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Network premiere for fumarase-insufficient cells

Date: Jan 16, 2018

Author: Ryan De Vooght-Johnson

Fumarase is an important enzyme, and work with rats suggested that low levels may affect amino acid levels and possibly be associated with hypertension. Scientists in China have examined the metabolites of human cells that had been genetically altered to be deficient in fumarase, comparing them to the metabolites from control cells using GC-MS and chemometric methods, such as pathway analysis.

Read More thumbnail image: Network premiere for fumarase-insufficient cells

Journal Highlight: Metabolite profiling of peppers of various colors reveals relationships between tocopherol, carotenoid, and phytosterol content

Date: Jan 8, 2018

Author: separationsNOW

The contents of various metabolites in peppers of various colors (green, red, pale green, and violet peppers) and in a high-pungency (green) pepper have been measured and correlated using PCA, Pearson's correlation analysis and hierarchical clustering analysis.

Read More thumbnail image: Journal Highlight Metabolite profiling of peppers of various colors reveals relationships between tocopherol carotenoid and phytosterol content

Chemometrics gets to the root of TCM UHPLC data

Date: Jan 1, 2018

Author: Ryan De Vooght-Johnson

Morinda root, or ba ji tian, is commonly used in traditional Chinese medicine for a variety of conditions, but there is a lack of analytical methods that give an overall picture of the active compounds present. Researchers from the Institute of Medicinal Plant Development in China have developed a method using UHPLC to assay 11 bioactive compounds in morinda root, classifying samples by means of hierarchical cluster analysis, principal component analysis and partial least-squares discriminant analysis.

Read More thumbnail image: Chemometrics gets to the root of TCM UHPLC data

Chemometrics shown to fix complexity of herbal mix

Date: Dec 14, 2017

Author: Ryan De Vooght-Johnson

Lianqiao Baidu pills are a popular traditional Chinese medicine made from a mixture of herbal ingredients, but up to now there has been no accurate way to analyse their quality. Researchers from Shenyang Pharmaceutical University in China categorised the quality of this material using extraction, HPLC, measurements of its antioxidant power and chemometric methods.

Read More thumbnail image: Chemometrics shown to fix complexity of herbal mix

Journal Highlight: Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC-Q-TOF/MS and multivariate data analysis

Date: Dec 4, 2017

Author: separationsNOW

The underlying mechanism of cytotoxicity on HepG2 cells of cationic liposomes, used in drug and gene delivery has been studied by LC/MS supported by multivariate data analysis and statistics.

Read More thumbnail image: Journal Highlight Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC-Q-TOFMS and multivariate data analysis

Box–Behnken design makes rhubarb extracts fine

Date: Dec 1, 2017

Author: Ryan De Vooght-Johnson

Medicinal rhubarb has long being used in traditional Chinese medicine, but accurate assays of its many active compounds are hampered by the expense of analytical standards. Scientists from Tianjin University and Tianjin University of Traditional Chinese Medicine have developed a new methods of assaying multiple rhubarb compounds by quantitative analysis of multi-components with a single marker (QAMS), while also optimising their extraction with a Box–Behnken design.

Read More thumbnail image: BoxBehnken design makes rhubarb extracts fine

CID detects triglyceride positional isomers

Date: Nov 15, 2017

Author: Ryan De Vooght-Johnson

The amount and types of triglycerides (fats and oils) in the diet are linked to a number of disease conditions, but current methods of determining the exact position of the fatty acids on the glycerol portion of these compounds are slow and cumbersome. Scientists from the University of Massachusetts Boston have devised a new method employing mass spectrometry to distinguish between the different positional isomers of triglycerides.

Read More thumbnail image: CID detects triglyceride positional isomers

Journal Highlight: Edible mushrooms: a potential source of essential amino acids, glucans and minerals

Date: Nov 6, 2017

Author: separationsNOW

The main chemical and biochemical constituents of nine edible mushrooms have been evaluated, principal component analysis to group the mushrooms according to their amino acids, glucans and chemical composition.

Read More thumbnail image: Journal Highlight Edible mushrooms a potential source of essential amino acids glucans and minerals

Clever chemometrics catches funny honey cheats

Date: Nov 1, 2017

Author: Ryan De Vooght-Johnson

Honey commands a variety of prices, depending in part on the source of the nectar from which it is derived, which may lead to fraudulent false labelling. Scientists from the Chinese Academy of Inspection and Quarantine in Beijing and Agilent Technologies (China) have devised a new method for detecting the source of honey samples, using GC-MS combined with chemometric methods.

Read More thumbnail image: Clever chemometrics catches funny honey cheats

Small peaks are amplified when stochastic noise is applied

Date: Oct 15, 2017

Author: Ryan De Vooght-Johnson

Small chromatographic peaks that are hidden by baseline noise can be made clearer by employing stochastic resonance, which involves the addition of a limited amount of additional noise. Researchers from China Pharmaceutical University in Nanjing, Nanjing University of Chinese Medicine and Nanjing Changao Pharmaceutical Technology have reported an improved algorithm for the amplification of peaks using stochastic resonance, demonstrating its use with two different examples.

Read More thumbnail image: Small peaks are amplified when stochastic noise is applied
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