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Combined immuno‐purification and detection of recombinant erythropoietins and activin receptor type II‐Fc fusion proteins by isoelectric focusing for application in doping control

Published: Aug 28, 2018

Author(s): Laurent Martin, Michel Audran, Alexandre Marchand

Journal: Drug Testing and Analysis

Abstract Iso‐electric focusing (IEF) was the first method established to discriminate endogenous and recombinant erythropoietins (rEPOs). It is still approved by the World Anti‐Doping Agency (WADA) as an initial testing procedure to detect erythropoiesis stimulating agents (ESAs) in doping control samples. However EPO‐Fc, one of the prohibited rEPOs designated by WADA, is not detectable with the actual IEF conditions. Other newly...

Read More thumbnail image: Combined immunopurification and detection of recombinant erythropoietins and activin receptor type IIFc fusion proteins by isoelectric focusing for application in doping control

A rapid and sensitive method for the quantitative analysis of ibuprofen and its metabolites in equine urine samples by gas chromatography with tandem mass spectrometry

Published: Aug 28, 2018

Author(s): Emilia Waraksa, Mateusz Kacper Woźniak, Ewa Kłodzińska, Robert Wrzesień, Barbara Bobrowska‐Korczak, Jacek Namieśnik

Journal: Journal of Separation Science

Abstract Ibuprofen is widely used in human and veterinary medicine for the treatment of chronic pain as well as rheumatic and musculoskeletal disorders. However, the analgesic and anti‐inflammatory properties of Ibuprofen have contributed to frequent drug abuse in equestrian sports. A sensitive and rapid gas chromatography with tandem mass spectrometry based method with a simple liquid‐liquid extraction and derivatization requiring...

Read More thumbnail image: A rapid and sensitive method for the quantitative analysis of ibuprofen and its metabolites in equine urine samples by gas chromatography with tandem mass spectrometry

Analysis of inorganic cations and amino acids in high salinity samples by capillary electrophoresis and conductivity detection: Implications for in‐situ exploration of ocean worlds

Published: Aug 28, 2018

Author(s): Mauro Sergio Ferreira Santos, Thiago Gomes Cordeiro, Aaron C. Noell, Carlos D. Garcia, Maria F. Mora

Journal: ELECTROPHORESIS

Abstract With growing interest in exploring ocean worlds, such as Europa and Enceladus, there is a fundamental need to develop liquid‐based analytical techniques capable of handling high salinity samples while performing both bulk and trace species measurements. In this context, CE with capacitively coupled contactless conductivity detection (CE–C4D) has tremendous potential. One of its advantages is that this combination allows the detection...

Read More thumbnail image: Analysis of inorganic cations and amino acids in high salinity samples by capillary electrophoresis and conductivity detection Implications for insitu exploration of ocean worlds

Selective separation and purification of β‐estradiol from marine sediment using an optimized core–shell molecularly imprinted polymer

Published: Aug 28, 2018

Author(s): Xiuping He, Ziru Lian, Jiangtao Wang

Journal: Journal of Separation Science

Abstract The core–shell molecularly imprinted polymers were optimized to provide reliable connections that allow molecularly imprinted polymers to be fixed on SiO2 surface for the efficient separation and purification of β‐estradiol from marine sediment for the first time. To achieve the goal, different preparation methods were used and finally the polymer using 3‐methacryloxypropyltrimethoxysilane as coupling agent exhibited the...

Read More thumbnail image: Selective separation and purification of estradiol from marine sediment using an optimized coreshell molecularly imprinted polymer

Rapid quantification of aloin A and B in aloe plants and aloe‐containing beverages, and pharmaceutical preparations by microchip capillary electrophoresis with laser induced fluorescence detection

Published: Aug 28, 2018

Author(s): Meng‐Wei Xiao, Xiao‐Lin Bai, Yi‐Ming Liu, Li Yang, Ya‐Dong Hu, Xun Liao

Journal: Journal of Separation Science

Abstract A microchip capillary electrophoresis coupled with laser induced fluorescence detection method for the fast determination of aloin was developed and comprehensively applied for the quantification of aloin A and B present in seven aloe plant species, 42 aloin‐containing crude drugs, ten aloe pharmaceutical preparations, and four aloe gel‐containing functional foods. The excitation and emission wavelengths for detection...

