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Adsorbed hollow fiber‐based biological fingerprinting for the discovery of platelet aggregation inhibitors from Danshen–Honghua decoction

Published: Apr 11, 2018

Author(s): Qian Zhang, Cheng‐Ning Tan, Ya‐li Wang, Wen‐Jing Liu, Feng‐Qing Yang, Hua Chen, Zhi‐Ning Xia

Journal: Journal of Separation Science

Abstract For lead compound discovery from natural products, hollow fiber cell fishing with chromatographic analysis is a newly developed method. In this study, an adsorbed hollow fiber‐based biological fingerprinting method was firstly developed to discover potential platelet aggregation inhibitors from Danshen–Honghua decoction. Platelets were seeded on the fiber and their survival rate was tested. Results indicated that more than...

Read More thumbnail image: Adsorbed hollow fiberbased biological fingerprinting for the discovery of platelet aggregation inhibitors from DanshenHonghua decoction

Graphene oxide composites for magnetic solid‐phase extraction of trace cytokinins in plant samples followed by liquid chromatography–tandem mass spectrometry

Published: Apr 11, 2018

Author(s): Zhenfang Cheng, Fuyou Du, Qun Qin, Lingshun Sun, Qiulian Zeng, Guihua Ruan, Jianping Li

Journal: Journal of Separation Science

Abstract In this work, an easy, effective, and sensitive method based on graphene oxide@silica@magnetite composites as adsorbent of magnetic solid‐phase extraction combined with liquid chromatography and tandem mass spectrometry, was established and validated for the trace analysis of cytokinins in different plants. The prepared magnetic composite was characterized by infrared spectroscopy, transmission electron microscopy,...

Read More thumbnail image: Graphene oxide composites for magnetic solidphase extraction of trace cytokinins in plant samples followed by liquid chromatographytandem mass spectrometry

A laser Raman tweezers study of eryptosis

Published: Apr 11, 2018

Author(s): Surekha Barkur, Deepak Mathur, Santhosh Chidangil

Journal: Journal of Raman Spectroscopy

Abstract Eryptosis—the suicidal death of erythrocytes—is characterized by membrane blebbing and cell shrinkage. Eryptosis can be triggered by various xenobiotics such as carbon monoxide, lead, and amyloid, and by stressors such as oxidative stress, osmotic shock, and rapid alteration of ambient conditions. We have used Raman tweezers spectroscopy to study eryptosis in single, live cells and have attempted to explore the underlying...

Read More thumbnail image: A laser Raman tweezers study of eryptosis

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Published: Apr 10, 2018

Author(s): Michael F. Santillo, Mapa S.T. Mapa

Journal: Drug Testing and Analysis

Abstract Products marketed as dietary supplements for sexual enhancement are frequently adulterated with phosphodiesterase‐5 (PDE5) inhibitors, which are erectile dysfunction drugs or their analogs that can cause adverse health effects. Due to widespread adulteration, a rapid screening assay was developed to detect PDE5 inhibitors in adulterated products. The assay employs fluorescence detection and is based on measuring inhibition...

Read More thumbnail image: Phosphodiesterase PDE5 inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

Published: Apr 10, 2018

Author(s): Alfonso Mastropietro, Simone Porcelli, Marcello Cadioli, Letizia Rasica, Elisa Scalco, Simonetta Gerevini, Mauro Marzorati, Giovanna Rizzo

Journal: NMR in Biomedicine

The main aim of this paper was to propose triggered intravoxel incoherent motion (IVIM) imaging sequences for the evaluation of perfusion changes in calf muscles before, during and after isometric intermittent exercise. Twelve healthy volunteers were involved in the study. The subjects were asked to perform intermittent isometric plantar flexions inside the MRI bore. MRI of the calf muscles was performed on a...

Read More thumbnail image: Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

Single breath‐hold 3D cardiac T 1 mapping using through‐time spiral GRAPPA

Published: Apr 10, 2018

Author(s): Yong Chen, Wei‐Ching Lo, Jesse I. Hamilton, Kestutis Barkauskas, Haris Saybasili, Katherine L. Wright, Joshua Batesole, Mark A. Griswold, Vikas Gulani, Nicole Seiberlich

Journal: NMR in Biomedicine

The quantification of cardiac T1 relaxation time holds great potential for the detection of various cardiac diseases. However, as a result of both cardiac and respiratory motion, only one two‐dimensional T1 map can be acquired in one breath‐hold with most current techniques, which limits its application for whole heart evaluation in routine clinical practice. In this study, an electrocardiogram (ECG)‐triggered three‐dimensional Look–Locker method...

