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Small peaks are amplified when stochastic noise is applied

Date: Oct 15, 2017

Author: Ryan De Vooght-Johnson

Small chromatographic peaks that are hidden by baseline noise can be made clearer by employing stochastic resonance, which involves the addition of a limited amount of additional noise. Researchers from China Pharmaceutical University in Nanjing, Nanjing University of Chinese Medicine and Nanjing Changao Pharmaceutical Technology have reported an improved algorithm for the amplification of peaks using stochastic resonance, demonstrating its use with two different examples.

Read More thumbnail image: Small peaks are amplified when stochastic noise is applied

Journal Highlight: Statistical model based HPLC analytical method adjustment strategy to adapt to different sets of analytes in complicated samples

Date: Oct 9, 2017

Author: separationsNOW

HPLC data of traditional Chinese medicines acquired with design of experiments methodology were utilised to build retention models for all the analytes and interferences shown in the chromatograms with multivariate statistical modelling methods.

Read More thumbnail image: Journal Highlight Statistical model based HPLC analytical method adjustment strategy to adapt to different sets of analytes in complicated samples

Discover leading research in cannabis detection

Date: Oct 3, 2017

Author:

Cannabinoid research from an analytical viewpoint is rapidly developing as a more liberal approach to the medical, legal and social issues of the drug is adopted. Start reading our cannabinoid collection of papers here - free to access until the end of December.

Read More thumbnail image: Discover leading research in cannabis detection

Informatics securely separates snow lotus species

Date: Oct 1, 2017

Author: Ryan De Vooght-Johnson

The snow lotus is a plant used in traditional Chinese medicine, but there has long been confusion between the three different Saussurea species called by this name. Researchers from Hong Kong Baptist University, the Chinese University of Hong Kong and the Sichuan Academy of Chinese Medical Sciences used UHPLC-MS together with principal component analysis (PCA) and hierarchical cluster analysis (HCA) to distinguish between the three species on the basis of their typical chemical composition.

Read More thumbnail image: Informatics securely separates snow lotus species

Mixed-mode model made for medicinal antibodies

Date: Sep 16, 2017

Author: Ryan De Vooght-Johnson

Mixed-mode chromatography (MMC), which combines the properties of ion-exchange chromatography (IEC) and hydrophobic interaction chromatography (HIC), is increasingly used for the purification of various proteins, such as medicinal antibodies. Scientists from Mannheim University of Applied Sciences and Roche Pharmaceuticals’ Munich site developed equations to predict the elution of a bispecific antibody from an MMC column.

Read More thumbnail image: Mixed-mode model made for medicinal antibodies

Journal Highlight: Fast and simple discriminative analysis of anthocyanins-containing berries using LC/MS spectral data

Date: Sep 11, 2017

Author: separationsNOW

An alternative approach for the quality assessment and discrimination of anthocyanin-containing berries has been developed using mass spectral data acquired in a short analytical time rather than UV or MS chromatograms.

Read More thumbnail image: Journal Highlight Fast and simple discriminative analysis of anthocyanins-containing berries using LCMS spectral data

MS muddle made manageable by mulitplierz software

Date: Sep 6, 2017

Author: Ryan De Vooght-Johnson

The diversity of current mass spectrometry methods and software tools has led to multiple arrays of data that are not readily comparable. Researchers from Harvard Medical School and the Dana-Farber Cancer Institute in Boston have reported on the latest version of their multiplierz software, which aims to provide a common platform for mass spectrometry proteomic data.

Read More thumbnail image: MS muddle made manageable by mulitplierz software

No standards involved, but are all problems solved?

Date: Aug 15, 2017

Author: Ryan De Vooght-Johnson

Modern analytical techniques, such as HRMS (high-resolution mass spectrometry), enable the simultaneous detection of a large number of compounds, but normally rely on analytical standards of all the compounds being available, which may not be the case. Researchers from the Zurich Official Food Control Authority have developed an LC-HRMS method that identifies compounds without the use of standards, demonstrating its efficiency by identifying veterinary compounds spiked into meat and fish extracts.

Read More thumbnail image: No standards involved but are all problems solved

Journal Highlight: Untargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men: A noninvasive detection of spermatogenesis

Date: Aug 8, 2017

Author: separationsNOW

Untargeted metabolomic profiling of the seminal plasma in men with nonobstructive azoospermia was studied by GC/MS and advance chemometrics, leading to 36 potential biomarkers of the condition.

Read More thumbnail image: Journal Highlight Untargeted metabolomic profiling of seminal plasma in nonobstructive azoospermia men A noninvasive detection of spermatogenesis

Hydrophilic interactions change along with volume fractions

Date: Aug 1, 2017

Author: Ryan De Vooght-Johnson

Hydrophilic interaction liquid chromatography (HILIC) is a relatively new method, so theoretical work on the relationships between its parameters is not as extensive as with older techniques. Scientists from the University of Belgrade looked at the association between peak retention and mobile phase composition for HILIC on the antipsychotic drug olanzapine and its impurities using various theoretical models.

Read More thumbnail image: Hydrophilic interactions change along with volume fractions
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