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Material processed with 58,000‐year‐old grindstones from Sibudu (KwaZulu‐Natal, South Africa) identified by means of Raman microspectroscopy

Published: Feb 27, 2018

Author(s): Marine Wojcieszak

Journal: Journal of Raman Spectroscopy

Abstract Despite their high potential for understanding past human behaviours, the study of grindstones is limited in the literature compared with other forms of lithic tools. This paper reports the combination of optical microscopy and Raman microspectroscopy for understanding the uses of a selection of six grindstones from the post‐Howiesons Poort layers at Sibudu, South Africa, dating to 58,000 years ago. Five of the...

Read More thumbnail image: Material processed with 58000yearold grindstones from Sibudu KwaZuluNatal South Africa identified by means of Raman microspectroscopy

Raman spectroscopy coupled to chemometrics to discriminate provenance and geological age of amber

Published: Feb 27, 2018

Author(s): Manuel David Peris‐Díaz, Barbara Łydżba‐Kopczyńska, Enrique Sentandreu

Journal: Journal of Raman Spectroscopy

Abstract Raman spectroscopy coupled to partial least squares (PLS) was used for the classification of amber samples according to their provenance and geological age. Spectral data were from samples from Czech Republic, Baltic region, and objects dated back from Upper Cretaceous and Cenozoic ages. Intensity ratio of two wavenumbers has been used as indicator of both geological age and provenance amber so far. ...

Read More thumbnail image: Raman spectroscopy coupled to chemometrics to discriminate provenance and geological age of amber

A comparison of pulsed and continuous lasers for high‐temperature Raman measurements of anhydrite

Published: Feb 27, 2018

Author(s): John Kirtley, Victoria Leichner, Benjamin R. Anderson, Hergen Eilers

Journal: Journal of Raman Spectroscopy

Abstract Oxygen carrier particles (OCPs) serve as fuel oxidant in emerging chemical looping combustion systems. However, chemical looping combustion process optimization is hindered by the lack of online sensors for measurements of OCP oxidation states at temperatures up to 1,000 °C and pressures up to 10 atm. We are investigating Raman spectroscopy as a potential solution, as this technique is known for its ability to...

Read More thumbnail image: A comparison of pulsed and continuous lasers for hightemperature Raman measurements of anhydrite

Quantification of acyclovir in dermal interstitial fluid and human serum by ultra‐high‐performance liquid–high‐resolution tandem mass spectrometry for topical bioequivalence evaluation

Published: Feb 27, 2018

Author(s): Denise Schimek, Reingard Raml, Kevin A. Francesconi, Manfred Bodenlenz, Frank Sinner

Journal: Biomedical Chromatography

Abstract Time–concentration curves for the topical anti‐viral drug acyclovir can provide valuable information for drug development. Open flow microperfusion is used for continuous sampling of dermal interstitial fluid but it requires validated methods for subsequent sample analysis. Therefore, we developed a sensitive, selective and high‐throughput ultra‐high‐performance liquid chromatography–high‐resolution tandem mass spectrometry...

Read More thumbnail image: Quantification of acyclovir in dermal interstitial fluid and human serum by ultrahighperformance liquidhighresolution tandem mass spectrometry for topical bioequivalence evaluation

Feasibility of peak volume algorithm in electrothermal vaporization microwave plasma atomic emission spectrometry

Published: Feb 27, 2018

Author(s): Jin Shan, Wei Jin, Bingwen Yu, Yangwei Ying, Dan Zhu, Haixiang Yu, Yuwei Yan, Qinhan Jin

Journal: Journal of Chemometrics

Abstract Electro‐thermal vaporization has served as an alternative sample introduction method in atomic spectrometry for some time and provided a better solution for quick analysis of complicated samples because of its high sensitivity and effective separation of analyte from matrix materials. The quick heating process produces sharp signals that can provide much better limits of detection with significant improvements compared with...

