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Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry

Published: Mar 2, 2018

Author(s): Yunliang Zheng, Meihua Lin, Xingjiang Hu, You Zhai, Qiao Zhang, Yan Lou, Jianzhong ShenTu, Lihua Wu

Journal: Journal of Separation Science

Abstract Physalins are the major steroidal constituent of Physalis plants and display a range of biological activities. For this study, a rapid and sensitive high‐performance liquid chromatography with triple quadrupole mass spectrometry method was developed for the simultaneous quantification of six physalins. Specifically, it was for the quantification of physalin A, physalin B, physalin D, physalin G, 4,7‐didehydroneophysalin B, and...

Read More thumbnail image: Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry

Quantitative analysis of Yb 4d photoelectron spectrum of metallic Yb

Published: Mar 2, 2018

Author(s): N. Pauly, F. Yubero, S. Tougaard

Journal: Surface and Interface Analysis

The measured Yb 4d3/2 intensity is larger than the Yb 4d5/2 in X‐ray photoelectron (XPS) emission of metallic Yb, which is unexpected. The shape and intensity of photoelectron peaks are strongly affected by extrinsic excitations due to electron transport out of the surface (including bulk and surface effects) and to intrinsic excitations due to the sudden creation of the static core hole. To quantitatively extract from experimental XPS...

Read More thumbnail image: Quantitative analysis of Yb 4d photoelectron spectrum of metallic Yb

Fabrication of magnetic zinc adeninate metal–organic frameworks for the extraction of benzodiazepines from urine and wastewater

Published: Mar 2, 2018

Author(s): Suling Zhang, Weixuan Yao, Defeng Fu, Chunxiao Zhang, Hongting Zhao

Journal: Journal of Separation Science

Abstract In this study, an alternative method for synthesizing magnetic cobalt adeninate metal–organic frameworks was developed, and the synthesized materials were examined for their potential application for separating and enriching benzodiazepines from complex samples. Benzodiazepines, widely used as hypnotics, muscle relaxants, sedatives, and anxiolytics, are a class of drugs that require accurate detection and monitoring....

Read More thumbnail image: Fabrication of magnetic zinc adeninate metalorganic frameworks for the extraction of benzodiazepines from urine and wastewater

Electrochemical characterization of PVA/SA nanofibers obtained by electrospinning processing

Published: Mar 2, 2018

Author(s): A. Covelo, K. K. Gómez, P. Corona‐Lira, A. C. Ramírez‐Reivich, M. Hernández

Journal: Surface and Interface Analysis

Sodium alginate (SA), a linear polysaccharide which is present in different forms, is commonly used for tissue engineering. One of the main challenges of using SA in tissue engineering consists of the fabrication of nanoparticles/nanofibres for cell culture scaffolds. Because SA has been developed for medical purposes, it is necessary to measure, among others, the electrochemical properties because they provide information of biological...

Read More thumbnail image: Electrochemical characterization of PVASA nanofibers obtained by electrospinning processing

Surface and microstructural analyses of a Roman quadrans dating back to first century ad

Published: Mar 2, 2018

Author(s): A.C. Ruggiero, S. Kaciulis, A. Mezzi, R. Montanari, P. Soltani, A. Varone

Journal: Surface and Interface Analysis

The paper reports the results of the analyses performed on a Roman quadrans dating back to the first century ad, belonging to a group of more than 8.000 coins found in the bed of river Tiber during an archaeological research in 1987–1988. The quadrans was examined by means of X‐ray diffraction, scanning electron microscopy, energy dispersion spectroscopy, and X‐ray photoelectron spectroscopy. Energy dispersion spectroscopy...

Read More thumbnail image: Surface and microstructural analyses of a Roman quadrans dating back to first century ad

Reduction and covalent modification of graphene‐oxide by nitrogen in glow discharge plasma

Published: Mar 2, 2018

Author(s): M. Mohai, K. László, I. Bertóti

Journal: Surface and Interface Analysis

In this work, we performed plasma treatment of thin layers of graphene oxide samples in various nitrogen containing gases (mainly NH3 and N2). Experiments were performed in the preparation chamber of the X‐ray photoelectron spectrometer, allowing “in situ” characterization of the treated surface. Introduction of nitrogen into the top surface was intensified by applying negative voltage on the sample between 0 and 300 V accelerating...

Read More thumbnail image: Reduction and covalent modification of grapheneoxide by nitrogen in glow discharge plasma

Metabolite identification of the antimalarial naphthoquine using liquid chromatography–tandem high‐resolution mass spectrometry in combination with multiple data‐mining tools

Published: Mar 2, 2018

Author(s): Yanhong Sun, Shuqi Wang, Jianbo Ji, Guangxi Zhai, Jie Xing

Journal: Biomedical Chromatography

Abstract Naphthoquine (NQ) is one of important partner drugs of artemisinin‐based combination therapy (ACT), which is recommended for the treatment of uncomplicated Plasmodium falciparum. NQ shows a high cure rate after a single oral administration. It is absorbed quickly (time to peak concentration 2–4 h) and has a long elimination half‐life (255 h). However, the metabolism of NQ has not been clarified. In this work, the metabolite ...

