EarlyView Articles

Skip to Navigation

The very latest articles from the scientific literature
on Wiley Online Library...


You can keep up-to date on these EarlyView articles, which focus on spectroscopy
and separation science:

Earlyview RSS Feed

rss

Filter by Journal

Browse By Journal

First identification of a diuretic, hydrochlorothiazide, in hair: Application to a doping case and interpretation of the results

Published: Jul 18, 2018

Author(s): L. Gheddar, JS. Raul, P. Kintz

Journal: Drug Testing and Analysis

Abstract An athlete contested an adverse analytical finding involving hydrochlorothiazide, and requested our laboratory for testing his hair. As there is no reference in the literature about identification of hydrochlorothiazide in hair, several volunteers were first enrolled (4 after a single 25 mg administration and 10 with daily therapeutic treatment). A specific method was developed by ultra‐performance liquid...

Read More thumbnail image: First identification of a diuretic hydrochlorothiazide in hair Application to a doping case and interpretation of the results

Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual‐agent imaging of metabolism and perfusion

Published: Jul 18, 2018

Author(s): Jessie E. Lee, Chris J. Diederich, Robert Bok, Renuka Sriram, Romelyn Delos Santos, Susan M. Noworolski, Vasant A. Salgaonkar, Matthew S. Adams, Daniel B. Vigneron, John Kurhanewicz

Journal: NMR in Biomedicine

The goal of the study was to establish early hyperpolarized (HP) 13C MRI metabolic and perfusion changes that predict effective high‐intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual‐agent (13C pyruvate and 13C urea) 13C MRI/multiparametric 1H MRI approach was used to measure prostate cancer metabolism and perfusion 3–4 h, 1 d, and 5 d after exposure to...

Read More thumbnail image: Assessing highintensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dualagent imaging of metabolism and perfusion

Investigation of potential toxic components based on the identification of Genkwa Flos chemical constituents and their metabolites by high‐performance liquid chromatography coupled with a Q Exactive high‐resolution benchtop quadrupole Orbitrap mass spectrometer

Published: Jul 18, 2018

Author(s): Zhipeng Wang, Yanjie Chu, Yuanyuan Zhang, Yu Chen, Jingjing Zhang, Xiaohui Chen

Journal: Journal of Separation Science

Abstract Genkwa Flos, a famous traditional Chinese medicine has been reported to have significant hepatotoxicity. A high‐throughput and reliable method was established to explore potential toxic components by high‐performance liquid chromatography coupled with a Q Exactive high‐performance benchtop quadrupole‐Orbitrap mass spectrometer. A total of 68 compounds including 22 chemical components and 46 metabolites were tentatively...

Read More thumbnail image: Investigation of potential toxic components based on the identification of Genkwa Flos chemical constituents and their metabolites by highperformance liquid chromatography coupled with a Q Exactive highresolution benchtop quadrupole Orbitrap mass spectrometer

Design of a forward view antenna for prostate imaging at 7 T

Published: Jul 18, 2018

Author(s): Bart R. Steensma, Ingmar Voogt, Abe J. Werf, Cornelis A.T. Berg, Peter R. Luijten, Dennis W.J. Klomp, Alexander J.E. Raaijmakers

Journal: NMR in Biomedicine

Purpose To design a forward view antenna for prostate imaging at 7 T, which is placed between the legs of the subject in addition to a dipole array. Materials and methods The forward view antenna is realized by placing a cross‐dipole antenna at the end of a small rectangular waveguide. Quadrature drive of the cross‐dipole can excite a circularly polarized...

Read More thumbnail image: Design of a forward view antenna for prostate imaging at 7T

Optical sectioning in multifoci Raman hyperspectral imaging

Published: Jul 18, 2018

Author(s): Zhiyu Liao, Faris Sinjab, Hany M. Elsheikha, Ioan Notingher

Journal: Journal of Raman Spectroscopy

Abstract In this study, we compared the depth discrimination and speed performance of multifoci Raman hyperspectral imaging with the reference standard of a single laser point confocal Raman mapping. A liquid crystal spatial light modulator was employed for the generation of multifoci laser beams, and a digital micromirror device was used as a software‐configurable reflective pinhole array. The patterns of the laser foci and pinhole...