Read More thumbnail image: Single breathhold 3D cardiac T 1 mapping using throughtime spiral GRAPPA

Hyperpolarized ketone body metabolism in the rat heart

Published: Apr 10, 2018

Author(s): Jack J. Miller, Daniel R. Ball, Angus Z. Lau, Damian J. Tyler

Journal: NMR in Biomedicine

The aim of this work was to investigate the use of 13C‐labelled acetoacetate and β‐hydroxybutyrate as novel hyperpolarized substrates in the study of cardiac metabolism. [1‐13C]Acetoacetate was synthesized by catalysed hydrolysis, and both it and [1‐13C]β‐hydroxybutyrate were hyperpolarized by dissolution dynamic nuclear polarization (DNP). Their metabolism was studied in isolated, perfused rat hearts. Hyperpolarized [1‐13C]acetoacetate metabolism was also...

Read More thumbnail image: Hyperpolarized ketone body metabolism in the rat heart

Structural and electronics properties of Rh‐doped SnO 2 (110) surfaces: Ab‐initio calculations

Published: Apr 10, 2018

Author(s): F. Bouamra, A. Boumeddiene

Journal: Surface and Interface Analysis

Structural and electronics properties of SnO2(110)‐doped Rh surfaces have been calculated for different atomic Rh/Sn ratio: 9.09%, 14.28%, 20%, and 26.31% using a density functional theory (DFT) at B3LYP level with CRYSTAL09 program. These structures are obtained by substitution of Rh atoms with tin Sn atoms of the most outer atomic faces of SnO2(110) surfaces, which contain Sn and O atoms. Relaxation parameters, band structures, and projected...

Read More thumbnail image: Structural and electronics properties of Rhdoped SnO 2 110 surfaces Abinitio calculations

Development and characterization of hydrophobic anodized aluminum layer to act as a long‐lasting protective film in corrosion

Published: Apr 10, 2018

Author(s): R. Jaimes‐Ramírez, A. Covelo, S. E. Rodil, P. Corona‐Lira, A. C. Ramírez‐Reivich, M. Hernández

Journal: Surface and Interface Analysis

This work focuses on the development of a novel hydrophobic process for anodized aluminum AA2024‐T3 which consists of a combination of corrosion inhibitors: sodium metavanadate with a γ‐irradiated fluoropolymer. The anodizing films, formed in sulfuric acid media, were sealed by using different aqueous solutions such as boiling water, potassium dichromate, and cerium nitrate. The corrosion resistance results obtained by electrochemical...

Read More thumbnail image: Development and characterization of hydrophobic anodized aluminum layer to act as a longlasting protective film in corrosion

Identification of Native and Posttranslationally Modified HLA‐B*57:01‐Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Published: Apr 6, 2018

Author(s): Sri H. Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda W.S. Yeung, Nicole A. Mifsud, Secondo Sonza, Patricia T. Illing, Elias N. Glaros, Robert J. Center, Shane R. Thomas, Stephen J. Kent, Nicola Ternette, Damian F. J. Purcell, Jamie Rossjohn, Anthony W. Purcell

Journal: PROTEOMICS

Abstract The recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the ER. These peptide‐HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T‐cells leading to the eradication of the infected cell. Here, naturally...

Read More thumbnail image: Identification of Native and Posttranslationally Modified HLAB5701Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Translating Immunopeptidomics to Immunotherapy‐Decision‐Making for Patient and Personalized Target Selection

Published: Apr 6, 2018

Author(s): Jens Fritsche, Barbara Rakitsch, Franziska Hoffgaard, Michael Römer, Heiko Schuster, Daniel J. Kowalewski, Martin Priemer, Vlatka Stos‐Zweifel, Helen Hörzer, Arun Satelli, Annika Sonntag, Valentina Goldfinger, Colette Song, Andrea Mahr, Martina Ott, Oliver Schoor, Toni Weinschenk

Journal: PROTEOMICS

Abstract Immunotherapy is revolutionizing cancer treatment and has shown success in particular for tumors with a high mutational load. These effects have been linked to neoantigens derived from patient‐specific mutations. To expand efficacious immunotherapy approaches to the vast majority of tumor types and patient populations carrying only a few mutations and maybe not a single presented neoepitope, it is necessary to expand the...

