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Journal Highlight: Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application

Date: Jul 4, 2018

Author: separationsNOW

Indian researchers used fluorescence and photodiode array detectors, with high‐performance liquid chromatography, to determine piribedil, an anti‐Parkinson's drug, in plasma and brain samples from rats.

Read More thumbnail image: Journal Highlight Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application

Journal Highlight: Membrane proteome of invasive retinoblastoma: Differential proteins and biomarkers

Date: Jul 2, 2018

Author: separationsNOW

The first comprehensive quantitative membrane proteomic atlas of the differentially regulated proteins in retinoblastoma compared to the retina has identified potential biomarkers for this childhood cancer.

Read More thumbnail image: Journal Highlight Membrane proteome of invasive retinoblastoma Differential proteins and biomarkers

Graphene oxide nanomaterials: Toxicity mechanisms

Date: Jul 1, 2018

Author: Steve Down

Typical environmental levels of graphene oxide nanoparticles modify the abundances of nearly 250 proteins in zebrafish larvae, tested as a model aquatic species, and bring about malformations and increased mortality, a new proteomics study has revealed.

Read More thumbnail image: Graphene oxide nanomaterials Toxicity mechanisms

Journal Highlight: Microbial and metabolic multi‐omic correlations in systemic sclerosis patients

Date: Jun 25, 2018

Author: separationsNOW

The fecal microbiota and plasma metabolomes of patients with systemic sclerosis have been characterised, showing that a reduced model of nine bacteria can differentiate patients from healthy controls.

Read More thumbnail image: Journal Highlight Microbial and metabolic multiomic correlations in systemic sclerosis patients

Journal Highlight: High‐resolution capillary zone electrophoresis for transferrin glycoform analysis associated with congenital disorders of glycosylation

Date: Jun 25, 2018

Author: separationsNOW

Swiss scientists used high-resolution capillary zone electrophoresis to assess the transferrin profile in blood serum of patients with eight different congenital disorders of glycosylation.

Read More thumbnail image: Journal Highlight Highresolution capillary zone electrophoresis for transferrin glycoform analysis associated with congenital disorders of glycosylation

Journal Highlight: Hydrochemistry of Lake Rara: A high mountain lake in western Nepal

Date: Jun 25, 2018

Author: separationsNOW

Scientists from Nepal have used ion chromatography to analyze the ions in water samples from Lake Rara, a high mountain lake in western Nepal.

Read More thumbnail image: Journal Highlight Hydrochemistry of Lake Rara A high mountain lake in western Nepal

Journal Highlight: Use of Response Surface Methodology (RSM) for the identification of the best extraction conditions for headspace SPME of the volatile profile of cv. Arbequina extra‐virgin olive oil

Date: Jun 25, 2018

Author: separationsNOW

Scientists from Spain and Portugal have used a mathematical model to identify the optimum extraction conditions for assessing the volatile profile of extra virgin olive oils by headspace solid‐phase microextraction and gas chromatography‐mass spectrometry.

Read More thumbnail image: Journal Highlight Use of Response Surface Methodology RSM for the identification of the best extraction conditions for headspace SPME of the volatile profile of cv_ Arbequina extravirgin olive oil

Cannabis compounds in cords captured by UHPLC

Date: Jun 18, 2018

Author: Ryan De Vooght-Johnson

The use of cannabis during pregnancy can lead to adverse effects on babies so objective methods are needed to determine whether cannabis has been taken. Scientists from the City University of New York and the University of Santiago de Compostela, Spain, devised a new UHPLC-MS/MS method for detecting the main active ingredient of cannabis (THC) and its metabolites in umbilical cords.

Read More thumbnail image: Cannabis compounds in cords captured by UHPLC

Journal Highlight: Evaluation of coal‐related model compounds using a tandem mass spectrometry

Date: Jun 18, 2018

Author: separationsNOW

A tandem mass spectrometric technique using GC/Q‐TOFMS has been established for the selection of precursor ion/product ion pairs for monitoring coal conversion products.

Read More thumbnail image: Journal Highlight Evaluation of coalrelated model compounds using a tandem mass spectrometry

Breast milk biomarkers: Determining differently-expressed proteins in breast milk

Date: Jun 18, 2018

Author: Jon Evans

Scientists in the US used two-dimensional gel electrophoresis to try to find biomarkers of breast cancer in the breast milk of a woman who had developed cancer in just one breast.

Read More thumbnail image: Breast milk biomarkers Determining differently-expressed proteins in breast milk
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