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Quantitative evaluation of sulfation position prevalence in chondroitin sulphate by Raman spectroscopy

Published: Feb 5, 2019

Author(s): Miriam López‐Álvarez, Estefanía López‐Senra, Jesús Valcárcel, José Antonio Vázquez, Julia Serra, Pío González

Journal: Journal of Raman Spectroscopy

Abstract Chondroitin sulphate (CS) as a major component of the extracellular matrix of numerous connective tissues is responsible for biomechanical properties such as resistance and elasticity. It occurs in different isomeric forms with different sites and degrees of sulfation. The characterization of crude CS and quantitative isomeric identification by high‐performance liquid chromatography (HPLC) requires specific enzymes, expensive reagents, and a complicated analytical process. Poor...

Read More thumbnail image: Quantitative evaluation of sulfation position prevalence in chondroitin sulphate by Raman spectroscopy

Study of a terrestrial Martian analogue: Geochemical characterization of the Meñakoz outcrops (Biscay, Spain)

Published: Feb 5, 2019

Author(s): Patricia Ruiz‐Galende, Imanol Torre‐Fdez, Julene Aramendia, Leticia Gómez‐Nubla, Kepa Castro, Gorka Arana, Juan Manuel Madariaga

Journal: Journal of Raman Spectroscopy

Abstract The necessity to create databases for the proper interpretation of the results obtained by the rovers that will be sent by ESA to Mars implies the study of terrestrial Martian analogues. In this work, the Meñakoz outcrops, which are basaltic volcanic rocks interbedded with Turonian sediments coming from a Cretaceous submarine volcano outcrop located in Biscay (northern Spain), have been studied and proposed as a Martian analogue. Considering that Raman and near infrared spectroscopies...

Read More thumbnail image: Study of a terrestrial Martian analogue Geochemical characterization of the Menakoz outcrops Biscay Spain

Detox shampoos for EtG and FAEE in hair – Results from in vitro experiments

Published: Feb 5, 2019

Author(s): Marc Luginbühl, Britt Bekaert, Silke Suesse, Wolfgang Weinmann

Journal: Drug Testing and Analysis

Abstract The assessment of alcohol consumption behavior in hair is well established in forensic toxicology. The Society of Hair Testing (SoHT) recommends the direct alcohol markers ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE) for the detection of past alcohol consumption. In this study, we investigated if detox shampoos which are sold online can have an impact on EtG or FAEE concentrations in hair. According to customer reviews, positive drug testing results could be avoided...

Read More thumbnail image: Detox shampoos for EtG and FAEE in hair  Results from in vitro experiments

Ligand fishing of anti‐neurodegenerative components from Lonicera japonica using magnetic nanoparticles immobilised with monoamine oxidase B

Published: Feb 5, 2019

Author(s): Gui‐Fang Wu, Xiao‐Lan Jiang, Yu‐Zhou Gong, Ya‐Dong Hu, Xiao‐Lin Bai, Xun Liao

Journal: Journal of Separation Science

Abstract In this work, monoamine oxidase B was immobilised onto magnetic nanoparticles to prepare a new type of affinity solid‐phase extraction adsorbent, which was used to extract the possible anti‐neurodegenerative components from the Lonicera japonica flower extracts. Coupled with high‐performance liquid chromatography with mass spectrometry, two monoamine oxidase B ligands were fished‐out and identified as isochlorogenic acid A and isochlorogenic acid C, which were found to be inhibitors...

Read More thumbnail image: Ligand fishing of antineurodegenerative components from Lonicera japonica using magnetic nanoparticles immobilised with monoamine oxidase B

Selective enrichment and quantification of okadaic acid in shellfish using an immunomagnetic‐bead‐based liquid chromatography with tandem mass spectrometry assay

Published: Feb 5, 2019

Author(s): Jiaqi Chen, Zhijun Tan, Haiyan Wu, Jixing Peng, Yuxiu Zhai, Mengmeng Guo

Journal: Journal of Separation Science

Abstract Okadaic acid is a marine biotoxin that primarily occurs in shellfish and can cause diarrheic shellfish poisoning in humans. When analyzing biological samples using liquid chromatography with tandem mass spectrometry, the presence of complex matrices is a major issue. Thus, it is crucial to selectively and simply extract the target analyte from samples and minimize matrix effects simultaneously. To meet this need, an immunomagnetic‐bead‐based liquid chromatography with tandem mass...

