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Hybrid femtosecond/picosecond pure‐rotational coherent anti‐Stokes Raman scattering with chirped probe pulses

Published: Oct 27, 2017

Author(s): Chaobo Yang, David Escofet‐Martin, Derek Dunn‐Rankin, Yu‐Chien Chien, Xin Yu, Shaul Mukamel

Journal: Journal of Raman Spectroscopy

Abstract The influence of probe laser chirp on hybrid femtosecond/picosecond pure‐rotational coherent anti‐Stokes Raman scattering is studied theoretically and experimentally. Experiments of N2(hybrid fs/ps pure‐rotational coherent anti‐Stokes Raman scattering) are carried out using an in‐house built second harmonic bandwidth compressor, results with different probe chirps of are reported. The experimental spectra are fitted with and without ...

Read More thumbnail image: Hybrid femtosecondpicosecond purerotational coherent antiStokes Raman scattering with chirped probe pulses

Application of a screening method for fentanyl and its analogues using UHPLC‐QTOF‐MS with data‐independent acquisition (DIA) in MS E mode and retrospective analysis of authentic forensic blood samples

Published: Oct 27, 2017

Author(s): Carolina Noble, Petur Weihe Dalsgaard, Sys Stybe Johansen, Kristian Linnet

Journal: Drug Testing and Analysis

Abstract The steady appearance of new fentanyl analogues and the associated overdose deaths require the development of sensitive screening approaches to detect these compounds in biological samples and seizures. We developed a targeted screening method to detect 50 4‐anilidopiperidine‐related fentanyl analogues in whole blood using ultra‐high performance liquid chromatography quadrupole time‐of‐flight mass spectrometry in...

Read More thumbnail image: Application of a screening method for fentanyl and its analogues using UHPLCQTOFMS with dataindependent acquisition DIA in MS E mode and retrospective analysis of authentic forensic blood samples

European guidelines for workplace drug testing in oral fluid

Published: Oct 27, 2017

Author(s): Michaela Brcak, Olof Beck, Tessa Bosch, Duncan Carmichael, Nadia Fucci, Claire George, Mark Piper, Alberto Salomone, Wim Schielen, Stefan Steinmeyer, Sanna Taskinen, Wolfgang Weinmann

Journal: Drug Testing and Analysis

Abstract These guidelines for Legally Defensible Workplace Drug Testing have been prepared and updated by the European Workplace Drug Testing Society (EWDTS). The European Guidelines are designed to establish best practice procedures whilst allowing individual countries to operate within the requirements of national customs and legislation. The EWDTS recommends that all European laboratories that undertake legally defensible...

Read More thumbnail image: European guidelines for workplace drug testing in oral fluid

Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice

Published: Oct 27, 2017

Author(s): Hongli Du, Hai Zhang, Yahong Zhao, Min Liu, Anni Chen, Shiyu Liu, Dan Xue, Yanjun Liu, Guoqing Zhang

Journal: Biomedical Chromatography

Abstract In recent years, vascular depression has become the focus of international attention. Yangxinshi Tablet (YXST) is usually used in cthe linic for the treatment of arrhythmia and heart failure, but we found that it also has antidepressive effects. The objective of the study was to identify biomarkers related to vascular depression in hippocampus and explore the antidepressive effects of YXST on the mouse model. Untargeted...

Read More thumbnail image: Metabolic analysis of the antidepressive effects of Yangxinshi Tablet in a vascular depression model in mice

Development of an LC–MS/MS method for quantification of two isomeric phenylpropenes and the application to pharmacokinetic studies in rats

Published: Oct 27, 2017

Author(s): Qiong Yang, Zhipeng Deng, Fang Zhang, Peilu Sun, Jun Li, Wanjin Zheng

Journal: Biomedical Chromatography

Abstract Isomers β‐asarone and α‐asarone have recently been demonstrated to have differential pharmacological activities. Here, we report an LC–MS/MS method developed using acetonitrile to extract two isomeric phenylpropenes from rat plasma. Separation was achieved using a XDB‐C18 column (100 × 2.1 mm; i.d., 1.8 μm) with a mobile phase of methanol–0.1% formic acid (55:45, v/v) at a flow rate of 0.3 mL/min. Calibration curves ranging from 5.20 to 2080 ng/mL...

Read More thumbnail image: Development of an LCMSMS method for quantification of two isomeric phenylpropenes and the application to pharmacokinetic studies in rats

Steroid profile and IRMS analysis of musk administration for doping control

Published: Oct 27, 2017

Author(s): Jingzhu Wang, Yi He, Xin Liu, Zhiyong Yang, Wenning Yang

Journal: Drug Testing and Analysis

Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south‐east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing prohibited substances employed for doping by the State Food and Drug Administration of China. The application of musk pod...