Read More thumbnail image: Translating Immunopeptidomics to ImmunotherapyDecisionMaking for Patient and Personalized Target Selection

Development and validation of an LC‐ESI‐MS/MS method for the quantification of D‐84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET

Published: Apr 6, 2018

Author(s): Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T. Wanner

Journal: Biomedical Chromatography

Abstract MS Binding Assays represent a label‐free alternative to radioligand binding assays. In this study, we present an LC‐ESI‐MS/MS method for the quantification of (R,R)‐4‐(2‐benzhydryloxyethyl)‐1‐(4‐fluorobenzyl)piperidin‐3‐ol [(R,R)‐D‐84, (R,R)‐1], (S,S)‐reboxetine [(S,S)‐2], and (S)‐citalopram [(S)‐3] employed as highly selective nonlabeled reporter ligands in MS Binding Assays addressing the dopamine [DAT, (R,R)‐D‐84], norepinephrine [NET,...

Read More thumbnail image: Development and validation of an LCESIMSMS method for the quantification of D84 reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT hSERT and hNET

Spectral decomposition of R aman spectra of mixed‐phase TiO2 thin films on Si and silicate substrates

Published: Apr 6, 2018

Author(s): Sebastian Schipporeit, Dieter Mergel

Journal: Journal of Raman Spectroscopy

Abstract We present a method to fit Raman spectra of TiO2 thin films on silicon wafers, fused silica, and crown glass with adjustable model spectra of the different components of the substrate and the thin film. With reasonable restrictions of the fitting parameters, the method developed in this paper allows a simultaneous fit to the measured spectra. The TiO2 thin film spectrum is split into one spectrum for the amorphous phase and spectra for...

Read More thumbnail image: Spectral decomposition of R aman spectra of mixedphase TiO2 thin films on Si and silicate substrates

Raman scattering and phase transitions in (NH4)3TiF7

Published: Apr 6, 2018

Author(s): Y.V. Gerasimova, A.S. Oreshonkov, N.M. Laptash, A.S. Krylov, A.R. Aliev, E.M. Roginskii

Journal: Journal of Raman Spectroscopy

Abstract Raman spectra of (NH4)3TiF7 within spectral range 10–3,400 cm−1 at temperatures 8–370 K are recorded, which revealed 2 phase transitions at temperatures T1 = 355 K and T2 = 283 K. First principles calculations of lattice dynamics and assignment of the observed lines to specific vibrational types are performed. The first phase transition is classified as an “order–disorder” one. Manifestation of 97 cm−1...

Read More thumbnail image: Raman scattering and phase transitions in NH43TiF7

Full‐field XRF instrument for cultural heritage: Application to the study of a Caillebotte painting

Published: Apr 6, 2018

Author(s): Philippe Walter, Philippe Sarrazin, Marc Gailhanou, Dominique Hérouard, Antoine Verney, David Blake

Journal: X-Ray Spectrometry

A novel full‐field X‐ray fluorescence spectrometer developed for cultural heritage applications is presented. Named “CartiX,” it was designed for routine deployment in the field (museum, archeological site) and uses a concept under development at NASA for planetary exploration. CartiX utilizes 2 miniature X‐ray tubes, a square pore Micro‐channel Plate X‐ray Optic, and a direct‐illumination CCD camera to collect spatially resolved X‐ray...

Read More thumbnail image: Fullfield XRF instrument for cultural heritage Application to the study of a Caillebotte painting

Quantitative determination of meloxicam in dog plasma by high performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study

Published: Apr 4, 2018

Author(s): Yongzhi Tian, Xiao Wu, Mingjie Zhang, Longshan Zhao, Zhili Xiong, Feng Qin

Journal: Biomedical Chromatography

Abstract A rapid, selective and sensitive high‐performance liquid chromatography–tandem mass spectrometry (HPLC‐MS/MS) method was developed to determine meloxicam in beagle dog plasma. Sample pretreatment involved a one‐step protein precipitation with methanol of 0.1 mL plasma. Analysis was performed on a Venusil ASB‐C18 column with mobile phase consisting of methanol–water (containing 0.1% formic acid) (75:25, v/v). The detection was performed...