Read More thumbnail image: Optical sectioning in multifoci Raman hyperspectral imaging

Simulation of positron and electron elastic mean free path and diffusion angle on DNA nucleobases from 10 eV to 100 keV

Published: Jul 18, 2018

Author(s): Nabila Yasmina Aouina, Zine‐El‐Abidine Chaoui

Journal: Surface and Interface Analysis

Positron and electron interaction collisions in living cells are efficiently simulated by Monte Carlo (MC) codes where huge data tables are needed. Present study provides detailed results of charged particles elastic interactions needed in MC on DNA nucleobases (adenine, thymine, cytosine and guanine, deoxyribose, and phosphoric acid). Indeed, electron and positron elastic cross sections, elastic mean free paths, and elastic angular...

Read More thumbnail image: Simulation of positron and electron elastic mean free path and diffusion angle on DNA nucleobases from 10 eV to 100 keV

Examination and analysis of Indian silver punch‐marked coins employing WD‐XRF and other noninvasive techniques

Published: Jul 18, 2018

Author(s): Divija Mamania, M.R. Singh, U.S. Lal

Journal: Surface and Interface Analysis

The archaeometallurgical analysis of ancient silver coins provides useful information regarding fabrication methodology, provenance, and trade route and explains large diversification in elementary composition, weight, and physical features. The present investigation deals with the chemical analysis and examination of the processing history of Indian punch‐marked silver coins dating to 400–200 bc. The chemical analysis was carried out by...

Read More thumbnail image: Examination and analysis of Indian silver punchmarked coins employing WDXRF and other noninvasive techniques

Response surface design as a powerful tool for the development of environmentally benign HPLC methods for the determination of two antihypertensive combinations: Greenness assessment by two green analytical chemistry evaluation tools

Published: Jul 17, 2018

Author(s): Ahmed Hemdan, Ragaa Magdy, Maha Farouk

Journal: Journal of Separation Science

Abstract Interest in implementing green chemistry principles in analytical chemistry has grown dramatically in the past few years. The solvents used have the major influence on the greenness of the method. Most conventional high‐performance liquid chromatography methods employed utilize solvents that are “hazardous for the environment”. In the present study, two‐factor three‐level response surface design was exploited to develop...

Read More thumbnail image: Response surface design as a powerful tool for the development of environmentally benign HPLC methods for the determination of two antihypertensive combinations Greenness assessment by two green analytical chemistry evaluation tools

Deep ultraviolet initiated excited state dynamics of riboflavin and flavin mononucleotide

Published: Jul 17, 2018

Author(s): Sudeb Ghosh, Mrinalini Puranik

Journal: Journal of Raman Spectroscopy

Abstract Flavins are cofactors in several light‐activated enzymes and therefore their excited states are found to involve in many photobiological processes. Excited state dynamics of flavin compounds corresponding to their first singlet state (S1) has been studied using a plethora of techniques, whereas studies related to highly absorbing ultraviolet excited states are lacking. Here, we study the ultrafast excited state dynamics of riboflavin...

Read More thumbnail image: Deep ultraviolet initiated excited state dynamics of riboflavin and flavin mononucleotide

Early detection of zinc deficit with confocal Raman spectroscopy

Published: Jul 17, 2018

Author(s): Xiaoyu Zhao, Lijing Cai

Journal: Journal of Raman Spectroscopy

Abstract Zinc deficit is one of the most important reasons for botanical disease. It can occur in many forms, for example, as rice blast, bacterial stripe, bacterial blight, and false smut. All these diseases will greatly lead to lower yields during rice harvest. In these paper, we show that Raman spectroscopy provides a single, fast, and sensitive method for detecting zinc deficit, especially during early forms of zinc deficiency....

Read More thumbnail image: Early detection of zinc deficit with confocal Raman spectroscopy

Development of plasmonic U‐bent plastic optical fiber probes for surface enhanced Raman scattering based biosensing

Published: Jul 17, 2018

Author(s): Christina Grace Danny, A. Subrahmanyam, V.V.R. Sai

Journal: Journal of Raman Spectroscopy

Abstract Evanescent wave‐based excitation of noble metal nanostructures on fiber core surface allows simultaneous excitation over a larger area in comparison with free space coupling, and hence highly suitable for development of surface‐enhanced Raman scattering (SERS)‐based sensor applications. This study describes the development of plasmonically active U‐bent plastic optical fiber (POF) probes for SERS‐based sensing. The SERS...

