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Proteomics biomarkers for solid tumors: Current status and future prospects

Published: Jun 11, 2018

Author(s): Iwona Belczacka, Agnieszka Latosinska, Jochen Metzger, David Marx, Antonia Vlahou, Harald Mischak, Maria Frantzi

Journal: Mass Spectrometry Reviews

Cancer is a heterogeneous multifactorial disease, which continues to be one of the main causes of death worldwide. Despite the extensive efforts for establishing accurate diagnostic assays and efficient therapeutic schemes, disease prevalence is on the rise, in part, however, also due to improved early detection. For years, studies were focused on genomics and transcriptomics, aiming at the discovery of new tests...

Read More thumbnail image: Proteomics biomarkers for solid tumors Current status and future prospects

Simultaneous quantitation of rosuvastatin and ezetimibe in human plasma by LC–MS/MS: Pharmacokinetic study of fixed‐dose formulation and separate tablets

Published: Jun 11, 2018

Author(s): Abhaysingh Bhadoriya, Mallika Sanyal, Priyanka A. Shah, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract A simple, high‐throughput and highly sensitive liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) method has been developed for the simultaneous estimation of rosuvastatin and free ezetimibe. Liquid–liquid extraction was carried out using methyl‐tert butyl ether after prior acidification from 300 μL human plasma. The recovery for both the analytes and their deuterated internal standards (ISs) ranged from...

Read More thumbnail image: Simultaneous quantitation of rosuvastatin and ezetimibe in human plasma by LCMSMS Pharmacokinetic study of fixeddose formulation and separate tablets

Development of an HPLC‐DAD method for the determination of five alkaloids in Stephania yunnanensis Lo and in rat plasma after oral dose of Stephania yunnanensis Lo extracts

Published: Jun 11, 2018

Author(s): Aiyi Xin, Yaming Zhang, Yanxia Zhang, Duolong Di, Junxi Liu

Journal: Biomedical Chromatography

Abstract For the rational utilization and the quantitative quality control of the Stephania yunnanensis Lo, an HPLC‐DAD method was developed for the quantitative and simultaneous determination of five alkaloids in rat plasma (stepharine, sinomenine, palmatine, isocorydine and tetrahydropalmatine), which were the main active chemical constituents of this plant and belong to four kinds of isoquinoline‐type alkaloids (protoberberine, morphine,...

Read More thumbnail image: Development of an HPLCDAD method for the determination of five alkaloids in Stephania yunnanensis Lo and in rat plasma after oral dose of Stephania yunnanensis Lo extracts

Chiral separation of isoxanthohumol and 8‐prenylnaringenin in beer, hop pellets and hops by HPLC with chiral columns

Published: Jun 11, 2018

Author(s): Hyuga Moriya, Sohei Tanaka, Yukari Iida, Satomi Kitagawa, Sen‐ichi Aizawa, Atsushi Taga, Hiroyuki Terashima, Atsushi Yamamoto, Shuji Kodama

Journal: Biomedical Chromatography

Abstract Xanthohumol, isoxanthohumol, and 8‐prenylnaringenin in beer, hop and hop pellet samples were analyzed by HPLC using an InertSustain phenyl column and the mobile phase containing 40% methanol and 12% 2‐propanol. Fractions of isoxanthohumol and 8‐prenylnaringenin obtained by the above HPLC were separately collected. Isoxanthohumol and 8‐prenylnaringenin were enantioseparated by HPLC using a Chiralcel OD‐H column with a mobile...

Read More thumbnail image: Chiral separation of isoxanthohumol and 8prenylnaringenin in beer hop pellets and hops by HPLC with chiral columns

Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal‐derived foods, soil, and water

Published: Jun 10, 2018

Author(s): Ying Zhang, Xiaohu Wu, Tingting Duan, Jun Xu, Fengshou Dong, Xingang Liu, Xiaogang Li, Pengqiang Du, Yongquan Zheng

Journal: Journal of Separation Science

Abstract An ultra high‐performance liquid chromatography with tandem triple quadrupole mass spectrometry residue method was developed and validated for the quantification and identification of dinotefuran and its main metabolites 1‐methyl‐3‐(tetrahydro‐3‐furylmethyl) urea and 1‐methyl‐3‐(tetrahydro‐3‐furylmethyl) guanidine in fruit (watermelon), vegetable (cucumber), cereal (rice), animal‐derived foods (milk, egg, and pork), soil,...

