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An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Published: Jan 19, 2018

Author(s): Pranov Ramana, Jan Schejbal, Kristof Houthoofd, Johan Martens, Erwin Adams, Patrick Augustijns, Zdenĕk Glatz, Ann Schepdael

Journal: ELECTROPHORESIS

Abstract In this paper, we demonstrate the effectiveness of a new 3D printed magnet holder that enables capture of magnetic microparticles in commercially available capillary electrophoresis equipment with a liquid or air based coolant system. The design as well as the method to capture magnetic microparticles inside the capillary are discussed. This setup was tested at temperature and pH values suitable for performing enzymatic...

Read More thumbnail image: An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

Synthesis of boronate‐functionalized organic‐inorganic hybrid monolithic column for the separation of cis‐diol containing compounds at low pH

Published: Jan 19, 2018

Author(s): Heqing Zhao, Haixia Lyu, Wenfei Qin, Zenghong Xie

Journal: ELECTROPHORESIS

Abstract In this work, an organic‐inorganic hybrid boronate affinity monolithic column was prepared via “one‐pot” process using 4‐vinylphenylboronic acid as organic monomer and divinylbenzene as cross‐linker. The effects of reaction temperature, solvents and composition of organic monomers on the column properties (e.g. morphology, permeability, and mechanical stability) were investigated. A series of test compounds including small...

Read More thumbnail image: Synthesis of boronatefunctionalized organicinorganic hybrid monolithic column for the separation of cisdiol containing compounds at low pH

From micro‐ to macro‐structures in multiple sclerosis: what is the added value of diffusion imaging

Published: Jan 19, 2018

Author(s): Mara Cercignani, Claudia Gandini Wheeler‐Kingshott

Journal: NMR in Biomedicine

Diffusion imaging has been instrumental in understanding damage to the central nervous system as a result of its sensitivity to microstructural changes. Clinical applications of diffusion imaging have grown exponentially over the past couple of decades in many neurological and neurodegenerative diseases, such as multiple sclerosis (MS). For several reasons, MS has been extensively researched using advanced neuroimaging techniques, which...

Read More thumbnail image: From micro to macrostructures in multiple sclerosis what is the added value of diffusion imaging

Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition

Published: Jan 19, 2018

Author(s): Shannon B. Donnola, Connie M. Piccone, Lan Lu, Joshua Batesole, Jane Little, Katherine M. Dell, Chris A. Flask

Journal: NMR in Biomedicine

Chronic kidney disease (CKD) occurs in over one‐third of patients with sickle cell disease (SCD) and can progress to end‐stage renal disease. Unfortunately, current clinical assessments of kidney function are insensitive to early‐stage CKD. Previous studies have shown that diffusion magnetic resonance imaging (MRI) can sensitively detect regional renal microstructural changes associated with early‐stage CKD. However, previous MRI studies...

Read More thumbnail image: Diffusion tensor imaging MRI of sickle cell kidney disease initial results and comparison with iron deposition

Viral Short ORFs and Their Possible Functions

Published: Jan 19, 2018

Author(s): Yaara Finkel, Noam Stern‐Ginossar, Michal Schwartz

Journal: PROTEOMICS

Abstract Definition of functional genomic elements is one of the greater challenges of the genomic era. Traditionally, putative short open reading frames (sORFs) coding for less than 100 amino acids were disregarded due to computational and experimental limitations; however, it has become clear over the past several years that translation of sORFs is pervasive and serves diverse functions. The development of ribosome profiling,...

Read More thumbnail image: Viral Short ORFs and Their Possible Functions

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

Published: Jan 19, 2018

Author(s): Karolina Pietrowska, Diana Anna Dmuchowska, Pawel Krasnicki, Aleksandra Bujalska, Paulina Samczuk, Ewa Parfieniuk, Tomasz Kowalczyk, Malgorzata Wojnar, Zofia Mariak, Adam Kretowski, Michal Ciborowski

Journal: ELECTROPHORESIS

Abstract Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is nowadays frequently implemented to understand pathophysiological processes responsible for disease occurrence and progression. It has also been used recently to study the metabolic composition of aqueous humor (AH). AH is a transparent fluid which...

