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Morphine addiction: Enzyme activity

Date: May 16, 2017

Author: Steve Down

Polish scientists have measured the activities of four enzymes in the brain implicated in the mechanism of morphine addiction in the search for therapeutic targets which do not produce the serious side effects during pain treatment.

Read More thumbnail image: Morphine addiction Enzyme activity

Osteoporosis biomarkers: Serum proteomics

Date: May 1, 2017

Author: Steve Down

A large-scale study of older men in the US has identified a number of proteins in serum that are good candidates for biomarkers of future hip bone loss and fracture by correlation with the bone mineral density measurements.

Read More thumbnail image: Osteoporosis biomarkers Serum proteomics

Journal Highlight: Database of optimized proteomic quantitative methods for human drug disposition-related proteins for applications in physiologically based pharmacokinetic modeling

Date: May 1, 2017

Author: separationsNOW

An open access repository of validated LC-MS/MS MRM methods for quantifying 284 important proteins associated with drug absorption, distribution, metabolism, and excretion has been created.

Read More thumbnail image: Journal Highlight Database of optimized proteomic quantitative methods for human drug disposition-related proteins for applications in physiologically based pharmacokinetic modeling

Milk whey glycoproteins: Interspecies comparison

Date: Apr 15, 2017

Author: Steve Down

A comprehensive examination of the glycoproteins in the milk whey from several mammals by Chinese researchers has identified more than 200 N-glycosylation sites, the majority of which have not been reported previously.

Read More thumbnail image: Milk whey glycoproteins Interspecies comparison

Journal Highlight: Sample clean-up strategies for electrospray ionization mass spectrometry applications in bottom-up proteomics: Trends from 2012–2016

Date: Apr 3, 2017

Author: separationsNOW

Research papers from 2012–2016 on strategies for removal of salts and surfactants prior to electrospray ionization MS analysis in bottom-up proteomics, mostly based on SPE and membrane-based FASP, have been reviewed.

Read More thumbnail image: Journal Highlight Sample clean-up strategies for electrospray ionization mass spectrometry applications in bottom-up proteomics Trends from 20122016

Forensic body fluids: Protein biomarkers

Date: Apr 2, 2017

Author: Steve Down

Biological stains such as urine, saliva and seminal fluid can be distinguished from each other using panels of unique protein biomarkers, offering a reliable way to assign the origin of a DNA profile in forensic cases, say researchers in the USA.

Read More thumbnail image: Forensic body fluids Protein biomarkers

Ant venom: Protein and peptide profiles

Date: Mar 16, 2017

Author: Steve Down

Peptides and proteins in the venom of the South American bullet ant have been compared following two extraction methods, with the ultimate aim of finding new drug and biopesticide candidates.

Read More thumbnail image: Ant venom Protein and peptide profiles

Journal Highlight: Genomics, transcriptomics and proteomics: enabling insights into social evolution and disease challenges for managed and wild bees

Date: Mar 6, 2017

Author: separationsNOW

Recent developments in honey bee and native bee research in the genomic era are discussed, covering progress in genome sequencing and functional annotation, enabled comparative genomics, social evolution and health.

Read More thumbnail image: Journal Highlight Genomics transcriptomics and proteomics enabling insights into social evolution and disease challenges for managed and wild bees

Saliva for disease biomarkers: Gender and acid stimulation effects

Date: Mar 1, 2017

Author: Steve Down

A more complete understanding of the effects of gender and acid simulation on the saliva proteome has been provided by scientists in China to help support the search for disease-specific biomarkers.

Read More thumbnail image: Saliva for disease biomarkers Gender and acid stimulation effects

Neutrophils and surgical trauma: Protein alterations

Date: Feb 15, 2017

Author: Steve Down

The activation of neutrophils following surgery has been studied by proteomic techniques to reveal some of the biochemical processes that are affected by trauma, offering therapeutic targets to treat post-operative complications.

Read More thumbnail image: Neutrophils and surgical trauma Protein alterations
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