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Enantioseparation and determination of dufulin enantiomers in cucumber and soil by chiral liquid chromatography–tandem mass spectrometry

Published: Apr 2, 2018

Author(s): Haizhen Zhang, Min Huang, Weiwei Yu, A'wei Zhang, Kankan Zhang, Deyu Hu

Journal: Biomedical Chromatography

Abstract A simple and rapid method for enantioselective determination of dufulin in cucumber and soil was developed by liquid chromatography with tandem mass spectrometry. The enantiomers were separated on a Superchiral S‐OD chiral cellulose tris(3,5‐dimethylphenylcarbamate) column at 20°C, with a mixture of acetonitrile and water (0.1% formic acid; 52:48, v/v) as mobile phase at a flow rate of 0.65 mL/min. The pretreatment conditions were...

Read More thumbnail image: Enantioseparation and determination of dufulin enantiomers in cucumber and soil by chiral liquid chromatographytandem mass spectrometry

Quantification of amlodipine and atorvastatin in human plasma by UPLC–MS/MS method and its application to a bioequivalence study

Published: Apr 2, 2018

Author(s): Mamdouh R. Rezk, Kamal A. Badr

Journal: Biomedical Chromatography

Abstract A robust, rapid and sensitive UPLC–MS/MS method has been developed, optimized and validated for the determination of amlodipine (AML) and atorvastatin (ATO) in human plasma using eplerenone as an internal standard (IS). Multiple‐reaction monitoring in positive electrospray ionization mode was utilized in Xevo TQD LC–MS/MS. Double extraction was used in sample preparation using diethyl ether and ethyl acetate. The prepared...

Read More thumbnail image: Quantification of amlodipine and atorvastatin in human plasma by UPLCMSMS method and its application to a bioequivalence study

Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains

Published: Mar 30, 2018

Author(s): Dan Wu, Qiang Li, Frances J. Northington, Jiangyang Zhang

Journal: NMR in Biomedicine

Recent advances in diffusion MRI employ multiple diffusion encoding schemes with varying diffusion direction, weighting, and diffusion time to investigate specific microstructural properties in biological tissues. In this study, we examined time‐dependent diffusion kurtosis contrast in adult mouse brains and in neonatal mouse brains after hypoxic–ischemic (HI) injury. In vivo diffusion kurtosis maps were acquired with a short diffusion time using an...

Read More thumbnail image: Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains

Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia: Results from a multiple‐inflow‐time arterial spin labelling study

Published: Mar 30, 2018

Author(s): Jamie M. Kawadler, Patrick W. Hales, Simon Barker, Timothy C. S. Cox, Fenella J. Kirkham, Chris A. Clark

Journal: NMR in Biomedicine

Sickle cell anaemia (SCA) is associated with chronic anaemia and oxygen desaturation, which elevate cerebral blood flow (CBF) and increase the risk of neurocognitive complications. Arterial spin labelling (ASL) provides a methodology for measuring CBF non‐invasively; however, ASL techniques using only a single inflow time are not sufficient to fully characterize abnormal haemodynamic behaviour in SCA. This study investigated haemodynamic...

Read More thumbnail image: Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia Results from a multipleinflowtime arterial spin labelling study

Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Published: Mar 30, 2018

Author(s): Claudio A. Téllez Soto, Lázaro P. Medeiros‐Neto, Laurita Santos, André B.O. Santos, Isabelle Ferreira, Priyanka Singh, Renata A. Canevari, Aírton A. Martin

Journal: Journal of Raman Spectroscopy

Abstract Thirty thyroid samples of normal and abnormal tissues were analyzed by infrared and confocal Raman Spectroscopy. We studied the Amide I (1,720–1,580 cm−1) spectral region in order to determine different components of the proteins' secondary structure in the samples. Peak positions of the Amide I bands were determined using the second derivative and Fourier self‐deconvolution of infrared and Raman spectra. We obtained...

Read More thumbnail image: Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Formation of cyanide compounds during preparation of gold surfaces evidenced by surface‐enhanced R aman spectroscopy

Published: Mar 30, 2018

Author(s): A. Merlen, C. Pardanaud, S. Coussan, C. Panagiotopoulos, O. Grauby, Carmen M. Ruiz

Journal: Journal of Raman Spectroscopy

Abstract We report surface‐enhanced Raman spectroscopy (SERS) measurements on nanostructured gold surfaces prepared using a primary vacuum sputtering technique. Even if no molecules have been deposited on the metallic surface, a clear Raman signal is observed. A very intense and sharp peak around 2,100 cm−1 together with low‐wavenumber modes are visible. The comparison between the experimental spectra and those obtained using ...

Read More thumbnail image: Formation of cyanide compounds during preparation of gold surfaces evidenced by surfaceenhanced R aman spectroscopy

Theoretical methods for calculations of optical phonons in BiOBr: Analysis and correction of propagated errors

Published: Mar 30, 2018

Author(s): Mateus M. Ferrer, João Elias F.S. Rodrigues, Marcio A.P. Almeida, Francisco Moura, Elson Longo, Paulo S. Pizani, Julio R. Sambrano

Journal: Journal of Raman Spectroscopy

Abstract Theoretical and experimental methods were employed to investigate the vibrational modes of BiOBr. Wavenumber prediction and assignments of the infrared and Raman modes were performed using density functional theory and lattice dynamics calculations. The theoretical models were directly compared with the experimental results of particles fabricated using the microwave‐assisted hydrothermal method and results reported in...