Read More thumbnail image: Rapid quantification of aloinA and B in aloe plants and aloecontaining beverages and pharmaceutical preparations by microchip capillary electrophoresis with laser induced fluorescence detection

Complete detoxification reaction by NO reduction with CO over nano‐sized copper‐substituted Cr 2 O 3

Published: Aug 28, 2018

Author(s): Rahul D. Kerkar, Mithil S. Fal Desai, Arun V. Salker

Journal: Surface and Interface Analysis

Simultaneous detoxification of nitric oxide and carbon monoxide was investigated over fibrous pristine and copper‐substituted Cr2O3 catalysts. Catalysts were synthesized using glycine combustion method. The prepared catalysts were characterized using X‐ray diffraction, infrared spectroscopy, diffuse reflectance spectra, SEM‐energy‐dispersive X‐ray, transmission electron microscopy, XPS, H2‐temperature programmed reduction, and...

Read More thumbnail image: Complete detoxification reaction by NO reduction with CO over nanosized coppersubstituted Cr 2 O 3

Temperature‐dependent magnetic and synchrotron radiation–based structural study of Fe/Al multilayers

Published: Aug 28, 2018

Author(s): Ranjeet Brajpuriya

Journal: Surface and Interface Analysis

This paper shows in situ annealing study of interface reaction of Fe/Al multilayer structure (MLS) grown by ion beam sputtering (IBS). The structural studies with respect to thermal annealing were carried out using synchrotron‐based grazing incidence X‐ray diffraction (GIXRD) and X‐ray reflectivity (XRR), at P08, high‐resolution XRD beamline. In situ annealing was done in a range from 200°C to 400°C. The structural studies show that (1)...

Read More thumbnail image: Temperaturedependent magnetic and synchrotron radiationbased structural study of FeAl multilayers

Predicting efficiency of NECEEM‐based partitioning of protein binders from nonbinders in DNA‐encoded libraries

Published: Aug 28, 2018

Author(s): Sven Kochmann, An T. H. Le, Ryan Hili, Sergey N. Krylov

Journal: ELECTROPHORESIS

Abstract Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) is an affinity method for separating binder‐target complexes from nonbinders by gel‐free CE. NECEEM is a promising high‐efficiency method for partitioning protein binders from nonbinders in DNA‐encoded libraries (DEL), such binders are used as “hits” in drug development. It is important to be able to predict the efficiency of NECEEM‐based...

Read More thumbnail image: Predicting efficiency of NECEEMbased partitioning of protein binders from nonbinders in DNAencoded libraries

Near‐field enhancements and surface plasmon polaritons with multifunctional oxide thin films

Published: Aug 28, 2018

Author(s): Chahinez Dab, Reji Thomas, Thameur Hajlaoui, Andreas Ruediger

Journal: Journal of Raman Spectroscopy

Abstract The thickness of multifunctional oxide films directly affects the localized enhancement of the electromagnetic field and hence is a key factor for realizing novel photonic or optoelectronic devices. To this end, we theoretically exploit the principle of tip‐enhanced Raman spectroscopy on the surface of multifunctional oxide films (bismuth ferrite and barium titanate) on a gold substrate. An electromagnetic field enhancement...

Read More thumbnail image: Nearfield enhancements and surface plasmon polaritons with multifunctional oxide thin films

A rapid classification and identification method applied to the analysis of glycosides in Bupleuri radix and liquorice by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Published: Aug 27, 2018

Author(s): Lanlan Shan, Na Yang, Yiwei Zhao, Xue Sheng, Shenshen Yang, Yubo Li

Journal: Journal of Separation Science

Abstract Bupleuri radix and liquorice are commonly used as a hepatoprotectants. Their main effective ingredients are triterpenoid saponins. It is known that the saponins in liquorice and Bupleuri radix not only promote the metabolism of sugar and lipids but also have anti‐inflammatory functions and hepatoprotective effect. However, the complexity of these compounds results in difficulty in studying their pharmacodynamics and mechanism. In this ...