Read More thumbnail image: Quantitative determination of meloxicam in dog plasma by high performance liquid chromatographytandem mass spectrometry and its application in a pharmacokinetic study

A validated, sensitive electrophoretic method for the detection of activin receptor type II‐Fc fusion proteins in human blood

Published: Apr 4, 2018

Author(s): L. Martin, N. Zouhiri, M. Audran, A. Marchand

Journal: Drug Testing and Analysis

Abstract New therapeutic proteins that trap circulating members of the transforming growth factor (TGF) beta superfamily (activins and growth differentiation factors) show promising effects on erythropoiesis and muscular growth. They are dimeric recombinant fusion proteins composed of the extracellular domain of a human activin receptor (ActRIIA or IIB) linked to the Fc part of human IgG1. Sotatercept (ActRIIA‐Fc) and Luspatercept...

Read More thumbnail image: A validated sensitive electrophoretic method for the detection of activin receptor type IIFc fusion proteins in human blood

Ultra‐fast liquid chromatography coupled with electrospray ionization time‐of‐flight mass spectrometry for the rapid phenolic profiling of red maple ( Acer rubrum ) leaves

Published: Apr 4, 2018

Author(s): Chunting Li, Navindra P. Seeram

Journal: Journal of Separation Science

Abstract The red maple (Acer rubrum) species is economically important to North America because of its sap, which is used to produce maple syrup. In addition, various other red maple plant parts, including leaves, were used as a traditional medicine by the Native Americans. Currently, red maple leaves are being used for nutraceutical and cosmetic applications but there are no published analytical methods for comprehensive...

Read More thumbnail image: Ultrafast liquid chromatography coupled with electrospray ionization timeofflight mass spectrometry for the rapid phenolic profiling of red maple  Acer rubrum  leaves

High‐throughput multipesticides residue analysis in earthworms by the improvement of purification method: Development and application of magnetic Fe 3 O 4 ‐SiO 2 nanoparticles based dispersive solid‐phase extraction

Published: Apr 4, 2018

Author(s): Yuhan Sun, Peipei Qi, Tao Cang, Zhiwei Wang, Xiangyun Wang, Xuewei Yang, Lidong Wang, Xiahong Xu, Qiang Wang, Xinquan Wang, Changshan Zhao

Journal: Journal of Separation Science

Abstract As a key representative organism, earthworms can directly illustrate the influence of pesticides on environmental organisms in soil ecosystems. The present work aimed to develop a high‐throughput multipesticides residue analytical method for earthworms using solid–liquid extraction with acetonitrile as the solvent and magnetic material‐based dispersive solid‐phase extraction for purification. Magnetic Fe3O4 nanoparticles...

Read More thumbnail image: Highthroughput multipesticides residue analysis in earthworms by the improvement of purification method Development and application of magnetic Fe 3 O 4 SiO 2 nanoparticles based dispersive solidphase extraction

Characterization of imatinib mesylate formulations distributed in South American countries: Determination of genotoxic impurities by UHPLC–MS/MS and dissolution profile

Published: Apr 3, 2018

Author(s): Fernanda Caroline Wolff, Thaís Luise Dillenburg, Marina Venzon Antunes, Rafael Linden, Sandrine Comparsi Wagner, Simone G. Verza

Journal: Biomedical Chromatography

Abstract Imatinib mesylate (IM) is an anti‐neoplasic drug used for the treatment of cancer. Recent new guidelines specify daily doses and concentration limits for genotoxic impurities (GTIs) in pharmaceutical final products. Therefore, in this work an analytical method using UHPLC–MS/MS was developed, validated and applied to characterize IM tablets for two GTIs: N‐(2‐methyl‐5‐aminophenyl)‐4‐(3‐pyridyl)‐2‐pyrimidine amine (Imp. 1), and...

Read More thumbnail image: Characterization of imatinib mesylate formulations distributed in South American countries Determination of genotoxic impurities by UHPLCMSMS and dissolution profile
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