Read More thumbnail image: Feasibility of peak volume algorithm in electrothermal vaporization microwave plasma atomic emission spectrometry

Material data mining in Nianyi Chen's scientific family

Published: Feb 27, 2018

Author(s): Wencong Lu, Wei Lv, Qing Zhang, Kailiang Lu, Xiaobo Ji

Journal: Journal of Chemometrics

Abstract The origin of the material data mining (MDM) field in China can be traced back to Professor Nianyi Chen's pioneering contributions in the 80s of the 20th century. His scientific protégés have inherited his research legacy and been continuously pursuing research in this field. The present article provides an overview on the MDM research conducted by Nianyi Chen's scientific family, by reviewing these achievements of the...

Read More thumbnail image: Material data mining in Nianyi Chens scientific family

Growth hormone isoform‐differential mass spectrometry for doping control purposes

Published: Feb 26, 2018

Author(s): Cristian Arsene, Dirk Schulze, Anita Röthke, Mario Thevis, André Henrion

Journal: Drug Testing and Analysis

Abstract Mass spectrometry (MS) allows for monitoring growth hormone (GH) isoform compositions at high specificity. It is demonstrated that this capability can be used to reliably detect alterations as elicited by (putative) doping with 22 kDa‐GH. Sample treatment consists of enzymatic protein cleavage, followed by 2‐step liquid chromatography clean‐up, prior to analysis by MS. The protocol does not depend on antibodies for...

Read More thumbnail image: Growth hormone isoformdifferential massspectrometry for doping control purposes

Computational Tools for the Identification and Interpretation of Sequence Motifs in Immunopeptidomes

Published: Feb 26, 2018

Author(s): Bruno Alvarez, Carolina Barra, Morten Nielsen, Massimo Andreatta

Journal: PROTEOMICS

Abstract Recent advances in proteomics and mass‐spectrometry have widely expanded the detectable peptide repertoire presented by major histocompatibility complex (MHC) molecules on the cell surface, collectively known as the immunopeptidome. Finely characterizing the immunopeptidome brings about important basic insights into the mechanisms of antigen presentation, but can also reveal promising targets for vaccine development and...

Read More thumbnail image: Computational Tools for the Identification and Interpretation of Sequence Motifs in Immunopeptidomes

Rapid characterization of chemical constituents and metabolites of Qi‐Jing‐Sheng‐Bai granule by using UHPLC–Q‐TOF‐MS

Published: Feb 23, 2018

Author(s): Ran Wu, Shan Lin, Jinxin Wang, Saisai Tian, Xisong Ke, Yi Qu, Xinhui Tian, Xiaopo Qi, Ji Ye, Weidong Zhang

Journal: Journal of Separation Science

Abstract Qi‐Jing‐Sheng‐Bai granule is an effective traditional Chinese medicine formula that has been widely used for the treatment of leukopenia post radiotherapy or chemotherapy. However, its chemical constituents were still unclear, which hindered interpreting bioactive constituents and studying integrative mechanisms. In this study, we developed a three‐step strategy to characterize the chemical constituents and metabolites of...

Read More thumbnail image: Rapid characterization of chemical constituents and metabolites of QiJingShengBai granule by using UHPLCQTOFMS

2DE Gels: A Story of Love and Hate in Proteomics

Published: Feb 23, 2018

Author(s): Daniel Martins‐de‐Souza

Journal: PROTEOMICS

Read More thumbnail image: 2DE Gels A Story of Love and Hate in Proteomics

The Role of Mass Spectrometry and Proteogenomics in the Advancement of HLA Epitope Prediction

Published: Feb 23, 2018

Author(s): Amanda L. Creech, Ying S. Ting, Scott P. Goulding, John F.K. Sauld, Dominik Barthelme, Michael S. Rooney, Terri A. Addona, Jennifer G. Abelin

Journal: PROTEOMICS

Abstract A challenge in developing personalized cancer immunotherapies is the prediction of putative cancer‐specific antigens. Currently, predictive algorithms are used to infer binding of peptides to human leukocyte antigen (HLA) heterodimers to aid in the selection of putative epitope targets. One drawback of current epitope prediction algorithms is that they are trained on datasets containing biochemical HLA‐peptide binding data...

Read More thumbnail image: The Role of Mass Spectrometry and Proteogenomics in the Advancement of HLA Epitope Prediction

Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

Published: Feb 23, 2018

Author(s): Helena M. Bijen, Chopie Hassan, Michel G. D. Kester, George M. C. Janssen, Pleun Hombrink, Arnoud H. Ru, Jan Wouter Drijfhout, Hugo D. Meiring, Ad P. Jong, J. H. Frederik Falkenburg, Connie R. Jimenez, Mirjam H. M. Heemskerk, Peter A. Veelen

Journal: PROTEOMICS

Abstract Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on induction of graft versus leukemia by donor lymphocytes. Both graft versus leukemia and graft versus host disease are induced by T cells reactive against polymorphic peptides, called minor histocompatibility antigens (MiHA), which differ between patient and donor and are...

Read More thumbnail image: Specific TCell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

Sensitive and rapid determination of pyrethroids in human blood by gas chromatography–tandem mass spectrometry with ultrasound‐assisted dispersive liquid‐liquid microextraction

Published: Feb 23, 2018

Author(s): Xue Gao, Hao Guo, Junwei Wang, Qingbiao Zhao

Journal: Drug Testing and Analysis

Abstract In this study, a sensitive and fast procedure of ultrasonic‐assisted dispersive liquid‐liquid microextraction (UADLLME) coupled with gas chromatography–tandem mass spectrometry (GC–MS/MS) for the determination of major pyrethroid pesticides (permethrin, tetramethrin, bifenthrin, fenvalerate, flucythrinate, fluvalinate, fenpropathrin, deltamethrin, and cyhalothrin) in blood samples was developed. Response surface methodology...

Read More thumbnail image: Sensitive and rapid determination of pyrethroids in human blood by gas chromatographytandem mass spectrometry with ultrasoundassisted dispersive liquidliquid microextraction

The chemistry and pharmacology of synthetic cannabinoid SDB‐006 and its regioisomeric fluorinated and methoxylated analogs

Published: Feb 23, 2018

Author(s): Samuel D. Banister, Alexander Olson, Matthew Winchester, Jordyn Stuart, Amelia R. Edington, Richard C. Kevin, Mitchell Longworth, Marco Herrera, Mark Connor, Iain S. McGregor, Roy R. Gerona, Michael Kassiou

Journal: Drug Testing and Analysis

Abstract Synthetic cannabinoids are the largest and most structurally diverse class of new psychoactive substances, with manufacturers often using isomerism to evade detection and circumvent legal restriction. The regioisomeric methoxy‐ and fluorine‐substituted analogs of SDB‐006 (N‐benzyl‐1‐pentyl‐1H‐indole‐3‐carboxamide) were synthesized and could not be differentiated by gas chromatography–mass spectrometry (GC–MS), but were...

Read More thumbnail image: The chemistry and pharmacology of synthetic cannabinoid SDB006 and its regioisomeric fluorinated and methoxylated analogs

Comparative pharmacokinetics of trandolapril, its active metabolite, and verapamil in human plasma of Egyptian population using HPLC–MS/MS

Published: Feb 23, 2018

Author(s): Ragaa Magdy, Ahmed H. El‐Khatib, Ahmed Hemdan, Omar Abd Elaziz, Maha Farouk, Michael W. Linscheid

Journal: Drug Testing and Analysis

Abstract Trandolapril and verapamil are commonly used antihypertensive drugs. However, there is a lack of available data on the change of their pharmacokinetics in patients with liver or kidney impairment and hence the need for dose adjustment. In this article, a high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method was developed and validated for the monitoring of trandolapril, its active metabolite...

