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Geographical discrimination of Glechomae Herba based on fifteen phenolic constituents determined by LC–MS/MS method combined with chemometric methods

Published: Apr 12, 2018

Author(s): Ting Tan, Jing Zhang, Xu Xu, Wen‐Ping Huang, Yun Luo

Journal: Biomedical Chromatography

Abstract Glechomae Herba (GH) is rich in bioactive phenolic constituents and is widely used for treatment of cholelithiasis, urolithiasis and dropsy. The simultaneous determination of phenolic constituents in GH from different geographical origins is significant for authentication and quality control purposes. In this study, we developed a strategy integrating targeted analysis and chemometric methods for quality evaluation and...

Read More thumbnail image: Geographical discrimination of Glechomae Herba based on fifteen phenolic constituents determined by LCMSMS method combined with chemometric methods

Preparation and evaluation of open‐tubular capillary column combining a metal–organic framework and a brush‐shaped polymer for liquid chromatography

Published: Apr 12, 2018

Author(s): Kai Chen, Lingyi Zhang, Weibing Zhang

Journal: Journal of Separation Science

Abstract In this work, an open‐tubular capillary liquid‐phase column was prepared by modifying chain polymer on the inner surface of capillary and chemical bonding of metal organic frameworks, NH2‐UiO‐66, to the brushes of chain polymer (poly(glycidyl methacrylate)). Besides advantages of facial preparation and good permeability, the chain polymer effectively increases the modification amount of NH2‐UiO‐66 nanoparticles to increase the phase...

Read More thumbnail image: Preparation and evaluation of opentubular capillary column combining a metalorganic framework and a brushshaped polymer for liquid chromatography

Enantioseparation of ( RS )‐fexofenadine and enhanced detection as the diastereomeric amide and anhydride derivatives using liquid chromatography‐mass spectrometry

Published: Apr 11, 2018

Author(s): Poonam Malik, Ravi Bhushan

Journal: Biomedical Chromatography

Abstract Enantioselective analysis of (RS)‐fexofenadine was carried out by achiral HPLC via a derivatization approach using N‐hydroxy‐benzotriazolyl‐(S)‐naproxen ester (synthesized for this purpose) and three chirally pure amines as chiral derivatizing reagents. There occurred formation of amide and anhydride types of diastereomeric derivatives. These were separated and isolated by HPLC (analytical and preparative). The structures and...

Read More thumbnail image: Enantioseparation of  RS fexofenadine and enhanced detection as the diastereomeric amide and anhydride derivatives using liquid chromatographymass spectrometry

Residual level of dimethachlon in rice‐paddy field system and cooked rice determined by gas chromatography with electron capture detector

Published: Apr 11, 2018

Author(s): Caiyuan Sun, Lingrong Zeng, Jin Xu, Lei Zhong, Xinwen Han, Lingzhu Chen, Yuping Zhang, Deyu Hu

Journal: Biomedical Chromatography

Abstract In this study, a modified quick, easy, cheap, effective, rugged and safe method coupled with gas chromatography with electron capture detection was established to determine dimethachlon residues in paddy soil, rice husk, rice straw, brown rice and cooked rice. The limits of quantification of dimethachlon were 0.01 mg/kg for paddy soil, brown rice and cooked rice and 0.02 mg/kg for rice straw and rice husk. The mean...

Read More thumbnail image: Residual level of dimethachlon in ricepaddy field system and cooked rice determined by gas chromatography with electron capture detector

Quantification of cystine in human renal proximal tubule cells using liquid chromatography–tandem mass spectrometry

Published: Apr 11, 2018

Author(s): Amer Jamalpoor, Rolf W. Sparidans, Carla Pou Casellas, Johannes J.M. Rood, Mansi Joshi, Rosalinde Masereeuw, Manoe J. Janssen

Journal: Biomedical Chromatography

Abstract Nephropathic cystinosis is characterized by abnormal intralysosomal accumulation of cystine throughout the body, causing irreversible damage to various organs, particularly the kidneys. Cysteamine, the currently available treatment, can reduce lysosomal cystine and postpone disease progression. However, cysteamine poses serious side effects and does not address all of the symptoms of cystinosis. To screen for new treatment...

