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Journal Highlight: In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells

Date: Jan 4, 2016

Author: separationsNOW

An in-depth analysis of the lipopolysaccharide-induced secretome in human endothelial cells has led to the proposal of 19 new biomarker candidates for sepsis, including moesin.

Read More thumbnail image: Journal Highlight In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells

Stored red blood cells: Carbonylated proteins in blood banks

Date: Dec 17, 2015

Author: Steve Down

The oxidative damage inflicted upon proteins in red blood cells during storage in blood banks targets particular cellular processes, according to a recent proteomics study of carbonylated proteins.

Read More thumbnail image: Stored red blood cells Carbonylated proteins in blood banks

Autism spectrum disorder: Novel biomarkers revealed

Date: Dec 2, 2015

Author: Steve Down

Biomarker candidates for autism spectrum disorder have been identified in the saliva of children in a proteomics study by scientists in the US, raising the potential for early diagnosis, discrimination of subtypes and the identification of drug targets.

Read More thumbnail image: Autism spectrum disorder Novel biomarkers revealed

Journal Highlight: The proteomic analysis improved by cleavage kinetics-based fractionation of tryptic peptides

Date: Nov 30, 2015

Author: separationsNOW

A multi-stage digestion strategy to generate peptides with different trypsin cleavage kinetics has been described, each of the collected peptide fractions yielding many new protein identifications compared to the control group due to reduced complexity.

Read More thumbnail image: Journal Highlight The proteomic analysis improved by cleavage kinetics-based fractionation of tryptic peptides

Thyroid cancer diagnosis: Mass spec imaging reveals protein biomarker candidates

Date: Nov 15, 2015

Author: Steve Down

Imaging mass spectrometry has been used to differentiate between thyroid lesions from their proteomics profiles, leading to the possibility of biomarker identification for various lesions.

Read More thumbnail image: Thyroid cancer diagnosis Mass spec imaging reveals protein biomarker candidates

Oral disease progression: Protein clues

Date: Nov 2, 2015

Author: Steve Down

The proteomes of oral fluid collected from gingival crevices of healthy people and those with gingivitis and chronic periodontitis have been compared to try to understand the underlying biological processes that take place during oral disease progression.

Read More thumbnail image: Oral disease progression Protein clues

Journal Highlight: Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome

Date: Nov 1, 2015

Author: separationsNOW

An overview has been presented of the currently applied state-of-the-art cellular and sub-cellular prefractionation strategies used in the analysis of brain function in normal aging and neurodegenerative, psychiatric, and neurological diseases.

Read More thumbnail image: Journal Highlight Proteomics in neurodegenerative diseases Methods for obtaining a closer look at the neuronal proteome

Early lung cancer biomarker: Linked to squamous metaplasia

Date: Oct 15, 2015

Author: Steve Down

The effects of smoking on the plasma proteome of people with no signs of cancer were examined to see if there were any biomarkers of lung lesions that could be warnings of lung cancer to come, with one protein in particular standing out.

Read More thumbnail image: Early lung cancer biomarker Linked to squamous metaplasia

Protein biomarkers in sweat: Panel of defence proteins established

Date: Oct 1, 2015

Author: Steve Down

The proteins that form the chemical barrier in skin from healthy people have been characterised by sweat analysis, providing the basis for a new starting point for biomarker studies.

Read More thumbnail image: Protein biomarkers in sweat Panel of defence proteins established

Journal Highlight: Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping

Date: Sep 28, 2015

Author: separationsNOW

A collaborative study on the robustness and portability of a CE-MS method for peptide mapping was performed by an international team, consisting of 13 independent laboratories from academia and industry.

Read More thumbnail image: Journal Highlight Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping
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