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Amyloidosis classification: MALDI mass spectrometric imaging

Date: Dec 15, 2017

Author: Steve Down

Scientists in Germany have used mass spectrometry imaging coupled with ion mobility separation to identify amyloid peptides in a proof-of-concept study that will allow different types of amyloidosis to be classified.

Read More thumbnail image: Amyloidosis classification MALDI mass spectrometric imaging

Monitoring bone fracture healing: Protein signals

Date: Dec 1, 2017

Author: Steve Down

Scientists in the USA have uncovered a suite of proteins in serum that might be able to follow the progression of fracture healing and lead to the development of treatments to accelerate the process.

Read More thumbnail image: Monitoring bone fracture healing Protein signals

Journal Highlight: Tetrazole-based probes for integrated phenotypic screening, affinity-based proteome profiling, and sensitive detection of a cancer biomarker

Date: Nov 27, 2017

Author: separationsNOW

Phenotypic screening of a fully functionalized small-molecule library has been combined with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits in drug discovery.

Read More thumbnail image: Journal Highlight Tetrazole-based probes for integrated phenotypic screening affinity-based proteome profiling and sensitive detection of a cancer biomarker

Coffee break: Protein alterations after drinking

Date: Nov 15, 2017

Author: Steve Down

A proteomics study of coffee drinkers in Sweden has uncovered inverse associations with two proteins that have been linked to appetite suppression and a number of diseases, including respiratory disorders, Alzheimer's disease and cancer.

Read More thumbnail image: Coffee break Protein alterations after drinking

E-Cigarettes: As dangerous as cigarettes?

Date: Nov 1, 2017

Author: Steve Down

The safety of e-cigarettes has been thrown into doubt following new research which revealed that it induces high levels of proteins in the lungs that are linked with cystic fibrosis, COPD and bronchitis.

Read More thumbnail image: E-Cigarettes As dangerous as cigarettes

Journal Highlight: A robust protocol for the isolation of cellular proteins from Xanthomonas campestris to analyze the methionine effect in 2D-gel experiments

Date: Oct 30, 2017

Author: separationsNOW

A phenol extraction protocol developed for the purification of bacterial proteins that provides excellent 2D gel separation has been illustrated by examining the effects of methionine on the cellular proteome of Xanthomonas campestris.

Read More thumbnail image: Journal Highlight A robust protocol for the isolation of cellular proteins from Xanthomonas campestris to analyze the methionine effect in 2D-gel experiments

Influenza A proteins: Individual proteome variations

Date: Oct 15, 2017

Author: Steve Down

Scientists in the US have shown that the proteomes of normal human bronchial epithelial cells are unique for individual people and also respond to infection by the influenza A virus in different ways, findings which could be used to identify people more susceptible to the disease.

Read More thumbnail image: Influenza A proteins Individual proteome variations

Discover leading research in cannabis detection

Date: Oct 3, 2017

Author:

Cannabinoid research from an analytical viewpoint is rapidly developing as a more liberal approach to the medical, legal and social issues of the drug is adopted. Start reading our cannabinoid collection of papers here - free to access until the end of December.

Read More thumbnail image: Discover leading research in cannabis detection

Journal Highlight: A comparative analysis of human plasma and serum proteins by combining native PAGE, whole-gel slicing and quantitative LC-MS/MS: Utilizing native MS-electropherograms in proteomic analysis for discovering structure and interaction-correlated differences

Date: Oct 2, 2017

Author: separationsNOW

A new method combines native PAGE, whole-gel slicing and quantitative LC-MS/MS for the comparative analysis of proteins based not only on abundance, but also on their structures and interactions.

Read More thumbnail image: Journal Highlight A comparative analysis of human plasma and serum proteins by combining native PAGE whole-gel slicing and quantitative LC-MSMS Utilizing native MS-electropherograms in proteomic analysis for discovering structure and interaction-correlated differences

SCUBA diver proteome: Decompression stress vs. decompression sickness

Date: Oct 1, 2017

Author: Steve Down

In a follow-up study of the effects of decompression sickness on the proteome of rats, an international team of scientists has examined the effects of decompression stress on SCUBA divers in the absence of decompression sickness.

Read More thumbnail image: SCUBA diver proteome Decompression stress vs_ decompression sickness
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