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Acupuncture for vascular dementia: Proteins implicated

Date: Nov 15, 2018

Author: Steve Down

The molecular mechanisms behind the improvement of vascular dementia initiated by acupuncture have been investigated by Chinese scientists who used proteomics to indicate that proteins involved in oxidative stress, apoptosis and synaptic function were affected.

Read More thumbnail image: Acupuncture for vascular dementia Proteins implicated

Meat adulteration: Substitute meats and allergens

Date: Nov 2, 2018

Author: Steve Down

The adulteration of meat and meat products by other types of meat or allergenic foods such as egg white, soy and milk has been accomplished using a stable-isotope-labelled quantification strategy by scientists in Poland.

Read More thumbnail image: Meat adulteration Substitute meats and allergens

Journal Highlight: Updates of the in‐gel digestion method for protein analysis by mass spectrometry

Date: Oct 29, 2018

Author: separationsNOW

The in-gel digestion process for the analysis of proteins by LC/MS has been updated by using alternative reducing and alkylating agents and tryptic digestion buffers to give superior protein identification and sequence coverage with reduced side reactions and handling time.

Read More thumbnail image: Journal Highlight Updates of the ingel digestion method for protein analysis by mass spectrometry

Journal Highlight: Structural elucidation of trace components combining GC/MS, GC/IR, DFT‐calculation and synthesis ‐ Salinilactones, unprecedented bicyclic lactones from Salinispora bacteria

Date: Oct 15, 2018

Author: separationsNOW

Salinilactones displaying an unusual bicyclic [3.1.0]‐lactone skeleton that are structurally closely related to the A‐factor class of compounds have been identified in marine Salinispora bacteria using GC/MS, GC/IR, DFT‐calculation and synthesis.

Read More thumbnail image: Journal Highlight Structural elucidation of trace components combining GCMS GCIR DFTcalculation and synthesis  Salinilactones unprecedented bicyclic lactones from Salinispora bacteria

Forensic biofluids under fingernails: Combined genomic and proteomic approach

Date: Oct 15, 2018

Author: Steve Down

A combined approach involving DNA profiling and proteome analysis has been applied to the analysis of traces of biofluids trapped under fingernails to provide forensic evidence, using a single microswab for both procedures.

Read More thumbnail image: Forensic biofluids under fingernails Combined genomic and proteomic approach

Rapid enzyme digestion: Greater proteome coverage

Date: Oct 2, 2018

Author: Steve Down

Rapid enzymatic processing of proteins over a few minutes in proteomic studies to give only partial digestion is at least as good as complete digestion, say US researchers, providing a valid alternative that streamlines and speeds up proteome characterisation.

Read More thumbnail image: Rapid enzyme digestion Greater proteome coverage

Journal Highlight: Further evidence for sustainable alternatives to replace threatened animal horn based on quantitative proteomic analysis

Date: Oct 1, 2018

Author: separationsNOW

Quantitative proteomics has been used to compare the proteome in horns from endangered species (rhinoceros, Saiga antelope, Tibetan antelope) and common species (yak, water buffalo, goat) to build evidence for sustainable alternatives to replace animal horn from threatened species.

Read More thumbnail image: Journal Highlight Further evidence for sustainable alternatives to replace threatened animal horn based on quantitative proteomic analysis

Hepatitis C treatment: Antiviral response prediction

Date: Sep 17, 2018

Author: Steve Down

A combined proteomics and pharmacogenomics approach to the treatment of hepatitis C with direct acting antiviral therapies has identified three peptides derived from human corticosteroid binding globulin that can predict the response to treatment.

Read More thumbnail image: Hepatitis C treatment Antiviral response prediction

Journal Highlight: A perspective view of top‐down proteomics in snake venom research

Date: Sep 3, 2018

Author: separationsNOW

The advantages of intact protein measurements with top‐down mass spectrometric strategies compared with bottom-up procedures for identifying snake venom proteoforms and localizing their modifications and sequence variations have been discussed.

Read More thumbnail image: Journal Highlight A perspective view of topdown proteomics in snake venom research

Music therapy: Proteome implications

Date: Sep 1, 2018

Author: Steve Down

A proteomics study of the effects of musical stimulation on spatial learning and memory in rats has implicated a pair of proteins that could provide a basis for studying clinical applications of music therapy in humans.

Read More thumbnail image: Music therapy Proteome implications
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