Read More thumbnail image: A rapid classification and identification method applied to the analysis of glycosides in Bupleuri radix and liquorice by ultra high performance liquid chromatography coupled with quadrupole timeofflight mass spectrometry

A digest of capillary electrophoretic methods applied to lipid analyzes

Published: Aug 27, 2018

Author(s): Véréna Poinsot, Hai Yen Ta, Varravaddheay Ong Meang, Lucie Perquis, Pierre Gavard, Bernard Pipy, François Couderc

Journal: ELECTROPHORESIS

Abstract Lipids are naturally occurring organic compounds that can be classified into a number of types based on their solubility in nonpolar organic solvents, and are generally insoluble in water. The great structural variety of these various types of lipids has led them to be components of many different biological substances such as oils, waxes, cellular membranes, tissues and biological fluids. The use of capillary...

Read More thumbnail image: A digest of capillary electrophoretic methods applied to lipid analyzes

About the assessment of gold concentrations in tiny inclusions within sulfide mineral matrix: An electron microprobe study

Published: Aug 27, 2018

Author(s): Alexander L. Finkelshtein, Vasiliy V. Tatarinov, Evgeniya Finkelstein, Ludmila A. Pavlova, Raisa G. Kravtsova

Journal: X-Ray Spectrometry

A method for estimating the native gold composition in micron‐ and submicron‐sized inclusions in the matrix of a sulfide mineral with electron probe X‐ray microanalysis is proposed. Such inclusion sizes are comparable with or less than the X‐ray generation volume, and therefore, the analytical signal is a mixture of signals from the matrix elements and the inclusion elements, which significantly complicates the quantification. The...

Read More thumbnail image: About the assessment of gold concentrations in tiny inclusions within sulfide mineral matrix An electron microprobe study

Preparation and application of a magnetic plasticizer as a molecularly imprinted polymer adsorbing material for the determination of phthalic acid esters in aqueous samples

Published: Aug 26, 2018

Author(s): Shou‐Lian Wei, Wan‐Ting Liu, Xiao‐Chen Huang, Jin‐Kui Ma

Journal: Journal of Separation Science

Abstract A novel magnetic plasticizer molecularly imprinted polymer adsorbing material (MIP@mSiO2‐β‐CD@Fe3O4) was successfully synthesized for the determination of six phthalic acid esters in water, milk, and wine samples. The molecularly imprinted polymers were prepared via precipitation polymerization and a surface molecular imprinting technique, using a cyclodextrin‐modified magnetic meso‐porous material (mSiO2‐β‐CD@Fe3O4) as a magnetic...

Read More thumbnail image: Preparation and application of a magnetic plasticizer as a molecularly imprinted polymer adsorbing material for the determination of phthalic acid esters in aqueous samples

A miniaturized solid‐phase extraction adsorbent of calix[4]arene‐functionalized graphene oxide/polydopamine‐coated cellulose acetate for the analysis of aflatoxins in corn

Published: Aug 26, 2018

Author(s): Piyaluk Nurerk, Warapon Bunkoed, Proespichaya Kanatharana, Opas Bunkoed

Journal: Journal of Separation Science

Abstract A calix[4]arene‐functionalized graphene oxide/polydopamine‐coated cellulose acetate adsorbent was fabricated for the pre‐concentration of aflatoxins. The highly porous developed adsorbent does not produce the high backpressure that normally occurs in particle‐packed cartridges and its large surface area helps to improve adsorption. The highly efficient adsorption of aflatoxins by the hybrid adsorbent is facilitated via...

Read More thumbnail image: A miniaturized solidphase extraction adsorbent of calix4arenefunctionalized graphene oxidepolydopaminecoated cellulose acetate for the analysis of aflatoxins in corn

Synthesis of florisil materials modified with aliphatic or aromatic groups and the application for pipette‐tip solid‐phase extraction of rutin in orange peel

Published: Aug 26, 2018

Author(s): Liping Sun, Yuxin Ma, Hongying Wang, Tao Zhu

Journal: Journal of Separation Science

Abstract After being coupled, florisil was modified with four kinds of aliphatic or aromatic groups and were applied to the determination of rutin in orange peel sample by a pipette‐tip solid‐phase extraction method. The materials were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and specific surface area by Brunauer Emmett Teller N2 adsorption desorption...

Read More thumbnail image: Synthesis of florisil materials modified with aliphatic or aromatic groups and the application for pipettetip solidphase extraction of rutin in orange peel

An HPLC–MS/MS method for the simultaneous determination of luteolin and its major metabolites in rat plasma and its application to a pharmacokinetic study

Published: Aug 26, 2018

Author(s): Fuguo Shi, Hong Pan, Yuanfu Lu, Li Ding

Journal: Journal of Separation Science

Abstract A selective and accurate HPLC‐MS/MS method was established to simultaneously quantify luteolin and its active metabolites (diosmetin, chryseriol, and luteolin‐7‐O‐glucuronide) in rat plasma. The analytes were separated on a C18 column with a mobile phase of water containing 0.5% formic acid and acetonitrile under gradient elution to shorten the total chromatographic run time and increase the resolution of diosmetin and chryseriol. A...

Read More thumbnail image: An HPLCMSMS method for the simultaneous determination of luteolin and its major metabolites in rat plasma and its application to a pharmacokinetic study

Optimized in vivo brain glutamate measurement using long‐echo‐time semi‐LASER at 7 T

Published: Aug 24, 2018

Author(s): Dickson Wong, Amy L. Schranz, Robert Bartha

Journal: NMR in Biomedicine

A short echo time (TE) is commonly used for brain glutamate measurement by 1H MRS to minimize drawbacks of long TE such as signal modulation due to J evolution and T2 relaxation. However, J coupling causes the spectral patterns of glutamate to change with TE, and the shortest achievable TE may not produce the optimal glutamate measurement. The purpose of this study was to determine the optimal TE for glutamate measurement at 7 T using semi‐LASER (localization by...

Read More thumbnail image: Optimized in vivo brain glutamate measurement using longechotime semiLASER at 7 T

The Proteome of Enchytraeus crypticus —Exposure to CuO Nanomaterial and CuCl 2 —in Pursue of a Mechanistic Interpretation

Published: Aug 24, 2018

Author(s): Vera L. Maria, David Licha, Janeck J. Scott‐Fordsmand, Christian G. Huber, Mónica J.B. Amorim

Journal: PROTEOMICS

Abstract The transcriptome of the ecotoxicological model Enchytraeus crypticus (known as potworm) is well studied, but the downstream changes at the protein level remained a gap. Changes in the protein regulation following exposure to CuO nanomaterial (NM) and Cu salt (CuCl2) are investigated. HPLC‐MS/MS using tandem mass tags is used. CuO NM elicits higher number of differentially expressed proteins (DEPs) compared to CuCl2 with...

Read More thumbnail image: The Proteome of Enchytraeus crypticus Exposure to CuO Nanomaterial and CuCl 2 in Pursue of a Mechanistic Interpretation

Pharmacokinetics of Sijunzi decoction in rat plasma after oral administration using ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry

Published: Aug 23, 2018

Author(s): Gonglin Qu, Xuesong Qi, Shuai Shao, Chen Li, Chunyan Wang, Chengfang Wang, Qiao Gou

Journal: Biomedical Chromatography

Abstract Sijunzi decoction (SJZD) is one of the most well‐known traditional Chinese herbal formulations. This study elucidates the pharmacokinetics of SJZD in rat plasma after the administration of a single oral dose of 3 mL/kg using ultra‐high‐performance liquid chromatography electrospray ionization quadrupole–time of flight mass spectrometry (UHPLC‐ESI‐Q‐TOF/MS) with bergapten as an internal standard. The separation was performed...

Read More thumbnail image: Pharmacokinetics of Sijunzi decoction in rat plasma after oral administration using ultrahighperformance liquid chromatography electrospray ionization quadrupoletime of flight mass spectrometry

Quality evaluation for Radix Astragali based on fingerprint, indicative components selection and QAMS

Published: Aug 23, 2018

Author(s): Jun Huang, Lei Yin, Lin Dong, Hongfeng Quan, Rong Chen, Shiyao Hua, Jiahua Ma, Dongyan Guo, Xueyan Fu

Journal: Biomedical Chromatography

Abstract Radix Astragali (RA) is one of the most widely used Chinese herbs prescribed in many Chinese formulas to reinforce ‘Qi’ and treat vital energy deficiency. This study combined fingerprinting with quantitative analysis multi‐components by a single marker (QAMS) to improve the quality control standard for RA on the basis of existing quality control methods of traditional Chinese medicinal materials. UPLC‐ESI‐TOF‐MS technique...

Read More thumbnail image: Quality evaluation for Radix Astragali based on fingerprint indicative components selection and QAMS
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