Read More thumbnail image: An exploratory LCMSbased metabolomics study reveals differences in aqueous humor composition between diabetic and nondiabetic patients with cataract

Rapid screening of inorganic and organic anions in liquid by‐products from hydrothermal treatment of biomass by capillary electrophoresis

Published: Jan 19, 2018

Author(s): Nobutake Nakatani, Alexander Mosqueda, Joan Marc Cabot, Estrella Sanz Rodriguez, Kunio Yoshikawa, Brett Paull

Journal: ELECTROPHORESIS

Abstract A simple and rapid capillary electrophoresis method with capacitively coupled contactless conductivity detection (CE‐C4D) for the simultaneous determination of inorganic and organic anions in liquid product obtained from the hydrothermal treatment of biomass residues is presented. Under the optimal analytical conditions, limits of detection ranged from 1.8 to 9.4 μM for most target solutes and 53 μM for citrate. Relative standard...

Read More thumbnail image: Rapid screening of inorganic and organic anions in liquid byproducts from hydrothermal treatment of biomass by capillary electrophoresis

Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC‐MS/MS and its pharmacokinetic study

Published: Jan 19, 2018

Author(s): Sneha G. Nair, Daxesh P. Patel, Frank J. Gonzalez, Bhargav M. Patel, Puran Singhal, Darshan V. Chaudhary

Journal: Biomedical Chromatography

Abstract A selective, sensitive and rapid ultra‐performance liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of etonogestrel (ENG) and ethinyl estradiol (EE) in human plasma. The analytes and their deuterated internal standards, ENG‐d7 and EE‐d4, were extracted from plasma samples by solid‐phase extraction on HyperSep™ Retain PEP cartridges. The chromatographic...

Read More thumbnail image: Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLCMSMS and its pharmacokinetic study

Metabolic study of paeoniflorin and total paeony glucosides from Paeoniae Radix Rubra in rats by high‐performance liquid chromatography coupled with sequential mass spectrometry

Published: Jan 19, 2018

Author(s): Lijun Zhu, Shanshan Sun, Yanxi Hu, Yufeng Liu

Journal: Biomedical Chromatography

Abstract A clear understanding of the metabolism of Traditional Chinese Medicines is extremely important in their rational clinical application and effective material foundation research. A novel and reliable strategy was performed to find more metabolites of paeoniflorin, determine the metabolites of total paeony glucosides (TPG) by means of determining those metabolites of paeoniflorin, and compare the metabolism differences...

Read More thumbnail image: Metabolic study of paeoniflorin and total paeony glucosides from Paeoniae Radix Rubra in rats by highperformance liquid chromatography coupled with sequential mass spectrometry

Vibrational spectra of the rare‐occurring complex hydrogen arsenate minerals pharmacolite, picropharmacolite, and vladimirite: Dominance of R aman over IR spectroscopy to discriminate arsenate and hydrogen arsenate units

Published: Jan 18, 2018

Author(s): Petre Makreski, Jovica Todorov, Vasil Makrievski, Ljupčo Pejov, Gligor Jovanovski

Journal: Journal of Raman Spectroscopy

Abstract This work represents the first complete experimental and theoretical study of the infrared (IR) spectra of pharmacolite, Ca(AsO3OH)·2H2O; vladimirite, Ca4(AsO3OH)(AsO4)2·4H2O; and picropharmacolite, Ca4Mg(AsO3OH)2(AsO4)2·11H2O. IR spectra, collected at both room and liquid nitrogen temperature, have shown similar spectral view among minerals in the region of ν1 to ν4 modes, surprisingly not involving complexity in vladimirite and picropharmacolite...

Read More thumbnail image: Vibrational spectra of the rareoccurring complex hydrogen arsenate minerals pharmacolite picropharmacolite and vladimirite Dominance of R aman over IR spectroscopy to discriminate arsenate and hydrogen arsenate units

Mapping of Activity through Dichotomic Scores (MADS): A new chemoinformatic approach to detect activity‐rich structural regions

Published: Jan 18, 2018

Author(s): Roberto Todeschini, Viviana Consonni, Davide Ballabio, Francesca Grisoni

Journal: Journal of Chemometrics

Abstract A new chemoinformatic approach, called Mapping of Activity through Dichotomic Scores, is introduced. Its goal is the supervised projection of molecules, represented with strings of binary digits expressing the presence or absence of selected structural features, onto a novel 2‐dimensional space, which highlights regions of active (inactive) molecules of interest. At the same time, variables are projected onto a second...

