EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

Application of solid‐phase microextraction in current biomedical research

Published: Oct 26, 2018

Author(s): Anna Roszkowska, Natalia Miękus, Tomasz Bączek

Journal: Journal of Separation Science

Abstract Extraction of endogenous compounds and drugs and their corresponding metabolites from complex matrices, such as biofluids and solid tissues, requires adequate analytical approach facilitating qualitative and quantitative analysis. To this end, solid‐phase microextraction has been introduced as modern technology that is capable of efficient and high‐throughput extraction of compounds due to its ability to amalgamate...

Read More thumbnail image: Application of solidphase microextraction in current biomedical research

Corncob‐to‐xylose residue (CCXR) derived porous biochar as an excellent adsorbent to remove organic dyes from wastewater

Published: Oct 26, 2018

Author(s): Yanling Yu, Yuan Wan, Hongru Shang, Bin Wang, Peng Zhang, Yujie Feng

Journal: Surface and Interface Analysis

Biochar was prepared from corncob‐to‐xylose residue (CCXR) by KOH activation and anaerobic pyrolysis method. The effect of activation temperature on the microstructure of the biochar was studied. Results showed that the biochar prepared at 850°C (850NBC) possessed high specific surface area and exhibited excellent adsorption property. The maximum adsorption capacity of 2249 mg g−1 was obtained when 850NBC was used for treating...

Read More thumbnail image: Corncobtoxylose residue CCXR derived porous biochar as an excellent adsorbent to remove organic dyes from wastewater

Tissue distribution profiles of multiple major bioactive components in rats after intravenous administration of Xuebijing injection by UHPLC–Q–Orbitrap HRMS

Published: Oct 25, 2018

Author(s): Lihua Zuo, Zhi Sun, Zhenhui Wang, Daling Ding, Tanye Xu, Liwei Liu, Li Gao, Shuzhang Du, Jian Kang, Xiaojian Zhang

Journal: Biomedical Chromatography

Abstract Xuebijing injection (XBJI) is a traditional Chinese medicine prescription extracted from five Chinese herbs. Hydroxysafflor yellow A, oxypaeoniflorin, ferulic acid and benzoylpaeoniflorin are the main bioactive ingredients of XBJI. This paper presents an application of ultra‐high‐performance liquid chromatography–Q–exactive hybrid quadrupole–Orbitrap high‐resolution mass spectrometry (UHPLC–Q–Orbitrap HRMS) to quantify four...

Read More thumbnail image: Tissue distribution profiles of multiple major bioactive components in rats after intravenous administration of Xuebijing injection by UHPLCQOrbitrap HRMS

Development of analytical method for the quality control of the fruit bark of Punica granatum L. (pomegranate) and antichemotatic activity of extract and rich fraction in punicalagins

Published: Oct 25, 2018

Author(s): Bruno Alonso Sleifer, Melissa Schwanz, Leticia Jacobi Danielli, Miriam Anders Apel, Amélia Teresinha Henriques

Journal: Biomedical Chromatography

Abstract Pomegranate is of current interest owing to the existing potential for industrial uses of fruit peels. This includes its availability as a raw vegetable material, a byproduct that constitutes residue in the use of the species and is recognized as a functional product, and beneficial health properties, as will be demonstrated in the studies cited. Therefore, it is necessary to ensure its effectiveness and safety. Toward this...

Read More thumbnail image: Development of analytical method for the quality control of the fruit bark of Punica granatum L_ pomegranate and antichemotatic activity of extract and rich fraction in punicalagins

A rapid non‐target screening method for determining prohibited substances in human urine using liquid chromatography/high‐resolution tandem mass spectrometry

Published: Oct 25, 2018

Author(s): Boyoung Han, Hophil Min, Mijin Jeon, Byeori Kang, Jaeick Lee, Junghyun Son

Journal: Drug Testing and Analysis

Abstract Target analysis using liquid chromatography–tandem mass spectrometry is applied for rapidly detecting various prohibited doping substances. Frequent modification is required as additional substances are prohibited. We developed and validated a non‐target screening method requiring no further modification because it analyzes the full spectrum of data in fixed m/z ranges. Urine samples were extracted using solid‐phase...

