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Sum frequency generation study of immobilized 3‐aminopropyltriethoxysilane self‐assembled layer on Si(111) substrates

Published: Oct 10, 2018

Author(s): Thi Thu Hien Khuat, Lin Liang, Trong Tue Phan, Goro Mizutani, Harvey N. Rutt

Journal: Surface and Interface Analysis

Distribution and orientation of 3‐aminopropyltriethoxysilane (APTES) on a sensing surface play critical role on biosensor, but have not been fully investigated. In this work, the quality of APTES SAM immobilized on the Si(111) substrate was studied by observing sum frequency generation (SFG) response. The polarization, azimuthal angle, and position‐dependent SFG spectra of APTES coverage were obtained. In ppp and psp‐SFG spectra, the CH2...

Read More thumbnail image: Sum frequency generation study of immobilized 3aminopropyltriethoxysilane selfassembled layer on Si111 substrates

Identification of Moonlighting Proteins in Genomes Using Text Mining Techniques

Published: Oct 10, 2018

Author(s): Aashish Jain, Hareesh Gali, Daisuke Kihara

Journal: PROTEOMICS

Abstract Moonlighting proteins is an emerging concept for considering protein functions, which indicate proteins with two or more independent and distinct functions. An increasing number of moonlighting proteins have been reported in the past years; however, a systematic study of the topic has been hindered because the secondary functions of proteins are usually found serendipitously by experiments. Toward systematic identification...

Read More thumbnail image: Identification of Moonlighting Proteins in Genomes Using Text Mining Techniques

Metabolic fate of the new synthetic cannabinoid 7’N‐5F‐ADB in rat, human, and pooled human S9 studied by means of hyphenated high‐resolution mass spectrometry

Published: Oct 9, 2018

Author(s): Lilian H.J. Richter, Hans H. Maurer, Markus R. Meyer

Journal: Drug Testing and Analysis

Abstract New psychoactive substances (NPS) are an important issue in clinical/forensic toxicology. 7’N‐5F‐ADB, a synthetic cannabinoid derived from 5F‐ADB, appeared recently on the market. Up to now, no data about its mass spectral fragmentation pattern, metabolism, and thus suitable targets for toxicological urine screenings have been available. Therefore, the aim of this study was to elucidate the metabolic fate of 7’N‐5F‐ADB in...

Read More thumbnail image: Metabolic fate of the new synthetic cannabinoid 7N5FADB in rat human and pooled human S9 studied by means of hyphenated highresolution mass spectrometry

Development and validation of LC–MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Published: Oct 9, 2018

Author(s): Pavan Kumar Prathipati, Subhra Mandal, Christopher J. Destache

Journal: Biomedical Chromatography

Abstract A sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for quantification of bictegravir in human plasma. A small volume of only 50 μL aliquot of plasma was precipitated with acetonitrile containing an internal standard (IS). Chromatographic separation was performed on a Kinetex EVO C18 column, 50 × 3.0 mm, 5 μm using an isocratic mobile phase containing 80:20 acetonitrile–water with...

Read More thumbnail image: Development and validation of LCMSMS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Quantitative determination of six steroid alkaloids by sensitive hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats

Published: Oct 9, 2018

Author(s): Jianbo Chen, Lixue Chen, Meijia Li, Yinshi Sun

Journal: Biomedical Chromatography

Abstract In this study, a sensitive hydrophilic interaction liquid chromatography (HILIC) method was developed to determine pseudojervine (PJV), veratrosine (VTS), jervine (JV), veratramine (VTM), veramarine (VA) and veratroylzygadenine (VTG) in rat plasma. Separations were carried out using LC–MS/MS with a Chrom Matrix HP amide column (5 m, 10 cm × 3.0 mm i.d.). The mobile phases were (A) 0.01 mm formic acid and (B) acetonitrile....

Read More thumbnail image: Quantitative determination of six steroid alkaloids by sensitive hydrophilic interaction liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats

Advances in mass spectrometry‐based glycomics

Published: Oct 9, 2018

Author(s): Xue Dong, Yifan Huang, Byeong Gwan Cho, Jieqiang Zhong, Sakshi Gautam, Wenjing Peng, Seth D. Williamson, Alireza Banazadeh, Katya Y. Torres‐Ulloa, Yehia Mechref

Journal: ELECTROPHORESIS

Abstract The diversification of the chemical properties and biological functions of proteins is attained through posttranslational modifications, such as glycosylation. Glycans, which are covalently attached to proteins, play a vital role in cell activities. The microheterogeneity and complexity of glycan structures associated with proteins make comprehensive glycomic analysis challenging. However, recent advancements in mass...

Read More thumbnail image: Advances in mass spectrometrybased glycomics

Advances in mass spectrometry‐based glycoproteomics

Published: Oct 9, 2018

Author(s): Aiying Yu, Jingfu Zhao, Wenjing Peng, Alireza Banazadeh, Seth D. Williamson, Mona Goli, Yifan Huang, Yehia Mechref

Journal: ELECTROPHORESIS

Abstract Protein glycosylation, an important PTM, plays an essential role in a wide range of biological processes such as immune response, intercellular signaling, inflammation, and host–pathogen interaction. Aberrant glycosylation has been correlated with various diseases. However, studying protein glycosylation remains challenging because of low abundance, microheterogeneities of glycosylation sites, and poor ionization efficiency...

