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Influence of photoinduced isomerization on the chiral separation of novel liquid crystalline materials with a diazene moiety

Published: Jun 15, 2018

Author(s): Terézia Jurkovičová Vojtylová, Martin Cigl, Petra Tomášková, Věra Hamplová, David Sýkora

Journal: Journal of Separation Science

Abstract The influence of photoinduced isomerization on the enantiomeric separation of two newly synthesized liquid crystalline materials, liquid crystals 1 and 2, was studied by high‐performance liquid chromatography on a chiral stationary phase Chiralpack AD‐3. Both materials have one chiral center and one diazene moiety. The compounds were separated into their E and Z isomeric forms. The conditions and time scale of the...

Read More thumbnail image: Influence of photoinduced isomerization on the chiral separation of novel liquid crystalline materials with a diazene moiety

Rapid analysis of ultraviolet filters using dispersive liquid–liquid microextraction coupled to headspace gas chromatography and mass spectrometry

Published: Jun 15, 2018

Author(s): Stephen A. Pierson, María J. Trujillo‐Rodríguez, Jared L. Anderson

Journal: Journal of Separation Science

Abstract An ionic‐liquid‐based in situ dispersive liquid–liquid microextraction method coupled to headspace gas chromatography and mass spectrometry was developed for the rapid analysis of ultraviolet filters. The chemical structures of five ionic liquids were specifically designed to incorporate various functional groups for the favorable extraction of the target analytes. Extraction parameters including ionic liquid mass, molar...

Read More thumbnail image: Rapid analysis of ultraviolet filters using dispersive liquidliquid microextraction coupled to headspace gas chromatography and mass spectrometry

Fabrication of polymer‐modified magnetic nanoparticle based adsorbents for the capture and release of quinolones by manipulating the metal–coordination interaction

Published: Jun 15, 2018

Author(s): Mingming Zhang, Juan Qiao, Zhenwen Zhao, Shufeng Zhang, Li Qi

Journal: Journal of Separation Science

Abstract Functional polymers with a metal–coordination interaction have been fabricated for sample pretreatment. Poly(N‐4‐vinyl‐benzyl iminodiacetic acid‐co‐methacrylic acid‐co‐styrene)‐modified magnetic nanoparticles were prepared and used as solid‐phase extraction adsorbents for the analysis of quinolones by tuning the metal–coordination interaction. In the construction of the polymer‐based adsorbents, functional monomer (N‐(4‐vinyl)‐benzyl...

Read More thumbnail image: Fabrication of polymermodified magnetic nanoparticle based adsorbents for the capture and release of quinolones by manipulating the metalcoordination interaction

Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer's disease: Amyloid beta peptides and beyond

Published: Jun 15, 2018

Author(s): Giuseppe Grasso

Journal: Mass Spectrometry Reviews

Amyloid‐β peptide (Aβ) accumulation and aggregation have been considered for many years the main cause of Alzheimer's disease (AD), and therefore have been the principal target of investigation as well as of the proposed therapeutic approaches (Grasso [2011] Mass Spectrom Rev. 30: 347‐365). However, the amyloid cascade hypothesis, which considers Aβ accumulation the only causative agent of the disease, has proven to...

Read More thumbnail image: Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimers disease Amyloid beta peptides and beyond

Important considerations for the utilisation of methanolysis in steroid analysis

Published: Jun 14, 2018

Author(s): Marjaana Viljanto, Catarina Horro Pita, James Scarth, Christopher J. Walker, Andrew T. Kicman, Mark C. Parkin

Journal: Drug Testing and Analysis

Abstract The effective analysis of anabolic‐androgenic steroids in urine usually requires a suitable deconjugation method for the analysis of phase II metabolites such as sulphates and glucuronides. Acid hydrolysis using methanolysis is one adopted method of deconjugation that efficiently and rapidly cleaves both sulphates and glucuronides contemporaneously. The formation of artefactual by‐products is a known disadvantage of this...

Read More thumbnail image: Important considerations for the utilisation of methanolysis in steroid analysis

The effect of simulated space radiation on the N ‐glycosylation of human immunoglobulin G1

Published: Jun 14, 2018

Author(s): Mate Szarka, Szabolcs Szilasi, Boglarka Donczo, Daniel Sarkozy, Istvan Rajta, Andras Guttman

Journal: ELECTROPHORESIS

Abstract On a roundtrip to Mars, astronauts are expectedly exposed to an approximate amount of radiation that exceeds the lifetime limits on Earth. This elevated radiation dose is mainly due to Galactic Cosmic Rays and Solar Particle Events. Specific patterns of the N‐glycosylation of human Igs have already been associated with various ailments such as autoimmune diseases, malignant transformation, chronic inflammation, and ageing....

Read More thumbnail image: The effect of simulated space radiation on the N glycosylation of human immunoglobulin G1

Development of a fast CE method for high throughput screening of ecto‐5′‐nucleotidase inhibitors

Published: Jun 14, 2018

Author(s): Rabia Raza, Yu Bai, Huwei Liu

Journal: ELECTROPHORESIS

Abstract Overexpression of ecto‐5′‐nucleotidase is found to be linked to cancer progression and other diseases which makes screening of its inhibitors on demand. Unfortunately, there is scarcity of reported ecto‐5′‐nucleotidase inhibitors because of unavailability of simple, fast and efficient methods to study its inhibition. In this study, we have developed a very fast, reverse polarity capillary electrophoresis based method for...