Read More thumbnail image: Quantification of cystine in human renal proximal tubule cells using liquid chromatographytandem mass spectrometry

Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics

Published: Apr 11, 2018

Author(s): Fabio Marino

Journal: PROTEOMICS

Abstract Mass spectrometry (MS)‐based immunopeptidomics has developed as one of the leading methodologies for comprehensive characterization of in vivo presented human leukocyte antigen (HLA)‐bound peptides. Unveiling the identity of HLA‐bound peptides derived from diseased cells is crucial to gain knowledge on the constitution of efficient disease‐specific T cell responses. The HLA‐presented peptidome reflects the status of the...

Read More thumbnail image: Gaining Insight Into Posttranslationally Modified HIV Antigens and Their Underlying Characteristics

Complex investigation of extraction techniques applied for cyclitols and sugars isolation from different species of Solidago genus

Published: Apr 11, 2018

Author(s): Ileana‐Andreea Ratiu, Hossam Al‐Suod, Magdalena Ligor, Tomasz Ligor, Viorica Railean‐Plugaru, Bogusław Buszewski

Journal: ELECTROPHORESIS

Abstract Cyclitols are phytochemicals naturally occurring in plant material, which attracted an increasing interest due to multiple medicinal attributes, among which the most important are the antidiabetic, antioxidant, and anticancer properties. Due to their valuable properties, sugars are used in the food industry as sweeteners, preservatives, texture modifiers, fermentation substrates, and flavoring and coloring agents. In this...

Read More thumbnail image: Complex investigation of extraction techniques applied for cyclitols and sugars isolation from different species of Solidago genus

A preliminary origin‐tracking study of different densities urinary exosomes

Published: Apr 11, 2018

Author(s): Tao Lan, Xingjun Xi, Qiao Chu, Liang Zhao, Apeng Chen, Joann J. Lu, Fenghe Wang, Weibing Zhang

Journal: ELECTROPHORESIS

Abstract Based on density differences of different subpopulations of exosomes, two kinds of micro‐vesicles with different densities were captured from urine by a modified sucrose density gradient ultracentrifuge separation method. Verified by transmission electron microscope (TEM) and western blot, the results showed these two kinds of micro‐vesicles were all exosomes. And these two kinds of exosomes were analyzed by TEM, 2D...

Read More thumbnail image: A preliminary origintracking study of different densities urinary exosomes

Determination of ellagic acid by capillary electrophoresis in Argentinian wines

Published: Apr 11, 2018

Author(s): Adrian Spisso, Federico J. V. Gomez, María Fernanda Silva

Journal: ELECTROPHORESIS

Abstract Rising interest in ellagic acid (EA) present in functional foods is supported by its antimutagenic, anticarcinogenic, antiviral, antibacterial and antioxidative effects. The present approach presents for the first time the determination of ellagic acid and other phenolics in wines by miniaturized solid phase extraction prior to capillary zone electrophoresis (CZE) with UV. The extraction was performed using a home‐made...

Read More thumbnail image: Determination of ellagic acid by capillary electrophoresis in Argentinian wines

Tandem HILIC‐RP liquid chromatography for increased polarity coverage in food analysis

Published: Apr 11, 2018

Author(s): Daniel Hemmler, Silke S. Heinzmann, Katrin Wöhr, Philippe Schmitt‐Kopplin, Michael Witting

Journal: ELECTROPHORESIS

Abstract Comprehensive non‐targeted analysis of food products normally requires two complementary chromatographic runs to achieve maximum compound coverage. In this study, we present a sensitive tandem‐LC method, which combines RP and HILIC separation in a single run. The setup consists of a C18 trap column and two subsequently coupled analytical columns (HILIC and C18) which are operated in parallel. First, hydrophobic compounds...

