Peptide Hormones in Sports Drug Testing: Detection of Emerging Protein/Peptide Based Drugs by Means of LC-MS

Peptide Hormones in Sports Drug Testing:
Detection of Emerging Protein/Peptide Based Drugs by Means of LC-MS

Broadcast on November 10, 2016
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Therapeutic proteins and peptides have emerged as one of the most important classes of new pharmaceuticals. Several drug candidates with potential performance-enhancing properties are currently in preclinical or clinical development. The current version of the WADA Prohibited List includes a variety of protein/peptide-based doping agents, some of which can be detected in biological samples by using immunological and mass spectrometry-based approaches.

Dr. Katja Walpurgis and Andreas Thomas of the Center for Preventive Doping Research of the German Sport University Cologne will present novel classes of protein-/peptide-based drugs such as Fc-fusion proteins and discuss strategies for their detection in doping control samples by means of the ACQUITY UPLC System and the SYNAPT G2S.

What will I learn?

• How novel protein-/peptide-based drugs such as Fc-fusion proteins and therapeutic antibodies can be detected in human matrices by using different proteomics techniques in combination with high resolution mass spectrometry.
• How ion mobility can help to identify prohibited substances in complex biological matrices.

Who should attend?

• Sports doping laboratories (human and animal doping)
• Forensic toxicology laboratories
• Drug testing laboratories
• Institutes of legal medicine
• Police forensic laboratories
• State crime laboratories
• People involved in toxicology research
• People interested in detecting novel protein/peptide therapeutics

   Your Presenters

Dr Katja Walpurgis

Postdoctoral Researcher
Institute of Biochemistry,
German Sport University
Cologne

Katja Walpurgis: Biography

Katja Walpurgis is a postdoctoral researcher at the Center for Preventive Doping Research/Institute of Biochemistry of the German Sport University Cologne. Her work focuses on the development of novel detection methods for performance-enhancing protein drugs by using different proteomics techniques such as gel electrophoresis, western blotting, and high resolution accurate mass LC-MS.

Dr. Andreas Thomas

Senior Scientist
Institute of Biochemistry,
German Sport University
Cologne

Dr Andreas Thomas: Biography

Andreas Thomas works as a senior scientist in the field of doping control analysis for more than 12 years. His special interest is focused on identification of prohibited substances such as small molecules, peptides and proteins by means of LC-MS.

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