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T 1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate‐ 13 C

Published: Jun 27, 2017

Author(s): Francisco M. Martínez‐Santiesteban, Thien Phuoc Dang, Heeseung Lim, Albert P. Chen, Timothy J. Scholl

Journal: NMR in Biomedicine

In vivo pH mapping in tissue using hyperpolarized hydrogencarbonate‐13C has been proposed as a method to study tumor growth and treatment and other pathological conditions related to pH changes. The finite spin–lattice relaxation times (T1) of hyperpolarized media are a significant limiting factor for in vivo imaging. Relaxation times can be measured at standard magnetic fields (1.5 T, 3.0 T etc.), but no such data are available at low...

Read More thumbnail image: T 1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate 13 C

Chromatographic analysis of tryptophan metabolites

Published: Jun 26, 2017

Author(s): Ilona Sadok, Andrzej Gamian, Magdalena Maria Staniszewska

Journal: Journal of Separation Science

The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate‐limiting enzymes indoleamine 2,3‐dioxygenase, or tryptophan 2,3‐dioxygenase, depending on the tissue. The balanced kynurenine metabolism, which has been a subject of multiple studies...

Read More thumbnail image: Chromatographic analysis of tryptophan metabolites

Dispersive liquid–liquid microextraction of phenolic compounds from vegetable oils using a magnetic ionic liquid

Published: Jun 26, 2017

Author(s): Shuqiang Zhu, Lijun Wang, Along Su, Haixia Zhang

Journal: Journal of Separation Science

A novel method was developed for the determination of two endocrine‐disrupting chemicals, bisphenol A and 4‐nonylphenol, in vegetable oil by dispersive liquid–liquid microextraction followed by ultra high performance liquid chromatography with tandem mass spectrometry. Using a magnetic liquid as the microextraction solvent, several key parameters were optimized, including the type and volume of the magnetic liquid, extraction time, amount...

Read More thumbnail image: Dispersive liquidliquid microextraction of phenolic compounds from vegetable oils using a magnetic ionic liquid

Proteomic profiling of the hypothalamus in two mouse models of narcolepsy

Published: Jun 26, 2017

Author(s): Sausan Azzam, Daniela Schlatzer, David Nethery, Dania Saleh, Xiaolin Li, Afaf Akladious, Mark R. Chance, Kingman P. Strohl

Journal: PROTEOMICS

Narcolepsy is a disabling neurological disorder of sleepiness linked to the loss of neurons producing orexin neuropeptides in the hypothalamus. Two well‐characterized phenotypic mouse models of narcolepsy, loss‐of‐function (orexin‐knockout), and progressive loss of orexin (orexin/ataxin‐3) exist. The open question is whether the proteomics signatures of the hypothalamus would be different between the two models. To address this gap, we...

Read More thumbnail image: Proteomic profiling of the hypothalamus in two mouse models of narcolepsy

Separation of single‐base sequential isomers of single‐stranded DNA by capillary electrophoresis and its application in the discrimination of single‐base DNA mutations

Published: Jun 26, 2017

Author(s): Takao Sakurai, Hitoshi Hoshino, Toru Takahashi

Journal: Journal of Separation Science

Separation of single‐base substitution sequential DNA isomers remains one of the most challenging tasks in DNA separation by capillary electrophoresis. We developed a simple, versatile capillary electrophoresis technique for the separation of single‐base sequential isomers of DNA having the same chain length. This technique is based on charge differences resulting from the different protonation (acid dissociation) properties of the four...

Read More thumbnail image: Separation of singlebase sequential isomers of singlestranded DNA by capillary electrophoresis and its application in the discrimination of singlebase DNA mutations

Application of capability indices and control charts in the analytical method control strategy

Published: Jun 26, 2017

Author(s): Alexis Oliva, Matías Llabres Martinez

Journal: Journal of Separation Science

In this study, we assessed the usefulness of control charts in combination with the process capability indices, Cpm and Cpk, in the control strategy of an analytical method. The traditional X‐chart and moving range chart were used to monitor the analytical method over a 2‐year period. The results confirmed that the analytical method is in‐control and stable. Different criteria were used to establish the specifications limits (i.e. analyst...