Read More thumbnail image: A rapid nontarget screening method for determining prohibited substances in human urine using liquid chromatographyhighresolution tandem mass spectrometry

Case Study: Atypical δ 13 C values of urinary norandrosterone

Published: Oct 25, 2018

Author(s): Frank Hülsemann, Vassilios Gougoulidis, Thomas Schertel, Gregor Fusshöller, Ulrich Flenker, Thomas Piper, Mario Thevis

Journal: Drug Testing and Analysis

Abstract Isotope ratio mass spectrometry (IRMS) has been established in doping control analysis to identify the endogenous or exogenous origin of a variety of steroidal analytes including the 19‐norsteroid metabolite norandrosterone (NorA). NorA can be found naturally in human urine in trace amounts due to endogenous demethylation or in situ microbial degradation. The administration of nortestosterone (nandrolone) or different...

Read More thumbnail image: Case Study Atypical  13 C values of urinary norandrosterone

Pharmacokinetic studies of soyalkaloid A from Portulaca oleracea L. using ultra high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry and its antioxidant activity

Published: Oct 24, 2018

Author(s): Fen Xiu, Zheming Ying, Xixiang Ying, Guanlin Yang

Journal: Biomedical Chromatography

Abstract Soyalkaloid A was isolated from Portulaca oleracea L. for the first time in our laboratory and then a rapid and sensitive ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry (UHPLC–ESI–Q–TOF/MS) method with hesperidin as internal standard (IS) was developed and validated to investigate the pharmacokinetics of soyalkaloid A in rats after oral and intravenous...

Read More thumbnail image: Pharmacokinetic studies of soyalkaloid A from Portulaca oleracea L_ using ultra highperformance liquid chromatography electrospray ionization quadrupoletime of flight mass spectrometry and its antioxidant activity

Development and validation of a hydrophilic interaction ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for rapid simultaneous determination of 19 free amino acids in rat plasma and urine

Published: Oct 24, 2018

Author(s): Yongqing Wen, Xuemei Yuan, Feng Qin, Longshan Zhao, Zhili Xiong

Journal: Biomedical Chromatography

Abstract Determination of amino acids in biofluids is a challenging task because of difficulties deriving from their high polarity and matrix interference. A simple, reliable and high‐throughput hydrophilic interaction UHPLC–MS/MS method was developed and validated for the rapid simultaneous determination of 19 free amino acids in rat plasma and urine samples in this paper. Hydrophilic method with a Waters Acquity UPLC BEH Amide...

Read More thumbnail image: Development and validation of a hydrophilic interaction ultrahighperformance liquid chromatographytandem mass spectrometry method for rapid simultaneous determination of 19 free amino acids in rat plasma and urine

Recent advances in microfluidic cell sorting techniques based on both physical and biochemical principles

Published: Oct 24, 2018

Author(s): Wenlai Tang, Di Jiang, Zongan Li, Liya Zhu, Jianping Shi, Jiquan Yang, Nan Xiang

Journal: ELECTROPHORESIS

Abstract Microfluidic technologies for isolating cells of interest from a heterogeneous sample have attracted great attentions, due to the advantages of less sample consumption, simple operating procedure, and high separation accuracy. According to the working principles, the microfluidic cell sorting techniques can be categorized into biochemical (labeled) and physical (label‐free) methods. However, the inherent drawbacks of each...

Read More thumbnail image: Recent advances in microfluidic cell sorting techniques based on both physical and biochemical principles

Quantification of oleacein and oleuropein aglycone in olive oil using deuterated surrogates by normal‐phase ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Published: Oct 24, 2018

Author(s): Antonio Luque‐Muñoz, Ruben Tapia, Ali Haidour, Jose Justicia, Juan Manuel Cuerva

Journal: Journal of Separation Science

Abstract An analytical method for the analysis of relevant secoiridoid‐based components in olive oil, oleacein and oleuropein aglycone, is described using for the first time deuterated surrogates. 0.2 g of sample was necessary to perform the analysis using liquid‐liquid extraction and ultrasound‐assisted extraction with a mixture of methanol/water (4:1, v/v). To avoid the formation of by‐products, normal‐phase ultra high...

