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Surface‐enhanced Raman spectra on graphene

Published: Aug 29, 2017

Author(s): Johan Ek Weis, Jana Vejpravova, Tim Verhagen, Zuzana Melnikova, Sara Costa, Martin Kalbac

Journal: Journal of Raman Spectroscopy

Surface‐enhanced Raman spectroscopy is a valuable tool for inspection of trace concentrations of various molecules; hence, this method has a great potential for characterization of functionalised graphene. However, to make this method a reliable analytical tool, the influence of the metal–graphene interactions on Raman spectra of the graphene must be understood. Here, the surface‐enhanced Raman spectra of exfoliated single‐layer graphene...

Read More thumbnail image: Surfaceenhanced Raman spectra on graphene

Detection of cancerous kidney tissue by means of SERS spectroscopy of extracellular fluid

Published: Aug 29, 2017

Author(s): M. Velicka, M. Pucetaite, V. Urboniene, J. Ceponkus, F. Jankevicius, V. Sablinskas

Journal: Journal of Raman Spectroscopy

Abstract We present a novel approach for detection of cancerous kidney tissue areas by measuring surface enhanced Raman scattering (SERS) spectra of extracellular fluid taken from kidney tissue. The method is based on spectral analysis of the cancerous and normal tissue areas in order to find the specific spectral markers. The samples were prepared by sliding the kidney tissue over a substrate—calcium fluoride optical window. For...

Read More thumbnail image: Detection of cancerous kidney tissue by means of SERS spectroscopy of extracellular fluid

SERS analysis of selectively captured exosomes using an integrin‐specific peptide ligand

Published: Aug 29, 2017

Author(s): Changwon Lee, Randy Carney, Kit Lam, James W. Chan

Journal: Journal of Raman Spectroscopy

Abstract We demonstrate selective capturing of exosomes for surface‐enhanced Raman spectroscopy (SERS) analysis using a thiolated peptide ligand that is bound to the surface of silver nanoparticles via thiol‐metallic bond formation. The ligand preferentially binds to α3ß1 integrin over‐expressed in exosomes secreted from SKOV‐3 cancer cells. Several Raman peaks at 894 cm−1, 1,080 cm−1, 1,252 cm−1, 1,340 cm−1, and...

Read More thumbnail image: SERS analysis of selectively captured exosomes using an integrinspecific peptide ligand

Determination of materials and techniques involved in the mural paintings of San Miguel Church, Argentina

Published: Aug 29, 2017

Author(s): Marcos Tascon, Noemi Mastrangelo, Damasia Gallegos, Fernando Marte

Journal: Journal of Raman Spectroscopy

Abstract The research conducted on the mural paintings of the dome and aisles of the San Miguel Church, Buenos Aires, Argentina, is herein described in this work. Based on the results attained from the stratigraphic analysis, the technique implemented by the architect and artist Augusto Ferrari was secco. The composition of the mortar in the majority of the samples collected was gypsum (CaSO4 · 2 H2O) and calcite (CaCO3), whereas the...

Read More thumbnail image: Determination of materials and techniques involved in the mural paintings of San Miguel Church Argentina

Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Published: Aug 29, 2017

Author(s): Jun Ma, Rahul S. Pawar, Erich Grundel

Journal: Drug Testing and Analysis

Abstract We developed and validated a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method to detect and quantitate 14 anti‐diabetic, 2 anti‐obesity, and 3 cholesterol‐lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the Internet. Potential adulteration of such dietary...

Read More thumbnail image: Validation of an LCMSMS method for analysis of antidiabetic drugs in botanical dietary supplements labeled for blood sugar management

In‐source collision‐induced dissociation (IS‐CID): Applications, issues and structure elucidation with single‐stage mass analyzers

Published: Aug 29, 2017

Author(s): Jon F. Parcher, Mei Wang, Amar G. Chittiboyina, Ikhlas A. Khan

Journal: Drug Testing and Analysis

Abstract A discussion of the definition, advantages, and issues with the formation of ions in the transition region between an electrospray ionization (ESI) source and the ion optics of a mass analyzer is presented. The various types of ions formed in the so‐called in‐source collision‐induced dissociation (IS‐CID) process are illustrated. Applications of IS‐CID with single‐stage mass analyzers, such as structure elucidation and...

Read More thumbnail image: Insource collisioninduced dissociation ISCID Applications issues and structure elucidation with singlestage mass analyzers

Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography–high resolution mass spectrometry

Published: Aug 29, 2017

Author(s): Madeleine Pettersson Bergstrand, Markus R. Meyer, Olof Beck, Anders Helander

Journal: Drug Testing and Analysis

Abstract Over the past ~8 years, hundreds of unregulated new psychoactive substances (NPS) of various chemical categories have been introduced as recreational drugs through mainly open online trade. This study was performed to further investigate the human metabolic pattern of the NPS, or designer benzodiazepines flubromazolam and pyrazolam, and to propose analytical targets for urine drug testing of these substances. The urine...

