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Large proteins: FTICR to the rescue

Date: Dec 16, 2016

Author: Steve Down

A powerful FTICR mass spectrometer installed recently in the National High Magnetic Field Laboratory in the USA has successfully observed thousands of protein isoforms in a top-down analysis, many of them with molecular masses above 30 kDa.

Read More thumbnail image: Large proteins FTICR to the rescue

Biowarfare agents: Toxin testing

Date: Dec 2, 2016

Author: Steve Down

Toxins that have been added to foods as chemical and biological warfare agents can be detected using a novel proteomics approach which bypasses the need for antibody-based isolation by employing isotope-labelled versions of the toxins.

Read More thumbnail image: Biowarfare agents Toxin testing

Journal Highlight: A protein extraction method for low protein concentration solutions compatible with the proteomic analysis of rubber particles

Date: Nov 28, 2016

Author: separationsNOW

An existing borax and phenol-based method for extracting proteins from the washing solution of rubber particles from laticifer cells of the rubber tree has been improved to increase yields from low protein concentration samples.

Read More thumbnail image: Journal Highlight A protein extraction method for low protein concentration solutions compatible with the proteomic analysis of rubber particles

Drug-protein binding: New design route

Date: Nov 16, 2016

Author: Steve Down

The active plasma proteins that bind with the antibiotic ertapenem have been identified in a study that will improve drug design operations and allow tailoring of dosages for individual patients.

Read More thumbnail image: Drug-protein binding New design route

Alcoholic and non-alcoholic liver disease: Discriminating protein biomarkers

Date: Nov 1, 2016

Author: Steve Down

A set of proteins has been identified by Korean researchers that distinguish between alcoholic and non-alcoholic liver disease and could prove to be useful biomarkers for the harmful build up of triglycerides and fatty acids.

Read More thumbnail image: Alcoholic and non-alcoholic liver disease Discriminating protein biomarkers

Journal Highlight: Benchmarking sample preparation/digestion protocols reveals tube-gel being a fast and repeatable method for quantitative proteomics

Date: Nov 1, 2016

Author: separationsNOW

In the first global label-free quantitative comparison between tube-gel, stacking gel, and basic liquid digestion of proteins mixtures, the tube gel approach proved to be superior.

Read More thumbnail image: Journal Highlight Benchmarking sample preparationdigestion protocols reveals tube-gel being a fast and repeatable method for quantitative proteomics

Atmospheric aerosol proteins: Metaproteomics revelations

Date: Oct 15, 2016

Author: Steve Down

Proteins lurking in the particulates of atmospheric aerosols have been analysed by proteomics techniques, providing a way to assess risks to human health from bacteria and allergens that are present.

Read More thumbnail image: Atmospheric aerosol proteins Metaproteomics revelations

Journal Highlight: Proteomics of hydrophobic samples: Fast, robust and low-cost workflows for clinical approaches

Date: Oct 3, 2016

Author: separationsNOW

In a comparative study, the influence of nine sample preparation workflows and seven different lysis buffers for qualitative and quantitative analysis of the human adipose tissue proteome has been assessed.

Read More thumbnail image: Journal Highlight Proteomics of hydrophobic samples Fast robust and low-cost workflows for clinical approaches

Stress-induced immunosuppression: Proteomics clues

Date: Oct 1, 2016

Author: Steve Down

A proteomics study carried out in China has uncovered proteins that are affected by the onset of immunosuppression brought on by chronic stress, as a first step for elucidating the molecular processes behind the effect.

Read More thumbnail image: Stress-induced immunosuppression Proteomics clues

Red propolis: Anticancer mechanism probed

Date: Sep 15, 2016

Author: Steve Down

The mechanism by which red propolis acts as an anticancer agent can be clarified by the identification of proteins that are differentially expressed in a cancer cell line, say Brazilian researchers.

Read More thumbnail image: Red propolis Anticancer mechanism probed
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