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Frankincense: from biblical incense to anti-inflammatory

Date: Nov 1, 2015

Author: Ryan De Vooght-Johnson

Frankincense has been used as a traditional medicine for thousands of years, and its anti-inflammatory properties are now gathering interest in the pharmaceutical industry. In a new study, scientists describe a way of identifying the type of frankincense and evaluating its quality, which could be applied to other traditional medicines.

Read More thumbnail image: Frankincense from biblical incense to anti-inflammatory

Journal Highlight: Fingerprint analysis, multi-component quantitation, and antioxidant activity for the quality evaluation of Salvia miltiorrhiza var. alba by HPLC and chemometrics

Date: Oct 26, 2015

Author: separationsNOW

Chinese scientists have used liquid chromatography and various multivariate statistical techniques to identify the constituents of the medicial herb Salvia miltiorrhiza that are responsible for its antioxidant activity.

Read More thumbnail image: Journal Highlight Fingerprint analysis multi-component quantitation and antioxidant activity for the quality evaluation of Salvia miltiorrhiza var_ alba by HPLC and chemometrics

Proteins in parallel: New tool to compare protein expression could accelerate research

Date: Oct 12, 2015

Author: Ryan De Vooght-Johnson

Usually only a small percentage of proteins can be compared across samples in LC–MS/MS. A new software package, called MZDASoft, can integrate data from multiple samples, allowing clinical researchers to compare samples from many different patients.

Read More thumbnail image: Proteins in parallel New tool to compare protein expression could accelerate research

Bioinformatics tool rapidly verifies prostate cancer biomarkers

Date: Oct 1, 2015

Author: Ryan De Vooght-Johnson

Mass spectrometry is widely used to discover candidate biomarkers from complex samples of proteins. Yet, owing to sensitivity limitations, many biomarkers cannot be detected by standard mass spectrometers. Surface-activated chemical ionisation combined with an electrospray ionisation source can overcome some of these limitations.

Read More thumbnail image: Bioinformatics tool rapidly verifies prostate cancer biomarkers

Journal Highlight: Cluster analysis of commercial samples of Bauhinia spp. using HPLC-UV/PDA and MCR-ALS/PCA without peak alignment procedure

Date: Sep 21, 2015

Author: separationsNOW

Using cluster analysis on HPLC data, scientists from Australia and Brazil have been able to identify authentic samples of a Brazilian medicinal plant used to treat hypoglycemia and diabetes.

Read More thumbnail image: Journal Highlight Cluster analysis of commercial samples of Bauhinia spp_ using HPLC-UVPDA and MCR-ALSPCA without peak alignment procedure

Journal Highlight: Derivatization of bisphenol A and its analogues with pyridine-3-sulfonyl chloride: multivariate optimization and fragmentation patterns by LC/Orbitrap MS

Date: Sep 14, 2015

Author: separationsNOW

Belgian researchers have used multivariate statistical techniques to investigate the fragmentation patterns produced when derivatized bisphenols are analyzed by liquid chromatography/mass spectrometry.

Read More thumbnail image: Journal Highlight Derivatization of bisphenol A and its analogues with pyridine-3-sulfonyl chloride multivariate optimization and fragmentation patterns by LCOrbitrap MS

Shaping up to DNA damage: A novel software tool for analyzing comet assays

Date: Sep 7, 2015

Author: Jon Evans

Comet assays are a widely-used method for identifying DNA damage, but a new software tool now allows them to determine how the DNA was damaged as well.

Read More thumbnail image: Shaping up to DNA damage A novel software tool for analyzing comet assays

Journal Highlight: A systems-level “misunderstanding”: the plasma metabolome in Huntington's disease

Date: Aug 17, 2015

Author: separationsNOW

By applying multivariate statistical modeling to the data produced by LC-MS, US scientists have identified some metabolomic perturbations characteristic of the neurodegenerative disorder known as Huntington's disease.

Read More thumbnail image: Journal Highlight A systems-level misunderstanding the plasma metabolome in Huntingtons disease

Journal Highlight: Numerical modeling of capillary electrophoresis – electrospray mass spectrometry interface design

Date: Aug 10, 2015

Author: separationsNOW

This review evaluates various different aspects of computer modeling and simulation of CE-ESI-MS interfaces, including electric field mediated flows, electrohydrodynamics and free fluid-surface methods.

Read More thumbnail image: Journal Highlight Numerical modeling of capillary electrophoresis  electrospray mass spectrometry interface design

Probably near the peak: A novel algorithm for peak detection

Date: Aug 3, 2015

Author: Jon Evans

Rather than use arbitrary thresholds to highlight analyte peaks, two Dutch chemists are using a form of probability originally developed in the 18th century.

Read More thumbnail image: Probably near the peak A novel algorithm for peak detection
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