Read More thumbnail image: Development of plasmonic Ubent plastic optical fiber probes for surface enhanced Raman scattering based biosensing

Exploring street art paintings by microspatially offset Raman spectroscopy

Published: Jul 17, 2018

Author(s): Alessandra Botteon, Chiara Colombo, Marco Realini, Susanna Bracci, Donata Magrini, Pavel Matousek, Claudia Conti

Journal: Journal of Raman Spectroscopy

Abstract Microspatially offset Raman spectroscopy (micro‐SORS) is a recently developed analytical technique combining SORS with microscopy. With this method, highly diffusely scattering microlayers such as painted stratigraphies can be noninvasively probed. In this study, we explore micro‐SORS for identifying the chemical composition of subsurface layers in real, street art mural paintings as a new nondestructive method for the...

Read More thumbnail image: Exploring street art paintings by microspatially offset Raman spectroscopy

Screening of seized cocaine samples using electrophoresis microchips with integrated contactless conductivity detection

Published: Jul 17, 2018

Author(s): Roger Cardoso Moreira, Brenda M. C. Costa, Mariana C. Marra, Mario H. P. Santana, Adriano O. Maldaner, Élvio D. Botelho, Thiago R. L. C. Paixão, Eduardo Mathias Richter, Wendell K. T. Coltro

Journal: ELECTROPHORESIS

Abstract This study describes the development of a new analytical method for the separation and detection of cocaine (COC) and its adulterants, or cutting agents, using microchip electrophoresis (ME) devices coupled with capacitively coupled contactless conductivity detection (C4D). All the experiments were carried out using a glass commercial ME device containing two pairs of integrated sensing electrodes. The running buffer...

Read More thumbnail image: Screening of seized cocaine samples using electrophoresis microchips with integrated contactless conductivity detection

Development and validation of HPTLC and green HPLC methods for determination of furosemide, spironolactone and canrenone, in pure forms, tablets and spiked human plasma

Published: Jul 16, 2018

Author(s): Ibrahim A. Naguib, Eglal A. Abdelaleem, Aml A. Emam, Nouruddin W. Ali, Fatma F. Abdallah

Journal: Biomedical Chromatography

Abstract Two selective and accurate chromatographic methods are presented for simultaneous quantitation of spironolactone (SP) and furosemide (FR) and canrenone (CN), the main degradation product and the main active metabolite of SP. Method A was HPTLC, where separation was completed on silica gel HPTLC F254 plates using ethyl acetate–triethylamine–acetic acid (9:0.7:0.5, by volume) as a developing system and UV detection at 254 nm. ...

Read More thumbnail image: Development and validation of HPTLC and green HPLC methods for determination of furosemide spironolactone and canrenone in pure forms tablets and spiked human plasma

Simultaneous determination of tapentadol and its carbamate prodrug in rat plasma by UPLC‐MS/MS and its application to a pharmacokinetic study

Published: Jul 16, 2018

Author(s): Cuiru Liu, Yingchao Li, Rujie Yang, Shuqi Zhang, Longshan Zhao, Tianhong Zhang

Journal: Biomedical Chromatography

Abstract A prodrug of tapentadol, namely tapentadol carbamate (WWJ01), was synthesized to improve the bioavailability of tapentadol owing to its extensive first‐pass metabolism. In this study, a highly rapid and sensitive UPLC‐MS/MS method was developed and validated for the simultaneous determination of tapentadol and WWJ01 in rat plasma with fluconazole as an internal standard. The analytes and internal standard were treated by...

