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Transgenic crops: The MIDAS touch for rapid protein detection

Date: Feb 15, 2016

Author: Steve Down

The identification of proteins in transgenic crops can be accelerated by a generic LC-tandem-MS method that targets tryptic peptides and does not require protein standards.

Read More thumbnail image: Transgenic crops The MIDAS touch for rapid protein detection

Journal Highlight: Combination of virtual and experimental 2DE together with ESI LC-MS/MS gives a clearer view about proteomes of human cells and plasma

Date: Feb 1, 2016

Author: separationsNOW

Virtual and experimental 2DE coupled with ESI LC-MS/MS was combined to give more detail on the human proteome, revealing that minor proteins species are heavily modified in cells and even more so in plasma.

Read More thumbnail image: Journal Highlight Combination of virtual and experimental 2DE together with ESI LC-MSMS gives a clearer view about proteomes of human cells and plasma

Bioscaffolds for tissue engineering: Residual proteins

Date: Feb 1, 2016

Author: Steve Down

The proteomes of biological scaffolds such as collagen and decellularised organs have been characterised by scientists in the US to help in the provision of better materials for organ replacement programmes.

Read More thumbnail image: Bioscaffolds for tissue engineering Residual proteins

Pulmonary nanoparticles: Biopathway analysis by proteomics

Date: Jan 15, 2016

Author: Steve Down

The effects of inhaled titanium dioxide nanoparticles on the biological functions in rats have been assessed following a proteomics study, with liver damage and blood coagulation being the greatest risks.

Read More thumbnail image: Pulmonary nanoparticles Biopathway analysis by proteomics

Orange juice authenticity: Proteomics fingerprinting

Date: Jan 4, 2016

Author: Steve Down

The proteomes of orange pulp and orange peel that exist during different stages of industrial processing have been defined and applied to the authentication of commercial juices and drinks.

Read More thumbnail image: Orange juice authenticity Proteomics fingerprinting

Journal Highlight: In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells

Date: Jan 4, 2016

Author: separationsNOW

An in-depth analysis of the lipopolysaccharide-induced secretome in human endothelial cells has led to the proposal of 19 new biomarker candidates for sepsis, including moesin.

Read More thumbnail image: Journal Highlight In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells

Stored red blood cells: Carbonylated proteins in blood banks

Date: Dec 17, 2015

Author: Steve Down

The oxidative damage inflicted upon proteins in red blood cells during storage in blood banks targets particular cellular processes, according to a recent proteomics study of carbonylated proteins.

Read More thumbnail image: Stored red blood cells Carbonylated proteins in blood banks

Autism spectrum disorder: Novel biomarkers revealed

Date: Dec 2, 2015

Author: Steve Down

Biomarker candidates for autism spectrum disorder have been identified in the saliva of children in a proteomics study by scientists in the US, raising the potential for early diagnosis, discrimination of subtypes and the identification of drug targets.

Read More thumbnail image: Autism spectrum disorder Novel biomarkers revealed

Journal Highlight: The proteomic analysis improved by cleavage kinetics-based fractionation of tryptic peptides

Date: Nov 30, 2015

Author: separationsNOW

A multi-stage digestion strategy to generate peptides with different trypsin cleavage kinetics has been described, each of the collected peptide fractions yielding many new protein identifications compared to the control group due to reduced complexity.

Read More thumbnail image: Journal Highlight The proteomic analysis improved by cleavage kinetics-based fractionation of tryptic peptides

Thyroid cancer diagnosis: Mass spec imaging reveals protein biomarker candidates

Date: Nov 15, 2015

Author: Steve Down

Imaging mass spectrometry has been used to differentiate between thyroid lesions from their proteomics profiles, leading to the possibility of biomarker identification for various lesions.

Read More thumbnail image: Thyroid cancer diagnosis Mass spec imaging reveals protein biomarker candidates
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