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Micro‐Raman spectroscopy of natural members along CuSbS2CuSbSe2 join

Published: May 29, 2018

Author(s): Jiří Sejkora, Elena Buixaderas, Pavel Škácha, Jakub Plášil

Journal: Journal of Raman Spectroscopy

Abstract Micro‐Raman spectroscopy was used to investigate the natural orthorhombic members (space group Pnma) along the CuSbS2–CuSbSe2 join: chalcostibite Cu1.01Sb1.00S1.99 from Dúbrava (Slovak Republic); Se‐rich chalcostibite Cu1.00(Sb0.99As0.02)Σ1.01(S1.29Se0.70)Σ1.99 and the new mineral příbramite Cu0.99(Sb1.03As0.01)Σ1.04(Se1.82S0.15)Σ1.97 both from the Příbram uranium and base‐metal district (Czech Republic). Stretching and bending vibrations of the pyramidal ...

Read More thumbnail image: MicroRaman spectroscopy of natural members along CuSbS2  CuSbSe2 join

The determination of capreomycin in human plasma by LC–MS/MS using ion‐pairing chromatography and solid‐phase extraction

Published: May 28, 2018

Author(s): Blessings Thuboy, Tracy Kellermann, Sandra Castel, Jennifer Norman, Anton Joubert, Anthony J. Garcia‐Prats, Anneke C. Hesseling, Lubbe Wiesner

Journal: Biomedical Chromatography

Abstract A bioanalytical method was developed and validated for the quantification of capreomycin (Cm) analogs, Cm IA and Cm IB, in human plasma. This implemented ion‐pairing solid phase extraction, followed by ion‐pairing high‐performance liquid chromatography, with tandem mass spectrometry detection. Chromatographic separation was achieved using a Discovery C18, 5 μm, 4.6 × 50 mm analytical column. An isocratic mobile phase consisting of...

Read More thumbnail image: The determination of capreomycin in human plasma by LCMSMS using ionpairing chromatography and solidphase extraction

Development and validation of a UPLC–MS method for the determination of galantamine in guinea pig plasma and its application to a pre‐clinical bioavailability study of novel galantamine formulations

Published: May 28, 2018

Author(s): Jiang Wang, Naresh Pavurala, Xiaoming Xu, Yellela S. R. Krishnaiah, Patrick J. Faustino

Journal: Biomedical Chromatography

Abstract To evaluate the bioavailability and pharmacokinetic profiles of two novel galantamine formulations as medical countermeasure products, an ultra‐performance liquid chromatography–single quadrupole mass spectrometry (UPLC–MS) method was developed and validated for quantifying galantamine in guinea pig plasma using solid‐phase extraction with a mixed mode strong cation exchange reversed‐phase cartridge. Chromatographic...

Read More thumbnail image: Development and validation of a UPLCMS method for the determination of galantamine in guinea pig plasma and its application to a preclinical bioavailability study of novel galantamine formulations

Encoding and readout strategies in magnetic resonance elastography

Published: May 28, 2018

Author(s): Christian Guenthner, Sebastian Kozerke

Journal: NMR in Biomedicine

Magnetic resonance elastography (MRE) has evolved significantly since its inception. Advances in motion‐encoding gradient design and readout strategies have led to improved encoding and signal‐to‐noise ratio (SNR) efficiencies, which in turn allow for higher spatial resolution, increased coverage, and/or shorter scan times. The purpose of this review is to summarize MRE wave‐encoding and readout approaches in a unified mathematical...

Read More thumbnail image: Encoding and readout strategies in magnetic resonance elastography

Graphene oxide layers modified by irradiation with 1.0 MeV Au + ions

Published: May 28, 2018

Author(s): Petr Malinský, Mariapompea Cutroneo, Anna Macková, Vladimir Hnatowicz, Kateřina Szökölová, Marie Bohačová, Jan Luxa, Zdeněk Sofer

Journal: Surface and Interface Analysis

Graphene oxide (GO) foils were modified by irradiation using 1.0 MeV Au+ ions, and their elemental composition before and after the ion irradiation was investigated using Rutherford back‐scattering spectroscopy (RBS). The surface morphology was studied using SEM, and changes in elemental composition and structure of GO in shallow subsurface were characterized by various spectroscopy techniques including X‐ray photoelectron spectroscopy and ...

