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New approach for determination of the degradation products of fenspiride hydrochloride found in oral liquid formulations

Published: Jan 22, 2018

Author(s): Bogdan I. Cioroiu, Ioana C. Caba, Irina Prisăcaru, Mona E. Cioroiu, Mihai I. Lazar, Marius Niculaua

Journal: Biomedical Chromatography

Abstract Fenspiride hydrochloride (FNS) is used in treating chronic inflammatory diseases, most commonly as a liquid oral solution. FNS produces degradation products along with fenspiride N‐oxide (FNO) and 1‐phenylethyl‐4‐hydroxy‐4‐aminomethyl piperidine hydrochloride (PHAP). We aimed to develop and validate a chromatographic method in order to identify the main degradation products in the presence of other compounds from a liquid ...

Read More thumbnail image: New approach for determination of the degradation products of fenspiride hydrochloride found in oral liquid formulations

A rapid, maskless 3D prototyping for fabrication of capillary circuits: Toward urinary protein detection

Published: Jan 22, 2018

Author(s): Sheng Yan, Yuanqing Zhu, Shi‐Yang Tang, Yuxing Li, Qianbin Zhao, Dan Yuan, Guolin Yun, Jun Zhang, Shiwu Zhang, Weihua Li

Journal: ELECTROPHORESIS

Abstract Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point‐of‐care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, maskless 3D prototyping for fabrication of capillary fluidic circuits using laser...

Read More thumbnail image: A rapid maskless 3D prototyping for fabrication of capillary circuits Toward urinary protein detection

Study of isomeric pentacyclic triterpene acids in traditional Chinese medicine of Forsythiae Fructus and their binding constants with β‐cyclodextrin by capillary electrophoresis

Published: Jan 22, 2018

Author(s): Tingjun Ren, Zhongqi Xu

Journal: ELECTROPHORESIS

Abstract In this study, a capillary zone electrophoresis (CZE) method was first developed to identify three microconstituents of isomeric pentacyclic triterpene acids (PTAs including oleanolic acid (OA), ursolic acid (UA) and betulinic acid (BA)) in Forsythiae Fructus (FF). The baseline separation of PTAs by CZE were eventually achieved in a background electrolyte (BGE) containing 50.0 mmol/L borax and 0.5 mmol/L β‐cyclodextrin (β‐CD)...

Read More thumbnail image: Study of isomeric pentacyclic triterpene acids in traditional Chinese medicine of Forsythiae Fructus and their binding constants with cyclodextrin by capillary electrophoresis

Electrophoretic large volume sample stacking for sensitive determination of the anti‐microbial agent pentamidine in rat plasma for pharmacological studies

Published: Jan 22, 2018

Author(s): Petr Tůma, Petr Heneberg, Šimon Vaculín, Dušan Koval

Journal: ELECTROPHORESIS

Abstract A sensitive capillary electrophoretic method with on‐line sample preconcentration by large volume sample stacking has been developed for determination of the anti‐microbial agent pentamidine. The separation is performed in a fused silica capillary coated with covalently bound hydroxypropyl cellulose, with an internal diameter of 50 μm and length of 31.5 cm; the background electrolyte was 100 mM acetic...

Read More thumbnail image: Electrophoretic large volume sample stacking for sensitive determination of the antimicrobial agent pentamidine in rat plasma for pharmacological studies

Enhanced cell trapping throughput using DC‐biased AC electric field in a dielectrophoresis‐based fluidic device with densely packed silica beads

Published: Jan 22, 2018

Author(s): Nuttawut Lewpiriyawong, Guolin Xu, Chun Yang

Journal: ELECTROPHORESIS

Abstract This paper presents the use of DC‐biased AC electric field for enhancing cell trapping throughput in an insulator‐based dielectrophoretic (iDEP) fluidic device with densely packed silica beads. Cell suspension is carried through the iDEP device by a pressure‐driven flow. Under an applied DC‐biased AC electric field, DEP trapping force is produced as a result of non‐uniform electric field induced by the gap of electrically...

