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Phospho‐ l ‐tyrosine‐agarose chromatography: Adsorption of human IgG and its proteolytic fragments

Published: Oct 23, 2018

Author(s): Gisele Luiza Pavan, Igor Tadeu Lazzarotto Bresolin, Aline Ferreira Velho Muzio, Daniele Celestino Cunha, Sonia Maria Alves Bueno

Journal: Biomedical Chromatography

Abstract The behavior of human immunoglobulin G (IgG) and antigen‐binding fragment (Fab fragment) adsorption onto phospho‐l‐tyrosine immobilized on agarose (P‐Tyr‐agarose) was evaluated by pseudoaffinity chromatography. The effects of buffer systems MES, MOPS, Bis–Tris, Tris–HCl and sodium phosphate (NaP) and pH on IgG adsorption were studied and high purity values were obtained (96%, based on ELISA analysis of albumin, transferrin and...

Read More thumbnail image: Phospho l tyrosineagarose chromatography Adsorption of human IgG and its proteolytic fragments

Using open‐tubular capillary electrochromatography with part‐coating column for binding constants determination of β 2 ‐adrenergic receptor with seven drugs

Published: Oct 23, 2018

Author(s): Chunye Liu, Xuejiao Zhang, Hui Jing, Jingshui Zhang, Yanqing Miao, Xifeng Zhai, Songyi Chen

Journal: ELECTROPHORESIS

Abstract An open‐tubular capillary electrochromatography method has been developed for the determination of binding constants between β2‐adrenergic receptor (β2‐AR) and seven drugs. β2‐AR was oriented immobilized onto one part of inner surface of capillary via microwave‐assisted technical synthesis. According to the linear relationship between coating length and the apparent mobility of analyte, the binding constant (Kb) can be obtained by...

Read More thumbnail image: Using opentubular capillary electrochromatography with partcoating column for binding constants determination of  2 adrenergic receptor with seven drugs

Laser interference‐based technique for dynamic measurement of single cell deformation manipulated by optical tweezers

Published: Oct 23, 2018

Author(s): Jiaqi Liu, Fan Zhang, Lianqing Zhu, Xinghua Qu, Daping Chu

Journal: ELECTROPHORESIS

Abstract A laser interference‐based method was proposed to measure the deformation response of cell manipulated by optical tweezers. This method was implemented experimentally by integrating a laser illuminating system and optical tweezers with an inverted microscope. Interference fringes generated by the transmitted and reflected lights were recorded by a complementary metal oxide semiconductor camera. From the acquired images,...

Read More thumbnail image: Laser interferencebased technique for dynamic measurement of single cell deformation manipulated by optical tweezers

Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia

Published: Oct 22, 2018

Author(s): Haijuan Zhi, Zhenwei Li, Yanping Deng, Peng Qi, Jinjun Hou, Wen Deng, Jinle Cheng, Wanying Wu, Dean Guo

Journal: Biomedical Chromatography

Abstract Salvia miltiorrhiza, one of the most well‐known herbal medicines, is commonly used for the treatment of coronary heart diseases in China. Besides traditional decoction slices (TDS), another relatively new product of S. miltiorrhiza, ultrafine granular powder (UGP; D90 < 45 μm), is also increasingly being used. In this paper, a UHPLC‐LTQ‐Orbitrap MS technique was developed for a metabolite profile study after oral administration of...

Read More thumbnail image: Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia

Inverse cationic ITP for separation of methadone enantiomers with sulfated β‐cyclodextrin as chiral selector

Published: Oct 22, 2018

Author(s): Saara Mikkonen, Jitka Caslavska, Petr Gebauer, Wolfgang Thormann

Journal: ELECTROPHORESIS

Abstract Chiral ITP of the weak base methadone using inverse cationic configurations with H+ as leading component and multiple isomer sulfated β‐CD (S‐β‐CD) as leading electrolyte (LE) additive, has been studied utilizing dynamic computer simulation, a calculation model based on steady‐state values of the ITP zones, and capillary ITP. By varying the amount of acidic S‐β‐CD in the LE composed of 3‐morpholino‐2‐hydroxypropanesulfonic acid and the...