Read More thumbnail image: Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatographyhigh resolution mass spectrometry

Prediction of pitting corrosion status of EN 1.4404 stainless steel by using a 2‐stage procedure based on support vector machines

Published: Aug 29, 2017

Author(s): María Jesús Jiménez‐Come, Ignacio José Turias Domínguez, Victora Matres

Journal: Journal of Chemometrics

Abstract The excellent properties of EN 1.4404 have made this material one of the most popular types of austenitic stainless steel used for many applications. However, in aggressive environments, this alloy may suffer corrosion. Electrochemical analyses have been extensively used in order to evaluate pitting corrosion behaviour of stainless steel. These techniques may be followed by microscopic analysis in order to determine the...

Read More thumbnail image: Prediction of pitting corrosion status of EN 1_4404 stainless steel by using a 2stage procedure based on support vector machines

Quionolone carboxylic acid derivatives as HIV‐1 integrase inhibitors: Docking‐based HQSAR and topomer CoMFA analyses

Published: Aug 29, 2017

Author(s): Jianbo Tong, Pei Zhan, Xiang Simon Wang, Yingji Wu

Journal: Journal of Chemometrics

Abstract Quionolone carboxylic acid derivatives as inhibitors of HIV‐1 integrase were investigated as a potential class of drugs for the treatment of acquired immunodeficiency syndrome (AIDS). Hologram quantitative structure‐activity relationships (HQSAR) and translocation comparative molecular field vector analysis (topomer CoMFA) were applied to a series of 48 quionolone carboxylic acid derivatives. The most effective HQSAR model...

Read More thumbnail image: Quionolone carboxylic acid derivatives as HIV1 integrase inhibitors Dockingbased HQSAR and topomer CoMFA analyses

Chemometrics optimization for simultaneous adsorptive removal of ternary mixture of Cu(II), Cd(II), and Pb(II) by Fraxinus tree leaves

Published: Aug 29, 2017

Author(s): Javad Zolgharnein, Ali Shahmoradi, Maryam Bagtash, Saeideh Dermanaki Frahani, Peyman Zolgharnein

Journal: Journal of Chemometrics

Fraxinus tree leaves were successfully used to remove ternary mixture of Cu(II), Cd(II), and Pb(II) from an aqueous solution in a batch system. The simplex‐centroid mixture design was used for optimization of the biosorption process. The effective factors on biosorption process, such as pH, s (amount of biosorbent), and Ci initial concentrations of metal ions, were considered via a crossed mixture–process design. Optimal conditions were found ...

Read More thumbnail image: Chemometrics optimization for simultaneous adsorptive removal of ternary mixture of CuII CdII and PbII by Fraxinus tree leaves

Residual dynamic and risk assessment of dimethomorph in Swiss chard grown at two different sites

Published: Aug 28, 2017

Author(s): Md. Humayun Kabir, A. M. Abd El‐Aty, Md. Musfiqur Rahman, Hyung Suk Chung, Han Sol Lee, Mi‐Ra Kim, Byung‐Joon Chang, Jing Wang, Ho‐Chul Shin, Jae‐Han Shim

Journal: Biomedical Chromatography

Abstract Residue analysis of dimethomorph in Swiss chard cultivated at two different locations under greenhouse conditions was conducted using high‐performance liquid chromatography–ultraviolet detection and confirmed by tandem mass spectrometry. The randomly collected samples (over 14 days) were extracted with acetonitrile and purified using a Florisil solid‐phase extraction cartridge. Linearity over a concentration range of...

Read More thumbnail image: Residual dynamic and risk assessment of dimethomorph in Swiss chard grown at two different sites

Preparation and characterization of a Cu (II)‐IDA poly HEMA monolith syringe for proteomic applications

Published: Aug 28, 2017

Author(s): Ashish Khaparde, Vijayalakshmi M. A., Kishore K. R. Tetala

Journal: ELECTROPHORESIS

Herein, we report the preparation of a metal‐chelate immobilized hydrophilic poly hydroxyethylmethacrylate‐based monolith of 100 μL volume in a plastic syringe. The monolith is elastic in nature, contains well interconnected pores with a permeability (k) of 1.3 × 10−12 m2. Immobilization of iminodiacetic acid (IDA) is performed via schiff base reaction. Adsortion of IgG on this copper‐IDA monolith is of langmuir isotherm with a...

Read More thumbnail image: Preparation and characterization of a Cu IIIDA poly HEMA monolith syringe for proteomic applications

Derivatisation for separation and detection in capillary electrophoresis (2015–2017)

Published: Aug 25, 2017

Author(s): Alain Wuethrich, Joselito P. Quirino

Journal: ELECTROPHORESIS

Derivatisation is an integrated part of many analytical workflows to enable separation and detection of the analytes. In CE, derivatisation is adapted in the four modes of pre‐capillary, in‐line, in‐capillary, and post‐capillary derivatisation. In this review, we discuss the progress in derivatisation from February 2015 to May 2017 from multiple points of view including sections about the derivatisation modes, derivatisation to improve...