Read More thumbnail image: Tandem HILICRP liquid chromatography for increased polarity coverage in food analysis

Facile preparation of magnetic molecularly imprinted polymers for the selective extraction and determination of dexamethasone in skincare cosmetics using HPLC

Published: Apr 11, 2018

Author(s): Wei Du, Bilin Zhang, Pengqi Guo, Guoning Chen, Chun Chang, Qiang Fu

Journal: Journal of Separation Science

Abstract Dexamethasone‐imprinted polymers were fabricated by reversible addition–fragmentation chain transfer polymerization on the surface of magnetic nanoparticles under mild polymerization conditions, which exhibited a narrow polydispersity and high selectivity for dexamethasone extraction. The dexamethasone‐imprinted polymers were characterized by scanning electron microscopy, transmission electron microscope, Fourier transform...

Read More thumbnail image: Facile preparation of magnetic molecularly imprinted polymers for the selective extraction and determination of dexamethasone in skincare cosmetics using HPLC

Adsorbed hollow fiber‐based biological fingerprinting for the discovery of platelet aggregation inhibitors from Danshen–Honghua decoction

Published: Apr 11, 2018

Author(s): Qian Zhang, Cheng‐Ning Tan, Ya‐li Wang, Wen‐Jing Liu, Feng‐Qing Yang, Hua Chen, Zhi‐Ning Xia

Journal: Journal of Separation Science

Abstract For lead compound discovery from natural products, hollow fiber cell fishing with chromatographic analysis is a newly developed method. In this study, an adsorbed hollow fiber‐based biological fingerprinting method was firstly developed to discover potential platelet aggregation inhibitors from Danshen–Honghua decoction. Platelets were seeded on the fiber and their survival rate was tested. Results indicated that more than...

Read More thumbnail image: Adsorbed hollow fiberbased biological fingerprinting for the discovery of platelet aggregation inhibitors from DanshenHonghua decoction

Graphene oxide composites for magnetic solid‐phase extraction of trace cytokinins in plant samples followed by liquid chromatography–tandem mass spectrometry

Published: Apr 11, 2018

Author(s): Zhenfang Cheng, Fuyou Du, Qun Qin, Lingshun Sun, Qiulian Zeng, Guihua Ruan, Jianping Li

Journal: Journal of Separation Science

Abstract In this work, an easy, effective, and sensitive method based on graphene oxide@silica@magnetite composites as adsorbent of magnetic solid‐phase extraction combined with liquid chromatography and tandem mass spectrometry, was established and validated for the trace analysis of cytokinins in different plants. The prepared magnetic composite was characterized by infrared spectroscopy, transmission electron microscopy,...

Read More thumbnail image: Graphene oxide composites for magnetic solidphase extraction of trace cytokinins in plant samples followed by liquid chromatographytandem mass spectrometry

A laser Raman tweezers study of eryptosis

Published: Apr 11, 2018

Author(s): Surekha Barkur, Deepak Mathur, Santhosh Chidangil

Journal: Journal of Raman Spectroscopy

Abstract Eryptosis—the suicidal death of erythrocytes—is characterized by membrane blebbing and cell shrinkage. Eryptosis can be triggered by various xenobiotics such as carbon monoxide, lead, and amyloid, and by stressors such as oxidative stress, osmotic shock, and rapid alteration of ambient conditions. We have used Raman tweezers spectroscopy to study eryptosis in single, live cells and have attempted to explore the underlying...

Read More thumbnail image: A laser Raman tweezers study of eryptosis

Phosphodiesterase (PDE5) inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Published: Apr 10, 2018

Author(s): Michael F. Santillo, Mapa S.T. Mapa

Journal: Drug Testing and Analysis

Abstract Products marketed as dietary supplements for sexual enhancement are frequently adulterated with phosphodiesterase‐5 (PDE5) inhibitors, which are erectile dysfunction drugs or their analogs that can cause adverse health effects. Due to widespread adulteration, a rapid screening assay was developed to detect PDE5 inhibitors in adulterated products. The assay employs fluorescence detection and is based on measuring inhibition...