Read More thumbnail image: Enhanced cell trapping throughput using DCbiased AC electric field in a dielectrophoresisbased fluidic device with densely packed silica beads

Optimization of pressurized liquid extraction by response surface methodology of Goji berry ( Lycium barbarum L .) phenolic bioactive compounds

Published: Jan 22, 2018

Author(s): Giusy Tripodo, Elena Ibáñez, Alejandro Cifuentes, Bienvenida Gilbert‐López, Chiara Fanali

Journal: ELECTROPHORESIS

Abstract Pressurized liquid extraction (PLE) has been used for the first time in this work to extract phenolic compounds from Goji berries according to a multilevel factorial design using response surface methodology. The global yield (% w/dw, weight/dry‐weight), total phenolic content (TPC), total flavonoid (TF) and antioxidant activity (determined via ABTS assay, expressed as TEAC value) were used as response variables to study...

Read More thumbnail image: Optimization of pressurized liquid extraction by response surface methodology of Goji berry  Lycium barbarum L _ phenolic bioactive compounds

What is the best ethanol‐water ratio for the extraction of antioxidants from rosemary? Impact of the solvent on yield, composition, and activity of the extracts

Published: Jan 22, 2018

Author(s): Magali Jacotet‐Navarro, Mickaël Laguerre, Anne‐Sylvie Fabiano‐Tixier, Mathieu Tenon, Nicolas Feuillère, Antoine Bily, Farid Chemat

Journal: ELECTROPHORESIS

Abstract Extracts rich in antioxidants, such as rosemary extracts, are currently obtained by extraction of the plant material using hydro‐alcoholic mixtures with high ethanol content. As this ratio is generally chosen by default and scarcely optimized, we intended to investigate the impact of the hydro‐alcoholic composition on extract characteristics such as extraction yield, composition profile in selected compounds, and...

Read More thumbnail image: What is the best ethanolwater ratio for the extraction of antioxidants from rosemary Impact of the solvent on yield composition and activity of the extracts

On the properties of residual dipolar coupling alignment tensors: Simulations illuminate how residual dipolar couplings depend on the relative orientations of the magnetic field, the director of the alignment phase and the bond vectors

Published: Jan 22, 2018

Author(s): Chris P. Lepper, Martin A.K. Williams, Patrick J.B. Edwards

Journal: Concepts in Magnetic Resonance Part A

Abstract The measurement of residual dipolar couplings (RDCs) exhibited by samples prepared in suitable alignment media can help in the elucidation of macromolecular structures. For any dipolar interactions that are not averaged to zero by molecular reorientations RDCs provide information about the possible orientations of the averaged interactions to the magnetic field. As such they contain information about the permitted relative...

Read More thumbnail image: On the properties of residual dipolar coupling alignment tensors Simulations illuminate how residual dipolar couplings depend on the relative orientations of the magnetic field the director of the alignment phase and the bond vectors

An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Published: Jan 19, 2018

Author(s): Pranov Ramana, Jan Schejbal, Kristof Houthoofd, Johan Martens, Erwin Adams, Patrick Augustijns, Zdenĕk Glatz, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract In this paper, we demonstrate the effectiveness of a new 3D printed magnet holder that enables capture of magnetic microparticles in commercially available capillary electrophoresis equipment with a liquid or air based coolant system. The design as well as the method to capture magnetic microparticles inside the capillary are discussed. This setup was tested at temperature and pH values suitable for performing enzymatic...

Read More thumbnail image: An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Published: Jan 19, 2018

Author(s): Pranov Ramana, Jan Schejbal, Kristof Houthoofd, Johan Martens, Erwin Adams, Patrick Augustijns, Zdenĕk Glatz, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract In this paper, we demonstrate the effectiveness of a new 3D printed magnet holder that enables capture of magnetic microparticles in commercially available capillary electrophoresis equipment with a liquid or air based coolant system. The design as well as the method to capture magnetic microparticles inside the capillary are discussed. This setup was tested at temperature and pH values suitable for performing enzymatic...