Read More thumbnail image: Mapping of Activity through Dichotomic Scores MADS A new chemoinformatic approach to detect activityrich structural regions

Raman spectroscopy and density functional theory study of energetically closely separated C 2 ′‐endo and C 3 ′‐endo pentose forms in purine nucleoside analogue drug‐gold conjugates

Published: Jan 18, 2018

Author(s): Erdene‐Ochir Ganbold, Thanh Danh Nguyen, Nguyen Hoang Ly, Sang‐Woo Joo, Linzi Li, B. Moon Kim

Journal: Journal of Raman Spectroscopy

Abstract We performed a vibrational analysis of a cyclin‐dependent kinase inhibitor as an anticancer drug using Raman spectroscopy and quantum mechanical calculations. BMK‐Y101, a purine nucleoside analogue cyclin‐dependent kinase inhibitor, was found to adsorb on gold nanoparticles as evidenced by ultraviolet–visible absorption spectroscopy. Density functional theory (DFT) calculations were introduced to examine the energetic...

Read More thumbnail image: Raman spectroscopy and density functional theory study of energetically closely separated C 2 endo and C 3 endo pentose forms in purine nucleoside analogue druggold conjugates

Basalt fibers functionalized with gold nanoparticles for in‐tube solid‐phase microextraction

Published: Jan 18, 2018

Author(s): Juanjuan Feng, Yu Tian, Xiuqin Wang, Chuannan Luo, Min Sun

Journal: Journal of Separation Science

Abstract Basalt fibers were functionalized with gold nanoparticles and characterized by scanning electron microscopy and energy‐dispersive X‐ray spectroscopy. An in‐tube solid‐phase microextraction device was developed by packing the functionalized basalt fibers in a polyether ether ketone tube. The device was connected into high performance liquid chromatography equipment with a diode array detector to build online enrichment and...

Read More thumbnail image: Basalt fibers functionalized with gold nanoparticles for intube solidphase microextraction

Analysis of bioactive components and multi‐component pharmacokinetics of saponins from the leaves of Panax notoginseng in rat plasma after oral administration by LC–MS/MS

Published: Jan 18, 2018

Author(s): Zhengcai Ju, Jia Li, Han Han, Li Yang, Zhengtao Wang

Journal: Journal of Separation Science

Abstract In this study, simple ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight mass tandem mass spectrometry is used to characterize the absorbed components in rat plasma after the oral administration of saponins from the leaves of Panax notoginseng. Seventeen prototype compounds are structurally characterized. Furthermore, a simple and sensitive liquid chromatography with tandem mass spectrometry...

Read More thumbnail image: Analysis of bioactive components and multicomponent pharmacokinetics of saponins from the leaves of Panax notoginseng in rat plasma after oral administration by LCMSMS

Determination of the clean‐up efficiency of the solid‐phase extraction of rosemary extracts: Application of full‐factorial design in hyphenation with Gaussian peak fit function

Published: Jan 18, 2018

Author(s): Florian Meischl, Christian Günter Kirchler, Michael Andreas Jäger, Christian Wolfgang Huck, Matthias Rainer

Journal: Journal of Separation Science

Abstract We present a novel method for the quantitative determination of the clean‐up efficiency to provide a calculated parameter for peak purity through iterative fitting in conjunction with design of experiments. Rosemary extracts were used and analyzed before and after solid‐phase extraction using a self‐fabricated mixed‐mode sorbent based on poly(N‐vinylimidazole/ethylene glycol dimethacrylate). Optimization was performed by variation of...

