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Induced pluripotent stem cells: Proteomics test

Date: Feb 2, 2017

Author: Steve Down

Induced pluripotent human stem cells can be distinguished from non-pluripotent cells within minutes using a novel proteomics assay that targets 15 biomarker peptides originating from 4 particular transcription factors.

Read More thumbnail image: Induced pluripotent stem cells Proteomics test

Journal Highlight: Comparison of sample preparation techniques for large-scale proteomics

Date: Jan 30, 2017

Author: separationsNOW

The performances of several common sample preparation techniques for proteomic characterization of HeLa lysates have been compared, proteome sequence coverage increasing to 38% when combining all workflows.

Read More thumbnail image: Journal Highlight Comparison of sample preparation techniques for large-scale proteomics

Acute kidney injury: Biomarker protocol with labelled proteins

Date: Jan 15, 2017

Author: Steve Down

A novel method for accurately measuring multiple biomarkers of acute kidney injury that was developed in France uses isotope-labelled protein standards and can be rolled out to other diseases in different clinical scenarios.

Read More thumbnail image: Acute kidney injury Biomarker protocol with labelled proteins

Nasal cancer prognosis: 14-3-3 epsilon predictor for asparaginase treatment

Date: Jan 4, 2017

Author: Steve Down

The response of patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) to treatment with asparaginase can be predicted by levels of the protein 14-3-3 epsilon, say Chinese scientists.

Read More thumbnail image: Nasal cancer prognosis 14-3-3 epsilon predictor for asparaginase treatment

Journal Highlight: Standardization of sample homogenization for mosquito identification using an innovative proteomic tool based on protein profiling

Date: Jan 1, 2017

Author: separationsNOW

Manual grinding of Anopheles gambiae Giles and Aedes albopictus mosquitoes at the adult and larval developmental stages was compared to automated homogenization for protein profiling by MALDI-TOF MS.

Read More thumbnail image: Journal Highlight Standardization of sample homogenization for mosquito identification using an innovative proteomic tool based on protein profiling

Large proteins: FTICR to the rescue

Date: Dec 16, 2016

Author: Steve Down

A powerful FTICR mass spectrometer installed recently in the National High Magnetic Field Laboratory in the USA has successfully observed thousands of protein isoforms in a top-down analysis, many of them with molecular masses above 30 kDa.

Read More thumbnail image: Large proteins FTICR to the rescue

Biowarfare agents: Toxin testing

Date: Dec 2, 2016

Author: Steve Down

Toxins that have been added to foods as chemical and biological warfare agents can be detected using a novel proteomics approach which bypasses the need for antibody-based isolation by employing isotope-labelled versions of the toxins.

Read More thumbnail image: Biowarfare agents Toxin testing

Journal Highlight: A protein extraction method for low protein concentration solutions compatible with the proteomic analysis of rubber particles

Date: Nov 28, 2016

Author: separationsNOW

An existing borax and phenol-based method for extracting proteins from the washing solution of rubber particles from laticifer cells of the rubber tree has been improved to increase yields from low protein concentration samples.

Read More thumbnail image: Journal Highlight A protein extraction method for low protein concentration solutions compatible with the proteomic analysis of rubber particles

Drug-protein binding: New design route

Date: Nov 16, 2016

Author: Steve Down

The active plasma proteins that bind with the antibiotic ertapenem have been identified in a study that will improve drug design operations and allow tailoring of dosages for individual patients.

Read More thumbnail image: Drug-protein binding New design route

Alcoholic and non-alcoholic liver disease: Discriminating protein biomarkers

Date: Nov 1, 2016

Author: Steve Down

A set of proteins has been identified by Korean researchers that distinguish between alcoholic and non-alcoholic liver disease and could prove to be useful biomarkers for the harmful build up of triglycerides and fatty acids.

Read More thumbnail image: Alcoholic and non-alcoholic liver disease Discriminating protein biomarkers
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