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Alzheimer's biomarkers: Novel metabolites and protein candidates

Date: Jun 15, 2017

Author: Steve Down

Scientists in China have identified a range of potential biomarkers of Alzheimer's disease from a metabolomics and proteomics study of the rat model, providing insight into diagnosis of the condition and candidates for therapeutic targets.

Read More thumbnail image: Alzheimers biomarkers Novel metabolites and protein candidates

LC on a nano-scale measures steroids in the whale

Date: Jun 15, 2017

Author: Ryan De Vooght-Johnson

Measurements of the levels of steroid hormones in live whales is crucial to understanding their health and breeding capacity. Researchers from Texas Tech University and the University of Alaska Fairbanks have devised a novel nano-LC-MS/MS method of steroid analysis that requires smaller blubber samples than existing techniques.

Read More thumbnail image: LC on a nano-scale measures steroids in the whale

Plastic packaging pongs profiled by 2D GC

Date: Jun 15, 2017

Author: Ryan De Vooght-Johnson

Ideally, waste plastic packaging should be able to be recycled to make food packaging, but the presence of unpleasant odours means that this is rarely attempted. Scientists from two German institutions, the Friedrich-Alexander University of Erlangen-Nuremberg and the Fraunhofer Institute for Process Engineering and Packaging at Freising, used a combination of 1D GC, 2D GC, mass spectrometry and sensory analysis to detect compounds with strong odours in waste plastic packaging.

Read More thumbnail image: Plastic packaging pongs profiled by 2D GC

From heartbreak to happiness with in-house MS database

Date: Jun 15, 2017

Author: Ryan De Vooght-Johnson

Gelsemium elegans is a toxic plant of interest for its possible medical uses. Scientists from Hunan Agricultural University in China used a combination of LC-MS/MS and an in-house database of the accurate masses of previously detected Gelsemium compounds to tentatively identify a wide range of the many components in a crude extract from the plant.

Read More thumbnail image: From heartbreak to happiness with in-house MS database

Essence of wheat bran: Separating ferulic acid from complex sugars

Date: Jun 12, 2017

Author: Jon Evans

Using anion-exchange chromatography, French scientists have found a way to increase the number of useful products that can be obtained from wheat bran.

Read More thumbnail image: Essence of wheat bran Separating ferulic acid from complex sugars

Journal Highlight: Simple extraction method for quantification of phenothiazine residues in pork muscle using LC–triple quadrupole tandem MS

Date: Jun 12, 2017

Author: separationsNOW

Researchers in South Korea have developed a novel liquid-liquid method for extracting the drug phenothiazine, which is used to treat gastrointestinal nematodes in livestock, from pork muscle prior to analysis by liquid chromatography–tandem mass spectrometry.

Read More thumbnail image: Journal Highlight Simple extraction method for quantification of phenothiazine residues in pork muscle using LCtriple quadrupole tandem MS

Journal Highlight: Flow cytometry and CE analyses in ethanol-stressed Oenococcus oeni strains and changes assessment of membrane fatty acid composition

Date: Jun 12, 2017

Author: separationsNOW

Italian scientists have used capillary electrophoresis and flow cytometry to investigate the dynamics and physiological heterogeneity of the bacterium Oenococcus oeni when exposed to ethanol.

Read More thumbnail image: Journal Highlight Flow cytometry and CE analyses in ethanol-stressed Oenococcus oeni strains and changes assessment of membrane fatty acid composition

Journal Highlight: Combination of SDS-PAGE and intact mass analysis for rapid determination of heterogeneities in monoclonal antibody therapeutics

Date: Jun 12, 2017

Author: separationsNOW

Pharmaceutical scientists in Japan have shown that a combination of gel electrophoresis and intact mass analysis can play a pivotal role in the rapid and precise characterization of monoclonal antibodies.

Read More thumbnail image: Journal Highlight Combination of SDS-PAGE and intact mass analysis for rapid determination of heterogeneities in monoclonal antibody therapeutics

Journal Highlight: Validation of analytical method for α-dicarbonyl compounds using gas chromatography–nitrogen phosphorous detector and their levels in alcoholic beverages

Date: Jun 12, 2017

Author: separationsNOW

A GC-NPD method has been developed to measure α-dicarbonyl compounds including glyoxal, methylglyoxal and diacetyl in 101 alcoholic beverages then perform exposure assessments.

Read More thumbnail image: Journal Highlight Validation of analytical method for -dicarbonyl compounds using gas chromatographynitrogen phosphorous detector and their levels in alcoholic beverages

Journal Highlight: Proteomics applications in dental derived stem cells

Date: Jun 10, 2017

Author: separationsNOW

An overview has been presented of proteomics studies in the context of stem cell research, focusing on dental-derived stem cell types as well as current challenges and opportunities.

Read More thumbnail image: Journal Highlight Proteomics applications in dental derived stem cells
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