Read More thumbnail image: Application of capability indices and control charts in the analytical method control strategy

Efficient approach for the extraction of proanthocyanidins from Cinnamomum longepaniculatum leaves using ultrasonic irradiation and an evaluation of their inhibition activity on digestive enzymes and antioxidant activity in vitro

Published: Jun 23, 2017

Author(s): Zaizhi Liu, Kailin Mo, Shimin Fei, Yuangang Zu, Lei Yang

Journal: Journal of Separation Science

Proanthocyanidins were separated for the first time from Cinnamomum longepaniculatum leaves. An experiment‐based extraction strategy was used to research the efficiency of an ultrasound‐assisted method for proanthocyanidins extraction. The Plackett–Burman design results revealed that the ultrasonication time, ultrasonic power and liquid/solid ratio were the most significant parameters among the six variables in the extraction process. Upon further ...

Read More thumbnail image: Efficient approach for the extraction of proanthocyanidins from Cinnamomum longepaniculatum leaves using ultrasonic irradiation and an evaluation of their inhibition activity on digestive enzymes and antioxidant activity in vitro

Trypsin inhibitor screening in traditional Chinese medicine by using an immobilized enzyme microreactor in capillary and molecular docking study

Published: Jun 23, 2017

Author(s): Mengxia Cheng, Zilin Chen

Journal: Journal of Separation Science

A trypsin immobilized enzyme microreactor was successfully prepared in capillary for studying enzyme kinetics of trypsin and online screening of trypsin inhibitors from traditional Chinese medicine through capillary electrophoresis. Trypsin was immobilized on the inner wall at the inlet of the capillary treated with polydopamine. The rest of the capillary was used as a separation channel. The parameters including the separation efficiency...

Read More thumbnail image: Trypsin inhibitor screening in traditional Chinese medicine by using an immobilized enzyme microreactor in capillary and molecular docking study

Development of a novel hollow‐fiber liquid‐phase microextraction based on oil‐in‐salt and its comparison with conventional one

Published: Jun 23, 2017

Author(s): Miao‐miao Li, Shuang Hu, Xuan Chen, Xiao‐hong Bai

Journal: Journal of Separation Science

A novel hollow‐fiber liquid‐phase microextraction based on oil‐in‐salt was proposed and introduced for the simultaneous extraction and enrichment of the main active compounds of hesperidin, honokiol, shikonin, magnolol, emodin, and β,β′‐dimethylacrylshikonin in a formula of Zi‐Cao‐Cheng‐Qi decoction and the single herb, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Radix et Rhizoma, and Lithospermum erythrorhizon, composing the formula...

Read More thumbnail image: Development of a novel hollowfiber liquidphase microextraction based on oilinsalt and its comparison with conventional one

Direct comparison of high‐temporal‐resolution CINE MRI with Doppler ultrasound for assessment of diastolic dysfunction in mice

Published: Jun 23, 2017

Author(s): Thomas A. Roberts, Anthony N. Price, Laurence H. Jackson, Valerie Taylor, Anna L. David, Mark F. Lythgoe, Daniel J. Stuckey

Journal: NMR in Biomedicine

Diastolic dysfunction is a sensitive early indicator of heart failure and can provide additional data to conventional measures of systolic function. Transmitral Doppler ultrasound, which measures the one‐dimensional flow of blood through the mitral valve, is currently the preferred method for the measurement of diastolic function, but the measurement of the left ventricular volume changes using high‐temporal‐resolution cinematic magnetic...

Read More thumbnail image: Direct comparison of hightemporalresolution CINE MRI with Doppler ultrasound for assessment of diastolic dysfunction in mice

Uncorrelated component analysis on manifold for statistical process monitoring

Published: Jun 23, 2017

Author(s): Qilong Jia, Yingwei Zhang, Lirong Zhai, Lin Feng

Journal: Journal of Chemometrics

A novel process modeling approach referred to as locally invariant uncorrelated component analysis (LIUCA) is proposed for the purpose of statistical process monitoring. The contributions are as follows: (1) LIUCA intends to find a part‐based representation subspace in which two data points are close to each other, if they are close in the k‐nearest neighbor graph; (2) LIUCA can exploit the geometrical structure of the data space, which will improve...