Read More thumbnail image: Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants animalderived foods soil and water

Application of liquid–liquid microextraction for the effective separation and simultaneous determination of 11 pharmaceuticals in wastewater samples using high‐performance liquid chromatography with tandem mass spectrometry

Published: Jun 10, 2018

Author(s): Alina Diuzheva, József Balogh, József Jekő, Zoltán Cziáky

Journal: Journal of Separation Science

Abstract A dispersive liquid–liquid microextraction method for the simultaneous determination of 11 pharmaceuticals has been developed. The method is based on a microextraction procedure applied to wastewater samples from different regions of Hungary followed by high‐performance liquid chromatography with mass spectrometry. The effect of the nature of the extractant, dispersive solvent, different additives, and extraction time were...

Read More thumbnail image: Application of liquidliquid microextraction for the effective separation and simultaneous determination of 11 pharmaceuticals in wastewater samples using highperformance liquid chromatography with tandem mass spectrometry

Cost‐efficient magnetic nanoporous carbon derived from citrus peel for the selective adsorption of seven insecticides

Published: Jun 10, 2018

Author(s): Yuantao Zhou, Shurui Cao, Cunxian Xi, Jiuyan Chen, Lei Zhang, Xianliang Li, Guomin Wang, Zhiqiong Chen

Journal: Journal of Separation Science

Abstract A magnetic solid‐phase extraction adsorbent that consisted of citrus peel‐derived nanoporous carbon and silica‐coated Fe3O4 microspheres (C/SiO2@Fe3O4) was successfully fabricated by co‐precipitation. As a modifier for magnetic microspheres, citrus peel‐derived nanoporous carbon was not only economical and renewable for its raw material, but exerted enormous nanosized pore structure, which could directly influence the type of adsorbed...

Read More thumbnail image: Costefficientmagnetic nanoporous carbon derived from citrus peel for the selective adsorption of seven insecticides

Protonation of polyaniline‐coated silica stationary phase affects the retention behavior of neutral hydrophobic solutes in reversed‐phase capillary liquid chromatography

Published: Jun 10, 2018

Author(s): Lukáš Taraba, Tomáš Křížek, Petr Kozlík, Ondřej Hodek, Pavel Coufal

Journal: Journal of Separation Science

Abstract Because of its high conductivity when acid doped, polyaniline is known as a synthetic metal and is used in a wide range of applications, such as supercapacitors, biosensors, electrochromic devices, or solar and fuel cells. Emeraldine is the partly oxidized, stable form of polyaniline, consisting of alternating diaminobenzenoid and iminoquinoid segments. When acidified, the nitrogen atoms of emeraldine become protonated. Due...

Read More thumbnail image: Protonation of polyanilinecoated silica stationary phase affects the retention behavior of neutral hydrophobic solutes in reversedphase capillary liquid chromatography

Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline

Published: Jun 10, 2018

Author(s): Chao Du, Gilles P. Wezel

Journal: PROTEOMICS

Abstract Natural products (NPs) are a major source of compounds for medical, agricultural, and biotechnological industries. Many of these compounds are of microbial origin, and, in particular, from Actinobacteria or filamentous fungi. To successfully identify novel compounds that correlate to a bioactivity of interest, or discover new enzymes with desired functions, systematic multiomics approaches have been developed over the...

Read More thumbnail image: Mining for Microbial Gems Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline

Utilizing two detectors in the measurement of trichloroacetic acid in human urine by reaction headspace gas chromatography

Published: Jun 8, 2018

Author(s): Wei‐Qi Xie, Yi‐Xian Gong, Kong‐Xian Yu

Journal: Biomedical Chromatography

Abstract A reaction headspace gas chromatography (HS‐GC) technique was investigated for quantitatively analyzing trichloroacetic acid in human urine. This method is based on the decomposition reaction of trichloroacetic acid under high‐temperature conditions. The carbon dioxide and chloroform formed from the decomposition reaction can be respectively detected by the thermal conductivity detection HS‐GC and flame ionization detection...

