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Capillary electrophoresis‐based approaches for the study of affinity interactions combined with various sensitive and nontraditional detection techniques

Published: Jan 11, 2019

Author(s): Hana Nevídalová, Lenka Michalcová, Zdeněk Glatz

Journal: ELECTROPHORESIS

Abstract Nearly all processes in living organisms are controlled and regulated by the synergy of many biomolecule interactions involving proteins, peptides, nucleic acids, nucleotides, saccharides, and small molecular weight ligands. There is growing interest in understanding them, not only for the purposes of interactomics as an essential part of system biology, but also in their further elucidation in disease pathology, diagnostics, and treatment. The necessity of detailed investigation of...

Read More thumbnail image: Capillary electrophoresisbased approaches for the study of affinity interactions combined with various sensitive and nontraditional detection techniques

Confinement effects on DNA hybridization in electrokinetic micro‐ and nanofluidic systems

Published: Jan 11, 2019

Author(s): Alex M. Downs, Christopher McCallum, Sumita Pennathur

Journal: ELECTROPHORESIS

Abstract Spatial confinement, within cells or micro‐ and nanofabricated devices, impacts the conformation and binding kinetics of biomolecules. Understanding the role of spatial confinement on molecular behavior is important for comprehending diverse biological phenomena, as well as for designing biosensors. Specifically, the behavior of molecular binding under an applied electric field is of importance in the development of electrokinetic biosensors. Here, we investigate whether confinement...

Read More thumbnail image: Confinement effects on DNA hybridization in electrokinetic micro and nanofluidic systems

Testing for AB‐PINACA in human hair: Distribution in head hair versus pubic hair

Published: Jan 10, 2019

Author(s): Nadia Arbouche, Jean‐Sebastien Raul, Delphine Garnier, Pascal Kintz, Alice Ameline

Journal: Drug Testing and Analysis

Abstract Synthetic cannabinoid receptor agonists were first identified in herbal products in 2008 advertised as a legal replacement for cannabis. These herbal incense are usually called “spice” and among these, one product in particular has gained popularity: AB‐PINACA (N‐[(2S)‐1‐Amino‐3‐methyl‐1‐oxobutan‐2‐yl]‐1‐pentyl‐1H‐indazole‐3‐carboxamide). This drug has been discovered to have a stronger binding to human cannabinoid CB1 and CB2 receptors than ∆9‐THC.While some articles have been...

Read More thumbnail image: Testing for ABPINACA in human hair Distribution in head hair versus pubic hair

Estimation of HIV‐1 viral load in plasma of HIV‐1‐infected people based on the associated Raman spectroscopic peaks

Published: Jan 10, 2019

Author(s): Ben Otange, Zephania Birech, Ronald Rop, Julius Oyugi

Journal: Journal of Raman Spectroscopy

Abstract Most HIV viral load determination techniques available commercially are anchored on direct measurements of either HIV ribonucleic acid (RNA), provirus DNA, or viral antigen. Such techniques often require expensive reagents which makes the process expensive. This study reported the feasibility of label‐free determination of HIV‐1 viral load in plasma based on the consequence of the virus in the components of plasma. The study aimed to provide a relatively cheap and faster HIV‐1...

Read More thumbnail image: Estimation of HIV1 viral load in plasma of HIV1infected people based on the associated Raman spectroscopic peaks

Extraction technology, component analysis, and in vitro antioxidant and antibacterial activities of total flavonoids and fatty acids from Tribulus terrestris L. fruits

Published: Jan 10, 2019

Author(s): Chunlian Tian, Zehui Zhang, Hong Wang, Yuru Guo, Jihang Zhao, Mingchun Liu

Journal: Biomedical Chromatography

Abstract The current study focused on the extraction technology, components analysis, in vitro antioxidant and antibacterial activities of total flavonoids and fatty acids from Tribulus terrestris L. fruits. The extraction process of total flavonoids and fatty acids was optimized by the response surface method, and the compositions were identified from the two extracts by HPLC–DAD–ESI–MS− and GC–MS, respectively. In addition, the antioxidant and antibacterial activities were evaluated by assay...

Read More thumbnail image: Extraction technology component analysis and in vitro antioxidant and antibacterial activities of total flavonoids and fatty acids from Tribulus terrestris L_ fruits

A comparison of two PLS‐based approaches to structural equation modeling

Published: Jan 9, 2019

Author(s): Rosaria Romano, Oliver Tomic, Kristian H. Liland, Age Smilde, Tormod Næs

Journal: Journal of Chemometrics

A new approach to path modeling, named SO‐PLS path modeling, is presented that is flexible, graphically oriented and allows for handling multidimensional blocks and diagnosing missing paths. New definitions of total, direct, and indirect effects in terms of explained variances are proposed. The method is tested on two well‐known data sets in the PLS‐PM literature.

Read More thumbnail image: A comparison of two PLSbased approaches to structural equation modeling

A career in Chemometrics: An interview with Paul Gemperline

Published: Jan 9, 2019

Author(s): Paul Trevorrow, Paul Gemperline

Journal: Journal of Chemometrics

Read More thumbnail image: A career in Chemometrics An interview with Paul Gemperline

Cross striation in human permanent and deciduous enamel measured with confocal Raman microscopy

Published: Jan 9, 2019

Author(s): Alban Desoutter, Amel Slimani, Rand Al‐Obaidi, Stephane Barthélemi, Frederic Cuisinier, Hervé Tassery, Hamideh Salehi

Journal: Journal of Raman Spectroscopy

Abstract Dental enamel is the most mineralized tissue in the human body and has a very complex organization. The aim of the present study was to evaluate chemical composition and orientation of crystals in human enamel cross striation using confocal Raman microscope. Slices of teeth were prepared and scanned using a confocal Raman microscope. Cross striation spacing was calculated according to the variation of PO43− peak intensity. The measurements showed a characteristic length between two...

Read More thumbnail image: Cross striation in human permanent and deciduous enamel measured with confocal Raman microscopy

Study of pancreatic lipase inhibition kinetics and LC–QTOF–MS‐based identification of bioactive constituents of Momordica charantia fruits

Published: Jan 9, 2019

Author(s): Joydeb Chanda, Pulok K. Mukherjee, Rajarshi Biswas, Dipankar Malakar, Manoj Pillai

Journal: Biomedical Chromatography

Abstract The different parts of Momordica charantia have been reported to have several therapeutic applications against hyperglycemia and hypercholesterolemia associated with pancreatic lipase (PL). Inhibition of this enzyme prevents the absorption of dietary triglyceride in the intestine, and thus exerts an anti‐obesity effect. This study aimed to investigate the bioactive constituents of the fruits of M. charantia (MCF) extract and fractions against pancreatic PL followed by study of their...

Read More thumbnail image: Study of pancreatic lipase inhibition kinetics and LCQTOFMSbased identification of bioactive constituents of Momordica charantia fruits

Electrophoresis of megaDalton proteins inside colloidal silica

Published: Jan 9, 2019

Author(s): Tamika S. Ragland, Melody D. Gossage, Michael D. Furtaw, Jon P. Anderson, David L. Steffens, Mary J. Wirth

Journal: ELECTROPHORESIS

Abstract With the growth of the biopharmaceutical industry, there is a need for rapid size‐analysis of proteins on the megaDalton scale. The large pore sizes needed for such separations cannot be easily reached by pushing the current limits of size‐exclusion chromatography or gel electrophoresis. The concept detailed here is the formation of arbitrarily wide pores by packing nonporous colloidal silica in capillaries. This method can be called packed‐capillary electrophoresis, or “pCE”....

Read More thumbnail image: Electrophoresis of megaDalton proteins inside colloidal silica

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

Published: Jan 9, 2019

Author(s): Ziwen Yuan, Lijia Zhong, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Xiaosong Zhang, Yanqiao Wen, Lihong Yang, Yanming Wei

Journal: Biomedical Chromatography

Abstract Angelica sinensis (Danggui, DG) parched with alcohol (Jiu Danggui, JDG) and charred DG are the main processed products of DG, which are used to treat blood stasis syndrome (BSS). However, their therapeutic effect and mechanisms are still unclear. Based on an acute rat BSS model, the intervention effects of DG and its processed products (DGPPs) were evaluated by the hemorheology and coagulation function parameters. Meanwhile, plasma and urine metabolites were detected and analyzed by...

Read More thumbnail image: Metabolomics study on promoting blood circulation and ameliorating blood stasis Investigating the mechanism of Angelica sinensis and its processed products

Application of mass spectrometry in silkworm research—Review

Published: Jan 8, 2019

Author(s): Fan Sun, Chong Jun Ye, Bing Li, Taichu Wang, Tao Fan

Journal: Biomedical Chromatography

Abstract In this first mass spectrometry‐focused review paper, we will review current applications of mass spectrometry in the area of silkworm research. We will focus our review on the following two most important areas as they are currently being researched by scientists. Firstly, the proteomics of proteins in the process of silkworm lifecycle has generated knowledge about previous undetected proteins, some of which might possess therapeutic effects. Secondly, fatty acids, which are the...

Read More thumbnail image: Application of mass spectrometry in silkworm researchReview

Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3‐MeO‐PCP, doxylamine, and chlormequat

Published: Jan 8, 2019

Author(s): Sophie Allard, Pierre‐Marie Allard, Isabelle Morel, Thomas Gicquel

Journal: Drug Testing and Analysis

Abstract Untargeted toxicological screening is an analytical challenge, given the high number of molecules and metabolites to be detected and the constant appearance of new psychoactive substances (NPS). The combination of liquid chromatography with high‐resolution tandem mass spectrometry (HRMS/MS) in a data‐dependent acquisition mode generates a large volume of high quality spectral data. Commercial software for processing MS data acquired during untargeted screening experiments usually...

Read More thumbnail image: Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3MeOPCP doxylamine and chlormequat

Cisplatin interacting with buffering media and cysteine: Molecular insight due to Raman microspectroscopy

Published: Jan 8, 2019

Author(s): Karolína M. Šišková

Journal: Journal of Raman Spectroscopy

Abstract The solvation of cisplatin, [Pt(NH3)2Cl2], a widely used chemotherapeutical drug, regarded on molecular level in model media is often overlooked by researchers. It is, however, essential in several aspects. The solvation was monitored by using Raman scattering microspectroscopy. This technique being used for the first time enables us to focus the laser beam several micrometers above the dissolving crystals of cisplatin, allowing to monitor the process of cisplatin dissolution in situ....

Read More thumbnail image: Cisplatin interacting with buffering media and cysteine Molecular insight due to Raman microspectroscopy

Determination of olanzapine for therapeutic drug monitoring in schizophrenia patients by LC/MS method

Published: Jan 7, 2019

Author(s): Mevlut Albayrak, Yucel Kadioglu, Mehmet Emrah Yaman, Onur Senol, Elif Oral

Journal: Biomedical Chromatography

Abstract Olanzapine is an atypical antipsychotic drug from the thienobenzodiazepine family which displays efficacy in patients with schizophrenia and related psychoses. A novel LC/MS method was developed and validated for determination of olanzapine in schizophrenia patients' plasma. A liquid–liquid extraction procedure was carried out using 5 mL diethyl ether–diisopropyl ether mixture (1:1, v/v). Average recovery of the extraction procedure was 94.8%. Chromatographic separation was performed...

Read More thumbnail image: Determination of olanzapine for therapeutic drug monitoring in schizophrenia patients by LCMS method

LC–ESI–MS/MS determination of copanlisib, a novel PI3K inhibitor, in mouse plasma and its application to a pharmacokinetic study in mice

Published: Jan 7, 2019

Author(s): Sreekanth Dittakavi, Ramesh Mullangi

Journal: Biomedical Chromatography

Abstract A sensitive, selective and rapid LC–ESI–MS/MS method has been developed and validated for the quantification of copanlisib in mouse plasma using enasidenib as an internal standard (IS) as per regulatory guideline. Copanlisib and the IS were extracted from mouse plasma using ethyl acetate as an extraction solvent and chromatographed using an isocratic mobile phase (0.2% formic acid–acetonitrile; 25:75, v/v) on a HyPURITY C18 column. Copanlisib and the IS eluted at ~0.95 and 2.00 min,...

Read More thumbnail image: LCESIMSMS determination of copanlisib a novel PI3K inhibitor in mouse plasma and its application to a pharmacokinetic study in mice

Stability and degradation products of imipenem applying high‐resolution mass spectrometry: An analytical study focused on solutions for infusion

Published: Jan 7, 2019

Author(s): Fábio Souza Barbosa, Leonardo Capra Pezzi, Marisa Tsao, Tiago Franco de Oliveira, Sandra Manoela Dias Macedo, Elfrides E.S. Schapoval, Andreas S.L. Mendez

Journal: Biomedical Chromatography

Abstract Carbapenems show recognized instability in aqueous solutions; therefore some care must be taken in their handling and preparation and their use in the hospital environment. The stability and degradation products of imipenem were investigated from conditions that simulate its clinical use. For this, a simple stability‐indicating method by HPLC‐DAD was validated with a focus on the quantitation of drug concentration remaining from infusion solutions (sodium chloride 0.9% and glucose...

Read More thumbnail image: Stability and degradation products of imipenem applying highresolution mass spectrometry An analytical study focused on solutions for infusion

Quantification and pharmacokinetic study of entrectinib in rat plasma using ultra‐performance liquid chromatography tandem mass spectrometry

Published: Jan 7, 2019

Author(s): Qiong Wang, Ping Fang, Lulu Zheng, Lei Ye

Journal: Biomedical Chromatography

Abstract To characterize the preclinical plasma pharmacokinetics of entrectinib, a reproducible and precise assay is necessary. In this study, we developed and validated a simple ultra‐performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) method for the measurement of entrectinib using carbamazepine as the internal standard in rat plasma. Sample preparation was a simple protein precipitation with acetonitrile, then entrectinib was eluted on an Acquity UPLC BEH C18 column...

Read More thumbnail image: Quantification and pharmacokinetic study of entrectinib in rat plasma using ultraperformance liquid chromatography tandem mass spectrometry

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC–QTOF–MS method

Published: Jan 7, 2019

Author(s): David Paul, Shruti Surendran, Patheparapu Chandrakala, Nanjappan Satheeshkumar

Journal: Biomedical Chromatography

Abstract Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co‐administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK‐4/6 primarily metabolized by CYP3A enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague–Dawley rats, a rapid and sensitive UHPLC–QTOF–MS method was...

Read More thumbnail image: An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLCQTOFMS method

Development of a high‐performance liquid chromatography method with fluorescence detection for the routine quantification of tamoxifen, endoxifen and 4‐hydroxytamoxifen in plasma from breast cancer patients

Published: Jan 7, 2019

Author(s): Jorge‐Aarón Rangel‐Méndez, Manlio‐Joaquin Graniel‐Sabido, Juan‐Francisco Sánchez‐Cruz, Rosa Moo‐Puc

Journal: Biomedical Chromatography

Abstract To date, several methods for the quantification of tamoxifen and its metabolites have been developed, most of which employ liquid chromatography tandem–mass spectrometry (LC–MS/MS). These methods are highly sensitive and reproducible, but are also time‐consuming and require expensive equipment; one of their main disadvantages is matrix ionization effects. A more viable option, particularly in developing countries, is high‐performance liquid chromatography coupled with UV or...

Read More thumbnail image: Development of a highperformance liquid chromatography method with fluorescence detection for the routine quantification of tamoxifen endoxifen and 4hydroxytamoxifen in plasma from breast cancer patients
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