Read More thumbnail image: Uncorrelated component analysis on manifold for statistical process monitoring

Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium

Published: Jun 23, 2017

Author(s): Linlu Qi, Mo Hu, Jiaqi Fu, Yanhua Liu, Mei Wu, Kaiwen Yu, Xiaoyun Liu

Journal: PROTEOMICS

Systems‐level analyses have the capability to offer new insight into host–pathogen interactions on the molecular level. Using Salmonella infection of host epithelial cells as a model system, we previously analyzed intracellular bacterial proteome as a window into pathogens’ adaptations to their host environment [Infect. Immun. 2015; J. Proteome Res. 2017]. Herein we extended our efforts to quantitatively examine protein expression of host cells...

Read More thumbnail image: Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium

Proteomic analysis of hair shafts from monozygotic twins: Expression profiles and genetically variant peptides

Published: Jun 23, 2017

Author(s): Pei‐Wen Wu, Katelyn E. Mason, Blythe P. Durbin‐Johnson, Michelle Salemi, Brett S. Phinney, David M. Rocke, Glendon J. Parker, Robert H. Rice

Journal: PROTEOMICS

Forensic association of hair shaft evidence with individuals is currently assessed by comparing mitochondrial DNA haplotypes of reference and casework samples, primarily for exclusionary purposes. Present work tests and validates more recent proteomic approaches to extract quantitative transcriptional and genetic information from hair samples of monozygotic twin pairs, which would be predicted to partition away from unrelated individuals...

Read More thumbnail image: Proteomic analysis of hair shafts from monozygotic twins Expression profiles and genetically variant peptides

Ephedra alkaloid contents of Chinese herbal formulae sold in Taiwan

Published: Jun 23, 2017

Author(s): Chih‐Wei Chang, Szu‐Yun Hsu, Guan‐Qian Huang, Mei‐Chich Hsu

Journal: Drug Testing and Analysis

Consumption of Ephedra alkaloids is prohibited in‐competition by the World Anti‐Doping Agency (WADA). In Taiwan, colds are often treated with Chinese herbal formulae containing Herba Ephedrae. We screened products sold in Taiwan and preliminarily assessed their relationships with WADA threshold violations. Fifty‐six concentrated powder products, including 19 Chinese herbal formulae that contained Herba Ephedrae, were collected. The...

Read More thumbnail image: Ephedra alkaloid contents of Chinese herbal formulae sold in Taiwan

Diffusion MRI microstructure models with in vivo human brain Connectome data: results from a multi‐group comparison

Published: Jun 23, 2017

Author(s): Uran Ferizi, Benoit Scherrer, Torben Schneider, Mohammad Alipoor, Odin Eufracio, Rutger H.J. Fick, Rachid Deriche, Markus Nilsson, Ana K. Loya‐Olivas, Mariano Rivera, Dirk H.J. Poot, Alonso Ramirez‐Manzanares, Jose L. Marroquin, Ariel Rokem, Christian Pötter, Robert F. Dougherty, Ken Sakaie, Claudia Wheeler‐Kingshott, Simon K. Warfield, Thomas Witzel, Lawrence L. Wald, José G. Raya, Daniel C. Alexander

Journal: NMR in Biomedicine

A large number of mathematical models have been proposed to describe the measured signal in diffusion‐weighted (DW) magnetic resonance imaging (MRI). However, model comparison to date focuses only on specific subclasses, e.g. compartment models or signal models, and little or no information is available in the literature on how performance varies among the different types of models. To address this deficiency, we organized the ‘White...

