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Journal Highlight: Cell‐free DNA blood collection tubes are appropriate for clinical proteomics: A demonstration in colorectal cancer

Date: Apr 30, 2018

Author: separationsNOW

A proteomics study of colorectal cancer patients has shown that optimized blood collection tubes are appropriate for low‐abundant plasma protein analysis and can be used with confidence for clinical proteomics.

Read More thumbnail image: Journal Highlight Cellfree DNA blood collection tubes are appropriate for clinical proteomics A demonstration in colorectal cancer

Anton Checkov: Cause of death questioned

Date: Apr 15, 2018

Author: Steve Down

Proteome analysis of brown stains on archived personal items of Anton Checkov has yielded proteins related to Mycobacterium tuberculosis, confirming that he had tuberculosis at time of death, but another protein suggests that there may have been a different cause of death.

Read More thumbnail image: Anton Checkov Cause of death questioned

Journal Highlight: 'One‐pot' sample processing method for proteome‐wide analysis of microbial cells and spores

Date: Apr 3, 2018

Author: separationsNOW

A simple 'one‐pot' method for the proteome analysis of bacterial spores has been demonstrated for Bacillus subtilis, Bacillus cereus and Peptoclostridium difficile, yielding to the identification of >1000 across all spore layers of the three organisms.

Read More thumbnail image: Journal Highlight Onepot sample processing method for proteomewide analysis of microbial cells and spores

Asthma at work: Proteomics search for biomarkers

Date: Apr 1, 2018

Author: Steve Down

Nasal protein profiling has been used to measure the responses of people exposed to airborne allergens like isocyanates and welding fumes, leading to several candidate biomarkers for work-related asthma.

Read More thumbnail image: Asthma at work Proteomics search for biomarkers

Mortality biomarkers: Peptides and proteins

Date: Mar 15, 2018

Author: Steve Down

A large-scale proteomics study on older men has identified a number of peptides and proteins that are associated with five-year mortality, most of them arising from non-cancer deaths and implicating a number of biological pathways, especially inflammation.

Read More thumbnail image: Mortality biomarkers Peptides and proteins

Journal Highlight: Comparative evaluation of five protocols for protein extraction from stony corals (Scleractinia) for proteomics

Date: Mar 5, 2018

Author: separationsNOW

TRIzol, phenol-based extraction, trichloroacetic acid-acetone, glass bead-assisted extraction and a commercially available kit have been compared for the extraction of proteins from stony corals for analysis by 2-DE and MALDI-TOF-MS.

Read More thumbnail image: Journal Highlight Comparative evaluation of five protocols for protein extraction from stony corals Scleractinia for proteomics

Breast cancer in young women: Biomarkers from breast milk

Date: Mar 1, 2018

Author: Steve Down

A preliminary proteomics study of breast milk in younger women collected within two years of them being diagnosed with breast cancer has revealed a number of dysregulated proteins as potential candidates for early detection of the disease.

Read More thumbnail image: Breast cancer in young women Biomarkers from breast milk

Canine saliva: Inter-breed proteomics

Date: Feb 15, 2018

Author: Steve Down

The proteome of dog saliva differs between breeds and between individual animals of the same breed, say scientists in the UK, who compared differently sized breeds for the first time.

Read More thumbnail image: Canine saliva Inter-breed proteomics

Bioactive peptides from cyanobacteria: In silico prediction

Date: Feb 1, 2018

Author: Steve Down

A proteomics approach employing in silico digestion has been proposed as an alternative way to identify bioactive peptides in aquatic species, exemplified with the edible cyanobacterium Arthrospira platensis.

Read More thumbnail image: Bioactive peptides from cyanobacteria In silico prediction

Journal Highlight: Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis

Date: Jan 29, 2018

Author: separationsNOW

Affinity proteomics has been applied to analyse the proteins that are associated with the meiotic chromosome axis protein, ASY1, in Brassica oleracea anthers and meiocytes.

Read More thumbnail image: Journal Highlight Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis
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