Read More thumbnail image: Simultaneous determination of tapentadol and its carbamate prodrug in rat plasma by UPLCMSMS and its application to a pharmacokinetic study

Enhanced HPLC‐MS/MS method for the quantitative determination of the co‐administered drugs ceftriaxone sodium and lidocaine hydrochloride in human plasma following an intramuscular injection and application to a pharmacokinetic study

Published: Jul 16, 2018

Author(s): Dalia Mohamed, Maha Kamal

Journal: Biomedical Chromatography

Abstract A sensitive HPLC–MS/MS method was established for the quantification of ceftriaxone sodium (CFT) and lidocaine HCl (LDC) in human plasma utilizing cefixime (CFX) and tadalafil (TDA) as internal standards. The analytes were extracted from human plasma by protein precipitation using acetonitrile. Chromatographic separation was performed on Kinetex C18 (50.0 × 4.6 mm, 5 μm particle size) column with methanol–0.01 M ammonium acetate...

Read More thumbnail image: Enhanced HPLCMSMS method for the quantitative determination of the coadministered drugs ceftriaxone sodium and lidocaine hydrochloride in human plasma following an intramuscular injection and application to a pharmacokinetic study

Feasibility of quantitative ultrashort echo time (UTE)‐based methods for MRI of peripheral nerve

Published: Jul 16, 2018

Author(s): Shu‐Juan Fan, Jonathan Wong, Xin Cheng, Ya‐Jun Ma, Eric Y. Chang, Jiang Du, Sameer B. Shah

Journal: NMR in Biomedicine

Peripheral nerves are a composite tissue consisting of neurovascular elements packaged within a well‐organized extracellular matrix. Their composition, size, and anatomy render nerves a challenging medical imaging target. In contrast to morphological MRI, which represents the predominant approach to nerve imaging, quantitative MRI sequences can provide information regarding tissue composition. Here, we applied standard clinical...

Read More thumbnail image: Feasibility of quantitative ultrashort echo time UTEbased methods for MRI of peripheral nerve

Multi‐parametric T 2 * magnetic resonance fingerprinting using variable echo times

Published: Jul 16, 2018

Author(s): Cory R. Wyatt, Travis B. Smith, Manoj K. Sammi, William D. Rooney, Alexander R. Guimaraes

Journal: NMR in Biomedicine

The use of quantitative imaging biomarkers in the imaging of various disease states, including cancer and neurodegenerative disease, has increased in recent years. T1, T2, and T2* relaxation time constants have been shown to be affected by tissue structure or contrast infusion. Acquiring these biomarkers simultaneously in a multi‐parametric acquisition could provide more robust detection of tissue changes in various disease states...

Read More thumbnail image: Multiparametric T 2  magnetic resonance fingerprinting using variable echo times

Wireless amplified NMR detector for improved visibility of image contrast in heterogeneous lesions

Published: Jul 16, 2018

Author(s): Xianchun Zeng, Shengqiang Xu, Changyong Cao, Jian Wang, Chunqi Qian

Journal: NMR in Biomedicine

To demonstrate the capability of a wireless amplified NMR detector (WAND) to improve the visibility of lesion heterogeneity without the use of exogenous contrast agents, a cylindrically symmetric WAND was constructed to sensitively detect and simultaneously amplify MR signals emitted from adjacent tissues. Based on a two‐leg high‐pass birdcage coil design, this WAND could be activated by a pumping field aligned along the main field (B0),...

Read More thumbnail image: Wireless amplified NMR detector for improved visibility of image contrast in heterogeneous lesions

Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixed‐mode liquid chromatography with quadrupole time‐of‐flight mass spectroscopy with heated electrospray ionization

Published: Jul 16, 2018

Author(s): Ingus Perkons, Iveta Pugajeva, Vadims Bartkevics

Journal: Journal of Separation Science

Abstract An analytical method based on liquid chromatography with quadrupole time‐of‐flight mass spectrometry has been developed for the simultaneous determination of six aminoglycoside antibiotics in honey. The sample pretreatment included extraction with aqueous trichloroacetic acid followed by solid‐phase extraction on Strata‐X polymeric reversed phase cartridges. Liquid chromatography separation was performed on an Obelisc R...

Read More thumbnail image: Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixedmode liquid chromatography with quadrupole timeofflight mass spectroscopy with heated electrospray ionization
Page:   Prev 6 7 8 9 10 11 12 13 14 15 16 Next

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in spectroscopy? Visit our sister site spectroscopyNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved