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Hypoxia effects on muscles: Everest climbers in proteomics study

Date: Jan 8, 2015

Author: Steve Down

The biochemical responses of human muscles to extended periods of oxygen deprivation have been measured in participants of an expedition to Mount Everest using proteomics techniques.

Read More thumbnail image: Hypoxia effects on muscles Everest climbers in proteomics study

Journal Highlight: The utility of dried blood spots for proteomic studies: Looking forward to looking back

Date: Jan 2, 2015

Author: separationsNOW

This review focuses on the utility of dried blood spots in proteomics and the main challenges, facilitating their use for detecting major diseases of adulthood at the earliest possible time.

Read More thumbnail image: Journal Highlight The utility of dried blood spots for proteomic studies Looking forward to looking back

Modified Mediterranean diet: NMR metabolomics reveals changes caused by olive oil and nuts

Date: Dec 15, 2014

Author: Steve Down

People on the Mediterranean diet supplemented with nuts or extra virgin olive oil adopt a modified metabolism over three years, indicated by NMR-based metabolomics.

Read More thumbnail image: Modified Mediterranean diet NMR metabolomics reveals changes caused by olive oil and nuts

Psoriasis severity and treatment: Metabolomics uncovers amino acid biomarkers

Date: Dec 3, 2014

Author: Steve Down

A metabolomics study of the plasma from psoriasis sufferers has highlighted numerous circulating amino acids that increase in abundance with the severity of the disease but return towards normal levels following treatment with a protein drug that targets tumour necrosis factor alpha.

Read More thumbnail image: Psoriasis severity and treatment Metabolomics uncovers amino acid biomarkers

Journal Highlight: Defining the human gallbladder proteome by transcriptomics and affinity proteomics

Date: Dec 1, 2014

Author: separationsNOW

A genome-wide deep RNA sequencing analysis to identify the genes over-represented in the human gallbladder was complemented with antibody-based immunohistochemistry and the characterization of gallbladder-specific proteins with an elevated expression in the gallbladder.

Read More thumbnail image: Journal Highlight Defining the human gallbladder proteome by transcriptomics and affinity proteomics

Liver damage by lead acetate: Oxidised proteins and cell damage

Date: Nov 24, 2014

Author: Steve Down

Exposure to lead acetate on the skin results in oxidation of protein in the liver that could ultimately cause liver damage, say Taiwanese researchers.

Read More thumbnail image: Liver damage by lead acetate Oxidised proteins and cell damage

Viper venoms: Variations affect antivenom efficacy

Date: Nov 14, 2014

Author: Steve Down

The venoms of three closely related Middle Eastern vipers have widely different protein compositions, say an international team of scientists, who suggest that the single antivenom currently used for them all will offer limited success.

Read More thumbnail image: Viper venoms Variations affect antivenom efficacy

Journal Highlight: Case–controlled identification of colorectal cancer based on proteomic profiles and the potential for screening

Date: Nov 5, 2014

Author: separationsNOW

A serum peptide and protein biomarker signature determined by mass spectrometry can be used to distinguish colorectal cancer patients from healthy controls with high discriminative power, offering a relatively simple and cheap screening test.

Read More thumbnail image: Journal Highlight Casecontrolled identification of colorectal cancer based on proteomic profiles and the potential for screening

Ozone liver stress: Inhalation alters hepatic proteome

Date: Oct 15, 2014

Author: Steve Down

Exposure to ozone modifies the proteome of the rat liver, according to scientists in the USA, compounding the adverse health effects that are already recognised in other organs like the lungs and heart.

Read More thumbnail image: Ozone liver stress Inhalation alters hepatic proteome

Journal Highlight: Trends in proteomic analysis of human vitreous humor samples

Date: Oct 6, 2014

Author: separationsNOW

This review attempts to offer an overview of the proteomics techniques currently used with vitreous humor, exploring its methodological demands, exposing its advantages, and helping the reader to plan future experiences.

Read More thumbnail image: Journal Highlight Trends in proteomic analysis of human vitreous humor samples
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