Read More thumbnail image: Advances in mass spectrometrybased glycoproteomics

Enantiomers separation by capillary electrochromatography using polysaccharide‐based stationary phases

Published: Oct 9, 2018

Author(s): Giovanni D’ Orazio, María Asensio‐Ramos, Chiara Fanali

Journal: Journal of Separation Science

Abstract The separation of chiral compounds is an interesting and important topic of research because these compounds are involved in some biological processes, fundamentally in human health. Among the various application fields where enantiomers are remarkable, drug analysis has to be considered. Most of the drugs contain enantiomers and very often one of the two isomers could be pharmacologically more active or even dangerous....

Read More thumbnail image: Enantiomers separation by capillary electrochromatography using polysaccharidebased stationary phases

The New Face of the Lipid Droplet: Lipid Droplet Proteins

Published: Oct 9, 2018

Author(s): Congyan Zhang, Pingsheng Liu

Journal: PROTEOMICS

Abstract The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types. The accumulated proteomic data are reviewed for evidence of a protein targeting mechanism for the organelle. The...

Read More thumbnail image: The New Face of the Lipid Droplet Lipid Droplet Proteins

Determination of nitenpyram and 6‐chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

Published: Oct 9, 2018

Author(s): Nadeem Muhammad, Yun Zhang, Weixia Li, Yong‐Gang Zhao, Amjad Ali, Qamar Subhani, Tariq Mahmud, Junwei Liu, Hairong Cui, Yan Zhu

Journal: Journal of Separation Science

Abstract A simple, cost‐effective, sensitive, and quick method for the determination of nitenpyram and its metabolite 6‐chloronicotinic acid in environmental samples was developed by coupling an ion chromatograph with a fluorescence detector and a post‐column photochemical reactor. This developed analytical method involved a rapid sample extraction by modified and miniaturized quick, easy, cheap, effective, rugged, and safe method...

Read More thumbnail image: Determination of nitenpyram and 6chloronicotinic acid in environmental samples by ion chromatography coupled with online photochemically induced fluorescence detector

PHOTOIONIZATION AND PHOTOFRAGMENTATION IN MASS SPECTROMETRY WITH VISIBLE AND UV LASERS

Published: Oct 9, 2018

Author(s): Frank Gunzer, Sascha Krüger, Jürgen Grotemeyer

Journal: Mass Spectrometry Reviews

Ever since the introduction of laser technology to the field of mass spectrometry, several disciplines evolved providing solutions to challenging scientific and analytical tasks in research and industry. Among these are techniques involving multiphoton ionization such as Resonance‐Enhanced Multiphoton Ionization (REMPI, R2PI) and Mass‐Analyzed Threshold Ionization (MATI) spectroscopy, a variant of Zero Kinetic Energy...

Read More thumbnail image: PHOTOIONIZATION AND PHOTOFRAGMENTATION IN MASS SPECTROMETRY WITH VISIBLE AND UV LASERS

A method for improvement of mass resolution and isotope accuracy for laser ablation time‐of‐flight mass spectrometers

Published: Oct 9, 2018

Author(s): Reto Wiesendanger, Marek Tulej, Valentine Grimaudo, Alena Cedeño‐López, Rustam Lukmanov, Andreas Riedo, Peter Wurz

Journal: Journal of Chemometrics

Abstract Accumulation of spectra is a common approach for improvement of the signal‐to‐noise ratio (SNR) in mass spectrometry. However, severe degradation of the overall spectrum can occur if some individual mass spectra, affected by peak broadening, are included in the accumulation process. In this contribution, we discuss potential sources and effects of spectral distortions by using examples from mass spectra acquired by our...

Read More thumbnail image: A method for improvement of mass resolution and isotope accuracy for laser ablation timeofflight mass spectrometers

Performance of methods that separate common and distinct variation in multiple data blocks

Published: Oct 9, 2018

Author(s): Ingrid Måge, Age K. Smilde, Frans M. Kloet

Journal: Journal of Chemometrics

Abstract In many areas of science, multiple sets of data are collected from the samples. Such data sets can be analyzed by multiblock (or data fusion) methods. The aim is usually to get a holistic understanding of the system or better prediction of some response. Lately, several scientific groups have developed methods for separating common and distinct variation between multiple data blocks. Although the objective is the same, the strategies...

Read More thumbnail image: Performance of methods that separate common and distinct variation in multiple data blocks

AlSi ordering in albite: A combined single‐crystal X ‐ray diffraction and Raman spectroscopy study

Published: Oct 9, 2018

Author(s): Mario Tribaudino, G. Diego Gatta, Irene Aliatis, Danilo Bersani, Pier Paolo Lottici

Journal: Journal of Raman Spectroscopy

Abstract Raman spectra of a low albite single crystal were collected during annealing at 1076°C for up to 46 days. At seven annealing stages, the single crystal structure was refined by X‐ray intensity data to determine the degree of AlSi order using the tetrahedral bond distances. Single‐crystal X‐ray diffraction showed that residuals in the difference‐Fourier map of the electron density and atomic displacement parameters of...