Read More thumbnail image: Derivatisation for separation and detection in capillary electrophoresis 20152017

A simple method to estimate the isoelectric point of modified Tomato bushy stunt virus (TBSV) particles

Published: Aug 25, 2017

Author(s): Mario Braun, Wolfgang Gebauer, Gabriela Krczal, Christiane Ziegler, Christine Müller‐Renno, Kajohn Boonrod

Journal: ELECTROPHORESIS

We present a simple method to estimate the isoelectric point (pI) of Tomato Bushy Stunt particles. We demonstrate that the combination of agarose gels with different pH buffers can be used to electrophorese the virus particles and their migration patterns can be compared. This method allows us to estimate the pI of the virus particles (wild type, wt, and genetically modified particles) and to monitor the effect of the pI of modified peptide side...

Read More thumbnail image: A simple method to estimate the isoelectric point of modified Tomato bushy stunt virus TBSV particles

Serum N ‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma

Published: Aug 25, 2017

Author(s): Mengmeng Wang, Meng Fang, Jianhui Zhu, Huijuan Feng, Elisa Warner, Changhong Yi, Jun Ji, Xing Gu, Chunfang Gao

Journal: ELECTROPHORESIS

Extensive efforts have been devoted to improve the diagnosis of extrahepatic cholangiocarcinoma (ECCA) due to its silent clinical character and lack of effective diagnostic biomarkers. Specific alterations in N‐glycosylation of glycoproteins are considered a key component in cancer progression, which can serve as a distinct molecular signature for cancer detection. This study aims to find potential serum N‐glycan markers for ECCA. In total, 255 serum...

Read More thumbnail image: Serum N glycans outperform CA199 in diagnosis of extrahepatic cholangiocarcinoma

Quantitative spontaneous Raman scattering spectroscopy in artificial binary lipid membranes

Published: Aug 25, 2017

Author(s): S. Rieger, D. Grill, V. Gerke, C. Fallnich

Journal: Journal of Raman Spectroscopy

The cholesterol concentration in lipid membranes is an important parameter that influences signaling processes as well as the structure of membranes. We show that the cholesterol content in giant unilamellar vesicles from binary lipid mixtures of cholesterol and 1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphocholine can be quantitatively assessed with spontaneous Raman scattering spectroscopy. An analytical model employing correlation analysis...

Read More thumbnail image: Quantitative spontaneous Raman scattering spectroscopy in artificial binary lipid membranes

Validated LC–MS/MS method for quantitation of demethylbellidifolin in rat plasma and its application to pharmacokinetic and bioavailability studies

Published: Aug 24, 2017

Author(s): Jie Zhang, Huiyu Yan, Xiaoyu Qu, Wei Zhou

Journal: Biomedical Chromatography

Abstract Demethylbellidifolin, a major xanthone compound of Swertia davidi Franch, shows many beneficial pharmacological effects including antioxidation, anti‐inflammation, anti‐fibrosis and cardiovascular protection effects. In this research, a rapid and sensitive LC–MS/MS method for the quantitative analysis of demethylbellidifolin in rat plasma was developed. The demethylbellidifolin and internal standard of aurantio‐obtusin were extracted...

Read More thumbnail image: Validated LCMSMS method for quantitation of demethylbellidifolin in rat plasma and its application to pharmacokinetic and bioavailability studies

Tip‐enhanced Raman scattering of graphene

Published: Aug 24, 2017

Author(s): Ryan Beams

Journal: Journal of Raman Spectroscopy

This article reviews the mechanism of tip‐enhanced Raman spectroscopy (TERS) and its importance for characterizing graphene. The theoretical foundation of TERS and experimental implementation are discussed. Conventionally, Raman scattering is treated as a spatially incoherent process where the total signal is proportional to the scattering volume. However, in the near‐field regime, the scattered fields can add coherently because the TERS...

Read More thumbnail image: Tipenhanced Raman scattering of graphene

Heroin in Malaysia and Singapore

Published: Aug 24, 2017

Author(s): Maimonah Sulaiman, Vanitha Kunalan, Angeline T. W. Yap, Wendy J. L. Lim, Joey Joo Yee Ng, Samuel Wei Xiong Loh, K. B. Chan

Journal: Drug Testing and Analysis

Abstract Clandestine heroin laboratories have been a feature of the Malaysian illicit drug scene since soon after the abuse of heroin emerged in 1972. The first few clandestine heroin laboratories which synthesised heroin via the acetylation of imported morphine were uncovered in 1973 and 1977. By the mid‐1980s, this type of laboratory was replaced by heroin‐cutting laboratories whereby imported high‐grade heroin was cut to street...

Read More thumbnail image: Heroin in Malaysia and Singapore

Development and validation of an LC–MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription

Published: Aug 24, 2017

Author(s): Ajing Zhao, Li Zhang, Rong Li, Jiao Shang, Huihui Yi, Yuan Wang, Dian Zhang, Shixiang Wang, Minfeng Fang

Journal: Biomedical Chromatography

Abstract A sensitive, specific and accurate liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6′′′‐feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and...

Read More thumbnail image: Development and validation of an LCMSMS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription
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