Most Recent Thar Webinar on
Supercritical Fluid Chromatography (SFC)

Chiral Separations using SFC:
Analytical Applications from Discovery through Development

Peter Ridgway, Thar Instruments, Inc.

Listen to the archived version of this webinar

Broadcast on Tuesday, 24 June 2008

In the past decade, Supercritical Fluid Chromatography (SFC) has increasingly gained momentum in both pharmaceutical and chemical industries. The intrinsic low viscosity and high diffusivity of supercritical CO₂ has rendered SFC higher separation speeds and efficiency than traditional LC, especially in chiral analysis and purifications. Furthermore, the reduction in solvent consumption has made SFC an integral part of green chromatography.

In this webinar, Mr. Ridgway explained the fundamentals of supercritical fluids and Supercritical Fluid Chromatography, with a particular emphasis on enantio-selective separation. The typical work flow employing SFC in pharmaceutical industry is introduced. SFC's superiority in chiral analysis and purification, including speed, high hit rates, and cost-effectiveness are highlighted by a wide range of real industrial applications. The simplicity and some unique aspects of SFC method development, including column coupling, sample pooling, and parallel column screening are also demonstrated.