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Evaluation of the interaction between hydroxyapatite and bisphosphonate by nonlinear capillary electrochromatography

Published: Mar 27, 2017

Author(s): Deying Kong, Zilin Chen

Journal: Journal of Separation Science

Bisphosphonates are a class of chemical compounds used to treat diseases caused by increased bone resorption. Zoledronate is a third‐generation bisphosphonate drug. Hydroxyapatite is main mineral constituent of bones, which can be bound by bisphosphonates in vivo. In this work, we report a method of nonlinear capillary electrochromatography for study on the interaction between hydroxyapatite and bisphosphonate. Hydroxyapatite was modified...

Read More thumbnail image: Evaluation of the interaction between hydroxyapatite and bisphosphonate by nonlinear capillary electrochromatography

Separation of epimeric aromatic acid (−)‐menthol esters by countercurrent chromatography using hydroxypropyl‐β‐cyclodextrin as an additive

Published: Mar 27, 2017

Author(s): Xiaoping Wang, Liqiong Lv, Zhisi Bu, Jizhong Yan, Shengqiang Tong

Journal: Journal of Separation Science

The separation of ten epimeric aromatic acid (−)‐menthol esters by countercurrent chromatography with hydroxypropyl‐β‐cyclodextrin as the mobile phase additive was investigated, and methods for the analysis of all the epimeric esters by reversed‐phase high‐performance liquid chromatography were established. A biphasic solvent system composed of n‐hexane/20–70% methanol containing 50 mmol/L of hydroxypropyl‐β‐cyclodextrin (1:1, v/v) was selected,...

Read More thumbnail image: Separation of epimeric aromatic acid menthol esters by countercurrent chromatography using hydroxypropylcyclodextrin as an additive

Determination of bifonazole and identification of its photocatalytic degradation products using UPLC‐MS/MS

Published: Mar 26, 2017

Author(s): Agata Kryczyk, Paweł Żmudzki, Urszula Hubicka

Journal: Biomedical Chromatography

Abstract The main goal of the presented work was to investigate the effect of ZnO or/and TiO2 on the stability of bifonazole in solutions under UVA irradiation. To this end, a simple and reproducible UPLC method for the determination of bifonazole in the presence of its photocatalytic degradation products was developed. Linearity was studied in the range of 0.0046–0.15 mg mL−1 with a determination coefficient of 0.9996. Bifonazole underwent a...

Read More thumbnail image: Determination of bifonazole and identification of its photocatalytic degradation products using UPLCMSMS

Long‐chain unsaturated fatty acids as possible important metabolites for primary angle‐closure glaucoma based on targeted metabolomic analysis

Published: Mar 26, 2017

Author(s): Shengzhong Rong, Yang Li, Yue Guan, Lili Zhu, Qiang Zhou, Mucong Gao, Hongzhi Pan, Lina Zou, Dong Chang

Journal: Biomedical Chromatography

Abstract Primary angle‐closure glaucoma (PACG) is a severe chronic neurodegenerative disease in Asia. Identification of important metabolites associated with PACG is crucial for early intervention and advancing knowledge of the disease mechanism. We applied gas chromatography–mass spectrometry (GC‐MS) for targeted metabolomic analysis on serum samples from 38 newly diagnosed PACG patients and 48 controls. Palmitoleic acid (PA),...

Read More thumbnail image: Longchain unsaturated fatty acids as possible important metabolites for primary angleclosure glaucoma based on targeted metabolomic analysis

Combined spiroergometry and 31 P–MRS of human calf muscle during high‐intensity exercise

Published: Mar 24, 2017

Author(s): K. Moll, A. Gussew, C. Hein, N. Stutzig, J.R. Reichenbach

Journal: NMR in Biomedicine

Simultaneous measurements of pulmonary oxygen consumption (VO2), carbon dioxide exhalation (VCO2) and phosphorus magnetic resonance spectroscopy (31P–MRS) are valuable in physiological studies to evaluate muscle metabolism during specific loads. Therefore, the aim of this study was to adapt a commercially available spirometric device to enable measurements of VO2 and VCO2 whilst simultaneously performing 31P–MRS at 3 T. Volunteers performed intense plantar...