Read More thumbnail image: Metabolite identification of the antimalarial naphthoquine using liquid chromatographytandem highresolution mass spectrometry in combination with multiple datamining tools

In vivo microdialysis with ultra performance liquid chromatography–mass spectrometry for analysis of tetramethylpyrazine and its interaction with borneol in rat brain and blood

Published: Mar 2, 2018

Author(s): Weiguo Liao, Xiaojie Huang, Yongxin Yin, Bin Liu, Runzhi Zhu

Journal: Biomedical Chromatography

Abstract Tetramethylpyrazine (TMP) has been widely used in the treatment of ischemic cerebrovascular disease. However, the mechanism of TMP and how to increase its bioavailability need to be further explored. In our study, an in vivo microdialysis sampling technique coupled with ultra‐performance liquid chromatography–mass spectrometry method was developed to investigate the pharmacokinetic properties of TMP and its interaction with different...

Read More thumbnail image: In vivo microdialysis with ultra performance liquid chromatographymass spectrometry for analysis of tetramethylpyrazine and its interaction with borneol in rat brain and blood

Simultaneous determination of gelsemine and koumine in rat plasma by UPLC‐MS/MS and application to pharmacokinetic study after oral administration of Gelsemium elegans Benth extract

Published: Mar 2, 2018

Author(s): Lin Wang, Yanqing Wen, Fanhao Meng

Journal: Biomedical Chromatography

Abstract A simple, rapid and sensitive method using UPLC‐MS/MS was established and validated for simultaneous determination of gelsemine and koumine in rat plasma after oral administration of Gelsemium elegans Benth extract. Plasma was performed with methanol precipitation and berberine was chosen as the internal standard. Plasma samples were separated on an Acquity UPLC® BEH C18 column (3.0 × 50 mm, 1.7 μm) with gradient elution using...

Read More thumbnail image: Simultaneous determination of gelsemine and koumine in rat plasma by UPLCMSMS and application to pharmacokinetic study after oral administration of Gelsemium elegans Benth extract

In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy

Published: Mar 2, 2018

Author(s): Tanmoy Bhattacharjee, Leticia C. Fontana, Leandro Raniero, Juliana Ferreira‐Strixino

Journal: Journal of Raman Spectroscopy

Abstract Breast cancer is most fatal cancer among women worldwide. The high mortality can be attributed to late detection and low treatment efficacy. Treatment is difficult owing to the multitude of breast cancer subtypes and making decisions on therapeutic strategy difficult. A tool to predict treatment prognosis may greatly aid this decision making. Currently available prediction methods have low accuracy in addition to several...

Read More thumbnail image: In vivo Raman spectroscopy of breast tumors prephotodynamic and postphotodynamic therapy

Accelerated SDS depletion from proteins by transmembrane electrophoresis: Impacts of Joule heating

Published: Mar 1, 2018

Author(s): Nicole Unterlander, Alan Austin Doucette

Journal: ELECTROPHORESIS

Abstract SDS plays a key role in proteomics workflows, including protein extraction, solubilization and mass‐based separations (e.g. SDS‐PAGE, GELFrEE). However, SDS interferes with mass spectrometry and so it must be removed prior to analysis. We recently introduced an electrophoretic platform, termed transmembrane electrophoresis (TME), enabling extensive depletion of SDS from proteins in solution with exceptional protein yields....

Read More thumbnail image: Accelerated SDS depletion from proteins by transmembrane electrophoresis Impacts of Joule heating

Determination of 16 antineoplastic drugs by capillary electrophoresis with UV detection: Applications in quality control

Published: Mar 1, 2018

Author(s): Nicolas Guichard, Marie Ogereau, Ludivine Falaschi, Serge Rudaz, Julie Schappler, Pascal Bonnabry, Sandrine Fleury‐Souverain

Journal: ELECTROPHORESIS

Abstract Two capillary electrophoresis (CE) methods were developed for the analysis of 16 antineoplastic drugs contained in injectable pharmaceutical formulations. A capillary zone electrophoresis (CZE) method coupled to UV was developed with a background electrolyte (BGE) made of a 100 mM phosphate buffer at pH 2.5 containing 50% v/v of acetonitrile and dynamic coating of capillaries with Ceofix®. This method allowed the analysis...