Read More thumbnail image: Quantification of oleacein and oleuropein aglycone in olive oil using deuterated surrogates by normalphase ultra high performance liquid chromatography with quadrupole timeofflight mass spectrometry

Critical evaluation of microextraction pretreatment techniques – Part 1: Single drop and sorbent‐based techniques

Published: Oct 24, 2018

Author(s): Martina Havlikova, Radomir Cabala, Vera Pacakova, Miroslava Bursova, Zuzana Bosakova

Journal: Journal of Separation Science

Abstract Sample pretreatment techniques or preconcentration constitute a very important step before the analysis of environmental, clinical, pharmaceutical, and other complex samples. Thanks to extraction techniques it is possible to achieve higher method sensitivities and selectivities. Miniaturization microextraction methods make them more environmentally friendly and only small amounts of samples are required. In the past 30...

Read More thumbnail image: Critical evaluation of microextraction pretreatment techniques  Part 1 Single drop and sorbentbased techniques

Overview of sample introduction techniques prior to GC for the analysis of volatiles in solid materials

Published: Oct 24, 2018

Author(s): Adissu Alemayehu Asfaw, Juan Aspromonte, Kris Wolfs, Ann Schepdael, Erwin Adams

Journal: Journal of Separation Science

Abstract Sample preparation and introduction techniques are very critical steps in gas chromatography analysis and particularly in the analysis of volatiles in solid samples. In these cases, they can be divided into two main categories: direct and indirect approaches, based on how the solid sample is treated, i.e. with and without dissolution (or extraction) of analytes from the solid sample. To enable routine application, coupling...

Read More thumbnail image: Overview of sample introduction techniques prior to GC for the analysis of volatiles in solid materials

A database of Raman spectra of precious gemstones and minerals used as cut gems obtained using portable sequentially shifted excitation Raman spectrometer

Published: Oct 24, 2018

Author(s): Adam Culka, Jan Jehlička

Journal: Journal of Raman Spectroscopy

Abstract Raman spectra of 42 minerals, commonly and less frequently used as gemstones in gemmology s. s. or works of arts, have been recorded using a portable sequentially shifted excitation Raman spectrometer. Analyzed minerals include chrysoberyl, diamond, emerald, garnets, magnesiotaaffeite‐2N'2S (taaffeite), magnesiotaaffeite‐6N'3S (musgravite), ruby, topaz as well as other less precious minerals. Some minerals are represented by several...

Read More thumbnail image: A database of Raman spectra of precious gemstones and minerals used as cut gems obtained using portable sequentially shifted excitation Raman spectrometer

Localized and adaptive soft sensor based on an extreme learning machine with automated self‐correction strategies

Published: Oct 24, 2018

Author(s): Dominic V. Poerio, Steven D. Brown

Journal: Journal of Chemometrics

Abstract A novel, nonlinear soft sensor based on a localized, adaptive single‐layer feedforward neural network with random hidden layer weights, also called an extreme learning machine, combined with the recursive partial least squares algorithm to update the linear output layer weights, is explored. The soft sensor is highly adaptive with minimal operator input, and automated mechanisms are included to self‐correct numerous aspects...

Read More thumbnail image: Localized and adaptive soft sensor based on an extreme learning machine with automated selfcorrection strategies

Ionized magnesium and calcium concentration and their ratio in equine plasma samples as determined by a regulatory laboratory compared to a clinical reference laboratory

Published: Oct 23, 2018

Author(s): Stephen A. Schumacher, Jonathon Yardley, Alicia L. Bertone

Journal: Drug Testing and Analysis

Abstract Magnesium sulfate (MgSO4) was administered to calm competition horses. We evaluated the impact of regulatory requirements for the handling of blood samples on plasma ionized magnesium (iMg), ionized calcium (iCa), the iMg to iCa ratio, and pH. We hypothesized that iCa, iMg. and iMg/iCa would be similar among storage and collection methods. Four blood samples were collected from each of 50 horses on the same day: Group 1 –...

Read More thumbnail image: Ionized magnesium and calcium concentration and their ratio in equine plasma samples as determined by a regulatory laboratory compared to a clinical reference laboratory

Suspect and non‐target screening workflows to investigate the in vitro and in vivo metabolism of the synthetic cannabinoid 5Cl‐THJ‐018

Published: Oct 23, 2018

Author(s): Philippe Vervliet, Olivier Mortelé, Celine Gys, Maarten Degreef, Katrien Lanckmans, Kristof Maudens, Adrian Covaci, Alexander L.N. Nuijs, Foon Yin Lai

Journal: Drug Testing and Analysis

Abstract The use of synthetic cannabinoids causes similar effects as Δ9‐tetrahydrocannabinol and long‐term (ab)use can lead to health hazards and fatal intoxications. As most investigated synthetic cannabinoids undergo extensive biotransformation, almost no parent compound can be detected in urine, which hampers forensic investigations. Limited information about the biotransformation products of new synthetic cannabinoids makes the detection ...