Read More thumbnail image: Steroid profile and IRMS analysis of musk administration for doping control

Epiandrosterone sulfate prolongs the detectability of testosterone, 4‐androstenedione, and dihydrotestosterone misuse by means of carbon isotope ratio mass spectrometry

Published: Oct 27, 2017

Author(s): Thomas Piper, Marlen Putz, Wilhelm Schänzer, Valentin Pop, Malcolm D. McLeod, Dimanthi R. Uduwela, Bradley J. Stevenson, Mario Thevis

Journal: Drug Testing and Analysis

In the course of investigations into the metabolism of testosterone (T) by means of deuterated T and hydrogen isotope ratio mass spectrometry, a pronounced influence of the oral administration of T on sulfoconjugated steroid metabolites was observed. Especially in case of epiandrosterone sulfate (EPIA_S), the contribution of exogenous T to the urinary metabolite was traceable up to 8 days after a single oral dose of 40 mg of T. These...

Read More thumbnail image: Epiandrosterone sulfate prolongs the detectability of testosterone 4androstenedione and dihydrotestosterone misuse by means of carbon isotope ratio mass spectrometry

Radiomics in paediatric neuro‐oncology: A multicentre study on MRI texture analysis

Published: Oct 26, 2017

Author(s): Ahmed E. Fetit, Jan Novak, Daniel Rodriguez, Dorothee P. Auer, Christopher A. Clark, Richard G. Grundy, Andrew C. Peet, Theodoros N. Arvanitis

Journal: NMR in Biomedicine

Brain tumours are the most common solid cancers in children in the UK and are the most common cause of cancer deaths in this age group. Despite current advances in MRI, non‐invasive diagnosis of paediatric brain tumours has yet to find its way into routine clinical practice. Radiomics, the high‐throughput extraction and analysis of quantitative image features (e.g. texture), offers potential solutions for tumour characterization and...

Read More thumbnail image: Radiomics in paediatric neurooncology A multicentre study on MRI texture analysis

Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single‐channel transmitter–receiver and dynamic B 0 shimming

Published: Oct 26, 2017

Author(s): Byeong‐Yeul Lee, Xiao‐Hong Zhu, Myung Kyun Woo, Gregor Adriany, Scott Schillak, Wei Chen

Journal: NMR in Biomedicine

In vivo 31P magnetic resonance spectroscopy (MRS) provides a unique tool for the non‐invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of 31P spectra and imaging from two...

Read More thumbnail image: Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with singlechannel transmitterreceiver and dynamic B 0 shimming

Value of whole breast magnetic resonance elastography added to MRI for lesion characterization

Published: Oct 26, 2017

Author(s): Corinne Balleyguier, Aicha Ben Lakhdar, Ariane Dunant, Marie‐Christine Mathieu, Suzette Delaloge, Ralph Sinkus

Journal: NMR in Biomedicine

The purpose of this work was to assess the diagnostic value of magnetic resonance elastography (MRE) in addition to MRI to differentiate malignant from benign breast tumors, and the feasibility of performing MRE on the whole breast. MRE quantified biomechanical properties within the entire breast (50 slices) using an 11 min acquisition protocol at an isotropic image acquisition resolution of...

Read More thumbnail image: Value of whole breast magnetic resonance elastography added to MRI for lesion characterization

Hadamard editing of glutathione and macromolecule‐suppressed GABA

Published: Oct 26, 2017

Author(s): Georg Oeltzschner, Kimberly L. Chan, Muhammad G. Saleh, Mark Mikkelsen, Nicolaas A. Puts, Richard A. E. Edden

Journal: NMR in Biomedicine

The primary inhibitory neurotransmitter γ‐aminobutyric acid (GABA) and the major antioxidant glutathione (GSH) are compounds of high importance for the function and integrity of the human brain. In this study, a method for simultaneous J‐difference spectral‐edited magnetic resonance spectroscopy (MRS) of GSH and GABA with suppression of macromolecular (MM) signals at 3 T is proposed. MM‐suppressed Hadamard encoding and reconstruction of MEGA...

Read More thumbnail image: Hadamard editing of glutathione and macromoleculesuppressed GABA

Metabolomics toward personalized medicine

Published: Oct 26, 2017

Author(s): Minnie Jacob, Andreas L. Lopata, Majed Dasouki, Anas M. Abdel Rahman

Journal: Mass Spectrometry Reviews

Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for biomarker discovery and personalized medicine and has great potential to elucidate the ultimate product of the genomic processes. Over the last decade, metabolomics studies have identified several relevant biomarkers involved in complex clinical phenotypes using diverse biological systems. Most diseases result in signature...

Read More thumbnail image: Metabolomics toward personalized medicine

Strategies and Challenges in Identifying Function for Thousands of sORF‐Encoded Peptides in Meiosis

Published: Oct 26, 2017

Author(s): Ina Hollerer, Andrea Higdon, Gloria A. Brar

Journal: PROTEOMICS

Abstract Recent genomic analyses have revealed pervasive translation from formerly unrecognized short open reading frames (sORFs) during yeast meiosis. Despite their short length, which has caused these regions to be systematically overlooked by traditional gene annotation approaches, meiotic sORFs share many features with classical genes, implying the potential for similar types of cellular functions. We found that sORF expression...

Read More thumbnail image: Strategies and Challenges in Identifying Function for Thousands of sORFEncoded Peptides in Meiosis

HPLC–MS/MS analysis of peramivir in rat plasma: Elimination of matrix effect using the phospholipid‐removal solid‐phase extraction method

Published: Oct 25, 2017

Author(s): Mingdao Lei, Wei Gan, Yongbing Sun

Journal: Biomedical Chromatography

Abstract A simple HPLC–MS/MS method has been developed for the determination of peramivir in rat plasma in the present study. The analytes were separated on a C18 column (50 × 2.1 mm, 1.7 μm) and a triple‐quadrupole mass spectrometer equipped with an electrospray ionization source was applied for the detection. A phospholipid‐free cartridge solid‐phase extraction was used to pretreat the plasma and eliminate the endogenous...

Read More thumbnail image: HPLCMSMS analysis of peramivir in rat plasma Elimination of matrix effect using the phospholipidremoval solidphase extraction method

Secreted Tumor Antigens – Immune Biomarkers for Diagnosis and Therapy

Published: Oct 25, 2017

Author(s): Els Meeusen, Elgene Lim, Suresh Mathivanan

Journal: PROTEOMICS

Abstract With the advent of immunotherapies for cancer, there is growing interest in the identification of tumor antigens. Tumor antigens are self‐molecules altered through e.g. genetic mutations (neoantigens), protein truncation, protein misfolding, or abnormal posttranslational modifications. To induce an immune response, tumor antigens need to be secreted into the tumor environment and presented to the immune system in the...

Read More thumbnail image: Secreted Tumor Antigens  Immune Biomarkers for Diagnosis and Therapy

Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles

Published: Oct 25, 2017

Author(s): Priya Samuel, Muller Fabbri, David Raul Francisco Carter

Journal: PROTEOMICS

Abstract Drug resistance remains a major barrier to the successful treatment of cancer. The mechanisms by which therapeutic resistance arises are multifactorial. Recent evidence has shown that extracellular vesicles (EVs) play a role in mediating drug resistance. EVs are small vesicles carrying a variety of macromolecular cargo released by cells into the extracellular space and can be taken up into recipient cells, resulting in...

Read More thumbnail image: Mechanisms of Drug Resistance in Cancer The Role of Extracellular Vesicles

The next generation of capillary electrophoresis instruments: Performance of CE‐SDS protein analysis

Published: Oct 25, 2017

Author(s): Julia Kahle, Kai Jorrit Maul, Hermann Wätzig

Journal: ELECTROPHORESIS

Abstract Over the last decade, capillary electrophoresis gained tremendous importance, because it became an indispensible tool for the quality control of biologics, e.g. therapeutic antibodies. Consequently, there has been a continuous development within the CE market. Microchip techniques have been established in the last years. Further trends are complete solutions for specific applications by the usage of reagent kits. Step by...

Read More thumbnail image: The next generation of capillary electrophoresis instruments Performance of CESDS protein analysis

Sample preconcentration from dilute solutions on micro/nanofluidic platforms: A review

Published: Oct 25, 2017

Author(s): Lung‐Ming Fu, Hui‐Hsiung Hou, Ping‐Hsien Chiu, Ruey‐Jen Yang

Journal: ELECTROPHORESIS

Abstract Biochemical detection plays a critical role in many analytical fields. For example, blood samples include many proteins with relevance to disease diagnosis and therapeutic monitoring. Foods and beverages contain a large number of chemicals and compounds which must be quantified and characterized to ensure their compliance with safety standards. Detecting trace amounts of contaminants in ambient air or water samples is...

Read More thumbnail image: Sample preconcentration from dilute solutions on micronanofluidic platforms A review

Fundamentals of affinity cell separations

Published: Oct 25, 2017

Author(s): Ye Zhang, Veronica Lyons, Dimitri Pappas

Journal: ELECTROPHORESIS

Abstract Cell separations using affinity methods continue to be an enabling science for a wide variety of applications. In this review, we discuss the fundamental aspects of affinity separation, including the competing forces for cell capture and elution, cell‐surface interactions, and models for cell adhesion. Factors affecting separation performance such as bond affinity, contact area, and temperature are presented. We also...

Read More thumbnail image: Fundamentals of affinity cell separations

Rigid‐layer Raman‐active modes in N ‐layer transition metal dichalcogenides: interlayer force constants and hyperspectral Raman imaging

Published: Oct 23, 2017

Author(s): Guillaume Froehlicher, Etienne Lorchat, Olivia Zill, Michelangelo Romeo, Stéphane Berciaud

Journal: Journal of Raman Spectroscopy

We report a comparative study of rigid‐layer Raman‐active modes in N‐layer transition metal dichalcogenides. Trigonal prismatic (2Hc, such as MoSe2, MoTe2, WS2, and WSe2) and distorted octahedral (1T', such as ReS2 and ReSe2) phases are considered. The Raman‐active in‐plane interlayer shear modes and out‐of‐plane interlayer breathing modes appear as well‐defined features with wavenumbers in the range 0−40cm−1. These rigid‐layer modes are well described by an...

Read More thumbnail image: Rigidlayer Ramanactive modes in N layer transition metal dichalcogenides interlayer force constants and hyperspectral Raman imaging
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