Read More thumbnail image: AlSi ordering in albite A combined singlecrystal X ray diffraction and Raman spectroscopy study

Searching for biomarkers of chronic obstructive pulmonary disease using proteomics: The current state

Published: Oct 8, 2018

Author(s): Maddalena Cagnone, Roberta Salvini, Anna Bardoni, Marco Fumagalli, Paolo Iadarola, Simona Viglio

Journal: ELECTROPHORESIS

Abstract Detection of proteins which may be potential biomarkers of disorders represents a big step forward in understanding the molecular mechanisms that underlie pathological processes. In this context proteomics plays the important role of opening a path for the identification of molecular signatures that can potentially assist in early diagnosis of several clinical disturbances. Aim of this report is to provide an overview of...

Read More thumbnail image: Searching for biomarkers of chronic obstructive pulmonary disease using proteomics The current state

Actuation of adaptive liquid microlens droplet in microfluidic devices: A review

Published: Oct 8, 2018

Author(s): Gui‐Ping Zhu, Jia‐Feng Yao, Shi‐Hua Wu, Xi‐Dong Zhang

Journal: ELECTROPHORESIS

Abstract A significant growth of research on adaptive liquid lens is achieved over the past decades, and the field is still attracting increasing attentions, focusing on the transition from the current stage to the commercialized stage. The challenges faced are not limited to fabrication, material, small tuning range in focal lengths, additional control systems, limitations in special actuation methods and so on. In addition, the...

Read More thumbnail image: Actuation of adaptive liquid microlens droplet in microfluidic devices A review

Taxonomic Landscape of the Dark Proteomes: Whole‐Proteome Scale Interplay Between Structural Darkness, Intrinsic Disorder, and Crystallization Propensity

Published: Oct 8, 2018

Author(s): Gang Hu, Kui Wang, Jiangning Song, Vladimir N. Uversky, Lukasz Kurgan

Journal: PROTEOMICS

Abstract Growth rate of the protein sequence universe dramatically exceeds the speed of expansion for the protein structure universe, generating an immense dark proteome that includes proteins with unknown structure. A whole‐proteome scale analysis of 5.4 million proteins from 987 proteomes in the three domains of life and viruses to systematically dissect an interplay between structural coverage, degree of putative intrinsic...

Read More thumbnail image: Taxonomic Landscape of the Dark Proteomes WholeProteome Scale Interplay Between Structural Darkness Intrinsic Disorder and Crystallization Propensity

On hybrid electroosmotic kinetics for field‐effect‐reconfigurable nanoparticle trapping in a four‐terminal spiral microelectrode array

Published: Oct 5, 2018

Author(s): Yukun Ren, Chunlei Song, Weiyu Liu, Tianyi Jiang, Jingni Song, Qisheng Wu, Hongyuan Jiang

Journal: ELECTROPHORESIS

Abstract Induced‐charge electroosmosis (ICEO) has attracted tremendous popularity for driving fluid motion from the microfluidic community since the last decade, while less attention has been paid to ICEO‐based nanoparticle manipulation. We propose herein a unique concept of hybrid electroosmotic kinetics (HEK) in terms of bi‐phase ICEO (BICEO) actuated in a four‐terminal spiral electrode array, for effective electrokinetic...

Read More thumbnail image: On hybrid electroosmotic kinetics for fieldeffectreconfigurable nanoparticle trapping in a fourterminal spiral microelectrode array

On‐line electroextraction in capillary electrophoresis: Application on the determination of glutamic acid in soy sauces

Published: Oct 5, 2018

Author(s): Camila D. M. Campos, Felix G. R. Reyes, Andreas Manz, José A. F. da Silva

Journal: ELECTROPHORESIS

Abstract We present an on‐line, single step coupling between liquid‐liquid extraction and capillary electrophoresis with capacitively coupled contactless conductivity detection, which allows an efficient analysis of complex food matrices with high sodium content. The sodium depletion was demonstrated using an aqueous two‐phase system. The aqueous two‐phase system enables the electrically driven extraction of the target compounds....

Read More thumbnail image: Online electroextraction in capillary electrophoresis Application on the determination of glutamic acid in soy sauces

Microfluidic thread‐based electrode system to detect glucose and acetylthiocholine

Published: Oct 5, 2018

Author(s): Michelle Gaines, Maria Jose Gonzalez‐Guerrero, Kathryn Uchida, Frank A. Gomez

Journal: ELECTROPHORESIS

Abstract A reusable and simple to fabricate electrochemical sensor for the detection of glucose and acetylthiocholine using thread‐based electrodes and nylon thread is described. The fabrication of the device consisted of two steps. First, three nylon‐based electrodes (reference, working, and counter) were painted with one layer of conductive inks (silver and carbon ink, or silver/silver chloride ink). The electrodes were taped onto...

Read More thumbnail image: Microfluidic threadbased electrode system to detect glucose and acetylthiocholine
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