Read More thumbnail image: Graphene oxide layers modified by irradiation with 1_0 MeV Au  ions

Defining Cell Identity with Single‐Cell Omics

Published: May 28, 2018

Author(s): Laura Mincarelli, Ashleigh Lister, James Lipscombe, Iain C. Macaulay

Journal: PROTEOMICS

Abstract Cells are a fundamental unit of life, and the ability to study the phenotypes and behaviors of individual cells is crucial to understanding the workings of complex biological systems. Cell phenotypes (epigenomic, transcriptomic, proteomic, and metabolomic) exhibit dramatic heterogeneity between and within the different cell types and states underlying cellular functional diversity. Cell genotypes can also display...

Read More thumbnail image: Defining Cell Identity with SingleCell Omics

Mass Spectrometry Imaging of 3D Tissue Models

Published: May 28, 2018

Author(s): Cristina Russo, Emily E. L. Lewis, Lucy Flint, Malcolm R. Clench

Journal: PROTEOMICS

Abstract A 3D cell culture is an artificially created environment in which cells are permitted to grow/interact with their surroundings in all three dimensions. Derived from 3D cell culture, organoids are generally small‐scale constructs of cells that are fabricated in the laboratory to serve as 3D representations of in vivo tissues and organs. Due to regulatory, economic and societal issues concerning the use of animals in...

Read More thumbnail image: Mass Spectrometry Imaging of 3D Tissue Models

Probing the molecular regulation of lipopolysaccharide stress in piglet liver by comparative proteomics analysis

Published: May 28, 2018

Author(s): Bing Xia, Qingshi Meng, Xiaohui Feng, Xiangfang Tang, Anfeng Jia, Jinghai Feng, Sheng Zhang, Hongfu Zhang

Journal: ELECTROPHORESIS

Abstract Lipopolysaccharide (LPS) can induce inflammatory responses in piglets, causing immunological stress and tissue damage. However, chronic LPS infection may lead to LPS‐induced immunological stress resistance. The molecular mechanisms underlying LPS stress have not been fully elucidated. Here, we conducted a global comparative proteomics analysis to investigate the molecular regulation of LPS stress using an immunological...

Read More thumbnail image: Probing the molecular regulation of lipopolysaccharide stress in piglet liver by comparative proteomics analysis

Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube poly(styrene‐co‐divinylbenzene) composites and separation by capillary electrophoresis

Published: May 28, 2018

Author(s): Khaled Murtada, Fernando Andrés, Angel Ríos, Mohammed Zougagh

Journal: ELECTROPHORESIS

Abstract Poly(styrene‐co‐divinylbenzene)‐coated magnetic multiwalled carbon nanotube composite synthesized by in‐situ high temperature combination and precipitation polymerization of styrene‐co‐divinylbenzene has been employed as a magnetic sorbent for the solid phase extraction of antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram and sertraline were, afterwards, separated and determined by capillary...

Read More thumbnail image: Determination of antidepressants in human urine extracted by magnetic multiwalled carbon nanotube polystyrenecodivinylbenzene composites and separation by capillary electrophoresis

An HPLC‐UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications

Published: May 27, 2018

Author(s): Jagdish Mahale, Lynne M. Howells, Rajinder Singh, Robert G. Britton, Hong Cai, Karen Brown

Journal: Biomedical Chromatography

Abstract Curcumin, derived from turmeric, has been extensively investigated for its broad spectrum of biological activities. Previously reported HPLC‐UV methods have focussed on analysis of the parent compound. Here, a sensitive HPLC‐UV method was developed and partially validated, then used for the simultaneous determination of curcumin and its glucuronide and sulfate metabolites in plasma and lung tissue from mice. The assay was...