Read More thumbnail image: An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Synthesis of boronate‐functionalized organic‐inorganic hybrid monolithic column for the separation of cis‐diol containing compounds at low pH

Published: Jan 19, 2018

Author(s): Heqing Zhao, Haixia Lyu, Wenfei Qin, Zenghong Xie

Journal: ELECTROPHORESIS

Abstract In this work, an organic‐inorganic hybrid boronate affinity monolithic column was prepared via “one‐pot” process using 4‐vinylphenylboronic acid as organic monomer and divinylbenzene as cross‐linker. The effects of reaction temperature, solvents and composition of organic monomers on the column properties (e.g. morphology, permeability, and mechanical stability) were investigated. A series of test compounds including small...

Read More thumbnail image: Synthesis of boronatefunctionalized organicinorganic hybrid monolithic column for the separation of cisdiol containing compounds at low pH

Synthesis of boronate‐functionalized organic‐inorganic hybrid monolithic column for the separation of cis‐diol containing compounds at low pH

Published: Jan 19, 2018

Author(s): Heqing Zhao, Haixia Lyu, Wenfei Qin, Zenghong Xie

Journal: ELECTROPHORESIS

Abstract In this work, an organic‐inorganic hybrid boronate affinity monolithic column was prepared via “one‐pot” process using 4‐vinylphenylboronic acid as organic monomer and divinylbenzene as cross‐linker. The effects of reaction temperature, solvents and composition of organic monomers on the column properties (e.g. morphology, permeability, and mechanical stability) were investigated. A series of test compounds including small...

Read More thumbnail image: Synthesis of boronatefunctionalized organicinorganic hybrid monolithic column for the separation of cisdiol containing compounds at low pH

From micro‐ to macro‐structures in multiple sclerosis: what is the added value of diffusion imaging

Published: Jan 19, 2018

Author(s): Mara Cercignani, Claudia Gandini Wheeler‐Kingshott

Journal: NMR in Biomedicine

Diffusion imaging has been instrumental in understanding damage to the central nervous system as a result of its sensitivity to microstructural changes. Clinical applications of diffusion imaging have grown exponentially over the past couple of decades in many neurological and neurodegenerative diseases, such as multiple sclerosis (MS). For several reasons, MS has been extensively researched using advanced neuroimaging techniques, which...

Read More thumbnail image: From micro to macrostructures in multiple sclerosis what is the added value of diffusion imaging

From micro‐ to macro‐structures in multiple sclerosis: what is the added value of diffusion imaging

Published: Jan 19, 2018

Author(s): Mara Cercignani, Claudia Gandini Wheeler‐Kingshott

Journal: NMR in Biomedicine

Diffusion imaging has been instrumental in understanding damage to the central nervous system as a result of its sensitivity to microstructural changes. Clinical applications of diffusion imaging have grown exponentially over the past couple of decades in many neurological and neurodegenerative diseases, such as multiple sclerosis (MS). For several reasons, MS has been extensively researched using advanced neuroimaging techniques, which...

Read More thumbnail image: From micro to macrostructures in multiple sclerosis what is the added value of diffusion imaging

Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition

Published: Jan 19, 2018

Author(s): Shannon B. Donnola, Connie M. Piccone, Lan Lu, Joshua Batesole, Jane Little, Katherine M. Dell, Chris A. Flask

Journal: NMR in Biomedicine

Chronic kidney disease (CKD) occurs in over one‐third of patients with sickle cell disease (SCD) and can progress to end‐stage renal disease. Unfortunately, current clinical assessments of kidney function are insensitive to early‐stage CKD. Previous studies have shown that diffusion magnetic resonance imaging (MRI) can sensitively detect regional renal microstructural changes associated with early‐stage CKD. However, previous MRI studies...