Read More thumbnail image: Comparative pharmacokinetics of trandolapril its active metabolite and verapamil in human plasma of Egyptian population using HPLCMSMS

Quantification, dissipation behavior and risk assessment of ethion in green pea by gas chromatography‐electron capture detector

Published: Feb 23, 2018

Author(s): Ishrat Jan, Alamgir A. Dar, Sofi Mubashir, Ashraf Alam Wani, Malik Mukhtar, Khurshid A. Sofi, Irshad H. Dar, Javid A. Sofi

Journal: Journal of Separation Science

Abstract Residue investigation was carried out to scrutinize the persistence, dissipation behavior, half‐life, and risk assessment of ethion on green pea fruit by spraying ethion at the fruiting stage followed by another application at 10 day intervals. The samples were extracted by using a quick, easy, low‐cost, effective, rugged, and safe method, and the residues of ethion were analyzed by gas chromatography with electron capture...

Read More thumbnail image: Quantification dissipation behavior and risk assessment of ethion in green pea by gas chromatographyelectron capture detector

Preparation of iron‐based MIL‐101 functionalized polydopamine@Fe 3 O 4 magnetic composites for extracting sulfonylurea herbicides from environmental water and vegetable samples

Published: Feb 23, 2018

Author(s): Yulan Deng, Ruiqi Zhang, Di Li, Peng Sun, Ping Su, Yi Yang

Journal: Journal of Separation Science

Abstract Here, we describe a simple one‐pot solvothermal method for synthesizing MIL‐101(Fe)@polydopamine@Fe3O4 composites from polydopamine‐modified Fe3O4 particles. The composite was used as a magnetic adsorbent to rapidly extract sulfonylurea herbicides. The herbicides were then analyzed by high‐performance liquid chromatography. The best possible extraction efficiencies were achieved by optimizing the most important extraction parameters,...

Read More thumbnail image: Preparation of ironbased MIL101 functionalized polydopamineFe 3 O 4 magnetic composites for extracting sulfonylurea herbicides from environmental water and vegetable samples

Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

Published: Feb 22, 2018

Author(s): Ping Guo, Jingjing Zhang, Xiaohui Chen, Longshan Zhao

Journal: Biomedical Chromatography

Abstract A molecularly imprinted polymer was synthesized and applied as a sorbent in the solid‐phase extraction device. The imprinted polymer was characterized by fourier‐transform infrared spectroscopy and scanning electron microscope. The results revealed that imprinted polymer possess sensitive selectivity and reliable adsorption properties for five NSAIDs. The imprinted polymer was successfully applied to the pre‐concentration...

Read More thumbnail image: Preparation of dummy templateimprinted polymers for the rapid extraction of nonsteroidal antiinflammatory drugs residues in aquatic environmental samples

Simultaneous LC‐MS/MS bioanalysis of etoposide and paclitaxel in mouse tissues and plasma after oral administration of self‐microemulsifying drug‐delivery systems

Published: Feb 22, 2018

Author(s): Dan Li, Gang Zhao, Weipeng Ai, Gao Li, Luqin Si, Jiangeng Huang, Yunzhou Chen, Sanlan Wu

Journal: Biomedical Chromatography

Abstract In this study, a liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed and validated to simultaneously determine the anticancer drugs etoposide and paclitaxel in mouse plasma and tissues including liver, kidney, lung, heart, spleen and brain. The analytes were extracted from the matrices of interest by liquid–liquid extraction using methyl tert‐butyl ether–dichloromethane (1:1, v/v). Chromatographic separation...

Read More thumbnail image: Simultaneous LCMSMS bioanalysis of etoposide and paclitaxel in mouse tissues and plasma after oral administration of selfmicroemulsifying drugdelivery systems

Silicon carbide nanomaterial as a coating for solid‐phase microextraction

Published: Feb 22, 2018

Author(s): Yu Tian, Juanjuan Feng, Xiuqin Wang, Min Sun, Chuannan Luo

Journal: Journal of Separation Science

Abstract Silicon carbide has excellent properties, such as corrosion resistance, high strength, oxidation resistance, high temperature, and so on. Based on these properties, silicon carbide was coated on stainless‐steel wire and used as a solid‐phase microextraction coating, and polycyclic aromatic hydrocarbons were employed as model analytes. Using gas chromatography, some important factors that affect the extraction efficiency...

Read More thumbnail image: Silicon carbide nanomaterial as a coating for solidphase microextraction
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