Read More thumbnail image: Selective enrichment and quantification of okadaic acid in shellfish using an immunomagneticbeadbased liquid chromatography with tandem mass spectrometry assay

Combination of a modified quick, easy, cheap, efficient, rugged, and safe extraction method with a deep eutectic solvent based microwave‐assisted dispersive liquid–liquid microextraction: Application in extraction and preconcentration of multiclass pesticide residues in tomato samples

Published: Feb 5, 2019

Author(s): Mir Ali Farajzadeh, Hessamaddin Sohrabi, Ali Mohebbi, Mohammad Reza Afshar Mogaddam

Journal: Journal of Separation Science

Abstract In this study, a new two–step extraction procedure based on the combination of a modified quick, easy, cheap, effective, rugged, and safe extraction method with a deep eutectic solvent based microwave‐assisted dispersive liquid–liquid microextraction has been developed for the extraction of multiclass pesticides in tomato samples before their analysis by gas chromatography with flame ionization detection. In this method, initially, an aliquot of tomato is crushed and diluted with...

Read More thumbnail image: Combination of a modified quick easy cheap efficient rugged and safe extraction method with a deep eutectic solvent based microwaveassisted dispersive liquidliquid microextraction Application in extraction and preconcentration of multiclass pesticide residues in tomato samples

Simultaneous detection of four flavonoids and two alkaloids in rat plasma by LC–MS/MS and its application to a comparative study of the pharmacokinetics between Abri Herba and Abri mollis Herba extract after oral administration

Published: Feb 5, 2019

Author(s): Ruina Liu, Wenying Yan, Qingjie Han, Tao Lv, Xin Wang, Xiaochen Liu, Xueyan Fan, Caifeng Meng, Chunying Wang

Journal: Journal of Separation Science

Abstract Abri Herba and Abri mollis Herba both were important members of the Leguminosae family in southwestern China. Abri mollis Herba was often used as Abri Herba due to their proximity, but there are few studies on pharmacokinetics to compare their main identical active compositions. A sensitive and selective high‐performance liquid chromatography with tandem mass spectrometry method in the positive/negative electrospray ionization switching mode was developed and validated for the...

Read More thumbnail image: Simultaneous detection of four flavonoids and two alkaloids in rat plasma by LCMSMS and its application to a comparative study of the pharmacokinetics between Abri Herba and Abri mollis Herba extract after oral administration

Fast fabrication of a hybrid monolithic column containing cyclic and aliphatic hydrophobic ligands via photo‐initiated thiol‐ene polymerization

Published: Feb 5, 2019

Author(s): Yan Wang, Shujuan Ma, Luwei Zhang, Na Zhang, Yanan Li, Junjie Ou, Yehua Shen, Mingliang Ye

Journal: Journal of Separation Science

Abstract Three monomers, octakis (3‐mercaptopropyl) octasilsesquioxane, 1,2,4‐trivinylcyclohexane and isophytol were employed to synthesize a novel monolithic stationary phase via photo‐initiated thiol‐ene click polymerization for reversed‐phase liquid chromatography. Several factors such as porogenic system, reaction time and the molar ratio of functional groups were investigated in detail. The resulting poly(POSS‐co‐TVCH‐co‐isophytol) monolithic column exhibited suitable permeability for...

Read More thumbnail image: Fast fabrication of a hybrid monolithic column containing cyclic and aliphatic hydrophobic ligands via photoinitiated thiolene polymerization

Marinobufagenin extraction from Rhinella marina toad glands: Alternative approaches for a systematized strategy

Published: Feb 5, 2019

Author(s): Charline Lenaerts, Mathilde Wells, Stéphanie Hambÿe, Bertrand Blankert

Journal: Journal of Separation Science

Abstract Marinobufagenin is a bufadienolide compound detected mainly in skin and parotoid gland secretions of Rhinella marina (L.) toad. Bufadienolides regulate the Na+/K+‐ATPase pump by inhibiting the cardiotonic steroid dependent‐site and act as cardiac inotropes with vasoconstrictive properties. Marinobufagenin and other bufadienolides, such as telocinobufagin and bufalin, are thought to be found endogenously in mammals in salt‐sensitive hypertensive states such as essential hypertension,...

Read More thumbnail image: Marinobufagenin extraction from Rhinella marina toad glands Alternative approaches for a systematized strategy

Two‐step signal amplification for high‐sensitivity detection of biomarkers using gold nanoparticle–based conjugates

Published: Feb 5, 2019

Author(s): Pengjuan Zhang, Jie Yang, Dingbin Liu

Journal: ELECTROPHORESIS

Abstract The measurement of biomarkers in bodily fluids is extremely important for diagnosing disease, monitoring disease progression, and evaluating treatment efficacy. In this paper, we present a highly sensitive and compatible gold nanoparticle (AuNP)‐based, two‐step signal amplification system for biomarker detection. First, AuNPs were coated onto the surfaces of 96‐well plates to generate rough surfaces, which enable immobilization of many more capture antibodies than a smooth substrate....