Read More thumbnail image: Utilizing two detectors in the measurement of trichloroacetic acid in human urine by reaction headspace gas chromatography

Pharmacokinetic and metabolism studies of bavachinin through ultra‐high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Published: Jun 8, 2018

Author(s): Jun Qian, Fan Xie, Yanhong Shi, Jinhang Li, Liuqiang Zhang, Yiming Li, Fujiang Guo, Rui Wang

Journal: Biomedical Chromatography

Abstract Bavachinin (BVC), one of the main bioactive prenylated flavonoids derived from Psoralea corylifolia Linn, has a wide variety of pharmacological effects, such as antiangiogenic, antitumor, antiallergic, anti‐inflammatory and antibacterial activities, especially as a pan‐peroxisome proliferator‐activated receptors agonist. A rapid and sensitive method for quantifying BVC in rat plasma was developed and validated through...

Read More thumbnail image: Pharmacokinetic and metabolism studies of bavachinin through ultrahighperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Probing the dynamics of dithiooxamide coordinated to gold nanoparticles using SERS

Published: Jun 8, 2018

Author(s): Daniel Grasseschi, Vitor M. Zamarion, Henrique E. Toma

Journal: Journal of Raman Spectroscopy

Abstract The substitution kinetics and specific binding modes of the dithiooxamide (dto) ligand at the metal surface have been investigated and interpreted on the light of theoretical and experimental Raman studies. By monitoring the vibrational properties of this ligand, it was shown that gold nanoparticles employed as surface‐enhanced effects (SERS) probes are strongly dependent on the coordination chemistry of the ligands at the...

Read More thumbnail image: Probing the dynamics of dithiooxamide coordinated to gold nanoparticles using SERS

Development and applications of nonlinear optical spectroscopy: 16th ECONOS/36th ECW meeting in Jena (Germany)

Published: Jun 8, 2018

Author(s): Michael Schmitt, Jürgen Popp, Johannes Kiefer, Julian Moger

Journal: Journal of Raman Spectroscopy

Read More thumbnail image: Development and applications of nonlinear optical spectroscopy 16th ECONOS36th ECW meeting in Jena Germany

Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris

Published: Jun 7, 2018

Author(s): Lin Chen, Yuetao Liu, Qingfeng Guo, Qingxia Zheng, Wancun Zhang

Journal: Biomedical Chromatography

Abstract A systematic study on the metabolome differences between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris was conducted using liquid chromatography−mass spectrometry. Principal component analysis and orthogonal projection on latent structure‐discriminant analysis results showed that C. militaris grown on solid rice medium (R‐CM) and C. militaris grown on tussah pupa (T‐CM) evidently separated and individually separated from...

Read More thumbnail image: Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris

Capillary electrophoresis, a method for the determination of nucleic acid ligands covalently attached to quantum dots representing a donor of Förster resonance energy transfer

Published: Jun 7, 2018

Author(s): Vladimíra Datinská, Karel Klepárník, Barbora Belšánová, Marek Minárik, František Foret

Journal: Journal of Separation Science

Abstract The synthesis and determination of the structure of a Förster resonance energy transfer probe intended for the detection of specific nucleic acid sequences are described here. The probe is based on the hybridization of oligonucleotide modified quantum dots with a fluorescently labeled nucleic acid sample resulting in changes of the fluorescence emission due to the energy transfer effect. The stoichiometry distribution of...

Read More thumbnail image: Capillary electrophoresis a method for the determination of nucleic acid ligands covalently attached to quantum dots representing a donor of Forster resonance energy transfer

Preparative free‐flow electrophoresis, a versatile technology complementing gradient centrifugation in the isolation of highly purified cell organelles

Published: Jun 7, 2018

Author(s): Markus Islinger, Robert Wildgruber, Alfred Völkl

Journal: ELECTROPHORESIS

Abstract Free‐flow electrophoresis (FFE) exploits differences in the overall charge of bio‐particles separating cells, organelles, macromolecules, ions, etc. according to their distinct electrophoretic mobility and isoelectric point (pI) values. Indeed, around a neutral pH organelles usually exhibit a negative surface charge, migrating in an electric field from the cathode toward the anode. Since its introduction more than five decades ago by...

