) for DW‐MRSI that samples k‐space with a density that is proportional to a spatial, isotropic Hanning window. The properties of two different DW‐CRTs were compared against a radially...

Read More thumbnail image: Densityweighted concentric rings k space trajectory for 1 H magnetic resonance spectroscopic imaging at 7T

Simultaneous LC–MS/MS analysis of eicosanoids and related metabolites in human serum, sputum and BALF

Published: Oct 17, 2017

Author(s): Rhishikesh Thakare, Yashpal S. Chhonker, Nagsen Gautam, Amy Nelson, Richard Casaburi, Gerard Criner, Mark T. Dransfield, Barry Make, Kendra K. Schmid, Stephen I. Rennard, Yazen Alnouti

Journal: Biomedical Chromatography

Abstract The differences among individual eicosanoids in eliciting different physiological and pathological responses are largely unknown because of the lack of valid and simple analytical methods for the quantification of individual eicosanoids and their metabolites in serum, sputum and bronchial alveolar lavage fluid (BALF). Therefore, a simple and sensitive LC–MS/MS method for the simultaneous quantification of 34 eicosanoids in...

Read More thumbnail image: Simultaneous LCMSMS analysis of eicosanoids and related metabolites in human serum sputum and BALF

Global quantification of phosphoproteins combining metabolic labeling and gel‐based proteomics in B. pumilus

Published: Oct 17, 2017

Author(s): Christian Hentschker, Carolin Dewald, Andreas Otto, Knut Büttner, Michael Hecker, Dörte Becher

Journal: ELECTROPHORESIS

Abstract Differential proteomics targeting the protein abundance is commonly used to follow changes in biological systems. Differences in localization and degree of post‐translational modifications of proteins including phosphorylations are of tremendous interest due to the anticipated role in molecular regulatory processes. Because of their particular low abundance in prokaryotes, identification and quantification of protein...

Read More thumbnail image: Global quantification of phosphoproteins combining metabolic labeling and gelbased proteomics in B_ pumilus

On gel electrophoresis of dielectric charged particles with hydrophobic surface: A combined theoretical and numerical study

Published: Oct 17, 2017

Author(s): Partha Sarathi Majee, Somnath Bhattacharyya, Partha Pratim Gopmandal, Hiroyuki Ohshima

Journal: ELECTROPHORESIS

Abstract A theoretical study on the gel electrophoresis of a charged particle incorporating the effects of dielectric polarization and surface hydrophobicity at the particle–liquid interface is made. A simplified model based on the weak applied field and low charge density assumption is also presented and compared with the full numerical model for a nonpolarizable particle to elucidate the nonlinear effects such as double layer...

Read More thumbnail image: On gel electrophoresis of dielectric charged particles with hydrophobic surface A combined theoretical and numerical study

Comparison of a polymeric pseudostationary phase in EKC with ODS stationary phase in RP‐HPLC

Published: Oct 17, 2017

Author(s): Xinjiong Ni, Min Zhang, Xiaoping Xing, Yuhua Cao, Guangqun Cao

Journal: ELECTROPHORESIS

Abstract Poly(stearyl methacrylate‐co‐methacrylic acid) (P(SMA‐co‐MAA)) was induced as pseudostationary phase (PSP) in electrokinetic chromatography (EKC). The n‐octadecyl groups in SMA were the same as that in octadecylsilane (ODS) C18 column. Thus, the present work focused on the comparison of selectivity between polymeric PSP and ODS stationary phase (SP), and the effect of organic modifiers on the selectivity of polymeric PSP and ODS ...

Read More thumbnail image: Comparison of a polymeric pseudostationary phase in EKC with ODS stationary phase in RPHPLC

Development of bufferless gel electrophoresis chip for easy preparation and rapid DNA separation

Published: Oct 17, 2017

Author(s): Sergiy Oleksandrov, Abdurazak Aman, Wanyoung Lim, Younghee Kim, Nam Ho Bae, Kyoung G. Lee, Seok Jae Lee, Sungsu Park

Journal: ELECTROPHORESIS

Abstract This work presents a handy, fast, and compact bufferless gel electrophoresis chip (BGEC), which consists of precast agarose gel confined in a disposable plastic body with electrodes. It does not require large volumes of buffer to fill reservoirs, or the process of immersing the gel in the buffer. It withstands voltages up to 28.4 V/cm, thereby allowing DNA separation within 10 min with a similar separation capability...