Read More thumbnail image: Twostep signal amplification for highsensitivity detection of biomarkers using gold nanoparticlebased conjugates

Size‐dependent electrophoretic migration and separation of water‐soluble gold nanoclusters by capillary electrophoresis

Published: Feb 5, 2019

Author(s): Ting Wan, Fenglin Tang, Yanru Yin, Maoxue Zhang, Martin M. F. Choi, Xiupei Yang

Journal: ELECTROPHORESIS

Abstract Recently, water‐soluble gold nanoclusters (AuNCs) have attracted more and more attention due to their unique properties. In this study, penicillamine‐protected gold nanoclusters (Pen‐AuNCs) were synthesized and initially fractionated by sequential size‐selective precipitation (SSSP). The crude Pen‐AuNCs and SSSP fractions were separated by capillary zone electrophoresis (CZE) with a diode array detector. The effects of key parameters, including the concentration of phosphate buffer,...

Read More thumbnail image: Sizedependent electrophoretic migration and separation of watersoluble gold nanoclusters by capillary electrophoresis

Dielectrophoretic trapping of single leukemic cells using the conventional and compact optical measurement systems

Published: Feb 5, 2019

Author(s): Hamideh Sharifi Noghabi, Mandy Soo, Avid Khamenehfar, Paul C.H. Li

Journal: ELECTROPHORESIS

Abstract Here, we report a microfluidic same‐single‐cell analysis to study the inhibition of multidrug resistance due to drug efflux on single leukemic cells. Drug efflux inhibition was investigated in the microfluidic chip using two different fluorescence detection systems, namely, a compact single‐cell bioanalyzer and the conventional optical detection system constructed from an inverted microscope and a microphotometer. More importantly, a compact signal generator was used to conduct...

Read More thumbnail image: Dielectrophoretic trapping of single leukemic cells using the conventional and compact optical measurement systems

Detection of RNA‐protein interactions using a highly sensitive non‐radioactive electrophoretic mobility shift assay

Published: Feb 5, 2019

Author(s): Gerasimos Daras, Anastasios Alatzas, Dikran Tsitsekian, Dimitris Templalexis, Stamatis Rigas, Polydefkis Hatzopoulos

Journal: ELECTROPHORESIS

Abstract Electrophoretic mobility shift assay (EMSA) is a sensitive technique useful in the identification and characterization of protein interactors with nucleic acids. This assay provides an efficient method to study DNA or RNA binding proteins and to identify nucleic acid substrates. The specific interaction plays important roles in many biological processes such as transcription, translation, splicing, and global gene expression. In this article, we have modified the EMSA technique and...

Read More thumbnail image: Detection of RNAprotein interactions using a highly sensitive nonradioactive electrophoretic mobility shift assay

Sebacic acid as corrosion inhibitor for hot‐dip galvanized (HDG) steel in 0.1 M NaCl

Published: Feb 4, 2019

Author(s): Michele Fedel, Mireille Poelman, Marjorie Olivier, Flavio Deflorian

Journal: Surface and Interface Analysis

The potential of sebacic acid as a corrosion inhibitor for hot‐dip galvanized steel in 0.1 M NaCl solution has been investigated. Different concentrations of the organic acid have been tested in order to understand the inhibition mechanism of the compound. The electrochemical test revealed a competitive mechanism between the dissolution of the metal in the acidified solution and the inhibition provided by the dicarboxylic species. The formation of a whitish layer consisting of zinc...

Read More thumbnail image: Sebacic acid as corrosion inhibitor for hotdip galvanized HDG steel in 0_1M NaCl

Molecular hydrogen‐induced nucleation of hydrogenated silicon nanocrystals at low temperature

Published: Feb 4, 2019

Author(s): Larbi Filali, Yamina Brahmi, Jamal Dine Sib, Fatiha Kail, Yahya Bouizem, Djamel Benlakehal, Kacem Zellama, Ahmed Bouhekka, Aissa Kebab, Larbi Chahed

Journal: Surface and Interface Analysis

Highly crystallized hydrogenated silicon layers were obtained via the treatment of hydrogenated polymorphous silicon films in a molecular hydrogen ambient. This contrasts other postdeposition studies that obtained nanocrystalline silicon films but necessitated either a plasma activation or high‐temperature annealing. The structure of the samples was analyzed by Raman spectroscopy to determine the crystallite volume fraction, which was found to increase up to 80% within 1 hour of treatment....