Read More thumbnail image: Inverse cationic ITP for separation of methadone enantiomers with sulfated cyclodextrin as chiral selector

Preface to the special issue of Mass Spectrometry Reviews

Published: Oct 22, 2018

Author(s): Dietmar Kuck, Jürgen Grotemeyer

Journal: Mass Spectrometry Reviews

Read More thumbnail image: Preface to the special issue of Mass Spectrometry Reviews

Analytical quantification, intoxication case series, and pharmacological mechanism of action for N ‐ethylnorpentylone ( N ‐ethylpentylone or ephylone)

Published: Oct 21, 2018

Author(s): Jose Luiz Costa, Kelly Francisco Cunha, Rafael Lanaro, Ricardo Leal Cunha, Donna Walther, Michael H. Baumann

Journal: Drug Testing and Analysis

Abstract Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N‐ethylnorpentylone (also known as N‐ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical presentation, and pharmacological mechanism of action for N‐ethylnorpentylone. Liquid chromatography coupled to tandem...

Read More thumbnail image: Analytical quantification intoxication case series and pharmacological mechanism of action for N ethylnorpentylone  N ethylpentylone or ephylone

Stimulated Raman scattering microscopy with long wavelengths for improved imaging depth

Published: Oct 21, 2018

Author(s): Miriam J.B. Moester, Liron Zada, Bart Fokker, Freek Ariese, Johannes F. Boer

Journal: Journal of Raman Spectroscopy

Abstract Stimulated Raman scattering (SRS) imaging is a fast, label‐free, and sensitive technique to map the distribution of a vibrational species in a microscopy setting. It has great potential for applications in many fields, such as lipid imaging in biomedicine. However, depth penetration of the light into the sample is an issue with any light‐based technique, especially with multiphoton techniques such as SRS. Using longer...

Read More thumbnail image: Stimulated Raman scattering microscopy with long wavelengths for improved imaging depth

Multiple incidence of the prescription diuretic hydrochlorothiazide in compounded nutritional supplements

Published: Oct 18, 2018

Author(s): Donata Favretto, Sindi Visentin, Salvatore Scrivano, Emanuele Roselli, Fabio Mattiazzi, Roberto Pertile, Susanna Vogliardi, Marianna Tucci, Massimo Montisci

Journal: Drug Testing and Analysis

Abstract Diuretic agents are prohibited in sports in‐ and out‐of‐competition according to the regulations of the World Anti‐Doping Agency (WADA) because of their possible masking effects on other doping agents in urine samples, and their ability to produce fast acute weight losses. Despite previous studies reported adverse analytical findings (AAFs) resulting from contaminations at ppm level (μg/g) of medicinal products, and...

Read More thumbnail image: Multiple incidence of the prescription diuretic hydrochlorothiazide in compounded nutritional supplements

Postmortem tissue distribution of morphine and its metabolites in a series of heroin‐related deaths

Published: Oct 18, 2018

Author(s): Peter D. Maskell, Nathan E. Wilson, L. Nitin Seetohul, Megan L. Crichton, Lewis J. Beer, Gail Drummond, Giorgia De Paoli

Journal: Drug Testing and Analysis

Abstract The abuse of heroin (diamorphine) and heroin‐related deaths are increasing around the world. The interpretation of the toxicological results from suspected heroin‐related deaths is notoriously difficult, especially in cases where there may be limited samples. To help forensic practitioners with heroin interpretation, we determined the concentration of morphine (M), morphine‐3‐glucuronide (M3G), and morphine‐6‐glucuronide...

