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Journal Highlight: Oxidative stress in asthmatic and non-asthmatic adolescent swimmers — A breathomics approach

Date: Sep 18, 2017

Author: separationsNOW

The effect of a swimming training session on oxidative stress markers of asthmatic compared to non-asthmatic elite swimmers using exhaled breath metabolomics has been investigated by GC×GC-ToFMS.

Read More thumbnail image: Journal Highlight Oxidative stress in asthmatic and non-asthmatic adolescent swimmers  A breathomics approach

Metabolites of deadly NPS elucidated by LC-MS

Date: Sep 16, 2017

Author: Ryan De Vooght-Johnson

Increasing amounts of new psychoactive substances (NPS), such as butyrfentanyl, are being used across Europe. Researchers from the University of Zurich used a combination of UHPLC and a QTOF (quadrupole time-of-flight) mass spectrometer to detect the metabolites of butyrfentanyl produced in-vitro and in-vivo.

Read More thumbnail image: Metabolites of deadly NPS elucidated by LC-MS

Mixed-mode model made for medicinal antibodies

Date: Sep 16, 2017

Author: Ryan De Vooght-Johnson

Mixed-mode chromatography (MMC), which combines the properties of ion-exchange chromatography (IEC) and hydrophobic interaction chromatography (HIC), is increasingly used for the purification of various proteins, such as medicinal antibodies. Scientists from Mannheim University of Applied Sciences and Roche Pharmaceuticals’ Munich site developed equations to predict the elution of a bispecific antibody from an MMC column.

Read More thumbnail image: Mixed-mode model made for medicinal antibodies

Dialysis membranes: Adsorbed proteins

Date: Sep 15, 2017

Author: Steve Down

The effects of protein adsorption on two types of hemodialysis membrane have been studied by Chinese scientists to identify the unwanted biochemical reactions that occur in an effort to design more efficient membrane materials.

Read More thumbnail image: Dialysis membranes Adsorbed proteins

Journal Highlight: Fast and simple discriminative analysis of anthocyanins-containing berries using LC/MS spectral data

Date: Sep 11, 2017

Author: separationsNOW

An alternative approach for the quality assessment and discrimination of anthocyanin-containing berries has been developed using mass spectral data acquired in a short analytical time rather than UV or MS chromatograms.

Read More thumbnail image: Journal Highlight Fast and simple discriminative analysis of anthocyanins-containing berries using LCMS spectral data

Gold-standard cyanide detection: IC and a gold electrode can detect cyanide in water

Date: Sep 11, 2017

Author: Jon Evans

By simply replacing a silver electrode with a gold one, Indian scientists have produced a sensitive ion chromatography method for detecting cyanide in water without any interference.

Read More thumbnail image: Gold-standard cyanide detection IC and a gold electrode can detect cyanide in water

Journal Highlight: Reliable HPLC separation, vibrational circular dichroism spectra, and absolute configurations of isoborneol enantiomers

Date: Sep 11, 2017

Author: separationsNOW

By combining an optical rotation detector with high-performance liquid chromatograpy, Chinese chemists have developed a novel method for separating isoborneol enantiomers.

Read More thumbnail image: Journal Highlight Reliable HPLC separation vibrational circular dichroism spectra and absolute configurations of isoborneol enantiomers

Journal Highlight: Development and validation of a high-throughput online SPE–LC–MS/MS method for the detection of gonyautoxins 1&4 and gonyautoxins 2&3 in human urine

Date: Sep 11, 2017

Author: separationsNOW

Scientists in the US have developed a method based on solid phase extraction with liquid chromatography and tandem mass spectrometry to identify several related paralytic shellfish toxins in human urine.

Read More thumbnail image: Journal Highlight Development and validation of a high-throughput online SPELCMSMS method for the detection of gonyautoxins 14 and gonyautoxins 23 in human urine

Journal Highlight: Inhibitory effect of blue light emitting diode on migration and invasion of cancer cells

Date: Sep 11, 2017

Author: separationsNOW

Korean researchers have used 2D gel electrophoresis to investigate the effect of blue light emitting diodes on protein expression in cancer cells.

Read More thumbnail image: Journal Highlight Inhibitory effect of blue light emitting diode on migration and invasion of cancer cells

MS muddle made manageable by mulitplierz software

Date: Sep 6, 2017

Author: Ryan De Vooght-Johnson

The diversity of current mass spectrometry methods and software tools has led to multiple arrays of data that are not readily comparable. Researchers from Harvard Medical School and the Dana-Farber Cancer Institute in Boston have reported on the latest version of their multiplierz software, which aims to provide a common platform for mass spectrometry proteomic data.

Read More thumbnail image: MS muddle made manageable by mulitplierz software
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