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Breast cancer biomarkers: Nipple discharge analysis

Date: Apr 2, 2016

Author: Steve Down

Promising biomarkers of invasive breast cancer have been uncovered by scientists in Japan who tapped into nipple discharge, an often ignored biofluid, as a source of locally secreted proteins.

Read More thumbnail image: Breast cancer biomarkers Nipple discharge analysis

Cell and lung transplantation: Protein biomarker for subsequent lung disease

Date: Mar 16, 2016

Author: Steve Down

A plasma protein has been earmarked as a potential marker for the onset of bronchiolitis obliterans syndrome, a life-threatening complication that can follow hematopoietic cell transplantation or lung transplantation.

Read More thumbnail image: Cell and lung transplantation Protein biomarker for subsequent lung disease

Dust mite allergens: Proteomics expands range

Date: Mar 1, 2016

Author: Steve Down

Novel protein allergens from a house dust mite have been revealed by a proteomics study which lends support to the allergen-specific immunotherapeutic approach to treatment.

Read More thumbnail image: Dust mite allergens Proteomics expands range

Journal Highlight: CE–ESI-MS for bottom-up proteomics: Advances in separation, interfacing and applications

Date: Feb 29, 2016

Author: separationsNOW

This review discusses newly developed hyphenation strategies for CE–ESI-MS and their application in bottom-up proteomics, as well as factors in the development of these methods.

Read More thumbnail image: Journal Highlight CEESI-MS for bottom-up proteomics Advances in separation interfacing and applications

Transgenic crops: The MIDAS touch for rapid protein detection

Date: Feb 15, 2016

Author: Steve Down

The identification of proteins in transgenic crops can be accelerated by a generic LC-tandem-MS method that targets tryptic peptides and does not require protein standards.

Read More thumbnail image: Transgenic crops The MIDAS touch for rapid protein detection

Journal Highlight: Combination of virtual and experimental 2DE together with ESI LC-MS/MS gives a clearer view about proteomes of human cells and plasma

Date: Feb 1, 2016

Author: separationsNOW

Virtual and experimental 2DE coupled with ESI LC-MS/MS was combined to give more detail on the human proteome, revealing that minor proteins species are heavily modified in cells and even more so in plasma.

Read More thumbnail image: Journal Highlight Combination of virtual and experimental 2DE together with ESI LC-MSMS gives a clearer view about proteomes of human cells and plasma

Bioscaffolds for tissue engineering: Residual proteins

Date: Feb 1, 2016

Author: Steve Down

The proteomes of biological scaffolds such as collagen and decellularised organs have been characterised by scientists in the US to help in the provision of better materials for organ replacement programmes.

Read More thumbnail image: Bioscaffolds for tissue engineering Residual proteins

Pulmonary nanoparticles: Biopathway analysis by proteomics

Date: Jan 15, 2016

Author: Steve Down

The effects of inhaled titanium dioxide nanoparticles on the biological functions in rats have been assessed following a proteomics study, with liver damage and blood coagulation being the greatest risks.

Read More thumbnail image: Pulmonary nanoparticles Biopathway analysis by proteomics

Orange juice authenticity: Proteomics fingerprinting

Date: Jan 4, 2016

Author: Steve Down

The proteomes of orange pulp and orange peel that exist during different stages of industrial processing have been defined and applied to the authentication of commercial juices and drinks.

Read More thumbnail image: Orange juice authenticity Proteomics fingerprinting

Journal Highlight: In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells

Date: Jan 4, 2016

Author: separationsNOW

An in-depth analysis of the lipopolysaccharide-induced secretome in human endothelial cells has led to the proposal of 19 new biomarker candidates for sepsis, including moesin.

Read More thumbnail image: Journal Highlight In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells
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