Read More thumbnail image: Diffusion MRI microstructure models with in vivo human brain Connectome data results from a multigroup comparison

Influence of bleaching and coloring on ethyl glucuronide content in human hair

Published: Jun 22, 2017

Author(s): Silvana Petzel‐Witt, Werner Pogoda, Cora Wunder, Alexander Paulke, Manfred Schubert‐Zsilavecz, Stefan W. Toennes

Journal: Drug Testing and Analysis

Ethyl glucuronide (EtG) is increasingly used in forensic toxicology as a marker for alcohol use in analyses of hair samples, especially in abstinence control. Some cosmetic treatments are considered to markedly reduce the EtG content. In view of especially many women with coloured hair the present study was performed to further investigate the effect of a variety of colouring procedures (bleaching, tinting, permanent and semi‐permanent...

Read More thumbnail image: Influence of bleaching and coloring on ethyl glucuronide content in human hair

Syringe‐to‐syringe dispersive liquid‐phase microextraction solidified floating organic drop combined with high‐performance liquid chromatography for the separation and quantification of ochratoxin A in food samples

Published: Jun 22, 2017

Author(s): Mohammad Asadi

Journal: Journal of Separation Science

A new, simple, and rapid syringe‐to‐syringe dispersive liquid‐phase microextraction with solidified floating organic drop was used for the separation and preconcentration of ochratoxin A from grain and juice samples before its quantification using high‐performance liquid chromatography and fluorescence detection. Factors influencing the microextraction efficiency of ochratoxin A, such as sample solution pH, type and volume of organic...

Read More thumbnail image: Syringetosyringe dispersive liquidphase microextraction solidified floating organic drop combined with highperformance liquid chromatography for the separation and quantification of ochratoxin A in food samples

Modified headspace solid‐phase microextraction for the determination of quantitative relationships between components of mixtures consisting of alcohols, esters, and ethers — impact of the vapor pressure difference of the compounds

Published: Jun 22, 2017

Author(s): Andrzej Lech Dawidowicz, Joanna Szewczyk, Michal P. Dybowski

Journal: Journal of Separation Science

The quantitative relationship between analytes established by the headspace solid‐phase microextraction procedure for multicomponent mixtures depends not only on the character and strength of interactions of individual components with solid‐phase microextraction fiber but also on their vapor pressure in the applied headspace solid‐phase microextraction system. This study proves that vapor pressure is of minor importance when the sample is...

Read More thumbnail image: Modified headspace solidphase microextraction for the determination of quantitative relationships between components of mixtures consisting of alcohols esters and ethers  impact of the vapor pressure difference of the compounds

Comparison between chaotropic and detergent‐based sample preparation workflow in tendon for mass spectrometry analysis

Published: Jun 22, 2017

Author(s): Yalda Ashraf Kharaz, Danae Zamboulis, Karen Sanders, Eithne Comerford, Peter Clegg, Mandy Peffers

Journal: PROTEOMICS

Exploring the tendon proteome is a challenging but important task for understanding the mechanisms of physiological/pathological processes during ageing and disease and for the development of new treatments. Several extraction methods have been utilised for tendon mass spectrometry, however different extraction methods have not been simultaneously compared. In the present study we compared protein extraction in tendon with two chaotropic...

Read More thumbnail image: Comparison between chaotropic and detergentbased sample preparation workflow in tendon for mass spectrometry analysis

Aptamer‐functionalized Fe 3 O 4 magnetic nanoparticles as a solid‐phase extraction adsorbent for the selective extraction of berberine from Cortex phellodendri

Published: Jun 22, 2017

Author(s): Ling‐Feng Jiang, Bo‐Cheng Chen, Ben Chen, Xue‐Jian Li, Hai‐Lin Liao, Wen‐Yan Zhang, Lin Wu

Journal: Journal of Separation Science

The extraction adsorbent was fabricated by immobilizing the highly specific recognition and binding of aptamer onto the surface of Fe3O4 magnetic nanoparticles, which not only acted as recognition elements to recognize and capture the target molecule berberine from the extract of Cortex phellodendri, but also could favor the rapid separation and purification of the bound berberine by using an external magnet. The developed solid‐phase...

Read More thumbnail image: Aptamerfunctionalized Fe 3 O 4 magnetic nanoparticles as a solidphase extraction adsorbent for the selective extraction of berberine from Cortex phellodendri
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