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Sputum proteome: Optimising label-free mapping

Date: Jul 15, 2018

Author: Steve Down

The healthy human sputum proteome has been derived in an international project, assessing the sources of variability and revealing a core set of 284 proteins that will be useful for studying patients with inflammatory respiratory diseases.

Read More thumbnail image: Sputum proteome Optimising label-free mapping

Journal Highlight: Membrane proteome of invasive retinoblastoma: Differential proteins and biomarkers

Date: Jul 2, 2018

Author: separationsNOW

The first comprehensive quantitative membrane proteomic atlas of the differentially regulated proteins in retinoblastoma compared to the retina has identified potential biomarkers for this childhood cancer.

Read More thumbnail image: Journal Highlight Membrane proteome of invasive retinoblastoma Differential proteins and biomarkers

Graphene oxide nanomaterials: Toxicity mechanisms

Date: Jul 1, 2018

Author: Steve Down

Typical environmental levels of graphene oxide nanoparticles modify the abundances of nearly 250 proteins in zebrafish larvae, tested as a model aquatic species, and bring about malformations and increased mortality, a new proteomics study has revealed.

Read More thumbnail image: Graphene oxide nanomaterials Toxicity mechanisms

Asthma control: Protein biomarkers

Date: Jun 15, 2018

Author: Steve Down

A proteomics study has identified a link between the levels of proteins in the serum and sputum of asthmatics for whom the disease is poorly controlled, providing early indications when further clinical intervention is needed to give a better outcome.

Read More thumbnail image: Asthma control Protein biomarkers

Journal Highlight: An integrated course based on two dimensional‐electrophoresis and mass spectrometry analysis to teach proteomic techniques for undergraduate students

Date: Jun 4, 2018

Author: separationsNOW

An integrated course based on 2D gel electrophoresis and mass spectrometry provides undergraduates with an opportunity to systematically understand the proteomic techniques and their applications in current scientific research.

Read More thumbnail image: Journal Highlight An integrated course based on two dimensionalelectrophoresis and mass spectrometry analysis to teach proteomic techniques for undergraduate students

Nicotine proteome effects: Tissue-specific alterations

Date: Jun 1, 2018

Author: Steve Down

US scientists have found that up to 126 proteins in seven tissue types were affected by oral exposure of mice to nicotine, sending warning signals to consumers who smoke electronic cigarettes under the misapprehension that they are safe.

Read More thumbnail image: Nicotine proteome effects Tissue-specific alterations

Sample preparation in proteomics: Method bias

Date: May 15, 2018

Author: Steve Down

A comparison of four commonly used proteomics sample preparation methods for head and neck tissues has revealed that there is no universal method, each having their own deficiencies and advantages.

Read More thumbnail image: Sample preparation in proteomics Method bias

Postmortem interval: Forensic proteomic pointers

Date: May 1, 2018

Author: Steve Down

A proteomics study of decaying bones has thrown up a number of proteins that might prove to be valuable markers of the skeletal postmortem interval as an aid to forensic scientists.

Read More thumbnail image: Postmortem interval Forensic proteomic pointers

Journal Highlight: Cell‐free DNA blood collection tubes are appropriate for clinical proteomics: A demonstration in colorectal cancer

Date: Apr 30, 2018

Author: separationsNOW

A proteomics study of colorectal cancer patients has shown that optimized blood collection tubes are appropriate for low‐abundant plasma protein analysis and can be used with confidence for clinical proteomics.

Read More thumbnail image: Journal Highlight Cellfree DNA blood collection tubes are appropriate for clinical proteomics A demonstration in colorectal cancer

Anton Checkov: Cause of death questioned

Date: Apr 15, 2018

Author: Steve Down

Proteome analysis of brown stains on archived personal items of Anton Checkov has yielded proteins related to Mycobacterium tuberculosis, confirming that he had tuberculosis at time of death, but another protein suggests that there may have been a different cause of death.

Read More thumbnail image: Anton Checkov Cause of death questioned
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