Read More thumbnail image: Determination of the cleanup efficiency of the solidphase extraction of rosemary extracts Application of fullfactorial design in hyphenation with Gaussian peak fit function

A validated LC‐MS/MS method for the determination of senkyunolide I in dog plasma and its application to a pharmacokinetic and bioavailability studies

Published: Jan 16, 2018

Author(s): Jin‐Qi Li, Jia‐Feng Wang, Jie Li, Shu‐han Zhang, Dan He, Rong‐Sheng Tong, Shu‐Ya She

Journal: Biomedical Chromatography

Abstract Senkyunolide I is one of the major bioactive components in the herbal medicine Ligusticum chuanxiong. The aim of this study was to develop and validate a fast, simple and sensitive LC‐MS/MS method for the determination of senkyunolide I in dog plasma. The plasma samples were processed with acetonitrile and separated on a Waters Acquity UPLC BEH C18 column (50 × 2.1 mm, 1.7 μm). The mobile phase consisted of 0.1% formic acid aqueous and...

Read More thumbnail image: A validated LCMSMS method for the determination of senkyunolide I in dog plasma and its application to a pharmacokinetic and bioavailability studies

The determination of polycyclic aromatic hydrocarbons in human urine by high‐resolution gas chromatography–mass spectrometry

Published: Jan 16, 2018

Author(s): Sung‐Hee Cho, Sun‐Kyung Lee, Chong Hyeak Kim

Journal: Biomedical Chromatography

Abstract Polycyclic aromatic hydrocarbons (PAHs), organic compounds formed by at least two condensed aromatic rings, are ubiquitous environmental pollutants that are produced by incomplete combustion of organic materials. PAHs have been classified as carcinogenIC to humans by the International Agency for Research on Cancer, because they can bind to DNA, causing mutations. Therefore, the levels of PAHs in human urine can be used as...

Read More thumbnail image: The determination of polycyclic aromatic hydrocarbons in human urine by highresolution gas chromatographymass spectrometry

Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol‐epoxy ring opening reaction

Published: Jan 16, 2018

Author(s): Gaowa Jin, Yanming Liu, Fan Yang, Dongping Yu, Jingyu Yan, Weijia Zhou, Zhimou Guo, Jianhua Zhu, Xinmiao Liang

Journal: Journal of Separation Science

Abstract A silica‐based reversed‐phase stationary phase bonding with phenyl and tetrazole groups was synthesized by thiol‐epoxy ring opening reaction. The bonded groups could not only provide hydrophobic interaction, but also π–π, hydrogen bonding, electrostatic interactions, and so on. The results of characterization with elemental analysis and solid‐state 13C cross‐polarization magic‐angle‐spinning NMR spectroscopy indicated the successful...

Read More thumbnail image: Synthesis and chromatographic evaluation of phenyltetrazole bonded stationary phase based on thiolepoxy ring opening reaction

Determination of sugars and cyclitols isolated from various morphological parts of Medicago sativa L

Published: Jan 16, 2018

Author(s): Hossam Al‐Suod, Ileana‐Andreea Ratiu, Magdalena Ligor, Tomasz Ligor, Bogusław Buszewski

Journal: Journal of Separation Science

Abstract Plant research interest has increased all over the world, and a large body of evidence has been collected to show the huge potential of medicinal plants in various disease treatments. Medicago sativa L., known as alfalfa, is a rich source of biologically active components and secondary metabolites and was frequently used from the ancient times both as fodder crop and as a traditional medicine in the treatment of various diseases....

Read More thumbnail image: Determination of sugars and cyclitols isolated from various morphological parts of Medicago sativa L

Dynamic evaluation of a trilobal capillary‐channeled polymer fiber shape for reversed phase protein separations and comparison to the eight‐channeled form

Published: Jan 16, 2018

Author(s): Lei Wang, Kathryn A. Stevens, Paul Haupt‐Renaud, R. Kenneth Marcus

Journal: Journal of Separation Science

Abstract A new, trilobal‐shaped capillary‐channeled polymer fiber is under development to address the issues of poor A‐term performance of the previous eight‐channeled form. The trilobal geometry should provide better packing homogeneity due to the fewer potential orientations of the symmetric fiber geometry. Comparisons of separation efficiency and peak shape were made between the two fiber shapes through several dynamic...

Read More thumbnail image: Dynamic evaluation of a trilobal capillarychanneled polymer fiber shape for reversed phase protein separations and comparison to the eightchanneled form
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