Read More thumbnail image: Preparative freeflow electrophoresis a versatile technology complementing gradient centrifugation in the isolation of highly purified cell organelles

Optimization of artemisinin extraction from Artemisia annua L. with supercritical carbon dioxide + ethanol using response surface methodology

Published: Jun 7, 2018

Author(s): Ozan Nazim Ciftci, Jessica Cahyadi, Selma E. Guigard, Marleny D. A. Saldaña

Journal: ELECTROPHORESIS

Abstract Malaria is a high priority life‐threatening public health concern in developing countries, and therefore there is a growing interest to obtain artemisinin for the production of artemisinin‐based combination therapy products. In this study, artemisinin was extracted from the Artemisia annua L. plant using supercritical carbon dioxide (SC‐CO2) modified with ethanol. Response surface methodology based on central composite rotatable design...

Read More thumbnail image: Optimization of artemisinin extraction from Artemisia annua L_ with supercritical carbon dioxide  ethanol using response surface methodology

A combined experimental and theoretical approach to determine X‐ray atomic fundamental quantities of tin

Published: Jun 7, 2018

Author(s): Y. Ménesguen, M.‐C. Lépy, J. M. Sampaio, J. P. Marques, F. Parente, M. Guerra, P. Indelicato, J. P. Santos, P. Hönicke, B. Beckhoff

Journal: X-Ray Spectrometry

The knowledge of atomic fundamental parameters, such as the mass attenuation coefficients or fluorescence yields with low uncertainties, is of decisive importance in elemental quantification involving X‐ray fluorescence analysis techniques. For example, several databases giving the mass attenuation coefficients are accessible and frequently used within a large community of users. These compilations are most often in good agreement for...

Read More thumbnail image: A combined experimental and theoretical approach to determine Xray atomic fundamental quantities of tin

Investigation of the pigment use in the Tomb of the Reliefs and other tombs in the Etruscan Banditaccia Necropolis

Published: Jun 7, 2018

Author(s): Matthias Alfeld, Cecilia Baraldi, Maria Cristina Gamberini, Philippe Walter

Journal: X-Ray Spectrometry

The pigment use in the Tomb of the Reliefs (fourth century BC) and four other tombs (seventh to fourth century BC) in the Etruscan Banditaccia Necropolis near Cerveteri, Italy, has been investigated. We made use of X‐ray fluorescence (XRF) and Raman spot analysis, XRF imaging, infrared luminescence and photography supported by Dstretch contrast enhancement. We identified the use of haematite, goethite, calcite, carbon black, manganese...

Read More thumbnail image: Investigation of the pigment use in the Tomb of the Reliefs and other tombs in the Etruscan Banditaccia Necropolis

Metabolic profiles of neratinib in rat by using ultra‐high‐performance liquid chromatography coupled with diode array detector and Q‐Exactive Orbitrap tandem mass spectrometry

Published: Jun 5, 2018

Author(s): Wen Liu, Sha Li, Yangke Wu, Xiao Yan, Y.‐M. Zhu, J.‐H. Huang, Zhuo Chen

Journal: Biomedical Chromatography

Abstract Neratinib is a tyrosine kinase inhibitor that has been approved by the US Food and Drug Administration for the treatment of breast cancer. However, its metabolism remains unknown. This study was carried out to investigate the in vitro and in vivo metabolism of neratinib using an UHPLC‐DAD‐Q Exactive Orbitrap‐MS instrument with dd‐MS2 on‐line data acquisition mode. The post‐acquisition data was processed using MetWorks software. Under the current...

Read More thumbnail image: Metabolic profiles of neratinib in rat by using ultrahighperformance liquid chromatography coupled with diode array detector and QExactive Orbitrap tandem mass spectrometry
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