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Informatics securely separates snow lotus species

Date: Oct 1, 2017

Author: Ryan De Vooght-Johnson

The snow lotus is a plant used in traditional Chinese medicine, but there has long been confusion between the three different Saussurea species called by this name. Researchers from Hong Kong Baptist University, the Chinese University of Hong Kong and the Sichuan Academy of Chinese Medical Sciences used UHPLC-MS together with principal component analysis (PCA) and hierarchical cluster analysis (HCA) to distinguish between the three species on the basis of their typical chemical composition.

Read More thumbnail image: Informatics securely separates snow lotus species

Mixed-mode model made for medicinal antibodies

Date: Sep 16, 2017

Author: Ryan De Vooght-Johnson

Mixed-mode chromatography (MMC), which combines the properties of ion-exchange chromatography (IEC) and hydrophobic interaction chromatography (HIC), is increasingly used for the purification of various proteins, such as medicinal antibodies. Scientists from Mannheim University of Applied Sciences and Roche Pharmaceuticals’ Munich site developed equations to predict the elution of a bispecific antibody from an MMC column.

Read More thumbnail image: Mixed-mode model made for medicinal antibodies

Journal Highlight: Fast and simple discriminative analysis of anthocyanins-containing berries using LC/MS spectral data

Date: Sep 11, 2017

Author: separationsNOW

An alternative approach for the quality assessment and discrimination of anthocyanin-containing berries has been developed using mass spectral data acquired in a short analytical time rather than UV or MS chromatograms.

Read More thumbnail image: Journal Highlight Fast and simple discriminative analysis of anthocyanins-containing berries using LCMS spectral data

MS muddle made manageable by mulitplierz software

Date: Sep 6, 2017

Author: Ryan De Vooght-Johnson

The diversity of current mass spectrometry methods and software tools has led to multiple arrays of data that are not readily comparable. Researchers from Harvard Medical School and the Dana-Farber Cancer Institute in Boston have reported on the latest version of their multiplierz software, which aims to provide a common platform for mass spectrometry proteomic data.

Read More thumbnail image: MS muddle made manageable by mulitplierz software

No standards involved, but are all problems solved?

Date: Aug 15, 2017

Author: Ryan De Vooght-Johnson

Modern analytical techniques, such as HRMS (high-resolution mass spectrometry), enable the simultaneous detection of a large number of compounds, but normally rely on analytical standards of all the compounds being available, which may not be the case. Researchers from the Zurich Official Food Control Authority have developed an LC-HRMS method that identifies compounds without the use of standards, demonstrating its efficiency by identifying veterinary compounds spiked into meat and fish extracts.

Read More thumbnail image: No standards involved but are all problems solved

Journal Highlight: Untargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men: A noninvasive detection of spermatogenesis

Date: Aug 8, 2017

Author: separationsNOW

Untargeted metabolomic profiling of the seminal plasma in men with nonobstructive azoospermia was studied by GC/MS and advance chemometrics, leading to 36 potential biomarkers of the condition.

Read More thumbnail image: Journal Highlight Untargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men A noninvasive detection of spermatogenesis

Hydrophilic interactions change along with volume fractions

Date: Aug 1, 2017

Author: Ryan De Vooght-Johnson

Hydrophilic interaction liquid chromatography (HILIC) is a relatively new method, so theoretical work on the relationships between its parameters is not as extensive as with older techniques. Scientists from the University of Belgrade looked at the association between peak retention and mobile phase composition for HILIC on the antipsychotic drug olanzapine and its impurities using various theoretical models.

Read More thumbnail image: Hydrophilic interactions change along with volume fractions

Weighing up ways of working out log P

Date: Jul 15, 2017

Author: Ryan De Vooght-Johnson

Lipophilicity is a key parameter affecting the activity of potential drug molecules, but there are many methods to calculate it. Scientists from the University of Belgrade examined various techniques for calculating the lipophilicity of a number of benzothiepino[3,2-c]pyridine derivatives, which were potential antifungal drugs.

Read More thumbnail image: Weighing up ways of working out log P

Journal Highlight: Synergetic use of principal component analysis applied to normed physicochemical measurements and GC × GC-MS to reveal the stabilization effect of selected essential oils on heated rapeseed oil

Date: Jul 10, 2017

Author: separationsNOW

The potential antioxidant effect of corainder and nutmeg essential oils on the thermal stability of rapeseed oil was determined by GCxGC/MS with PCA.

Read More thumbnail image: Journal Highlight Synergetic use of principal component analysis applied to normed physicochemical measurements and GC  GC-MS to reveal the stabilization effect of selected essential oils on heated rapeseed oil

DEREK peers at plethora of products in rat urine

Date: Jul 1, 2017

Author: Ryan De Vooght-Johnson

Fluvastatin is a commonly used statin compound, so it is important to carefully study its metabolites. Researchers based at the National Institutes of Pharmaceutical Education and Research in Hyderabad and S.A.S Nagar examined the metabolites of fluvastatin formed in vivo by rats, along with those formed in vitro by human or rat liver microsomes, using UHPLC-MS/MS. They subsequently ran in silico toxicity studies on these compounds.

Read More thumbnail image: DEREK peers at plethora of products in rat urine
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