Proteomics Delivers on its Promise: Using Innovative Mass Spectrometry to Pave the Way for Multi-protein Biomarker Verification

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Webinar

  • Date: Jun 15, 2010 - 15:00 - 16:00 (local time)
  • Categories: Proteomics & Genomics / Proteomics
thumbnail image: Proteomics Delivers on its Promise: Using Innovative Mass Spectrometry to Pave the Way for Multi-protein Biomarker Verification

Proteomics Webinar from Thermo Scientific

Thermo Scientific

Proteomics Delivers on its Promise:
Using Innovative Mass Spectrometry to Pave the Way
for Multi-protein Biomarker Verification

The primary goal of this presentation is to highlight a workflow for the integration of unbiased biomarker discovery with hypothesis-driven, targeted assay development in a seamless manner. Mass spectrometry has typically been the technology of choice in the search for proteomic biomarkers, but the translation of this information into high-throughput assays that facilitate the verification of putative markers has not been straightforward.

SRM-based assays provide a powerful vehicle for the verification and implementation of putative biomarker information derived from high resolution LC-MS/MS experiments because of their selectivity, sensitivity, robustness and speed.

In this report, we describe the development and application of bioinformatic algorithms, including a novel application of ROC curves allowing efficient mining of LC-MS/MS discovery data with subsequent integration into SRM methods, thus paving the way for future biomarker verification with larger clinical cohorts.



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Your Presenter

Dr. Mary F LopezMary F. Lopez, Ph.D.
Director, Thermo Fisher Scientific BRIMS

Dr. Lopez is currently Director of the Thermo Fisher Scientific BRIMS (Biomarker Research Initiatives in Mass Spectrometry) Center in Cambridge, MA where she is in charge of developing comprehensive, MS-based workflows from sample preparation to bioinformatic analysis for robust biomarker discovery and clinical validation. Previously, Dr. Lopez held positions as Strategic Collaborations Leader and Analytical Proteomics Business Leader at PerkinElmer Life and Analytical Sciences in Waltham, MA and Executive Vice President of Proteomics Research and Development at Proteome Systems.

Since 1989, Dr. Lopez has worked in the fields of proteomics, electrophoresis and protein chemistry and served as Vice President of Proteomics R&D at Genomic Solutions Inc., Director of Chromatography Applications, PerSeptive BioSystems and Senior Scientist, Millipore Corp. Dr. Lopez was a Post Doctoral NIH Fellow at MIT and received her Ph.D. in Botany from the University of Massachusetts, Amherst, MA in 1985. Dr. Lopez has published extensively in the Proteomics field and serves on the Scientific Advisory Board of the Buck Institute for Age Research in Novato, CA.

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