Read More thumbnail image: Theoretical methods for calculations of optical phonons in BiOBr Analysis and correction of propagated errors

Hydrogen/deuterium exchange in mass spectrometry

Published: Mar 30, 2018

Author(s): Yury Kostyukevich, Thamina Acter, Alexander Zherebker, Arif Ahmed, Sunghwan Kim, Eugene Nikolaev

Journal: Mass Spectrometry Reviews

The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of...

Read More thumbnail image: Hydrogendeuterium exchange in mass spectrometry

Electron‐ion reaction‐based dissociation: A powerful ion activation method for the elucidation of natural product structures

Published: Mar 30, 2018

Author(s): Xiangfeng Chen, Ze Wang, Y.‐L. Elaine Wong, Ri Wu, Feng Zhang, T.‐W. Dominic Chan

Journal: Mass Spectrometry Reviews

The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from...

Read More thumbnail image: Electronion reactionbased dissociation A powerful ion activation method for the elucidation of natural product structures

Molecules and elements for quantitative bioanalysis: The allure of using electrospray, MALDI, and ICP mass spectrometry side‐by‐side

Published: Mar 30, 2018

Author(s): Michael W. Linscheid

Journal: Mass Spectrometry Reviews

To understand biological processes, not only reliable identification, but quantification of constituents in biological processes play a pivotal role. This is especially true for the proteome: protein quantification must follow protein identification, since sometimes minute changes in abundance tell the real tale. To obtain quantitative data, many sophisticated strategies using electrospray and MALDI mass spectrometry...

Read More thumbnail image: Molecules and elements for quantitative bioanalysis The allure of using electrospray MALDI and ICP mass spectrometry sidebyside

Specific glycine to alanine mutation eliminates dynamic interaction of polymeric GlyT1a N‐terminus with Coomassie Brilliant Blue G‐250

Published: Mar 29, 2018

Author(s): Martina Baliova, Frantisek Jursky

Journal: ELECTROPHORESIS

Abstract We previously found that multimeric GlyT1aN16 protein exhibits increased diffusion in a polyacrylamide gel and shows an unusual time‐dependent absorbance rearrangement, as revealed by the Bradford assay. Here, we find that glycine to alanine mutation eliminates the absorbance shift, but not the altered diffusion properties of GlyT1aN16, indicating that these two phenomena are not interconnected. The absorbance shift is...

Read More thumbnail image: Specific glycine to alanine mutation eliminates dynamic interaction of polymeric GlyT1a Nterminus with Coomassie Brilliant Blue G250

Study of the enantiomeric separation of the anticholinergic drugs on two immobilized polysaccharide‐based chiral stationary phases by HPLC and the possible chiral recognition mechanisms

Published: Mar 29, 2018

Author(s): Meng Li, Yu Zhao, Li Zhou, Jia Yu, Jian Wang, Xingjie Guo

Journal: ELECTROPHORESIS

Abstract In this work, the enantiomeric separation of ten anticholinergic drugs was first examined on two derivative polysaccharide chiral stationary phases (CSPs), i.e., Chiralpak ID and Chiralpak IA in the normal phase mode. Except for scopolamine hydrobromide, the remaining nine analytes could be completely separated with good resolutions using both columns under the optimized mobile phase conditions. And the enantiomeric...

Read More thumbnail image: Study of the enantiomeric separation of the anticholinergic drugs on two immobilized polysaccharidebased chiral stationary phases by HPLC and the possible chiral recognition mechanisms

Investigation of pumping mechanism for non‐Newtonian blood flow with AC electrothermal forces in a microchannel by hybrid boundary element method and immersed boundary‐lattice Boltzmann method

Published: Mar 29, 2018

Author(s): Qinlong Ren

Journal: ELECTROPHORESIS

Abstract Efficient pumping of blood flow in a microfluidic device is essential for rapid detection of bacterial bloodstream infections (BSI) using alternating current (AC) electrokinetics. Compared with AC electro‐osmosis (ACEO) phenomenon, the advantage of AC electrothermal (ACET) mechanism is its capability of pumping biofluids with high electrical conductivities at a relatively high AC voltage frequency. In the current work, the...

Read More thumbnail image: Investigation of pumping mechanism for nonNewtonian blood flow with AC electrothermal forces in a microchannel by hybrid boundary element method and immersed boundarylattice Boltzmann method

Combined AC‐electrokinetic effects: Theoretical considerations on a three‐axial ellipsoidal model

Published: Mar 29, 2018

Author(s): Jan Gimsa

Journal: ELECTROPHORESIS

Abstract AC fields induce charges at the structural interfaces of particles or biological cells. The interaction of these charges with the field generates frequency‐dependent forces that are the basis for AC‐electrokinetic effects such as dielectrophoresis (DEP), electrorotation (ROT), electro‐orientation, and electro‐deformation. The effects can be used for the manipulation or dielectric single‐particle spectroscopy. The...