Read More thumbnail image: Suspect and nontarget screening workflows to investigate the in vitro and in vivo metabolism of the synthetic cannabinoid 5ClTHJ018

Development of a method for quantitative determination of the cytotoxic agent piplartine (piperlongumine) in multiple skin layers

Published: Oct 23, 2018

Author(s): Vanessa F. M. Carvalho, Daniela V. Giacone, Leticia V. Costa‐Lotufo, Edilberto Rocha Silveira, Luciana B. Lopes

Journal: Biomedical Chromatography

Abstract This study reports the development of a simple and reproducible method, with high rates of recovery, to extract the cytotoxic agent piplartine from skin layers, and a sensitive and rapid UV‐HPLC method for its quantification. Considering the potential of piplartine for topical treatment of skin cancer, this method may find application for formulation development and pharmacokinetics studies to assess cutaneous...

Read More thumbnail image: Development of a method for quantitative determination of the cytotoxic agent piplartine piperlongumine in multiple skin layers

Optimization and validation of an SBSE–HPLC–FD method using laboratory‐made stir bars for fluoxetine determination in human plasma

Published: Oct 23, 2018

Author(s): Letícia Aparecida Marques, Thaís Tiemi Nakahara, Tiago Bervelieri Madeira, Mariana Bortholazzi Almeida, Alessandra Maffei Monteiro, Maria Almeida Silva, Emanuel Carrilho, Luiz Gustavo Piccoli de Melo, Suzana Lucy Nixdorf

Journal: Biomedical Chromatography

Abstract Depression is the largest cause of disability worldwide, affecting 350 million people. Notwithstanding that clinical trials demonstrate antidepressants efficacy, the efficient response can vary individually concerning therapeutic dosage. Although important, plasma levels monitoring remains an analytical challenge whereas clean‐up and pre‐concentration represent critical steps. Therefore, this study aims to develop, optimize...

Read More thumbnail image: Optimization and validation of an SBSEHPLCFD method using laboratorymade stir bars for fluoxetine determination in human plasma

Analysis of the dissipation kinetics of thiophanate‐methyl and its metabolite carbendazim in apple leaves using a modified QuEChERS–UPLC–MS/MS method

Published: Oct 23, 2018

Author(s): Yuran Wang, Sen Lian, Xiangli Dong, Caixia Wang, Baohua Li, Pingliang Li

Journal: Biomedical Chromatography

Abstract As one of the main fungicides for the apple leaf disease control, thiophanate‐methyl (TM) mainly exerts its fungicidal activity in the form of its metabolite carbendazim (MBC), whose dissipation kinetics is very distinct from that of its parent but has been paid little attention. The aim of this work was to investigate the dissipation kinetics of TM and its active metabolite MBC in apple leaves using a modified...

Read More thumbnail image: Analysis of the dissipation kinetics of thiophanatemethyl and its metabolite carbendazim in apple leaves using a modified QuEChERSUPLCMSMS method

Phospho‐ l ‐tyrosine‐agarose chromatography: Adsorption of human IgG and its proteolytic fragments

Published: Oct 23, 2018

Author(s): Gisele Luiza Pavan, Igor Tadeu Lazzarotto Bresolin, Aline Ferreira Velho Muzio, Daniele Celestino Cunha, Sonia Maria Alves Bueno

Journal: Biomedical Chromatography

Abstract The behavior of human immunoglobulin G (IgG) and antigen‐binding fragment (Fab fragment) adsorption onto phospho‐l‐tyrosine immobilized on agarose (P‐Tyr‐agarose) was evaluated by pseudoaffinity chromatography. The effects of buffer systems MES, MOPS, Bis–Tris, Tris–HCl and sodium phosphate (NaP) and pH on IgG adsorption were studied and high purity values were obtained (96%, based on ELISA analysis of albumin, transferrin and...

Read More thumbnail image: Phospho l tyrosineagarose chromatography Adsorption of human IgG and its proteolytic fragments
Page:   Prev 8 9 10 11 12 13 14 15 16 17 18 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in spectroscopy? Visit our sister site spectroscopyNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved