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Journal Highlight: 2D-DIGE-based proteomic analysis of intracoronary versus peripheral arterial blood platelets: Upregulation of platelet activation biomarkers at the culprit site

Date: Sep 9, 2016

Author: separationsNOW

The proteomes of intracoronary and peripheral arterial platelets from STEMI patients were compared to highlight potential platelet biomarkers and drug targets related to the conditions.

Read More thumbnail image: Journal Highlight 2D-DIGE-based proteomic analysis of intracoronary versus peripheral arterial blood platelets Upregulation of platelet activation biomarkers at the culprit site

Growth hormone testing: Gene and protein markers

Date: Sep 6, 2016

Author: Steve Down

Two genes and a protein that appear in blood following consumption of human growth hormone have been proposed as biomarkers of abuse for sports drug testing programmes, offering better sensitivity than insulin-like growth factor-1.

Read More thumbnail image: Growth hormone testing Gene and protein markers

5000 Yeast proteins measured: Cultures with ten carbon sources compared by multiplexed MS

Date: Aug 17, 2016

Author: Steve Down

A modified mass spectrometric protocol with tandem mass tagging has been used to compare protein abundances in yeast cultures grown on ten different carbon sources, providing data for more than 5000 proteins.

Read More thumbnail image: 5000 Yeast proteins measured Cultures with ten carbon sources compared by multiplexed MS

Autoantibody as prostate cancer marker: Enhanced predictive ability in combination with PSA

Date: Aug 3, 2016

Author: Steve Down

A serological proteome analysis of European-African and African-American men has identified one particular natural antibody as a candidate biomarker for prostate cancer that gives high specificity when combined with the conventional PSA test.

Read More thumbnail image: Autoantibody as prostate cancer marker Enhanced predictive ability in combination with PSA

Journal Highlight: State-of-the-art housekeeping proteins for quantitative western blotting: Revisiting the first draft of the human proteome

Date: Aug 1, 2016

Author: separationsNOW

The recently released large-scale, human proteomic database ProteomicsDB, which includes 16,857 LC-tandem-MS data from 27 human tissues, has been examined to propose 20 ubiquitously- and constitutively-expressed, putative internal-reference controls for the quantification of differential protein expressions in Western blotting.

Read More thumbnail image: Journal Highlight State-of-the-art housekeeping proteins for quantitative western blotting Revisiting the first draft of the human proteome

Fingermark proteomics: Blood proteins by mass spec imaging

Date: Jul 19, 2016

Author: Steve Down

The proteins in blood that are present on a human fingermark can be identified by a mass spectrometric imaging technique that preserves the integrity of the ridge patterns so that the biometric information can also be extracted.

Read More thumbnail image: Fingermark proteomics Blood proteins by mass spec imaging

Gestational diabetes: Biomarkers of childhood obesity

Date: Jul 14, 2016

Author: Steve Down

Scientists in China have identified proteins in pregnant women who have gestational diabetes, a temporary intolerance to glucose, which might act as biomarkers for childhood obesity.

Read More thumbnail image: Gestational diabetes Biomarkers of childhood obesity

Journal Highlight: A capillary zone electrophoresis method to detect conformers and dimers of antithrombin in therapeutic preparations

Date: Jul 4, 2016

Author: separationsNOW

A CZE method, based on a neutral polyethylene oxide-coated capillary and a buffer close to physiological conditions, has been devised for the separation of more than eight forms of antithrombin.

Read More thumbnail image: Journal Highlight A capillary zone electrophoresis method to detect conformers and dimers of antithrombin in therapeutic preparations

Deep vein thrombosis and pulmonary embolism: Urinary peptide signs

Date: Jun 16, 2016

Author: Steve Down

There are a number of small peptides in urine that can signal the onset of deep vein thrombosis and pulmonary embolism, say a team of researchers, who hope that their findings will lead to a clinical test for the conditions.

Read More thumbnail image: Deep vein thrombosis and pulmonary embolism Urinary peptide signs

Protein imaging: The power of MALDI

Date: Jun 2, 2016

Author: Steve Down

The power of two different MALDI mass spectrometric techniques for visualising proteins in tissue segments has been demonstrated by US scientists who exploited high-speed scanning and improved spatial resolution capabilities.

Read More thumbnail image: Protein imaging The power of MALDI
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