Read More thumbnail image: Diffusion tensor imaging MRI of sickle cell kidney disease initial results and comparison with iron deposition

Viral Short ORFs and Their Possible Functions

Published: Jan 19, 2018

Author(s): Yaara Finkel, Noam Stern‐Ginossar, Michal Schwartz

Journal: PROTEOMICS

Abstract Definition of functional genomic elements is one of the greater challenges of the genomic era. Traditionally, putative short open reading frames (sORFs) coding for less than 100 amino acids were disregarded due to computational and experimental limitations; however, it has become clear over the past several years that translation of sORFs is pervasive and serves diverse functions. The development of ribosome profiling,...

Read More thumbnail image: Viral Short ORFs and Their Possible Functions

Viral Short ORFs and Their Possible Functions

Published: Jan 19, 2018

Author(s): Yaara Finkel, Noam Stern‐Ginossar, Michal Schwartz

Journal: PROTEOMICS

Abstract Definition of functional genomic elements is one of the greater challenges of the genomic era. Traditionally, putative short open reading frames (sORFs) coding for less than 100 amino acids were disregarded due to computational and experimental limitations; however, it has become clear over the past several years that translation of sORFs is pervasive and serves diverse functions. The development of ribosome profiling,...

Read More thumbnail image: Viral Short ORFs and Their Possible Functions

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

Published: Jan 19, 2018

Author(s): Karolina Pietrowska, Diana Anna Dmuchowska, Pawel Krasnicki, Aleksandra Bujalska, Paulina Samczuk, Ewa Parfieniuk, Tomasz Kowalczyk, Malgorzata Wojnar, Zofia Mariak, Adam Kretowski, Michal Ciborowski

Journal: ELECTROPHORESIS

Abstract Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is nowadays frequently implemented to understand pathophysiological processes responsible for disease occurrence and progression. It has also been used recently to study the metabolic composition of aqueous humor (AH). AH is a transparent fluid which...

Read More thumbnail image: An exploratory LCMSbased metabolomics study reveals differences in aqueous humor composition between diabetic and nondiabetic patients with cataract

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

Published: Jan 19, 2018

Author(s): Karolina Pietrowska, Diana Anna Dmuchowska, Pawel Krasnicki, Aleksandra Bujalska, Paulina Samczuk, Ewa Parfieniuk, Tomasz Kowalczyk, Malgorzata Wojnar, Zofia Mariak, Adam Kretowski, Michal Ciborowski

Journal: ELECTROPHORESIS

Abstract Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is nowadays frequently implemented to understand pathophysiological processes responsible for disease occurrence and progression. It has also been used recently to study the metabolic composition of aqueous humor (AH). AH is a transparent fluid which...

Read More thumbnail image: An exploratory LCMSbased metabolomics study reveals differences in aqueous humor composition between diabetic and nondiabetic patients with cataract

Rapid screening of inorganic and organic anions in liquid by‐products from hydrothermal treatment of biomass by capillary electrophoresis

Published: Jan 19, 2018

Author(s): Nobutake Nakatani, Alexander Mosqueda, Joan Marc Cabot, Estrella Sanz Rodriguez, Kunio Yoshikawa, Brett Paull

Journal: ELECTROPHORESIS

Abstract A simple and rapid capillary electrophoresis method with capacitively coupled contactless conductivity detection (CE‐C4D) for the simultaneous determination of inorganic and organic anions in liquid product obtained from the hydrothermal treatment of biomass residues is presented. Under the optimal analytical conditions, limits of detection ranged from 1.8 to 9.4 μM for most target solutes and 53 μM for citrate. Relative standard...

Read More thumbnail image: Rapid screening of inorganic and organic anions in liquid byproducts from hydrothermal treatment of biomass by capillary electrophoresis
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