Read More thumbnail image: Development of bufferless gel electrophoresis chip for easy preparation and rapid DNA separation

Ensemble calibration for the spectral quantitative analysis of complex samples

Published: Oct 17, 2017

Author(s): Xihui Bian, Pengyao Diwu, Yirui Liu, Peng Liu, Qian Li, Xiaoyao Tan

Journal: Journal of Chemometrics

Abstract Ensemble strategies have gained increasing attention in multivariate calibration for quantitative analysis of complex samples. The aim of ensemble calibration is to obtain a more accurate, stable, and robust prediction by combining the predictions of multiple submodels. The generation and calibration of the training subsets, as well as the integration of the submodels, are three keys to the success of ensemble calibration....

Read More thumbnail image: Ensemble calibration for the spectral quantitative analysis of complex samples

Different localizations of drugs simultaneously administered in a strand of hair by micro‐segmental analysis

Published: Oct 17, 2017

Author(s): Kenji Kuwayama, Hajime Miyaguchi, Yuko T. Iwata, Tatsuyuki Kanamori, Kenji Tsujikawa, Tadashi Yamamuro, Hiroki Segawa, Hiroyuki Inoue

Journal: Drug Testing and Analysis

Abstract Segmental hair analysis is used to estimate the time of drug intake at monthly precision in drug‐related crimes. Previously, we advanced this analytical method to specify the day of drug intake by cutting a strand of hair into 0.4‐mm segments, which correspond to daily hair growth. Herein, we investigated the distributions of 7 compounds in a strand of hair using micro‐segmental analysis. Several strands of hair were...

Read More thumbnail image: Different localizations of drugs simultaneously administered in a strand of hair by microsegmental analysis

Ionic liquids: solvents and sorbents in sample preparation

Published: Oct 17, 2017

Author(s): Kevin D. Clark, Miranda N. Emaus, Marcelino Varona, Ashley N. Bowers, Jared L. Anderson

Journal: Journal of Separation Science

Abstract The applications of ionic liquids (ILs) and IL‐derived sorbents are rapidly expanding. By careful selection of the cation and anion components, the physicochemical properties of ILs can be altered to meet the requirements of specific applications. Reports of IL solvents possessing high selectivity for specific analytes are numerous and continue to motivate the development of new IL‐based sample preparation methods that are...

Read More thumbnail image: Ionic liquids solvents and sorbents in sample preparation

Improving the frame rates of Raman image sequences recorded with integral field spectroscopy using windowing and binning methods

Published: Oct 17, 2017

Author(s): Benito Moralejo, Elmar Schmälzlin, Daniel Bodenmüller, Thomas Fechner, Martin M. Roth

Journal: Journal of Raman Spectroscopy

Abstract Astrophysicists use Integral Field Spectroscopy to record spectrally resolved images of faint galaxies. Transferred to imaging Raman spectroscopy, this technique significantly accelerates the capture of Raman images as the simultaneous acquisition of multiple spectra makes scanning procedures obsolete. Furthermore, sequentially collected Raman images result in image sequences thus allowing to monitor Raman features in the...

Read More thumbnail image: Improving the frame rates of Raman image sequences recorded with integral field spectroscopy using windowing and binning methods

SERS investigation of neocuproine adsorption on silver: Influence of electrode potential on methyl groups

Published: Oct 17, 2017

Author(s): Elena V. Solovyeva, Assima Rakhimbekova, Yulia V. Lanchuk, Liubov A. Myund, Anna S. Denisova

Journal: Journal of Raman Spectroscopy

Abstract Study of molecules adsorption on charged surfaces is important for biologically relevant substances where the potential at the interface such as living cell membrane is a significant parameter in the processes of their transportation or transmembrane penetration. In this work, a hybrid optical/electrochemical surface‐enhanced Raman scattering (SERS) technique was applied to get new insight into the adsorption state and...

Read More thumbnail image: SERS investigation of neocuproine adsorption on silver Influence of electrode potential on methyl groups

Relation between plasmonic tip emission and electromagnetic enhancement evidenced in tip‐enhanced Raman spectroscopy

Published: Oct 17, 2017

Author(s): J. Plathier, A. Merlen, A. Pignolet, A. Ruediger

Journal: Journal of Raman Spectroscopy

Abstract We report tip‐enhanced Raman spectroscopy measurements of single wall carbon nanotubes deposited on a barium titanate substrate. The tip‐enhanced Raman spectroscopy mappings demonstrate that the evolution of the gold tip enhanced luminescence is strongly correlated with the intensity of the Raman modes from the single wall carbon nanotubes and the substrate. As the tip emission is directly related to the plasmonic...

