Comprehensive Characterization of Proteins using a Novel Orbitrap Tribrid Mass Spectrometer – The Game Changer for PTM Analysis

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Webinar

  • Date: Dec 3, 2013 - 15:00 - 16:00 (local time)
  • Presenter: Shannon Eliuk and Rosa VinerThermo
  • Categories: Proteomics & Genomics / Proteomics / Base Peak
thumbnail image: Comprehensive Characterization of Proteins using a Novel Orbitrap Tribrid Mass Spectrometer – The Game Changer for PTM Analysis

Comprehensive Characterization of Proteins using a
Novel Orbitrap Tribrid Mass Spectrometer:
The Game Changer for PTM Analysis


Broadcast on December 3, 2013
his webinar is now available on-demand.
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Phosphorylation and glycosylation are two common posttranslational modifications (PTMs) of proteins that perform critical roles in the regulation of many cellular processes including cell cycle, signal transduction pathways, recognition, gene expression and cellular immunity.

Mass spectrometry is a powerful tool for the detection and identification of PTMs. Comprehensive characterization of proteins include localization of the modification site, characterization of structures and quantification of the various modified forms to fully understand the effect on protein function. Electron Transfer Dissociation (ETD) is a fragmentation technique that has been used enthusiastically for peptide identification, localization of labile post-translational modifications (PTMs) and sequence polymorphisms.

This webinar demonstrates the advantages of using a novel Orbitrap mass spectrometer for qualitative and quantitative PTM analysis. The novel arrangement of the three mass analyzers plus advances in software not only increases the rate of high quality ETD spectra, but also the ease of routinely obtaining high quality ETD data.

Enhanced peptide ID will be discussed as well as PTM identification and localization for both phosphorylation and glycosylation.

Key Learning Objectives:

  • Understanding unique capabilities of Orbitrap Fusion MS and ETD for PTM analysis
  • Complete quantitative and qualitative PTM workflows

Who Should Attend?

  • Protein Chemists
  • Biologists
  • Proteomics Researchers 

Your Presenters

Shannon Eliuk

Shannon Eliuk

New Technology Development Specialist
Life Science Mass Spectrometry
Thermo Fisher Scientific

Shannon Eliuk: Biography

Shannon Eliuk did her graduate studies at University of Alabama at Birmingham focusing on applying mass spectrometry to study protein oxidation in Alzheimer's disease. She then joined the lab of Prof. Al Burlingame at University of California San Francisco as a post-doctoral scholar where she performed a variety of proteomics techniques including top down, middle down and bottom up proteomics combined with label free and SILAC-based quantitation to study histone modifications in embryonic stem cells. After joining Thermo Fisher Scientific three and a half years ago, she worked on many application and instrument development projects, most recently the exciting new development of Orbitrap Fusion with ETD.

Rosa Viner

Rosa Viner

Proteomics Program Manager
Life Science Mass Spectrometry
Thermo Fisher Scientifc

Rosa Viner: Biography

Rosa Viner holds a Ph.D. in Biochemistry and Biophysics from the Moscow State University, Russia. She joined Thermo Fisher Scientific in 2004 and is currently the Program Manager for proteomics at Thermo Fisher Scientific in San Jose, CA. She is involved in all areas of proteomics research with specific focus on relative quantification and PTM analysis. She also is responsible for the development of the next generation MS reagents and standards including TMT isobaric tags and glycoproteomics workflow.

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In association with:
  
Pittcon 2014

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