Read More thumbnail image: An HPLCUV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue Potential for preclinical applications

MA‐XRF study of 15th–17th century icons from the collection of the National Museum in Krakow, Poland

Published: May 27, 2018

Author(s): Małgorzata Walczak, Dominika Tarsińska‐Petruk, Michał Płotek, Maria Goryl, Mirosław P. Kruk

Journal: X-Ray Spectrometry

In 2015, the National Museum in Krakow, Poland, started a grant from the National Programme for the Development of Humanities, its goal to investigate an important collection of old Orthodox painting, including more than 50 15th to 17th century icons originating from the territory of the historical Orthodox Diocese of Przemyśl within the borders of the Polish Kingdom. The aim of researching the iconography,...

Read More thumbnail image: MAXRF study of 15th17th century icons from the collection of the National Museum in Krakow Poland

A liquid chromatography–tandem mass spectrometry method for the determination of cocaine and metabolites in blood and in dried blood spots collected from postmortem samples and evaluation of the stability over a 3‐month period

Published: May 25, 2018

Author(s): Matteo Moretti, Silvia Damiana Visonà, Francesca Freni, Ilaria Tomaciello, Claudia Vignali, Angelo Groppi, Luca Tajana, Antonio Marco Maria Osculati, Luca Morini

Journal: Drug Testing and Analysis

Abstract The aims of this study were (1) to identify and quantify cocaine (COC), benzoylecgonine (BE), ecgonine methyl ester (EME), and cocaethylene (CE) in DBS; (2) to compare dried blood spots (DBSs) analytical results with the routine blood analyses; (3) to monitor analytes stability on DBS within a 3‐month period. Eighty‐five μL of blood from postmortem cases were put on a card for DBS analysis and kept in the dark, at room...

Read More thumbnail image: A liquid chromatographytandem mass spectrometry method for the determination of cocaine and metabolites in blood and in dried blood spots collected from postmortem samples and evaluation of the stability over a 3month period

Continuous wave electron paramagnetic resonance of nitroxide biradicals in fluid solution

Published: May 25, 2018

Author(s): Sandra S. Eaton, Lukas B. Woodcock, Gareth R. Eaton

Journal: Concepts in Magnetic Resonance Part A

Abstract Nitroxide biradicals have been prepared with electron‐electron spin‐spin exchange interaction, J, ranging from weak to very strong. EPR spectra of these biradicals in fluid solution depend on the ratio of J to the nitrogen hyperfine coupling, AN, and the rates of interconversion between conformations with different values of J. For relatively rigid biradicals EPR spectra can be simulated as the superposition of AB splitting patterns arising from different...

Read More thumbnail image: Continuous wave electron paramagnetic resonance of nitroxide biradicals in fluid solution

Analysis of retinol, α ‐tocopherol, 25‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3 in plasma of patients with cardiovascular disease by HPLC–MS/MS method

Published: May 24, 2018

Author(s): Marta Karaźniewicz‐Łada, Anna Główka, Anna Komosa, Łukasz Kruszyna, Agnieszka Graczyk‐Szuster, Maciej Lesiak, Dagmara Sowińska, Juliusz Przysławski

Journal: Biomedical Chromatography

Abstract Fat‐soluble vitamins play a pivotal role in the progression of atherosclerosis and the development of cardiovascular disease. Therefore, plasma monitoring of their concentrations may be useful in the diagnosis of these disorders as well as in the process of treatment. The study aimed to develop and validate an HPLC–MS/MS method for determination of retinol, α‐tocopherol, 25‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3 in plasma of...

Read More thumbnail image: Analysis of retinol  tocopherol 25hydroxyvitamin D2 and 25hydroxyvitamin D3 in plasma of patients with cardiovascular disease by HPLCMSMS method

Fabrication of thioflavin‐ T ‐modified nanopillared SERS substrates for ultrasensitive beta‐amyloid peptide detection

Published: May 24, 2018

Author(s): Sevde Altuntas, Fatih Buyukserin

Journal: Journal of Raman Spectroscopy

Abstract Alzheimer disease (AD) is a major cause of death in the world, and despite intense efforts, there is still no cure for this neurodegenerative disorder. Therefore, early diagnosis of AD is of prime importance, and extensive studies are being conducted to improve the current early detection capabilities and to identify new potential biomarkers for this disease. Here in, we report the fabrication of a novel nanobiosensor...