Read More thumbnail image: Development of a fast CE method for high throughput screening of ecto5nucleotidase inhibitors

Cellulose membrane modified with polypyrrole as an extraction device for the determination of emerging contaminants in river water with gas chromatography–mass spectrometry

Published: Jun 14, 2018

Author(s): Bárbara Viero Noronha, Márcio Fernando Bergamini, Luiz Humberto Marcolino Junior, Bruno José Gonçalves da Silva

Journal: Journal of Separation Science

Abstract In this study, a simple, efficient, and reusable device based on cellulose membranes modified with polypyrrole was developed to extract 14 emerging contaminants from aqueous matrices. For chemical polymerization, a low‐cost cellulose membrane was immersed in 0.1 mol/L pyrrole and 0.5 mol/L ammonium persulfate for 40 min in an ice/water bath. The cellulose membranes modified with polypyrrole were accommodated...

Read More thumbnail image: Cellulose membrane modified with polypyrrole as an extraction device for the determination of emerging contaminants in river water with gas chromatographymass spectrometry

Updating chromatographic predictions by accounting ageing for single and tandem columns

Published: Jun 14, 2018

Author(s): Tamara Alvarez‐Segura, José Ramón Torres‐Lapasió, María Celia García‐Alvarez‐Coque

Journal: Journal of Separation Science

Abstract The most efficient optimization methodologies in liquid chromatography are based on the modeling and prediction of the chromatographic behavior for each compound in the sample. However, when the column suffers some ageing after the modeling process, predictions may differ significantly from the actual separation. Repeating the modeling is especially troublesome when several columns are involved, as is the case of coupled...

Read More thumbnail image: Updating chromatographic predictions by accounting ageing for single and tandem columns

In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins

Published: Jun 14, 2018

Author(s): Jean‐Marc Taymans, Marie‐Christine Chartier‐Harlin

Journal: PROTEOMICS

Abstract Defining a common and specific function for homologs of a novel protein family is not a trivial task. In their recent study, Tomkins and colleagues have addressed this challenge for the ROCO protein family by exploring interactomes of its four human members: MASL1, DAPK1, LRRK1, and LRRK2. ROCO proteins are characterized by a Ras‐GTPase domain embedded in complex multidomain proteins and a functional descriptor for this...

Read More thumbnail image: In silico and Wet Bench Interactomics Sheds Light on the Similitudes and Differences between Human ROCO Proteins

Separation and purification of intermediates for the preparation of naproxen from synthetic mixtures by countercurrent chromatography

Published: Jun 14, 2018

Author(s): Xujun Qiu, Liqiong Lv, Wenyu Sun, Chaoyue Wang, Jizhong Yan, Shengqiang Tong

Journal: Journal of Separation Science

Abstract Three key intermediates in the preparation of the nonsteroidal anti‐inflammatory drug naproxen were successfully separated and purified with high purity from synthetic mixtures by countercurrent chromatography with a selected biphasic solvent system. The biphasic solvent system composed of n‐hexane/ethyl acetate/methanol/water (9:1:9:1, v/v/v/v) was selected according to partition performance of the three components using...

Read More thumbnail image: Separation and purification of intermediates for the preparation of naproxen from synthetic mixtures by countercurrent chromatography

Liquid chromatography coupled with time‐of‐flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements

Published: Jun 14, 2018

Author(s): Yongqiang Liu, Navindra P. Seeram

Journal: Journal of Separation Science

Abstract Pomegranate (Punica granatum L.) fruit and flower extracts, which are rich sources of bioactive phenolics, are widely utilized as ingredients in botanical dietary supplements. While the phenolic characterization of extracts of pomegranate fruit has been previously studied by liquid chromatography with tandem mass spectrometry, there is lack of similar data for pomegranate flowers. Herein, liquid chromatography with...

Read More thumbnail image: Liquid chromatography coupled with timeofflight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements

Ultrafast capillary electrophoresis method for the simultaneous determination of ammonium and diphenhydramine in pharmaceutical samples

Published: Jun 14, 2018

Author(s): Brenda Maria Castro Costa, Mariana Cardoso Marra, Thiago da Costa Oliveira, Rodrigo Alejandro Abarza Munoz, Alex Domingues Batista, Claudimir Lucio do Lago, Eduardo Mathias Richter

Journal: Journal of Separation Science

Abstract Ammonium and diphenhydramine are active ingredients commonly found in the same pharmaceutical preparations. We report, for the first time, a sub‐minute method for the simultaneous determination of ammonium and diphenhydramine. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. Both analytes can be quantified in a single run (∼80 injections/h) using 30 mmol/L...

Read More thumbnail image: Ultrafast capillary electrophoresis method for the simultaneous determination of ammonium and diphenhydramine in pharmaceutical samples

Application of denaturing capillary electrophoresis for the detection of prognostic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes in brain tumors

Published: Jun 14, 2018

Author(s): Lucie Benesova, Barbora Belsanova, Filip Kramar, Tereza Halkova, Vladimir Benes, Marek Minarik

Journal: Journal of Separation Science

Abstract Malignant transformation in gliomas is frequently supplemented by somatic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes. It has recently emerged that mutations in these genes are associated with prolonged survival and should be used as prognostic factor in management of brain cancer patients. There are several approaches in use for the detection of isocitrate dehydrogenase 1 and 2 mutations;...

Read More thumbnail image: Application of denaturing capillary electrophoresis for the detection of prognostic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes in brain tumors

Gold surface plasmon crystal structure based‐on polystyrene template for biosensor application

Published: Jun 13, 2018

Author(s): Min‐Zhuo Cheng, Jing Zhang, Dequan Bao, Xiwei Huang

Journal: ELECTROPHORESIS

Abstract In this communication, we assembled ordered polystyrene (PS) microsphere array as a template with the drop‐coating method, and the oxygen plasma was used to etch the template to adjust the spacing between the PS microspheres. Nano‐triangular gold array and silver nano‐pyramid array were obtained by ion beam sputtering to deposit precious metal gold and silver. We observed the surface morphology of Au and Au/Ag composite...

Read More thumbnail image: Gold surface plasmon crystal structure basedon polystyrene template for biosensor application

CEST MRI of sepsis‐induced acute kidney injury

Published: Jun 13, 2018

Author(s): Jing Liu, Zheng Han, Guoli Chen, Yuguo Li, Jia Zhang, Jiadi Xu, Peter C.M. Zijl, Shuixing Zhang, Guanshu Liu

Journal: NMR in Biomedicine

Sepsis‐induced acute kidney injury (SAKI) is a major complication of kidney disease associated with increased mortality and faster progression. Therefore, the development of imaging biomarkers to detect septic AKI is of great clinical interest. In this study, we aimed to characterize the endogenous chemical exchange saturation transfer (CEST) MRI contrast in the lipopolysaccharide (LPS)‐induced SAKI mouse model and to investigate the use...

Read More thumbnail image: CEST MRI of sepsisinduced acute kidney injury

Reviewer Acknowledgements

Published: Jun 13, 2018

Author(s): John Griffiths

Journal: NMR in Biomedicine

Read More thumbnail image: Reviewer Acknowledgements

An accurate bacterial DNA quantification assay for HTS library preparation of human biological samples

Published: Jun 13, 2018

Author(s): Sarah Seashols‐Williams, Raquel Green, Denise Wohlfahrt, Angela Brand, Antonio Limjuco Tan‐Torres, Francy Nogales, J Paul Brooks, Baneshwar Singh

Journal: ELECTROPHORESIS

Abstract Sequencing and classification of microbial taxa within forensically relevant biological fluids has the potential for applications in the forensic science and biomedical fields. The quantity of bacterial DNA from human samples is currently estimated based on quantity of total DNA isolated. This method can miscalculate bacterial DNA quantity due to the mixed nature of the sample, and consequently library preparation is often...

Read More thumbnail image: An accurate bacterial DNA quantification assay for HTS library preparation of human biological samples

Pressurized hot water extraction of bioactive compounds from artichoke by‐products

Published: Jun 13, 2018

Author(s): Imma Pagano, Anna Lisa Piccinelli, Rita Celano, Luca Campone, Patrizia Gazzerro, Mariateresa Russo, Luca Rastrelli

Journal: ELECTROPHORESIS

Abstract Artichoke by‐products are a suitable source of health‐promoting ingredients for the production of dietary supplements and food additives. A pressurized hot water extraction (PHWE) was developed to recover caffeoylquinic acids (CQAs) and flavone glycosides (FLs) from agro‐industrial artichoke by‐products. The main factors influencing PHWE efficiency and CQA isomerization (temperature, numbers of cycles, modifier, and...

Read More thumbnail image: Pressurized hot water extraction of bioactive compounds from artichoke byproducts

Electromembrane extraction and capillary electrophoresis with capacitively coupled contactless conductivity detection: Multi‐extraction capabilities to analyses trace metals from saline samples

Published: Jun 13, 2018

Author(s): Macarena Silva, Carolina Mendiguchía, Carlos Moreno, Pavel Kubáň

Journal: ELECTROPHORESIS

Abstract Simultaneous electromembrane extraction (EME) of six trace metal cations (Cu2+, Zn2+, Co2+, Ni2+, Pb2+, Cd2+) from saline samples was investigated. CE with capacitively coupled contactless conductivity detection (C4D) was used to determine the metals in acceptor solutions due to its excellent compatibility with the minute volumes of acceptor solutions. Bis(2‐ethylhexyl)phosphate (DEHPA) was selected as a suitable nonselective modifier for EME...

Read More thumbnail image: Electromembrane extraction and capillary electrophoresis with capacitively coupled contactless conductivity detection Multiextraction capabilities to analyses trace metals from saline samples
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