Read More thumbnail image: Combined ACelectrokinetic effects Theoretical considerations on a threeaxial ellipsoidal model

Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection

Published: Mar 29, 2018

Author(s): Maria Guirro, Andrea Costa, Andreu Gual‐Grau, Jordi Mayneris‐Perxachs, Helena Torrell, Pol Herrero, Núria Canela, Lluís Arola

Journal: ELECTROPHORESIS

Abstract Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several...

Read More thumbnail image: Multiomics approach to elucidate the gut microbiota activity Metaproteomics and metagenomics connection

A novel sorbent based on carbon nanotube/amino‐functionalized sol–gel for the headspace solid‐phase microextraction of α‐bisabolol from medicinal plant samples using experimental design

Published: Mar 29, 2018

Author(s): Mina Yarazavi, Ebrahim Noroozian

Journal: Journal of Separation Science

Abstract A novel sol–gel coating on a stainless‐steel fiber was developed for the first time for the headspace solid‐phase microextraction and determination of α‐bisabolol with gas chromatography and flame ionization detection. The parameters influencing the efficiency of solid‐phase microextraction process, such as extraction time and temperature, pH, and ionic strength, were optimized by the experimental design method. Under...

Read More thumbnail image: A novel sorbent based on carbon nanotubeaminofunctionalized solgel for the headspace solidphase microextraction of bisabolol from medicinal plant samples using experimental design

Chemometrics comparison of gas chromatography with mass spectrometry and comprehensive two‐dimensional gas chromatography with time‐of‐flight mass spectrometry Daphnia magna metabolic profiles exposed to salinity

Published: Mar 29, 2018

Author(s): Hadi Parastar, Elba Garreta‐Lara, Bruno Campos, Carlos Barata, Silvia Lacorte, Roma Tauler

Journal: Journal of Separation Science

Abstract The performances of gas chromatography with mass spectrometry and of comprehensive two‐dimensional gas chromatography with time‐of‐flight mass spectrometry are examined through the comparison of Daphnia magna metabolic profiles. Gas chromatography with mass spectrometry and comprehensive two‐dimensional gas chromatography with mass spectrometry were used to compare the concentration changes of metabolites under saline conditions. In...

Read More thumbnail image: Chemometrics comparison of gas chromatography with mass spectrometry and comprehensive twodimensional gas chromatography with timeofflight mass spectrometry Daphnia magna metabolic profiles exposed to salinity

Detection of prohibited substances in equine hair by ultra‐high performance liquid chromatography–triple quadrupole mass spectrometry – application to doping control samples

Published: Mar 28, 2018

Author(s): B. Gray, M. Viljanto, E. Menzies, L. Vanhaecke

Journal: Drug Testing and Analysis

Abstract The detection of drugs in human hair samples has been performed by laboratories around the world for many years and the matrix is popular in disciplines, such as workplace drug testing. To date, however, hair has not become a routinely utilised matrix in sports drug detection. The analysis of hair samples offers several potential advantages to doping control laboratories, not least of which are the greatly extended...

Read More thumbnail image: Detection of prohibited substances in equine hair by ultrahigh performance liquid chromatographytriple quadrupole mass spectrometry  application to doping control samples

Prediction of designer drugs: Synthesis and spectroscopic analysis of synthetic cathinone analogs that may appear on the Swedish drug market

Published: Mar 28, 2018

Author(s): Andreas Carlsson, Veronica Sandgren, Stefan Svensson, Peter Konradsson, Simon Dunne, Martin Josefsson, Johan Dahlén

Journal: Drug Testing and Analysis

Abstract The use of hyphenated analytical techniques in forensic drug screening enables simultaneous identification of a wide range of different compounds. However, the appearance of drug seizures containing new substances, mainly new psychoactive substances (NPS), is steadily increasing. These new and other already known substances often possess structural similarities and consequently they exhibit spectral data with slight...

Read More thumbnail image: Prediction of designer drugs Synthesis and spectroscopic analysis of synthetic cathinone analogs that may appear on the Swedish drug market

Pharmacokinetics, tissue distribution, and excretion of FGF‐21 following subcutaneous administration in rats

Published: Mar 28, 2018

Author(s): Yufei He, Yazhuo Li, Zihong Wei, Xingyan Zhang, Jing Gao, Xiaojie Wang, Xiaokun Li, Weidang Wu, Wei Li, Xiulin Yi, Yong Zeng, Changxiao Liu

Journal: Drug Testing and Analysis

Abstract As one of the fibroblast growth factor (FGF) superfamily, FGF‐21 has been extensively investigated for its functions and roles since its discovery. It has been demonstrated to be one of the key regulators for glucose and lipid metabolism, and exhibits beneficial effects on cardiovascular disease. However, studies focusing on its pharmacokinetic behavior in vivo as a novel therapeutic agent have not been reported. In the...

Read More thumbnail image: Pharmacokinetics tissue distribution and excretion of FGF21 following subcutaneous administration in rats
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