Read More thumbnail image: Postmortem tissue distribution of morphine and its metabolites in a series of heroinrelated deaths

Preparation and adhesive properties of colored Ti/Zr‐based conversion coating on aluminum foil for lithium battery packaging

Published: Oct 18, 2018

Author(s): Yingying Gu, Songnan Wang, Shiai Xu

Journal: Surface and Interface Analysis

In this study, an aluminum (Al) foil used for lithium ion battery packaging film was treated with titanium (Ti)/zirconium (Zr) solution containing hexafluorotitanic acid and hexafluorozirconic acid using tannic acid as a colorant and metavanadate as an accelerator, respectively, and a golden conversion coating was successfully deposited on the surface of Al foil. The morphology and composition of the coating were characterized by scanning...

Read More thumbnail image: Preparation and adhesive properties of colored TiZrbased conversion coating on aluminum foil for lithium battery packaging

Proteomic fingerprinting of apple fruit, juice, and cider via combinatorial peptide ligand libraries and MS analysis

Published: Oct 18, 2018

Author(s): María Jesús Lerma‐García, Maria Nicoletti, Ernesto Francisco Simó‐Alfonso, Pier Giorgio Righetti, Elisa Fasoli

Journal: ELECTROPHORESIS

Abstract Combinatorial peptide ligand libraries coupled to MS was applied to extensively map the proteome of apple fruit, and to detect its presence in commercial apple juice and cider to evaluate their authenticity and genuineness. Using the Uniprot_Malus database, 96 proteins were detected in apples, among which 30 proteins were specifically captured via combinatorial peptide ligand libraries. Next, three proteins, previously recognized in...

Read More thumbnail image: Proteomic fingerprinting of apple fruit juice and cider via combinatorial peptide ligand libraries and MS analysis

Plasmon‐enhanced inelastic scattering by 2 D and 3 D superlattices made of silver nanocrystals

Published: Oct 18, 2018

Author(s): Alexa Courty, Maxime Bayle, Robert Carles

Journal: Journal of Raman Spectroscopy

Abstract The lattice dynamics of natural crystals, artificial superlattices, or self‐organized nanocrystals intimately mix confinement, coupling, periodicity, and dissipative effects. The low wavenumber vibrational response of the new class of nanomaterials called “supercrystals” does contain relevant information concerning finite size effects on atomic movements inside each nanocrystal, mechanical coupling between adjacent...

Read More thumbnail image: Plasmonenhanced inelastic scattering by 2 D and 3 D superlattices made of silver nanocrystals

Identification of new psychoactive substances ( NPS ) by Raman spectroscopy

Published: Oct 18, 2018

Author(s): Jone Omar, Boleslaw Slowikowski, Claude Guillou, Fabiano Reniero, Margaret Holland, Ana Boix

Journal: Journal of Raman Spectroscopy

Abstract There is an increasing need of developing methods for fast recognition and identification of new psychoactive substances (NPS). The chemical identification of these new substances produced with the intention of mimicking the effects of controlled drugs is a challenge for forensic and Customs laboratories. In this study, we aim to test the potential of Raman spectroscopy for the identification and classification of seized...

Read More thumbnail image: Identification of new psychoactive substances  NPS  by Raman spectroscopy

Probing the origin of dihydrofolate reductase inhibition via proteochemometric modeling

Published: Oct 18, 2018

Author(s): Safoura Hariri, Jahan B. Ghasemi, Farhad Shirini, Behnam Rasti

Journal: Journal of Chemometrics

Abstract Dihydrofolate reductase (DHFR) is an essential enzyme in the folate metabolism pathway and an important target of antineoplastic, antimicrobial, antiprotozoal, and antiinflammatory drugs. Despite the clinical effectiveness of current antifolate treatments, new drugs are needed to be designed due to developing resistance of this enzyme through multiple‐site mutagenesis. Understanding the factors affecting the ligand binding...