Read More thumbnail image: Phosphodiesterase PDE5 inhibition assay for rapid detection of erectile dysfunction drugs and analogs in sexual enhancement products

Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

Published: Apr 10, 2018

Author(s): Alfonso Mastropietro, Simone Porcelli, Marcello Cadioli, Letizia Rasica, Elisa Scalco, Simonetta Gerevini, Mauro Marzorati, Giovanna Rizzo

Journal: NMR in Biomedicine

The main aim of this paper was to propose triggered intravoxel incoherent motion (IVIM) imaging sequences for the evaluation of perfusion changes in calf muscles before, during and after isometric intermittent exercise. Twelve healthy volunteers were involved in the study. The subjects were asked to perform intermittent isometric plantar flexions inside the MRI bore. MRI of the calf muscles was performed on a...

Read More thumbnail image: Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

Single breath‐hold 3D cardiac T 1 mapping using through‐time spiral GRAPPA

Published: Apr 10, 2018

Author(s): Yong Chen, Wei‐Ching Lo, Jesse I. Hamilton, Kestutis Barkauskas, Haris Saybasili, Katherine L. Wright, Joshua Batesole, Mark A. Griswold, Vikas Gulani, Nicole Seiberlich

Journal: NMR in Biomedicine

The quantification of cardiac T1 relaxation time holds great potential for the detection of various cardiac diseases. However, as a result of both cardiac and respiratory motion, only one two‐dimensional T1 map can be acquired in one breath‐hold with most current techniques, which limits its application for whole heart evaluation in routine clinical practice. In this study, an electrocardiogram (ECG)‐triggered three‐dimensional Look–Locker method...

Read More thumbnail image: Single breathhold 3D cardiac T 1 mapping using throughtime spiral GRAPPA

Hyperpolarized ketone body metabolism in the rat heart

Published: Apr 10, 2018

Author(s): Jack J. Miller, Daniel R. Ball, Angus Z. Lau, Damian J. Tyler

Journal: NMR in Biomedicine

The aim of this work was to investigate the use of 13C‐labelled acetoacetate and β‐hydroxybutyrate as novel hyperpolarized substrates in the study of cardiac metabolism. [1‐13C]Acetoacetate was synthesized by catalysed hydrolysis, and both it and [1‐13C]β‐hydroxybutyrate were hyperpolarized by dissolution dynamic nuclear polarization (DNP). Their metabolism was studied in isolated, perfused rat hearts. Hyperpolarized [1‐13C]acetoacetate metabolism was also...

Read More thumbnail image: Hyperpolarized ketone body metabolism in the rat heart

Structural and electronics properties of Rh‐doped SnO 2 (110) surfaces: Ab‐initio calculations

Published: Apr 10, 2018

Author(s): F. Bouamra, A. Boumeddiene

Journal: Surface and Interface Analysis

Structural and electronics properties of SnO2(110)‐doped Rh surfaces have been calculated for different atomic Rh/Sn ratio: 9.09%, 14.28%, 20%, and 26.31% using a density functional theory (DFT) at B3LYP level with CRYSTAL09 program. These structures are obtained by substitution of Rh atoms with tin Sn atoms of the most outer atomic faces of SnO2(110) surfaces, which contain Sn and O atoms. Relaxation parameters, band structures, and projected...

Read More thumbnail image: Structural and electronics properties of Rhdoped SnO 2 110 surfaces Abinitio calculations

Development and characterization of hydrophobic anodized aluminum layer to act as a long‐lasting protective film in corrosion

Published: Apr 10, 2018

Author(s): R. Jaimes‐Ramírez, A. Covelo, S. E. Rodil, P. Corona‐Lira, A. C. Ramírez‐Reivich, M. Hernández

Journal: Surface and Interface Analysis

This work focuses on the development of a novel hydrophobic process for anodized aluminum AA2024‐T3 which consists of a combination of corrosion inhibitors: sodium metavanadate with a γ‐irradiated fluoropolymer. The anodizing films, formed in sulfuric acid media, were sealed by using different aqueous solutions such as boiling water, potassium dichromate, and cerium nitrate. The corrosion resistance results obtained by electrochemical...

Read More thumbnail image: Development and characterization of hydrophobic anodized aluminum layer to act as a longlasting protective film in corrosion
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