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Journal Highlight: Denaturing high‐performance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples

Date: Nov 5, 2018

Author: separationsNOW

Principal component analysis has been used to analyze the HPLC chromatograms from 3 different genes acquired under denaturing conditions to identify point mutations.

Read More thumbnail image: Journal Highlight Denaturing highperformance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples

Journal Highlight: Visualization and application of amino acid retention coefficients obtained from modeling of peptide retention

Date: Oct 8, 2018

Author: separationsNOW

A simple method for data inspection in liquid separations of peptides, especially multidimensional separations, using amino acid retention coefficients and their relative change across experiments improves comparability of data at no additional experimental cost.

Read More thumbnail image: Journal Highlight Visualization and application of amino acid retention coefficients obtained from modeling of peptide retention

Journal Highlight: Biomarkers of individual foods, and separation of diets using untargeted LC–MS‐based plasma metabolomics in a randomized controlled trial

Date: Sep 10, 2018

Author: separationsNOW

The effect of the new Nordic diet versus average Danish diet on plasma metabolic profiles has been investigated by LC/MS to identify biomarkers of diet compliance and metabolic effects, using supervised machine learning with feature selection.

Read More thumbnail image: Journal Highlight Biomarkers of individual foods and separation of diets using untargeted LCMSbased plasma metabolomics in a randomized controlled trial

Medicinal mixture made manageable by multiple product ion filtering

Date: Aug 31, 2018

Author: Ryan De Vooght-Johnson

Kai-xin-san is a traditional Chinese medicine (TCM) composed of four herbs and containing a very complex mixture of compounds. Researchers from Shenyang Pharmaceutical University, China, used LC-MS in combination with multiple product ion filtering (mPIF) to identify herbal constituents and metabolites in the plasma and brain tissue of rats that had been fed with the medication.

Read More thumbnail image: Medicinal mixture made manageable by multiple product ion filtering

Chemometrics captures cosmetic contamination compounds

Date: Aug 15, 2018

Author: Ryan De Vooght-Johnson

Glucocorticoid steroids are sometimes illegally added to face masks, but the unambiguous detection and quantification of such compounds can be difficult since they often have similar structures. Researchers from Hunan University, Changsha, China, used LC-MS in combination with an alternating trilinear decomposition (ATLD) algorithm to separate closely related glucocorticoids.

Read More thumbnail image: Chemometrics captures cosmetic contamination compounds

Prediction of GC RT shows impressive accuracy

Date: Aug 10, 2018

Author: Ryan De Vooght-Johnson

The accurate prediction of GC retention times from thermodynamic properties is useful in order to save time and money, but still remains a challenge. Scientists from the University of Alberta, Edmonton, Canada, developed a mathematical model for retention times, successfully applying it to five different compounds.

Read More thumbnail image: Prediction of GC RT shows impressive accuracy

Journal Highlight: Denaturing high‐performance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples

Date: Aug 6, 2018

Author: separationsNOW

PCA was applied to analyze the liquid chromatograms from 3 different genes to identify mutated samples in lymphoma and breast cancer patients with a good ratio of prediction.

Read More thumbnail image: Journal Highlight Denaturing highperformance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples

Journal Highlight: Sample preparation in foodomic analyses

Date: Jul 9, 2018

Author: separationsNOW

The use of highly sophisticated instruments for high‐performance and high‐throughput analyses, as well as miniaturization and the use of laboratory robotics in metabolomics, proteomics, peptidomics, and genomics, have been reviewed.

Read More thumbnail image: Journal Highlight Sample preparation in foodomic analyses

Journal Highlight: Microbial and metabolic multi‐omic correlations in systemic sclerosis patients

Date: Jun 25, 2018

Author: separationsNOW

The fecal microbiota and plasma metabolomes of patients with systemic sclerosis have been characterised, showing that a reduced model of nine bacteria can differentiate patients from healthy controls.

Read More thumbnail image: Journal Highlight Microbial and metabolic multiomic correlations in systemic sclerosis patients

Journal Highlight: Updating chromatographic predictions by accounting ageing for single and tandem columns

Date: Jun 11, 2018

Author: separationsNOW

Models for predicting chromatographic behaviour on single and coupled columns which have aged have been adapted to correct the time and peak profiles.

Read More thumbnail image: Journal Highlight Updating chromatographic predictions by accounting ageing for single and tandem columns
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