Read More thumbnail image: Molecular hydrogeninduced nucleation of hydrogenated silicon nanocrystals at low temperature

Ti (IV) attached‐phosphonic acid functionalized capillary monolith as a stationary phase for in‐syringe‐type fast and robust enrichment of phosphopeptides

Published: Feb 4, 2019

Author(s): Kouroush Salimi, Çiğdem Kip, Ömür Çelikbıçak, Duygu Deniz Usta, Aslı Pınar, Bekir Salih, Ali Tuncel

Journal: Biomedical Chromatography

Abstract In this study, poly(vinylphosphonic acid‐co‐ethylene dimethacrylate), poly(VPA‐co‐EDMA) capillary monolith was synthesized as a starting material for obtaining a stationary phase for microscale enrichment of phosphopeptides. The chelation of active phosphonate groups with Ti (IV) ions gave a macroporous monolithic column with a mean pore size of 5.4 μm. The phosphopeptides from different sources were enriched on Ti (IV)‐attached poly(VPA‐co‐EDMA) monolith using a syringe‐pump. The...

Read More thumbnail image: Ti IV attachedphosphonic acid functionalized capillary monolith as a stationary phase for insyringetype fast and robust enrichment of phosphopeptides

Peptide nucleic acid and amino acid modified peptide nucleic acid analysis by capillary zone electrophoresis

Published: Feb 4, 2019

Author(s): Xiaoqian Wang, Linsen Li, Rizwan Ullah Khan, Feng Qu

Journal: ELECTROPHORESIS

Abstract A rapid, high resolution, and low sample consumption CZE method is developed for peptide nucleic acid (PNA) analysis for the first time. 30% v/v acetonitrile in PNA sample and 20% v/v acetonitrile in 50 mM borax‐boric acid (pH 8.7) as BGE were employed after optimization. The calibration curves were linear for PNA concentration ranging from 1 to 50 μmol/L. LOD and LOQ of PNA were 0.2 and 1.0 μmol/L, respectively. Since the commercially available reagent gives rise to huge PNA peak and...

Read More thumbnail image: Peptide nucleic acid and amino acid modified peptide nucleic acid analysis by capillary zone electrophoresis

Auger electron spectroscopic analysis of corrosion products formed on A3003 aluminum alloy in model fresh water with different Zn2+ concentration

Published: Feb 4, 2019

Author(s): Kyohei Otani, Md. Saiful Islam, Masatoshi Sakairi, Akira Kaneko

Journal: Surface and Interface Analysis

The corrosion morphology and composition of corrosion products of A3003 formed in model fresh water with different Zn2+ concentrations were investigated by immersion tests combined with surface observations and analysis using an Auger electron spectroscope (AES). The cross‐sectional AES observations showed that the thickness of the corrosion product layer formed on A3003 decreases with increases in the Zn2+ concentration of the model fresh water. A cross‐sectional AES point analysis suggested...

Read More thumbnail image: Auger electron spectroscopic analysis of corrosion products formed on A3003 aluminum alloy in model fresh water with different Zn2 concentration

Click regulation of cyclodextrin primary face for the preparation of novel chiral stationary phases

Published: Feb 1, 2019

Author(s): Xuan Jin, Xiaoxuan Li, Yong Wang

Journal: ELECTROPHORESIS

Abstract In this study, a series of novel CD chiral stationary phases were fabricated by immobilization of mono‐6A‐deoxy‐N3‐cyclodextrin onto silica surfaces followed by click regulation of CD primary face with 4‐pentynoic acid (acidic moiety), 2‐propynylamine (alkaline moiety) and L‐propargylglycine (chiral amino acid moiety), respectively. Enantioseparations of various kinds of racemates including dansyl‐amino acids, chiral lactides and diketones were conducted in reversed phase modes on...

Read More thumbnail image: Click regulation of cyclodextrin primary face for the preparation of novel chiral stationary phases

Recommendations for reporting ion mobility Mass Spectrometry measurements

Published: Feb 1, 2019

Author(s): Valérie Gabelica, Alexandre A. Shvartsburg, Carlos Afonso, Perdita Barran, Justin L.P. Benesch, Christian Bleiholder, Michael T. Bowers, Aivett Bilbao, Matthew F. Bush, J. Larry Campbell, Iain D.G. Campuzano, Tim Causon, Brian H. Clowers, Colin S. Creaser, Edwin De Pauw, Johann Far, Francisco Fernandez‐Lima, John C. Fjeldsted, Kevin Giles, Michael Groessl, Christopher J. Hogan, Stephan Hann, Hugh I. Kim, Ruwan T. Kurulugama, Jody C. May, John A. McLean, Kevin Pagel, Keith Richardson, Mark E. Ridgeway, Frédéric Rosu, Frank Sobott, Konstantinos Thalassinos, Stephen J. Valentine, Thomas Wyttenbach

Journal: Mass Spectrometry Reviews

Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused...

Read More thumbnail image: Recommendations for reporting ion mobility Mass Spectrometry measurements
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