Read More thumbnail image: Combined spiroergometry and 31 PMRS of human calf muscle during highintensity exercise

Effects of overlapping electric double layer on mass transport of a macro‐solute across porous wall of a micro/nanochannel for power law fluid

Published: Mar 24, 2017

Author(s): Saikat Bhattacharjee, Mrinmoy Mondal, Sirshendu De

Journal: ELECTROPHORESIS

Effects of overlapping electric double layer and high wall potential on transport of a macrosolute for flow of a power law fluid through a microchannel with porous walls are studied in this work. The electric potential distribution is obtained by coupling the Poisson's equation without considering the Debye–Huckel approximation. The numerical solution shows that the center line potential can be 16% of wall potential at pH 8.5, at wall...

Read More thumbnail image: Effects of overlapping electric double layer on mass transport of a macrosolute across porous wall of a micronanochannel for power law fluid

An overview to nano‐scale analytical techniques: Nano‐liquid chromatography and capillary electrochromatography

Published: Mar 24, 2017

Author(s): Salvatore Fanali

Journal: ELECTROPHORESIS

Nano‐liquid chromatography (nano‐LC) and CEC are microfluidic techniques mainly used for analytical purposes. They have been applied to the separation and analysis of a large number of compounds, e.g., peptides, proteins, drugs, enantiomers, antibiotics, pesticides, nutraceutical, etc. Analytes separation is carried out into capillaries containing selected stationary phase. The mobile phase is moved either by a pump (nano‐LC) or by an...

Read More thumbnail image: An overview to nanoscale analytical techniques Nanoliquid chromatography and capillary electrochromatography

The use of online heart‐cutting high‐performance liquid chromatography coupled with linear ion trap mass spectrometry in the identification of impurities in vidarabine monophosphate

Published: Mar 24, 2017

Author(s): Hang Wang, Tongzhou Xu, Jiaojian Yuan

Journal: Journal of Separation Science

It is difficult to identify unknown impurities in nucleotide analogues by mass spectrometry because mass‐spectrometry‐incompatible mobile phases need to be used to separate the major ingredient from impurities. In this study, vidarabine monophosphate was selected, and unknown impurities were identified by online heart‐cutting two‐dimensional high‐performance liquid chromatography and linear ion trap mass spectrometry. The one‐dimensional...

Read More thumbnail image: The use of online heartcutting highperformance liquid chromatography coupled with linear ion trap mass spectrometry in the identification of impurities in vidarabine monophosphate

Stability studies of potent opioid analgesic, morphine‐6‐ O‐ sulfate in various buffers and biological matrices by HPLC‐DAD analysis

Published: Mar 24, 2017

Author(s): Jai Shankar K. Yadlapalli, Zaineb A.F. Albayati, Narasimha R. Penthala, Howard P. Hendrickson, Peter A. Crooks

Journal: Biomedical Chromatography

Abstract The 6‐O‐sulfate ester of morphine (M6S) has previously been shown to be an analgesic with greater potency and fewer side effects than morphine. However, being a sulfate ester derivative of morphine, the question exists as to whether this compound is stable in biological fluids and tissues with regard to pH‐ and esterase‐mediated degradation. To date, no studies have focused on the stability profile of M6S across the...

Read More thumbnail image: Stability studies of potent opioid analgesic morphine6 O sulfate in various buffers and biological matrices by HPLCDAD analysis

Fe/MCSAC catalysts surface modified with nitrogen DBD non‐thermal plasma for carbonyl sulfide catalytic hydrolysis activity enhancement

Published: Mar 24, 2017

Author(s): Gui Liu, Ping Ning, Feng Lu, Kai Li, Lihong Tang, Xin Song, Huibin Guo, Chi Wang

Journal: Surface and Interface Analysis

The removal of carbonyl sulfide (COS or S=C=O) from gas streams over Fe/microwave coconut‐shell activated carbon (MCSAC) catalysts modified by dielectric barrier discharge non‐thermal plasma (NTP) were investigated. The properties of Fe/MCSAC catalysts modified by NTP in different conditions, included kinds of reactors, treatment times and input voltages. The surface properties were evaluated by means of energy‐dispersive X‐ray...