Read More thumbnail image: Fabrication of thioflavin T modified nanopillared SERS substrates for ultrasensitive betaamyloid peptide detection

SILAR grown Ag nanoparticles as an efficient large area SERS substrate

Published: May 24, 2018

Author(s): Imran M. Shaikh, Shrikrishna D. Sartale

Journal: Journal of Raman Spectroscopy

Abstract Ag nanoparticles having different size and coverage are grown on large area glass substrate (~10 cm2) using low cost successive ionic layer adsorption and reduction (SILAR) method. The SILAR parameters, such as reduction time and growth cycles are optimized to grow Ag nanoparticles with appropriate size and coverage showing maximum surface enhanced Raman scattering (SERS) enhancement of Rhodamine 6 G(R6G). For fixed growth...

Read More thumbnail image: SILAR grown Ag nanoparticles as an efficient large area SERS substrate

Multivariate optimization and characterization of simultaneous removal of binary mixture of Cu(II) and Pb(II) using Fe 3 O 4 @MoS 2 nanoparticles

Published: May 24, 2018

Author(s): Javad Zolgharnein, Mahdieh Rastgordani

Journal: Journal of Chemometrics

Abstract In this study, a facile hydrothermal method was used for the synthesis of Fe3O4@MoS2 magnetic nanoparticles. Then, this compound was used as an efficient adsorbent for the simultaneous removal of Cu(II) and Pb(II) ions from water. The prepared nanoparticles were characterized by scanning electron microscopy, X‐ray diffraction, vibrating sample magnetometer, and Fourier transform infrared spectroscopy. In addition, the effect of...

Read More thumbnail image: Multivariate optimization and characterization of simultaneous removal of binary mixture of CuII and PbII using Fe 3 O 4 MoS 2 nanoparticles

A microfluidic glucose sensor incorporating a novel thread‐based electrode system

Published: May 24, 2018

Author(s): Michelle Gaines, Maria Jose Gonzalez‐Guerrero, Kathryn Uchida, Frank A. Gomez

Journal: ELECTROPHORESIS

Abstract An electrochemical sensor for the detection of glucose using thread‐based electrodes and fabric is described. This device is relatively simple to fabricate and can be used for multiple readings after washing with ethanol. The fabrication of the chip consisted of two steps. First, three thread‐based electrodes (reference, working, and counter) were fabricated by painting pieces of nylon thread with either layered silver ink...

Read More thumbnail image: A microfluidic glucose sensor incorporating a novel threadbased electrode system

Concurrent determination and separation of inorganic cations and anions in microchip electrophoresis with precisely controlled high‐voltage

Published: May 24, 2018

Author(s): Zhe Huang, Mingpeng Yang, Hui You, Yang Xie

Journal: ELECTROPHORESIS

Abstract An improved method for the concurrent determination and separation of cations and anions by microchip electrophoresis with capacitively coupled contactless conductivity detection (ME‐C4D) is described. Two kinds of microchip structures were designed. The first microchip has a long bent separation channel. And for the defects of the first microchip, the second microchip with a Y‐type separation channel has been proposed. The background ...

Read More thumbnail image: Concurrent determination and separation of inorganic cations and anions in microchip electrophoresis with precisely controlled highvoltage

Pressure‐assisted capillary electrophoresis frontal analysis for faster binding constant determination

Published: May 24, 2018

Author(s): Cheng Qian, Su Wang, Hengqing Fu, Robin F. B. Turner, Huihui Li, David D. Y. Chen

Journal: ELECTROPHORESIS

Abstract Adding external pressure during the process of capillary electrophoresis usually add to the band broadening, especially if the pressure induced flow is significant. The resolution is normally negatively affected in pressure‐assisted capillary electrophoresis (PACE). Frontal analysis (FA), however, can potentially benefit from using an external pressure while avoiding the drawbacks in other modes of CE. In this work,...

Read More thumbnail image: Pressureassisted capillary electrophoresis frontal analysis for faster binding constant determination
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