Read More thumbnail image: Determination of 16 antineoplastic drugs by capillary electrophoresis with UV detection Applications in quality control

Updates on resources, software tools, and databases for plant proteomics in 2016–2017

Published: Mar 1, 2018

Author(s): Biswapriya B. Misra

Journal: ELECTROPHORESIS

Abstract Proteomics data processing, annotation, and analysis can often lead to major hurdles in large‐scale high‐throughput bottom‐up proteomics experiments. Given the recent rise in protein‐based big datasets being generated, efforts in in silico tool development occurrences have had an unprecedented increase; so much so, that it has become increasingly difficult to keep track of all the advances in a particular academic year. However, these...

Read More thumbnail image: Updates on resources software tools and databases for plant proteomics in 20162017

Topics in chemometrics, TIC 2017, a personal report

Published: Feb 28, 2018

Author(s): Marcel Maeder

Journal: Journal of Chemometrics

Read More thumbnail image: Topics in chemometrics TIC 2017 a personal report

kNN based on probability density for fault detection in multimodal processes

Published: Feb 28, 2018

Author(s): Jinyu Guo, Xin Wang, Yuan Li

Journal: Journal of Chemometrics

Abstract Recently, k‐nearest neighbor rules (kNN) have drawn increasing attention for fault detection of multimodal industrial processes. However, the traditional kNN method performs poorly for weak faults in a dense mode when the dispersion degree of each mode is quite different. The reason is that the kNN statistics of weak faults are usually submerged by those of normal data in a mode with a high dispersion degree. To improve the...

Read More thumbnail image: kNN based on probability density for fault detection in multimodal processes

Supramolecular separation mechanism of pentafluorophenyl column using ibuprofen and omeprazole as markers: LC‐MS and simulation study

Published: Feb 28, 2018

Author(s): Afzal Hussain, Mohamed F. AlAjmi, Imran Ali

Journal: Biomedical Chromatography

Abstract The pentafluorophenyl (PFP) column is emerging as a new advancement in separation science to analyze a wide range of analytes and, thus, its separation mechanism at supramolecular level is significant. We developed a mechanism for the separation of ibuprofen and omeprazole using different combinations (ranging from 50:50 to 60:40) of water–acetonitrile containing 0.1% formic acid as the mobile phase. The column used was...

Read More thumbnail image: Supramolecular separation mechanism of pentafluorophenyl column using ibuprofen and omeprazole as markers LCMS and simulation study

Characterization of neuropeptide K processing in rat spinal cord S9 fractions using high‐resolution quadrupole–Orbitrap mass spectrometry

Published: Feb 27, 2018

Author(s): Jennifer Ben Salem, Bruno Nkambeu, Francis Beaudry

Journal: Biomedical Chromatography

Abstract Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinin peptides from neurons. We suspect that proteolysis regulates extracellular neuropeptide K (NPK) and neurokinin A (NKA) concentrations and NPK is a precursor of...

Read More thumbnail image: Characterization of neuropeptide K processing in rat spinal cord S9 fractions using highresolution quadrupoleOrbitrap mass spectrometry

Validated UPLC‐MS/MS method for quantification of seven compounds in rat plasma and tissues: Application to pharmacokinetic and tissue distribution studies in rats after oral administration of extract of Eclipta prostrata L.

Published: Feb 27, 2018

Author(s): Guangyan Du, Lingling Fu, Jun Jia, Xu Pang, Haiyang Yu, Youcai Zhang, Guanwei Fan, Xiumei Gao, Lifeng Han

Journal: Biomedical Chromatography

Abstract A rapid, sensitive and specific ultra‐high‐performance liquid chromatography coupled with tandem mass spectrometry (UPLC‐MS/MS) method was developed to investigate the pharmacokinetics and tissue distribution of Eclipta prostrata extract. Rats were orally administrated the 70% ethanol extract of E. prostrata, and their plasma as well as various organs were collected. The concentrations of seven main compounds, ecliptasaponin IV, ...

Read More thumbnail image: Validated UPLCMSMS method for quantification of seven compounds in rat plasma and tissues Application to pharmacokinetic and tissue distribution studies in rats after oral administration of extract of Eclipta prostrata L_

Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases

Published: Feb 27, 2018

Author(s): Liang Cui, Haitao Lu, Yie Hou Lee

Journal: Mass Spectrometry Reviews

In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply, researchers are now primed to uncover key metabolites and their associations with diseases. The employment of untargeted metabolomics has led to new biomarker discoveries and a better mechanistic understanding of diseases with applications in...

Read More thumbnail image: Challenges and emergent solutions for LCMSMS based untargeted metabolomics in diseases

Diffusion MRI visualization

Published: Feb 27, 2018

Author(s): Thomas Schultz, Anna Vilanova

Journal: NMR in Biomedicine

Modern diffusion magnetic resonance imaging (dMRI) acquires intricate volume datasets and biological meaning can only be found in the relationship between its different measurements. Suitable strategies for visualizing these complicated data have been key to interpretation by physicians and neuroscientists, for drawing conclusions on brain connectivity and for quality control. This article provides an overview of visualization solutions...

Read More thumbnail image: Diffusion MRI visualization
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