Read More thumbnail image: FeMCSAC catalysts surface modified with nitrogen DBD nonthermal plasma for carbonyl sulfide catalytic hydrolysis activity enhancement

The addition of clay on the mechanical properties of surface‐treated CF‐filled PA66 composites

Published: Mar 23, 2017

Author(s): Qiuxiang Chang, Haojie Zhao, Runqin He

Journal: Surface and Interface Analysis

Polyamide 66 (PA66) composites filled with clay and carbon fiber (CF) were prepared by twin‐screw extruder in order to study the influence of nanoparticle reinforcing effect on the mechanical behavior of the PA66 composites (CF/PA66). The mechanical property tests of the composites with and without clay were performed, and the fracture surface morphology was analyzed. The results show that the fracture surface area of the clay‐filled...

Read More thumbnail image: The addition of clay on the mechanical properties of surfacetreated CFfilled PA66 composites

Corrosion, wear, and cell culture studies of oxygen ion implanted Ni–Ti alloy

Published: Mar 23, 2017

Author(s): L. Mohan, Manjusha Chakraborty, S. Viswanathan, Chitra Mandal, Parthasarathi Bera, S. T. Aruna, C. Anandan

Journal: Surface and Interface Analysis

To increase the biocompatibility of nickel–titanium (Ni–Ti) alloy substrates, oxygen ions have been implanted by the plasma immersion ion implantation (PIII–O) technique at low temperature without affecting the substrate properties. The implanted Ni–Ti surface is characterized for microhardness and composition. Energy‐dispersive spectroscopy and X‐ray photoelectron spectroscopy investigations show the replacement of native oxide on the...

Read More thumbnail image: Corrosion wear and cell culture studies of oxygen ion implanted NiTi alloy

Surface treatment of 25‐μm Kapton film by ammonia for improvement of TiO 2 /SiO 2 coating's adhesion

Published: Mar 23, 2017

Author(s): Yanru Man, Zhonghua Li, Ming Shu, Kai Liu, Huitao Liu, Yuan Gao

Journal: Surface and Interface Analysis

Due to a smooth hydrophobic surface of Kapton film, it is very difficult to coat an inorganic oxide coating on its surface. In this study, the surface of Kapton was treated by NH3·H2O and silicon coupling agent to improve the polymer surface wettability. Changes in surface hydrophilicity were studied by contact angle measurement. The samples were irradiated by atomic oxygen (AO) in a ground‐based simulation system. TiO2/SiO2 multi‐layer coatings were...

Read More thumbnail image: Surface treatment of 25m Kapton film by ammonia for improvement of TiO 2 SiO 2 coatings adhesion

Chemical composition differentiation of Shen‐Shuai‐Ning granule between combined decoction and separated decoction using HPLC‐DAD‐ESI‐QTOF‐MS

Published: Mar 23, 2017

Author(s): Jianli Liu, Yu Zhang, Yimeng Hao, Ying Zhao, Yanjiao Li, Rulan Qin, Chongning Lv, Jincai Lu

Journal: Biomedical Chromatography

Abstract Shen‐Shuai‐Ning (SSN) granule, a traditional Chinese medicine formula, is widely used in clinical practice for treating chronic renal failure. However, its detailed chemical profile is unknown. Here, HPLC‐ESI‐QTOF‐MS was employed for the systematic chemical analysis of SSN. A total of 52 compounds were identified and the characteristic ions of the compounds were described. Furthermore, chemical consistency between the...

Read More thumbnail image: Chemical composition differentiation of ShenShuaiNing granule between combined decoction and separated decoction using HPLCDADESIQTOFMS

Molecular glycopathology by capillary electrophoresis: Analysis of the N‐glycome of formalin‐fixed paraffin‐embedded mouse tissue samples

Published: Mar 23, 2017

Author(s): Boglarka Donczo, Mate Szarka, Jozsef Tovari, Gyorgyi Ostoros, Eszter Csanky, Andras Guttman

Journal: ELECTROPHORESIS

Capillary electrophoresis with laser‐induced fluorescence (CE‐LIF) detection was used to analyze endoglycosidase released and fluorophore‐labeled N‐glycans from formalin‐fixed paraffin‐embedded (FFPE) mouse tissue samples of lung, brain, heart, spleen, liver, kidney and intestine. The FFPE samples were first deparaffinized followed by solubilization and glycoprotein retrieval. PNGase F mediated release of the N‐linked oligosaccharides was...