Read More thumbnail image: Probing the origin of dihydrofolate reductase inhibition via proteochemometric modeling

Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): Long‐term monitoring of its intake by chiral LC–MS/MS analysis of cocaine‐positive hair samples

Published: Oct 17, 2018

Author(s): Milena M. Madry, Thomas Kraemer, Markus R. Baumgartner

Journal: Drug Testing and Analysis

Abstract Recent studies indicate that not only the anthelminthic levamisole but also the racemate tetramisole (R‐/S‐phenyltetraimidazothiazole, PTHIT) was found as an adulterant for cocaine. We herein report on the investigation of the prevalence of PTHIT among cocaine‐positive hair samples and the discrimination of the presence of its stereoisomers levamisole and dexamisole. Cocaine‐positive hair samples were collected in a forensic context in...

Read More thumbnail image: Cocaine adulteration with the anthelminthic tetramisole levamisoledexamisole Longterm monitoring of its intake by chiral LCMSMS analysis of cocainepositive hair samples

Semi‐quantitative determination of designer steroids by high‐performance liquid chromatography with ultraviolet detection in the absence of reference material

Published: Oct 17, 2018

Author(s): Sarah E. Voelker, Lisa M. Lorenz, Jonathan J. Litzau

Journal: Drug Testing and Analysis

Abstract New designer steroids are continually being encountered in dietary supplements that claim to increase muscle mass, but quantitative analysis of such ingredients is challenging due to the availability, quality, or cost of commercial reference materials. Although standard reference material typically becomes available for these emerging compounds, laboratories often face the challenge of finding properly certified materials...

Read More thumbnail image: Semiquantitative determination of designer steroids by highperformance liquid chromatography with ultraviolet detection in the absence of reference material

Identification of the anabolic steroid 6β‐chlorotestosterone in a dietary supplement

Published: Oct 17, 2018

Author(s): Travis M. Falconer, Rick A. Flurer, Mary B. Jones, Lisa M. Lorenz, Sarah E. Voelker

Journal: Drug Testing and Analysis

Abstract Capsules that were labeled to be performance‐enhancing dietary supplements obtained during an investigation were found to contain an unrecognized steroid‐like substance. This compound was isolated by liquid chromatography (LC) fraction collection and characterized using several qualitative analytical techniques, including ultraviolet (UV) spectroscopy, gas chromatography–mass spectrometry (GC–MS), liquid chromatography‐high...

Read More thumbnail image: Identification of the anabolic steroid 6chlorotestosterone in a dietary supplement

Lomerizine, trimetazidine and bis‐(4‐fluorophenyl)‐methylpiperazine in human urine after oral administration of lomerizine dihydrochloride: analysis by liquid chromatography‐high resolution‐tandem mass spectrometry

Published: Oct 17, 2018

Author(s): Masato Okano, Mitsuhiko Sato, Shinji Kageyama

Journal: Drug Testing and Analysis

Abstract In sports drugs testing, the differentiation between the abuse of the prohibited substance trimetazidine and that of the permitted drug lomerizine is required because trimetazidine is one of the metabolites of lomerizine. Therefore, it is important to identify a lomerizine‐specific metabolite in urine that allows making the distinction. In this study, a simple dilute‐and‐shoot method employing liquid chromatography–high...

Read More thumbnail image: Lomerizine trimetazidine and bis4fluorophenylmethylpiperazine in human urine after oral administration of lomerizine dihydrochloride analysis by liquid chromatographyhigh resolutiontandem mass spectrometry

Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone‐treated rats using GC–MS

Published: Oct 17, 2018

Author(s): Thidarat Intararuchikul, Narudol Teerapattarakan, Ratchanee Rodsiri, Mayuree Tantisira, Gert Wohlgemuth, Oliver Fiehn, Rossarin Tansawat

Journal: Biomedical Chromatography

Abstract Centella asiatica has been used as a culinary vegetable or medicinal herb. In this study, the hepatoprotective effect of the standardized extract of C. asiatica (ECa233) in rotenone‐treated rats was examined using a GC–MS‐based metabolomic approach. ECa233 contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Rats were randomly divided into three groups (with six rats/group): sham...

Read More thumbnail image: Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenonetreated rats using GCMS
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