Read More thumbnail image: Relation between plasmonic tip emission and electromagnetic enhancement evidenced in tipenhanced Raman spectroscopy

Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles

Published: Oct 16, 2017

Author(s): Michael Liem, Ching‐Seng Ang, Suresh Mathivanan

Journal: PROTEOMICS

Abstract Epidemiological studies suggest that diabetes and obesity increases the risk of colorectal cancer (CRC) and lowers the patient survival rate. An important attribute in diabetes and obesity is the presence of high levels of growth factors including insulin in blood which can activate the PI3K/Akt signalling pathway. Dysregulation of PI3K/Akt signalling pathway leads to sustained proliferative signals thereby allowing the...

Read More thumbnail image: Insulin Mediated Activation of PI3KAkt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles

Simultaneous determination of serum propafenone and its metabolites using high‐performance liquid chromatography

Published: Oct 15, 2017

Author(s): Yuki Shirayama, Kosuke Doki, Yukio Sekiguchi, Kazutaka Aonuma, Yukinao Kohda, Masato Homma

Journal: Biomedical Chromatography

Abstract Propafenone, a class Ic antiarrhythmic agent, is metabolized to 5‐hydroxypropafeone (5‐OHP) and N‐depropylpropafenone (NDPP). Simultaneous determination of serum propafenone and its metabolites was performed using HPLC equipped with a conventional octadecylsilyl silica column and ultraviolet detector. The wavelength was set at 250 nm. Propafenone and its metabolites in the serum were extracted using diethyl ether. The mobile phase...

Read More thumbnail image: Simultaneous determination of serum propafenone and its metabolites using highperformance liquid chromatography

Quantification through TLC‐densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves

Published: Oct 15, 2017

Author(s): Raphael S. Affonso, Josélia A. Lima, Bruno M. Lessa, João V. O. Caetano, Marcos T. Obara, Andréa B. Nóbrega, Eugenie Nepovimova, Kamil Musilek, Kamil Kuca, Gláucia B. C. A. Slana, Tanos C. C. França

Journal: Biomedical Chromatography

Abstract The rise of the mosquitoes‐transmitted diseases, like dengue, zika and chikungunya in Brazil in the last years has increased concerns on protection against mosquitoes bites. However, the prohibitive prices of the commercially available repellents for the majority of the Brazilian population has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of Indian clove (Syzygium aromaticum L.) as...

Read More thumbnail image: Quantification through TLCdensitometric analysis repellency and anticholinesterase activity of the homemade extract of Indian cloves

Dynamic residual pattern of azoxystrobin in Swiss chard with contribution to safety evaluation

Published: Oct 15, 2017

Author(s): Waziha Farha, A. M. Abd El‐Aty, Md. Musfiqur Rahman, Md. Humayun Kabir, Hyung Suk Chung, Han Sol Lee, Jong‐Sup Jeon, Jing Wang, Byung‐Joon Chang, Ho‐Chul Shin, Jae‐Han Shim

Journal: Biomedical Chromatography

Abstract This study aimed at quantifying the residual amount of azoxystrobin in Swiss chard samples grown under greenhouse conditions at two different locations (Gwangju and Naju, Republic of Korea). Samples were extracted with acetonitrile, separated by salting out, and subjected to purification by using solid‐phase extraction. The analyte was identified using liquid chromatography–ultraviolet detection. The linearity of the...

Read More thumbnail image: Dynamic residual pattern of azoxystrobin in Swiss chard with contribution to safety evaluation

A rapid and simple HPTLC assay for therapeutic drug monitoring of capecitabine in colorectal cancer patients

Published: Oct 15, 2017

Author(s): Sonali G. Thorat, Rupesh V. Chikhale, Madhukar R. Tajne

Journal: Biomedical Chromatography

Abstract Capecitabine is a prodrug of 5‐flurouracil, employed as a broad spectrum chemotherapeutic agent. It is also used as monotherapy or a combination chemotherapy agent for the treatment of colorectal cancer. Capecitabine is administered in combination with oxaliplatin and hence it is essential to determine that co‐administration does not affect its metabolism. To determine the plasma concentration of capecitabine a simple HPTLC...

Read More thumbnail image: A rapid and simple HPTLC assay for therapeutic drug monitoring of capecitabine in colorectal cancer patients
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