Read More thumbnail image: Molecular glycopathology by capillary electrophoresis Analysis of the Nglycome of formalinfixed paraffinembedded mouse tissue samples

Cellular proteomic analysis of porcine circovirus type 2 and classical swine fever virus coinfection in porcine kidney‐15 cells using isobaric tags for relative and absolute quantitation‐coupled LC‐MS/MS

Published: Mar 23, 2017

Author(s): Niu Zhou, Chunmei Fan, Song Liu, Jianwei Zhou, Yulan Jin, Xiaojuan Zheng, Qin Wang, Jue Liu, Hanchun Yang, Jinyan Gu, Jiyong Zhou

Journal: ELECTROPHORESIS

Viral coinfection or superinfection in host has caused public health concern and huge economic losses of farming industry. The influence of viral coinfection on cellular protein abundance is essential for viral pathogenesis. Based on a coinfection model for porcine circovirus type 2 (PCV2) and classical swine fever virus (CSFV) developed previously by our laboratory, isobaric tags for relative and absolute quantitation (iTRAQ)‐coupled...

Read More thumbnail image: Cellular proteomic analysis of porcine circovirus type 2 and classical swine fever virus coinfection in porcine kidney15 cells using isobaric tags for relative and absolute quantitationcoupled LCMSMS

Facile synthesis and application of teicoplanin‐modified magnetic microparticles for enantioseparation

Published: Mar 23, 2017

Author(s): Huijuan Wang, Xuehan An, Xiaojuan Deng, Guosheng Ding

Journal: ELECTROPHORESIS

A facile, mild method for the preparation of teicoplanin (TE) modified Fe3O4 microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe3O4@PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe3O4 MPs. Using the as‐synthesized materials as chiral adsorbents,...

Read More thumbnail image: Facile synthesis and application of teicoplaninmodified magnetic microparticles for enantioseparation

Effective length calibration method for processing the fluorescence signal detected by charge‐coupled device in capillary electrophoresis

Published: Mar 23, 2017

Author(s): Yi Ni, Chenchen Liu, Jin Chen, Qinmiao Chen, Xifang Zhu, Xiaoming Dou

Journal: Journal of Separation Science

A novel method named effective length calibration method has been developed to process the fluorescence signal detected by charge‐coupled device during capillary electrophoresis. The new method treated each pixel as an individual point detector, and effectively binned a large number of pixels into a final electropherogram without losing the narrow detection window defined by a single pixel. Capillary electrophoresis separations of DNA...

Read More thumbnail image: Effective length calibration method for processing the fluorescence signal detected by chargecoupled device in capillary electrophoresis

Rapid determination of trace semicarbazide in flour products by high‐performance liquid chromatography based on a nucleophilic substitution reaction

Published: Mar 23, 2017

Author(s): Tianfu Wei, Gongke Li, Zhuomin Zhang

Journal: Journal of Separation Science

Semicarbazide, a toxic food contaminant, widely exists in food products and it originates from the thermal degradation of a food additive of azodicarbonamide or a metabolite of nitrofurazone abused in meat specimens. Many previous methods for semicarbazide determination usually required expensive instruments, difficult‐to‐prepare monoclonal antibodies, and a long operation time. In this study, a high‐performance liquid chromatography...

Read More thumbnail image: Rapid determination of trace semicarbazide in flour products by highperformance liquid chromatography based on a nucleophilic substitution reaction

Fast and simultaneous determination of 12 polyphenols in apple peel and pulp by using chemometrics‐assisted high‐performance liquid chromatography with diode array detection

Published: Mar 23, 2017

Author(s): Tong Wang, Hai‐Long Wu, Li‐Xia Xie, Li Zhu, Zhi Liu, Xiao‐Dong Sun, Rong Xiao, Ru‐Qin Yu

Journal: Journal of Separation Science

In this work, a smart chemometrics‐enhanced strategy, high‐performance liquid chromatography, and diode array detection coupled with second‐order calibration method based on alternating trilinear decomposition algorithm was proposed to simultaneously quantify 12 polyphenols in different kinds of apple peel and pulp samples. The proposed strategy proved to be a powerful tool to solve the problems of coelution, unknown interferences, and...

Read More thumbnail image: Fast and simultaneous determination of 12 polyphenols in apple peel and pulp by using chemometricsassisted highperformance liquid chromatography with diode array detection
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